HER2-positive breast cancer is associated with aggressive behavior and reduced survival rates. Calcitriol restores the antiproliferative activity of antiestrogens in estrogen receptor (ER)-negative breast cancer cells by re-expressing ERα. Furt...
Survival rates for those with metastatic osteosarcoma (OS) have not improved over the last four decades. It is imperative that novel approaches to treating and curing OS be sought. We, therefore, turned our attention to Brusatol (Bru), a naturally oc...
The IGF-1Eb isoform has been proposed as a stress-responsive variant of IGF-1, yet its significance in cancer remains unclear. This investigation aims to clarify its role across breast, prostate and liver cancer cell lines and determine whether its l...
Electric vehicles (EVs), electric buses (EBs), and battery energy storage system (BESS), as both controllable power sources and load, play a great role in providing flexibility for the power grid, especially with the increased renewable energy penetr...
This paper presents the results of an experimental study involving 20 tests performed on elliptical concrete columns confined with externally bonded carbon fiber-reinforced polymer (EB-CFRP) laminates. The study aimed to evaluate the effects of ellip...
This study aims to assess the similarities and differences between Finland and Spain in terms of Leadership in Energy and Environmental Design for Existing Buildings (LEED-EB) Gold large office building-type projects transitioning from version 3 (v3)...
EB3 protein is expressed abundantly in the nervous system and transiently enters the dendritic spines at the tip of the growing microtubule, which leads to spine enlargement. Nevertheless, the role of dynamic microtubules, and particularly EB3 protei...
In this study, the effects of plasma assistance on the electron beam physical vapour deposition (EB-PVD) process were investigated using an industrial coater (Smart Coater ALD Vacuum Technologies GmbH) equipped with a dual hollow cathode system. This...
Background: Fetal growth restriction (FGR) is associated with placental dysfunction and adverse perinatal outcomes. Although insulin-like growth factor-1 (IGF-1) signaling is important for placental and fetal development, the mRNA expression, immunop...
Electron beam physical vapour deposition (EB-PVD) technology is a standard industrial method for the preparation of a thermal barrier coating (TBC) deposition on aeroengines. The internal stress of EB-PVD TBCs, including stress inside the top coating...
In a high-temperature, high-flame-velocity, and high-pressure gas corrosion environment, the intercolumnar pores and gaps of electron beam–physical vapor deposition (EB-PVD) thermal barrier coatings (TBCs) may serve as infiltration channels for...
The sharing of college food insecurity data with higher education administrators and stakeholders is essential to increase awareness of campus-specific food insecurity outcomes. This study utilized the evidence-Based forecast C-capture, A-assemble, S...
Due to the small variety of materials, the areas of application of additive manufacturing in the toolmaking industry are currently still limited. In order to overcome these material restrictions, AM material development for high carbon-containing iro...
Redundancy and lethality is a long-standing problem in genetics but generating minimal and lethal phenotypes in the knockouts of the same gene by different approaches drives this problem to a new high. In Asn (N)-linked glycosylation, a complex and u...
The solid particle erosion behavior of electron-beam physical vapor deposition (EB-PVD) thermal barrier coatings (TBCs) was numerically evaluated under thermal cycling conditions. The erosion rates were calculated based on the mechanics-based formula...
The paper aims to analyze the extent of Ecosystem Service (ESS) based Adaptation (EbA) to climate change in the policy-making process of Bangladesh. The paper is based on a three stage hybrid policy-making cycle: (i) agenda setting; (ii) policy formu...
The growing complexity of enterprise resource planning (ERP) systems necessitates intelligent approaches for dynamically identifying and evaluating key performance indicators (KPIs) that accurately reflect organizational performance. This paper propo...
The surface condition of the bond coat is an important factor governing the growth and microstructural development of electron-beam physical vapour deposition (EB-PVD) TBCs. In this study, 7 wt.% yttria-stabilised zirconia (7YSZ) coatings were deposi...
High-density polyethylene (HDPE) is a valuable material, but its application under certain operational conditions is limited by oxidation resistance. To mitigate this, rice husk ash (RHA), a silica-rich (~95%) byproduct, was incorporated as a reinfor...
Identifying factors that influence the choice of Leadership in Energy and Environmental Design (LEED) certification strategies for existing office building projects in the United States is a pressing issue requiring attention as it will help LEED pro...
Externally bonded fiber-reinforced polymer (EB-FRP) systems have been extensively investigated for tension strengthening concrete structures. Interpretation of the available evidence remains challenging because experimental methods, specimen scales,...
The stress and deformation sensitivity analysis of high earth-rock dams requires knowledge of the statistical mean and standard deviation of deformation parameters of dam materials. However, these parameters are typically determined through grouped t...
With the development of the automotive industry, the performance of commercial vehicle braking systems is crucial for road traffic safety. However, traditional braking systems are no longer able to meet the growing demand for response speed, control...
Electron beam physical vapour deposition (EB-PVD) is one of the most advanced technologies for manufacturing thermal barrier coatings (TBCs) with a columnar microstructure and excellent durability under high-temperature service conditions. This study...
12 December 2023
Betulin derivatives are proposed to serve as an alternative to the drugs already established in oncologic treatment. Drug-induced nephrotoxicity leading to acute kidney injury frequently accompanies cancer treatment, and thus there is a need to resea...
This paper extends the data-driven computational mechanics paradigm to nonlinear materials characterized by the Duncan–Chang Elastic-Bulk (E-B) constitutive model. Unlike in linear elastic systems, geotechnical media exhibit stress-dependent ta...
Electron beam powder bed fusion (EB-PBF) Ti6Al4V often exhibits high vertical surface roughness, limiting its use in high-end applications. In this study, an infrared continuous-wave laser was applied to precisely polish the vertical surface. An orth...
The impact of small deposits of calcium–magnesium–aluminium silicates (CMAS) on the top of thermal barrier coatings (TBCs) made of yttria-stabilised zirconia (YSZ) produced via electron-beam physical vapour deposition (EB-PVD) is shown to...
A comprehensive analysis of the notch toughness of Electron Beam Powder Bed Fused (EB-PBF) Ti-6Al-4V was conducted, which focused on the influence of build orientation and correlations with key mechanical properties. Horizontal and vertical specimens...
The purpose of this study was to investigate the influence of electron beam (EB) irradiation on the structure and physical properties of Nafion 117 membranes (in both acid and sodium forms) when they are irradiated in water and isopropanol as solvent...
In additive manufacturing, controlling hot cracking in non-weldable nickel-based superalloys poses a significant challenge for forming complex components. This study introduces a multiple preheating process for the forming surface in electron beam po...
Wasp venom allergy can trigger severe allergic reactions, and predicting these acute responses remains challenging. This study evaluates the utility of immune system indexes, particularly the eosinophil–basophil/lymphocyte (EB/LR) and eosinophi...
Rare-earth zirconates are proven to be very effective in restricting the CMAS attack against thermal barrier coatings (TBCs) by forming quick crystalline reaction products that seal the porosity against infiltration. The microstructural effects on th...
Tomographic synthetic aperture radar (TomoSAR) is an advanced three-dimensional (3D) synthetic aperture radar (SAR) imaging technology that can obtain multiple SAR images through multi-track observations, thereby reconstructing the 3D spatial structu...
NaCl is the most abundant salt in seawater, thermal barrier coatings (TBCs) face the challenge of chloride salt hot corrosion in the marine environment. In this work, we focus on evaluating the thermal corrosion cycling of 9 wt.% Y2O3-ZrO2 (YSZ) expo...
The transcription factor EB (TFEB) promotes protein degradation by the autophagy and lysosomal pathway (ALP) and overexpression of TFEB was suggested for the treatment of ALP-related diseases that often affect the heart. However, TFEB-mediated ALP in...
In this paper, the oxidation behavior of the 310H alloy coated with NiCrAlY using the EB-PVD method is studied after exposure to water at a high temperature and pressure (550 °C and 25 MPa) for different periods (720 h, 1440 h, and 2160 h). The E...
Thermal barrier coatings (TBCs) suffer from the thermo-chemo-mechanical coupling action of thermal shock and calcium–magnesium–alumina–silicate (CMAS) corrosion. However, the failure mechanism of TBCs under the synergistic effect of...
Cisplatin, a widely used anticancer agent, can cause nephrotoxicity, including both acute kidney injury (AKI) and chronic kidney diseases, by accumulating in renal tubular epithelial cells (TECs). Mitochondrial pathology plays an important role in th...
The cold gas dynamic spray (CGDS) method has been considered a promising technology to produce a metallic bond coat for thermal barrier coating (TBC) systems. In this study, CoNiCrAlY bond coats produced by CGDS method were coated with yttria-stabili...
There is a gap in the research on LEED-certified projects that has arisen from combining the “old” LEED system and “new” LEED version in green building practice. This study is focused on gold-certified office projects under LE...
A commitment to co-production in which social workers co-create research, knowledge, and practice with people from multi-disciplinary backgrounds and people with direct lived experience of accessing services, who are termed experts by experience (EbE...
To simulate the erosion damage behavior of thermal barrier coatings (TBCs) under actual service conditions in an aircraft engine environment, this study developed a multi-factor coupled test setup capable of simulating combined loading under high-tem...
Machine learning (ML) and deep learning (DL) for big data (BD) management are currently viable approaches that can significantly help in high-temperature materials design and development. ML-DL can accumulate knowledge by learning from existing data...
This study aimed to assess the impact of a four-point bonus system on recertification in Leadership in Energy and Environmental Design for Existing Buildings (LEED-EB) 2009 office space projects in four metropolitan cities: Washington, DC, Chicago, N...
Recent advances in autonomous driving have led to an increased use of LiDAR (Light Detection and Ranging) sensors for high-frequency 3D perceptions, resulting in massive data volumes that challenge in-vehicle networks, storage systems, and cloud-edge...
In the context of increasing interest in ecosystem-based adaptation (EbA), there remains a paucity of discussion regarding the transition from perception to practice in aiding farmer households to adapt to climate change (CC) while maintaining the pr...
Ecosystem-based adaptation (EbA) is a nature-based solution that has gained importance in the context of international climate policy, such as in the EU Adaptation Strategy (2013), which explicitly encourages its adoption and which should continue in...
Powder bed fusion of copper has been extensively investigated using both laser-based (PBF-LB/M) and electron beam-based (PBF-EB/M) additive manufacturing technologies. Each technique offers unique benefits as well as specific limitations. Near-infrar...
Epidermolysis bullosa (EB), also known as Butterfly skin, is a term for a heterogeneous group of rare genodermatosis disorders resulting in painful mucocutaneous blisters and extreme fragility with minor trauma or friction. The low prevalence and het...
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