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1,021 Results Found

  • Article
  • Open Access
6 Citations
1,865 Views
18 Pages

28 July 2022

The conventional torque sharing function (TSF) control strategy in a switched reluctance motor (SRM) has higher torque ripple due to the weak torque tracking ability with an increase in speed. A non-unity torque sharing function (NUTSF) is proposed i...

  • Article
  • Open Access
5 Citations
3,976 Views
15 Pages

CDC42-IQGAP Interactions Scrutinized: New Insights into the Binding Properties of the GAP-Related Domain

  • Niloufar Mosaddeghzadeh,
  • Silke Pudewell,
  • Farhad Bazgir,
  • Neda S. Kazemein Jasemi,
  • Oliver H. F. Krumbach,
  • Lothar Gremer,
  • Dieter Willbold,
  • Radovan Dvorsky and
  • Mohammad R. Ahmadian

The IQ motif-containing GTPase-activating protein (IQGAP) family composes of three highly-related and evolutionarily conserved paralogs (IQGAP1, IQGAP2 and IQGAP3), which fine tune as scaffolding proteins numerous fundamental cellular processes. IQGA...

  • Article
  • Open Access
880 Views
24 Pages

22 September 2025

A novel architectural design is proposed to optimize the thermal management of lithium-ion batteries (LiBs) through a software-enabled switching mechanism. This approach addresses critical challenges such as hot-spot generation, peak temperature rise...

  • Article
  • Open Access
4 Citations
5,497 Views
14 Pages

Binding Specificities of the Telomere Phage ϕKO2 Prophage Repressor CB and Lytic Repressor Cro

  • Jens Andre Hammerl,
  • Claudia Jäckel,
  • Erich Lanka,
  • Nicole Roschanski and
  • Stefan Hertwig

3 August 2016

Temperate bacteriophages possess a genetic switch which regulates the lytic and lysogenic cycle. The genomes of the temperate telomere phages N15, PY54, and ϕKO2 harbor a primary immunity region (immB) comprising genes for the prophage repressor (cI...

  • Article
  • Open Access
3 Citations
2,538 Views
22 Pages

A Novel Impedance Matching of Class DE Inverter for High Efficiency, Wide Impedance WPT System

  • Ping Wang,
  • Qian Li,
  • Yanming Liu,
  • Wei Yuan,
  • Kui Yan and
  • Zixu Pang

In high-frequency wireless power transfer (WPT) applications, Class D, E, and F inverters are most widely used. Class DE inverters combine the respective advantages of Class D and Class E inverters. However, the Class DE inverter is sensitive to chan...

  • Article
  • Open Access
1 Citations
911 Views
22 Pages

A novel architectural design is proposed to mitigate uneven thermal distribution, peak temperature, and heat spot generation, which are common issues that are observed in conventional battery packs. This approach features a multi-terminal configurati...

  • Article
  • Open Access
2,374 Views
13 Pages

30 November 2020

In the past, a two-dimensional aperture diffraction of light in the non-paraxial region could only be studied using the Huygens integral without functional forms. This work presents a special case—a one dimension slit where the functional form...

  • Article
  • Open Access
4 Citations
6,099 Views
12 Pages

20 December 2021

A 1.2 kV SiC MOSFET with an integrated heterojunction diode and p-shield region (IHP-MOSFET) was proposed and compared to a conventional SiC MOSFET (C-MOSFET) using numerical TCAD simulation. Due to the heterojunction diode (HJD) located at the mesa...

  • Article
  • Open Access
6 Citations
4,746 Views
15 Pages

Contribution to the Valuation of BRVM’s Assets: A Conditional CAPM Approach

  • Mamadou Cisse,
  • Mamadou Konte,
  • Mohamed Toure and
  • Smael Afolabi Assani

The conditional capital asset pricing model (CAPM) theory postulates that the systematic risk ( β ) of an asset or portfolio varies over time. Several dynamics are thus given to systematic risk in the literature. This article looks for the dynami...

  • Review
  • Open Access
272 Views
29 Pages

KRAS Inhibition in Pancreatic Ductal Adenocarcinoma

  • Roshini Pradeep,
  • Nooredeen Jamal Isbeih,
  • Freya F. Abraham,
  • Ehsan Noori,
  • Zachary P. Yeung and
  • Madappa N. Kundranda

21 January 2026

KRAS alterations are a hallmark of pancreatic ductal adenocarcinoma (PDAC) found in >90% of tumors. This review examines the historical evolution of the understanding of RAS and its central role in PDAC biology. We summarize the various downstream...

  • Article
  • Open Access
2 Citations
3,727 Views
26 Pages

Multi-formalism Models for Performance Engineering

  • Enrico Barbierato,
  • Marco Gribaudo and
  • Giuseppe Serazzi

Nowadays, the necessity to predict the performance of cloud and edge computing-based architectures has become paramount, in order to respond to the pressure of data growth and more aggressive level of service agreements. In this respect, the problem...

  • Article
  • Open Access
855 Views
30 Pages

Protein kinase CK2 is an important regulator of cell, embryo, and organism function whose transcript levels are often dysregulated in disease. Previous studies have primarily focused on the regulation of CK2 gene expression via the proximal promoter....

  • Article
  • Open Access
21 Citations
7,596 Views
27 Pages

22 September 2016

Speed profile optimization plays an important role in optimal train control. Considering the characteristics of an electrical locomotive with regenerative braking, this paper proposes a new algorithm for target speed profile approximation. This paper...

  • Article
  • Open Access
3 Citations
3,719 Views
11 Pages

Antiretroviral Therapy Switch in HIV-Infected Adults from a Regional HIV/AIDS Center in NE Romania

  • Isabela Ioana Loghin,
  • Șerban Alin Rusu,
  • Andrei Vâţă,
  • Mihaela Cobaschi,
  • Ion Cecan,
  • Carmen Manciuc and
  • Carmen Mihaela Dorobăţ

Background and Objectives: Antiretroviral therapy (ART) has revolutionized the management of HIV infection, transforming it from a once-debilitating disease to a chronic, manageable condition. However, challenges such as treatment resistance, medicat...

  • Article
  • Open Access
7 Citations
3,567 Views
15 Pages

19 January 2023

Odor source localization (OSL) robots are essential for safety and rescue teams to overcome the problem of human exposure to hazardous chemical plumes. However, owing to the complicated geometry of environments, it is almost impossible to construct t...

  • Brief Report
  • Open Access
7 Citations
2,613 Views
6 Pages

Lessons Learned and Future Perspectives for Rotavirus Vaccines Switch in the World Health Organization, Regional Office for Africa

  • Inacio Mandomando,
  • Augusto Messa,
  • Joseph Nsiari-Muzeyi Biey,
  • Gilson Paluku,
  • Mutale Mumba and
  • Jason M. Mwenda

3 April 2023

Background: Following the World Health Organization (WHO) recommendation, 38/47 countries have introduced rotavirus vaccines into the program of immunization in the WHO Regional Office for Africa (WHO/AFRO). Initially, two vaccines (Rotarix and Rotat...

  • Article
  • Open Access
6 Citations
3,840 Views
14 Pages

Evaluation of Different Scenarios to Switch the Whole Regional Bus Fleet of an Italian Alpine Region to Zero-Emission Buses

  • Wolfram Sparber,
  • Andrea Grotto,
  • Pietro Zambelli,
  • Roberto Vaccaro and
  • Alyona Zubaryeva

Public bus decarbonization is increasingly important to address the global issue of climate change. There are several challenges associated with large-scale introduction of zero-emission technologies in public fleets. This is especially the case in a...

  • Article
  • Open Access
285 Views
19 Pages

4 December 2025

Compared to switched reluctance motors, permanent magnet-assisted switched reluctance motor (PMa-SRM) have higher torque density, but the torque ripple remains severe, especially under high speeds or a heavy load. A novel torque shared function (TSF)...

  • Article
  • Open Access
2 Citations
932 Views
16 Pages

31 October 2024

By using a weighted average dwell time approach, the finite-region stability and stabilization problems are investigated for a class of two-dimensional switched systems with actuator saturation in the Fornasini–Marchesini local state-space mode...

  • Article
  • Open Access
1 Citations
2,386 Views
28 Pages

In this paper, the methodology for designing an asymmetrical four-phase 8/6 switched reluctance motor (SRM) that achieves approximately constant output power over a wide speed range is described. In an asymmetrical 8/6 SRM, orthogonal phase pairs are...

  • Article
  • Open Access
15 Citations
3,272 Views
13 Pages

Layered Metallic Vanadium Disulfide for Doubly Q-Switched Tm:YAP Laser with EOM: Experimental and Theoretical Investigations

  • Ziqun Niu,
  • Tianli Feng,
  • Tao Li,
  • Kejian Yang,
  • Jia Zhao,
  • Guiqiu Li,
  • Dechun Li,
  • Shengzhi Zhao,
  • Wenchao Qiao and
  • Kong Gao
  • + 2 authors

3 October 2021

In the current study, layered metallic vanadium disulfide (VS2) is fabricated by a liquid-phase exfoliation method, and its microstructures as well as optical characteristics are investigated. Based on first-principles calculations, the band structur...

  • Article
  • Open Access
6 Citations
3,723 Views
9 Pages

Rigorous Study on Hump Phenomena in Surrounding Channel Nanowire (SCNW) Tunnel Field-Effect Transistor (TFET)

  • Seung-Hyun Lee,
  • Jeong-Uk Park,
  • Garam Kim,
  • Dong-Woo Jee,
  • Jang Hyun Kim and
  • Sangwan Kim

22 May 2020

In this paper, analysis and optimization of surrounding channel nanowire (SCNW) tunnel field-effect transistor (TFET) has been discussed with the help of technology computer-aided design (TCAD) simulation. The SCNW TFET features an ultra-thin tunnel...

  • Article
  • Open Access
47 Citations
5,367 Views
21 Pages

Mutations of Intrinsically Disordered Protein Regions Can Drive Cancer but Lack Therapeutic Strategies

  • Bálint Mészáros,
  • Borbála Hajdu-Soltész,
  • András Zeke and
  • Zsuzsanna Dosztányi

4 March 2021

Many proteins contain intrinsically disordered regions (IDRs) which carry out important functions without relying on a single well-defined conformation. IDRs are increasingly recognized as critical elements of regulatory networks and have been also a...

  • Article
  • Open Access
354 Views
17 Pages

The Region of Attraction for Output Tracking in Probabilistic Boolean Control Networks

  • Bingquan Chen,
  • Yuyi Xue,
  • Meiyu Li,
  • Jin-Jin Mao and
  • Aiju Shi

17 November 2025

This paper investigates the asymptotic output tracking problem in probabilistic Boolean control networks by introducing the concept of the tracking region of attraction (TROA). For a constant reference signal, we provide a formal definition of the TR...

  • Article
  • Open Access
9 Citations
4,358 Views
24 Pages

9 August 2022

This paper studies the speed control strategy of a switched reluctance motor based on angle-position control (APC). The switched reluctance motor has three control parameters: turn-on angle, turn-off angle and voltage PWM duty cycle. This paper studi...

  • Article
  • Open Access
1,342 Views
9 Pages

18 December 2024

In this paper, a two-player nonzero-sum stochastic differential game problem is studied with both players using switching controls. A verification theorem associated with a set of variational inequalities is established as a sufficient criterion for...

  • Feature Paper
  • Review
  • Open Access
26 Citations
7,480 Views
18 Pages

The Regulation of Rab GTPases by Phosphorylation

  • Lejia Xu,
  • Yuki Nagai,
  • Yotaro Kajihara,
  • Genta Ito and
  • Taisuke Tomita

10 September 2021

Rab proteins are small GTPases that act as molecular switches for intracellular vesicle trafficking. Although their function is mainly regulated by regulatory proteins such as GTPase-activating proteins and guanine nucleotide exchange factors, recent...

  • Review
  • Open Access
6 Citations
4,007 Views
13 Pages

Polarization Switching in 2D Nanoscale Ferroelectrics: Computer Simulation and Experimental Data Analysis

  • Ekaterina Paramonova,
  • Vladimir Bystrov,
  • Xiangjian Meng,
  • Hong Shen,
  • Jianlu Wang and
  • Vladimir Fridkin

15 September 2020

The polarization switching kinetics of nanosized ferroelectric crystals and the transition between homogeneous and domain switching in nanoscale ferroelectric films are considered. Homogeneous switching according to the Ginzburg-Landau-Devonshire (LG...

  • Feature Paper
  • Article
  • Open Access
1,761 Views
18 Pages

27 September 2023

In this paper, a new methodology for comparing the cost-effectiveness of sustainable agricultural water policies during times of drought is developed. The methodology explicitly accounts for regional economic impacts from policy implementation and un...

  • Article
  • Open Access
9 Citations
2,701 Views
13 Pages

1 August 2022

This paper studies the stability of linear switched systems with time-varying delays and all unstable subsystems. According to the largest region function strategy, the state-dependent switching rule is designed. By bringing in integral inequality an...

  • Article
  • Open Access
16 Citations
3,053 Views
9 Pages

Tunable Infrared Optical Switch Based on Vanadium Dioxide

  • Qi Wang,
  • Shijie Zhang,
  • Chen Wang,
  • Rui Li,
  • Tianhan Cai and
  • Dawei Zhang

6 November 2021

A tunable infrared optical switch based on a plasmonic structure consisting of aluminum nanoarrays with a thin film of vanadium dioxide is proposed. This optical switch can realize arbitrary wavelength-selective optical switching in the mid-infrared...

  • Article
  • Open Access
15 Citations
4,838 Views
17 Pages

2 August 2018

Using the Markov regime switching approach, we investigate the dependency of short term sovereign credit default swap (SCDS) spread changes on a nation’s country-specific fundamental factors, local, regional and macroeconomic global factors. We...

  • Article
  • Open Access
5 Citations
5,091 Views
13 Pages

23 November 2019

Aimed at reducing the switching loss and common-mode voltage amplitude of high-power medium-voltage three-level inverter under low modulation index conditions, an improved synchronous space vector PWM strategy is proposed in this paper. The switching...

  • Article
  • Open Access
1 Citations
1,104 Views
17 Pages

21 December 2024

The voltage utilization in the PMSM control can be improved through the voltage angle control (VAC) method, thereby enhancing the control efficiency and output power capability. However, the traditional VAC method can only be applied to a high-speed...

  • Article
  • Open Access
11 Citations
3,723 Views
11 Pages

Au Nanoparticles as Template for Defect Formation in Memristive SrTiO3 Thin Films

  • Nicolas Raab,
  • Dirk Oliver Schmidt,
  • Hongchu Du,
  • Maximilian Kruth,
  • Ulrich Simon and
  • Regina Dittmann

23 October 2018

We investigated the possibility of tuning the local switching properties of memristive crystalline SrTiO 3 thin films by inserting nanoscale defect nucleation centers. For that purpose, we employed chemically-synthesized Au nanoparticles depo...

  • Article
  • Open Access
2 Citations
2,088 Views
10 Pages

28 February 2022

By introducing a switching scheme related to the state and time, a typical switched model alternating between a Duffing oscillator and van der Pol oscillator is established to explore the typical dynamical behaviors as well as the mechanism of the sw...

  • Article
  • Open Access
9 Citations
2,560 Views
12 Pages

Low Power Consumption Hybrid-Integrated Thermo-Optic Switch with Polymer Cladding and Silica Waveguide Core

  • Yuqi Xie,
  • Jiachen Han,
  • Tian Qin,
  • Xuyang Ge,
  • Xihan Wu,
  • Lu Liu,
  • Xubin Wu and
  • Yunji Yi

1 December 2022

Taking advantage of the large thermo-optical coefficient of polymer materials, a hybrid-integrated thermo-optic switch was designed and simulated. It is also compatible with the existing silica-based planar light-wave circuit (PLC) platform. To furth...

  • Article
  • Open Access
2,245 Views
13 Pages

Stratosphere: A Fast Virtual Circuit Switch Layer for Data Center Network

  • Lusha Mo,
  • Gaofeng Lv,
  • Baosheng Wang and
  • Xiangrui Yang

The hierarchical structure of the data center network is more and more unsuitable for increasing east-west traffic from virtual machines. Reconfigurable circuit switching is utilized to reduce regional hotspots, which causes the problem of routing os...

  • Article
  • Open Access
1,235 Views
11 Pages

The stability of the avalanche transistor’s (AT’s) switching-on process is essential for its extensive application in power semiconductors. The switching-on process was typically described in one-dimensional terms, overlooking the effects...

  • Article
  • Open Access
2 Citations
3,436 Views
13 Pages

A Novel SiC Vertical Planar MOSFET Design and Optimization for Improved Switching Performance

  • Rui Jin,
  • Zheyang Li,
  • Shijie Liu,
  • Ling Sang,
  • Xiran Chen,
  • Handoko Linewih,
  • Yu Zhong,
  • Feng He,
  • Yawei He and
  • Jisheng Han

13 December 2024

A novel cell topology for a vertical 1200 V SiC planar double-implanted MOSFET (DMOSFET) is proposed in this work. Based on the conventional linear cell topology and the calibrated two-dimensional (2D) technology computer-aided design (TCAD) model pa...

  • Article
  • Open Access
6 Citations
2,605 Views
21 Pages

Application of Inverse Design Approaches to the Discovery of Nonlinear Optical Switches

  • Eline Desmedt,
  • Léa Serrano Gimenez,
  • Freija De Vleeschouwer and
  • Mercedes Alonso

31 October 2023

Molecular switches, in which a stimulus induces a large and reversible change in molecular properties, are of significant interest in the domain of photonics. Due to their commutable redox states with distinct nonlinear optical (NLO) properties, hexa...

  • Article
  • Open Access
1 Citations
2,497 Views
17 Pages

31 August 2020

In this paper, we study the time optimal control problem in a DC-DC buck converter in the underdamped oscillatory regime. In particular, we derive analytic expressions for the admissible regions in the state space, satisfying the condition that every...

  • Article
  • Open Access
11 Citations
2,679 Views
12 Pages

22 August 2022

Combining tunable properties and various functionalities into a single metamaterial structure has become a novel research hotspot and can be used to tackle great challenges. The multifunctional metamaterial structure that combines absorption, linear-...

  • Article
  • Open Access
13 Citations
7,066 Views
13 Pages

Four-Dimensional Thermal Analysis of 888 nm Pumped Nd:YVO4 Dual-Rod Acousto-Optic Q-Switched Laser

  • Yijie Shen,
  • Wenqi Zhang,
  • Mali Gong,
  • Yuan Meng,
  • Yunbin Wang and
  • Xing Fu

A theoretical analysis upon the four-dimensional (4D) spatio-temporal temperature dependent dynamics of 888 nm pumped Nd:YVO 4 dual-rod laser is established, which is valid in both continuous-wave (CW) and acousto-optic (AO) Q-switched pulse...

  • Article
  • Open Access
11 Citations
8,368 Views
19 Pages

Design of a 7.5 kW Dual Active Bridge Converter in 650 V GaN Technology for Charging Applications

  • Alessio Alemanno,
  • Riccardo Morici,
  • Miguel Pretelli and
  • Corrado Florian

High-voltage GaN switches offer low conduction and commutation losses compared with their Si counterparts, enabling the development of high-efficiency switching-mode DC–DC converters with increased switching frequency, faster dynamics, and more...

  • Article
  • Open Access
9 Citations
2,965 Views
23 Pages

23 March 2023

G12 mutations heavily affect conformational transformation and activity of KRAS. In this study, Gaussian accelerated molecular dynamics (GaMD) simulations were performed on the GDP-bound wild-type (WT), G12A, G12D, and G12R KRAS to probe mutation-med...

  • Article
  • Open Access
8 Citations
2,907 Views
23 Pages

This paper proposes a lifespan extension technique for three-phase voltage inverters using hybrid offset voltage. The proposed method lengthens the inverter lifetime by independently adjusting the switching frequency of the three phases in accordance...

  • Article
  • Open Access
3 Citations
2,787 Views
14 Pages

3 November 2020

The present paper proposes a direct space vector modulation and novel balance algorithm for easy software application of three-level converters which operate in three-phase. In the case of the conventional space vector modulation, to get the on-state...

  • Article
  • Open Access
3 Citations
3,538 Views
18 Pages

PV String-Level Isolated DC–DC Power Optimizer with Wide Voltage Range

  • Hyungjin Kim,
  • Gibum Yu,
  • Jaehoon Kim and
  • Sewan Choi

29 March 2021

This paper proposes a photovoltaic (PV) string-level isolated DC–DC power optimizer with wide voltage range. A hybrid control scheme in which pulse frequency modulation (PFM) control and pulse width modulation (PWM) control are combined with a variab...

  • Article
  • Open Access
1,751 Views
25 Pages

To address the problem of problematic spray design inside mining anchor-digging equipment, a switching seal using a permanent magnet eddy current drive is initially presented here. The layer model of the permanent magnet eddy current structure is est...

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