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1,272 Results Found

  • Article
  • Open Access
11 Citations
3,501 Views
20 Pages

Gene Expression and K+ Uptake of Two Tomato Cultivars in Response to Sub-Optimal Temperature

  • Huan Gao,
  • Wanji Yang,
  • Chunxia Li,
  • Xingang Zhou,
  • Danmei Gao,
  • Muhammad Khashi u Rahman,
  • Naihui Li and
  • Fengzhi Wu

3 January 2020

Sub-optimal temperatures can adversely affect tomato (Solanum lycopersicum) growth, and K+ plays an important role in the cold tolerance of plants. However, gene expression and K+ uptake in tomato in response to sub-optimal temperatures are still not...

  • Article
  • Open Access
20 Citations
3,925 Views
16 Pages

The Metabolic Reprogramming Induced by Sub-Optimal Nutritional and Light Inputs in Soilless Cultivated Green and Red Butterhead Lettuce

  • Begoña Miras-Moreno,
  • Giandomenico Corrado,
  • Leilei Zhang,
  • Biancamaria Senizza,
  • Laura Righetti,
  • Renato Bruni,
  • Christophe El-Nakhel,
  • Maria Isabella Sifola,
  • Antonio Pannico and
  • Luigi Lucini
  • + 2 authors

2 September 2020

Sub-optimal growing conditions have a major effect on plants; therefore, large efforts are devoted to maximizing the availability of agricultural inputs to crops. To increase the sustainable use of non-renewable inputs, attention is currently given t...

  • Article
  • Open Access
9 Citations
3,253 Views
11 Pages

Ivermectin Treatment Response in Onchocerca Volvulus Infected Persons with Epilepsy: A Three-Country Short Cohort Study

  • Alfred Dusabimana,
  • Dan Bhwana,
  • Stephen Raimon,
  • Bruno P. Mmbando,
  • An Hotterbeekx,
  • Floribert Tepage,
  • Michel Mandro,
  • Joseph N. Siewe Fodjo,
  • Steven Abrams and
  • Robert Colebunders

Despite a long history of community-directed treatment with ivermectin (CDTI), a high ongoing Onchocerca volvulus transmission is observed in certain onchocerciasis-endemic regions in Africa with a high prevalence of epilepsy. We investigated factors...

  • Article
  • Open Access
814 Views
20 Pages

2 December 2025

Background: Shape memory alloy spring actuators offer significant potential for advanced actuation systems in exoskeletons, medical devices, and robotics, but adoption has been limited by slow activation speeds and insufficient design guidelines for...

  • Article
  • Open Access
13 Citations
4,944 Views
10 Pages

Ambroxol hydrochloride (ABX), an oral mucolytic drug available over the counter for many years, acts as a pharmacological chaperone for mutant glucocerebrosidase, albeit at higher doses. Proof-of-concept reports have been published over the past deca...

  • Article
  • Open Access
1 Citations
1,435 Views
25 Pages

12 March 2024

The suboptimal procedure under consideration, based on the MDR-EFE algorithm, provides sequential selection of relevant (in a sense) factors affecting the studied, in general, non-binary random response. The model is not assumed linear, the joint dis...

  • Article
  • Open Access
2,330 Views
14 Pages

Suboptimal light stress in grapevines is increasing worldwide with the spread of grapevine cultivation, which can affect grapevine physiology and productivity, such as in Southern China. Abscisic acid (ABA) is an important hormone in plant adaptive r...

  • Article
  • Open Access
4 Citations
4,331 Views
14 Pages

13 October 2023

European Society for Blood and Marrow Transplantation (EBMT) hematologic response categories comprehensively assess complement inhibitor responses in patients with paroxysmal nocturnal hemoglobinuria (PNH). Using data from the 16-week randomized cont...

  • Article
  • Open Access
2,322 Views
8 Pages

Can Individuals with Suboptimal Antibody Responses to Conventional Antiviral Vaccines Acquire Adequate Antibodies from SARS-CoV-2 mRNA Vaccination?

  • Wataru Ogura,
  • Kouki Ohtsuka,
  • Sachiko Matsuura,
  • Takahiro Okuyama,
  • Satsuki Matsushima,
  • Satoko Yamasaki,
  • Hiroyuki Miyagi,
  • Kumiko Sekiguchi,
  • Hiroaki Ohnishi and
  • Takashi Watanabe

3 May 2022

In Japan, healthcare workers (HCWs) are vaccinated against measles, rubella, chickenpox, mumps, and hepatitis B to prevent nosocomial infection; however, some do not produce sufficient antibodies (“suboptimal responders”). This study comp...

  • Article
  • Open Access
5 Citations
2,330 Views
11 Pages

Influence of Parental Health Locus of Control on Behavior, Self-Management and Metabolic Control, in Pediatric Patients with Type 1 Diabetes

  • Roberto Franceschi,
  • Marta Canale,
  • Enrico Maria Piras,
  • Lucia Galvagni,
  • Cinzia Vivori,
  • Vittoria Cauvin,
  • Massimo Soffiati and
  • Evelina Maines

27 September 2022

Background: Precision medicine in type 1 diabetes (T1D) treatment considers context and environmental data to subclassify patients. Parental Health Locus of Control PHLOC) could influence behavior, self-management, and metabolic control of children w...

  • Article
  • Open Access
1,240 Views
11 Pages

Predictors of Suboptimal Response After Radiofrequency Ablation of Benign Thyroid Nodules

  • Giacomo Di Filippo,
  • Fabio Medas,
  • Giulia Gobbo,
  • Leonardo Rossi,
  • Giovanni Lazzari,
  • Dorin Serbusca,
  • Eleonora Morelli,
  • Federico Cappellacci,
  • Marco Puccini and
  • Gian Luigi Canu
  • + 1 author

12 August 2025

Objective: Radiofrequency ablation (RFA) has gained recognition as a minimally invasive alternative to surgery for managing symptomatic benign thyroid nodules. However, predicting RFA efficacy remains challenging, especially in identifying patients w...

  • Article
  • Open Access
8 Citations
3,086 Views
19 Pages

ERAP1 and ERAP2 Haplotypes Influence Suboptimal HLA-B*27:05-Restricted Anti-Viral CD8+ T Cell Responses Cross-Reactive to Self-Epitopes

  • Valentina Tedeschi,
  • Giorgia Paldino,
  • Josephine Alba,
  • Emanuele Molteni,
  • Fabiana Paladini,
  • Rossana Scrivo,
  • Mattia Congia,
  • Alberto Cauli,
  • Rosalba Caccavale and
  • Maria Teresa Fiorillo
  • + 5 authors

28 August 2023

The human leukocyte antigen (HLA)-B*27 family of alleles is strongly associated with ankylosing spondylitis (AS), a chronic inflammatory disorder affecting the axial and peripheral joints, yet some HLA-B*27 variants not associated with AS have been s...

  • Article
  • Open Access
11 Citations
6,182 Views
26 Pages

Integrative Transcriptomic and Metabolomic Analysis at Organ Scale Reveals Gene Modules Involved in the Responses to Suboptimal Nitrogen Supply in Tomato

  • Begoña Renau-Morata,
  • Rosa-Victoria Molina,
  • Eugenio G. Minguet,
  • Jaime Cebolla-Cornejo,
  • Laura Carrillo,
  • Raúl Martí,
  • Víctor García-Carpintero,
  • Eva Jiménez-Benavente,
  • Lu Yang and
  • Sergio G. Nebauer
  • + 3 authors

29 June 2021

The development of high nitrogen use efficiency (NUE) cultivars under low N inputs is required for sustainable agriculture. To this end, in this study, we analyzed the impact of long-term suboptimal N conditions on the metabolome and transcriptome of...

  • Article
  • Open Access
4 Citations
2,217 Views
14 Pages

Ethylene Recovery via Pebax-Based Composite Membrane: Numerical Optimization

  • Nadia Hartini Suhaimi,
  • Norwahyu Jusoh,
  • Syafeeqa Syaza Rashidi,
  • Christine Wei Mann Ch’ng and
  • Nonni Soraya Sambudi

18 January 2023

Membrane technology, particularly polymeric membranes, is utilized in major industrial ethylene recovery owing to the very convenient and robust process. Thus, in this paper, a composite membrane (CM) comprising SAPO-34 and Pebax-1657 was employed to...

  • Article
  • Open Access
5 Citations
2,531 Views
14 Pages

29 June 2024

This paper proposes a novel approach that unifies a demand response (DR) with a master plan of the model predictive control method focusing on scheduling maintenance and replacement for suboptimal equipment in real-time solar power plants. By leverag...

  • Article
  • Open Access
6 Citations
1,829 Views
23 Pages

Experimental Investigation and Optimization of the Electrodeposition Parameters of Ni-Al2O3 Composite Coating Using the Taguchi Method

  • Ilias Reddah,
  • Laala Ghelani,
  • Sofiane Touati,
  • Farid Lekmine,
  • Pavol Hvizdoš,
  • Susana Devesa and
  • Haithem Boumediri

18 April 2025

In this work, an experimental investigation is conducted with the aim of optimizing the electrodeposition parameters for Ni-Al2O3 composite coatings using the Taguchi method. The presented research is structured into two complementary sections. The f...

  • Article
  • Open Access
4 Citations
1,873 Views
17 Pages

18 February 2025

In order to achieve precise shaping control of FeCoNi + 1%Y2O3 laser-directed energy deposition (LDED) coatings and to reveal the influence of LDED process parameters on coating morphology, the response surface methodology (RSM) is employed in this s...

  • Article
  • Open Access
6 Citations
2,203 Views
17 Pages

13 October 2022

In this work, NiCo2S4–graphene hybrids (NCS@G) with high electrochemical performance were prepared using a hydrothermal method. The response surface methodology (RSM), along with a central composite design (CCD), was used to investigate the eff...

  • Article
  • Open Access
2 Citations
2,448 Views
13 Pages

10 December 2022

Container technology enables rapid deployment of computing services, while edge computing reduces the latency of task computing and improves performance. However, there are limits to the types, number and performance of containers that can be support...

  • Article
  • Open Access
10 Citations
3,897 Views
7 Pages

Although medical students are at risk of contracting and transmitting communicable diseases, previous studies have demonstrated sub-optimal medical student immunity. The objective of this research was to determine the documented immunity of medical s...

  • Article
  • Open Access
7 Citations
2,094 Views
12 Pages

23 April 2025

This study aims to examine and optimize CO2 laser cutting parameters—namely, laser power, cutting speed, and focal plane position—when applied to polypropylene material using an experimental methodology. This research aims to improve cutt...

  • Article
  • Open Access
1 Citations
895 Views
16 Pages

15 May 2025

To enhance the mechanical properties and low-carbon characteristics of industrial solid waste concrete, this paper proposes a synergistic modification strategy using nano-SiO2 and sodium silicate. The nano-SiO2 sol and sodium silicate activator were...

  • Article
  • Open Access
1,183 Views
19 Pages

16 May 2025

Yellow rice wine is susceptible to aflatoxinB1 (AFB1) contamination, yet existing detection technologies suffer from limitations such as high false-positive rates, cumbersome operational protocols, or elevated costs, rendering them inadequate for lar...

  • Article
  • Open Access
34 Citations
5,257 Views
22 Pages

Supercritical CO2 Extraction of Bioactive Compounds from Mango (Mangifera indica L.) Peel and Pulp

  • José Villacís-Chiriboga,
  • Stefan Voorspoels,
  • Maarten Uyttebroek,
  • Jenny Ruales,
  • John Van Camp,
  • Edwin Vera and
  • Kathy Elst

17 September 2021

The potential of supercritical CO2 (SC-CO2) for the extraction of bioactive compounds from mango by-products was assessed. Carotenoid extraction was optimized using a design of experiments based on temperature (35, 55 and 70 °C), pressure (10 and 35...

  • Article
  • Open Access
7 Citations
2,218 Views
17 Pages

Optimization of Oil and Tocopherol Extraction from Maqui (Aristotelia chilensis (Mol.) Stuntz) by Supercritical CO2 Procedure

  • Camila Sánchez,
  • Alicia Rodríguez,
  • Francisca Reinoso,
  • Gretel Dovale-Rosabal,
  • Nalda Romero,
  • Alejandra Espinosa,
  • María Elsa Pando,
  • Benjamín Claria,
  • Rodrigo Valenzuela and
  • Santiago P. Aubourg
  • + 1 author

This study focused on the oil extraction from freeze-dried maqui (Aristotelia chilensis) by supercritical fluid extraction with carbon dioxide (SFE-CO2). The basic objective was to optimize the oil yield and the tocopherol concentration. A Box/Behnke...

  • Article
  • Open Access
2 Citations
1,799 Views
15 Pages

This study investigates the machining processes of Alloy 20 under different cooling conditions: Minimum Quantity Lubrication (MQL), Carbon Dioxide (CO2), and the hybrid MQL + CO2 approach. The research focuses on optimizing the cutting parameters, un...

  • Article
  • Open Access
1 Citations
1,433 Views
19 Pages

Recovery of Fennel Non-Polar Bioactives via Supercritical Carbon Dioxide Extraction

  • Nina Marčac Duraković,
  • Ena Cegledi,
  • Ivona Elez Garofulić,
  • Sandra Balbino,
  • Sandra Pedisić,
  • Stela Jokić,
  • Verica Dragović-Uzelac and
  • Maja Repajić

21 August 2024

This study aimed to determine the optimal pressure and temperature for the maximum extraction yield and recovery of lipophilic bioactive compounds (BACs) during the supercritical carbon dioxide extraction (SCO2) of fennel seeds. For this purpose, the...

  • Article
  • Open Access
1 Citations
1,603 Views
18 Pages

H2 Optimization of a New Type of Tuned Lever Inerter-like Mass Damper (TLIMD) for Attenuating Structure Vibrations

  • Kai Xu,
  • Weiwei Wang,
  • Hui Liang,
  • Aifeng Liu,
  • Jianmin Yang,
  • Jingzhou Gao and
  • Bei Chen

4 November 2024

The lever or the lever-type mechanism can achieve an inertia amplification effect by appropriately calibrating its structural configuration, and it is also proven to be one of the most cost-effective solution for the inerter realization compared with...

  • Article
  • Open Access
2 Citations
1,418 Views
17 Pages

Currently, large-scale burning is an important straw disposal method in most developing countries. To execute prescribed burning while mitigating air pollution, it is crucial to explore the maximum possible range of meteorological changes. This study...

  • Article
  • Open Access
710 Views
26 Pages

Carp Scales Modified with Cerium Oxide Nanoparticles as a New Bio-Adsorbent for Arsenic and Chromium Separation from Water

  • Zoran Bajić,
  • Uroš Z. Veličković,
  • Veljko Djokić,
  • Mihael Bučko,
  • Jovica Bogdanov,
  • Krstimir Pantić and
  • Aleksandar D. Marinković

19 September 2025

Different treatments of fish scales from carps (Cyprinus carpio) (FS)—mechanical milling, modified with cerium dioxide (CeO2) nanoparticles and controlled carbonization of FS and modification with CeO2—were applied to obtain FS, FS-CeO2 a...

  • Proceeding Paper
  • Open Access
183 Views
8 Pages

4 February 2026

This study aims to model and optimize the process parameters influencing the efficiency and yield of oil extraction from Mongolian sea buckthorn seeds using supercritical carbon dioxide (CO2). The experiments were planned using response surface metho...

  • Article
  • Open Access
32 Citations
3,684 Views
18 Pages

Investigation of Mechanical and Tribological Behaviors of Aluminum Based Hybrid Metal Matrix Composite and Multi-Objective Optimization

  • Biranu Kumsa Gonfa,
  • Devendra Sinha,
  • Umesh Kumar Vates,
  • Irfan Anjum Badruddin,
  • Mohamed Hussien,
  • Sarfaraz Kamangar,
  • Gyanendra Kumar Singh,
  • Gulam Mohammed Sayeed Ahmed,
  • Nand Jee Kanu and
  • Nazia Hossain

16 August 2022

Aluminum metal matrix composites are potential materials for aerospace and automobile industrial applications due to their enhanced mechanical and tribological properties. Aluminum reinforced with silicon carbide particles has been developed with enh...

  • Article
  • Open Access
133 Citations
9,334 Views
19 Pages

14 April 2019

Textile industries produce copious amounts of colored wastewater some of which are toxic to humans and aquatic biota. This study investigates optimization of a bench-scale UV-C photocatalytic process using a TiO2 catalyst suspension for degradation o...

  • Article
  • Open Access
15 Citations
3,767 Views
14 Pages

14 September 2020

Circular economy principles are based on the use of by-products from one operation as the raw materials in another. The aim of this work is to obtain extracts with high antioxidant capacity and resveratrol content for the superior capitalization of t...

  • Article
  • Open Access
7 Citations
3,838 Views
27 Pages

8 February 2020

In this paper, a statistical analysis with response surface methodology (RSM) has been used to investigate and optimize process variables for the greener synthesis of chloromethyl ethylene carbonate (CMEC) by carbon dioxide (CO2) and epichlorohydrin...

  • Proceeding Paper
  • Open Access
3 Citations
1,629 Views
7 Pages

This work focuses on how to best degrade organic pollutants from wastewater by immobilizing TiO2 on activated carbon peanut shells (ACPNS) using the co-precipitation method in a hydrothermal process under simulated solar light for the first time. The...

  • Review
  • Open Access
60 Citations
17,382 Views
33 Pages

Understanding Long COVID; Mitochondrial Health and Adaptation—Old Pathways, New Problems

  • Alistair V. W. Nunn,
  • Geoffrey W. Guy,
  • Wolfgang Brysch and
  • Jimmy D. Bell

Many people infected with the SARS-CoV-2 suffer long-term symptoms, such as “brain fog”, fatigue and clotting problems. Explanations for “long COVID” include immune imbalance, incomplete viral clearance and potentially, mitoch...

  • Proceeding Paper
  • Open Access
1 Citations
1,866 Views
7 Pages

10 November 2020

The application of medium-chain triglycerides (MCT) in food items can pave the way for its increased utilization and for consumers to avail of its benefits. Preliminary studies have indicated that soymilk enrichment with MCT requires the application...

  • Article
  • Open Access
2,548 Views
14 Pages

11 April 2025

Distributed inference in resource-constrained heterogeneous edge clusters is fundamentally limited by disparities in device capabilities and load imbalance issues. Existing methods predominantly focus on optimizing single-pipeline allocation schemes...

  • Article
  • Open Access
6 Citations
3,433 Views
14 Pages

Benralizumab in Patients with Severe Eosinophilic Asthma: A Multicentre Real-Life Experience

  • Giulia Scioscia,
  • Pasquale Tondo,
  • Santi Nolasco,
  • Corrado Pelaia,
  • Giovanna Elisiana Carpagnano,
  • Maria Filomena Caiaffa,
  • Giuseppe Valenti,
  • Angelantonio Maglio,
  • Francesco Papia and
  • Claudia Crimi
  • + 5 authors

28 June 2023

Background: Mepolizumab and benralizumab are monoclonal antibodies directed against anti-IL-5 and anti-IL5R, respectively, and their use reduces the exacerbation rate and maintains oral corticosteroid requirements in severe eosinophilic asthma. Previ...

  • Article
  • Open Access
10 Citations
2,957 Views
26 Pages

The particle swarm optimization algorithm (PSO) is a widely used swarm-based natural inspired optimization algorithm. However, it suffers search stagnation from being trapped into a sub-optimal solution in an optimization problem. This paper proposes...

  • Article
  • Open Access
12 Citations
5,307 Views
22 Pages

Higher Education Institutions (HEIs) are potent health promotion settings, uniquely positioned to aid societal efforts to combat non-communicable diseases (NCDs). International evidence suggests that health metrics and lifestyle behaviours of higher...

  • Article
  • Open Access
22 Citations
5,731 Views
18 Pages

Divergent Leaf Morpho-Physiological and Anatomical Adaptations of Four Lettuce Cultivars in Response to Different Greenhouse Irradiance Levels in Early Summer Season

  • Luigi Formisano,
  • Michele Ciriello,
  • Valerio Cirillo,
  • Antonio Pannico,
  • Christophe El-Nakhel,
  • Francesco Cristofano,
  • Luigi Giuseppe Duri,
  • Maria Giordano,
  • Youssef Rouphael and
  • Stefania De Pascale

9 June 2021

Lettuce (Lactuca sativa L.) is a winter-spring leafy vegetable, but the high demand for fresh products available year-round requires off-season production. However, the warm climate of the Mediterranean areas can impair the summer production of lettu...

  • Review
  • Open Access
73 Citations
17,198 Views
35 Pages

14 November 2014

Equine influenza (EI) is a major respiratory disease of horses, which is still causing substantial outbreaks worldwide despite several decades of surveillance and prevention. Alongside quarantine procedures, vaccination is widely used to prevent or l...

  • Review
  • Open Access
34 Citations
8,527 Views
31 Pages

Role of Hypoxia and Metabolism in the Development of Neointimal Hyperplasia in Arteriovenous Fistulas

  • Nirvana Sadaghianloo,
  • Julie Contenti,
  • Alan Dardik and
  • Nathalie M. Mazure

29 October 2019

For patients with end-stage renal disease requiring hemodialysis, their vascular access is both their lifeline and their Achilles heel. Despite being recommended as primary vascular access, the arteriovenous fistula (AVF) shows sub-optimal results, w...

  • Article
  • Open Access
32 Citations
5,023 Views
14 Pages

Developing Functional Relationships between Soil Moisture Content and Corn Early-Season Physiology, Growth, and Development

  • Ranadheer Reddy Vennam,
  • Purushothaman Ramamoorthy,
  • Sadikshya Poudel,
  • Kambham Raja Reddy,
  • William Brien Henry and
  • Raju Bheemanahalli

28 June 2023

Drought is a severe threat to agriculture production that affects all growth stages of plants, including corn (Zea mays L.). Any factor affecting early seedling growth and development will significantly impact yield. Despite the recurrence of low rai...

  • Review
  • Open Access
78 Citations
18,603 Views
47 Pages

5 December 2020

Pseudomonas aeruginosa is a leading cause of chronic respiratory infections in people with cystic fibrosis (CF), bronchiectasis or chronic obstructive pulmonary disease (COPD), and acute infections in immunocompromised individuals. The adaptability o...

  • Article
  • Open Access
20 Citations
5,505 Views
19 Pages

8 December 2021

Proportional integral-based particle swarm optimization (PSO) and deep deterministic policy gradient (DDPG) algorithms are applied to a permanent-magnet synchronous motor to track speed control. The proposed methods, based on notebooks, can deal with...

  • Review
  • Open Access
17 Citations
5,107 Views
12 Pages

Indicators of Visual Prognosis in Diabetic Macular Oedema

  • Sagnik Sen,
  • Kim Ramasamy and
  • Sobha Sivaprasad

Diabetic macular oedema (DMO) is an important cause of moderate vision loss in people with diabetes. Advances in imaging technology have shown that a significant proportion of patients with DMO respond sub-optimally to existing treatment options. Ide...

  • Review
  • Open Access
688 Citations
77,390 Views
24 Pages

Diabetic Wound-Healing Science

  • Jamie L. Burgess,
  • W. Austin Wyant,
  • Beatriz Abdo Abujamra,
  • Robert S. Kirsner and
  • Ivan Jozic

8 October 2021

Diabetes mellitus is an increasingly prevalent chronic metabolic disease characterized by prolonged hyperglycemia that leads to long-term health consequences. It is estimated that impaired healing of diabetic wounds affects approximately 25% of all p...

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