Lyme disease (LD), caused by infection with the tick-borne bacteria, Borrelia burgdorferi, is associated with a wide array of symptoms in human patients. Variations in clinical manifestations are thought to be influenced by genetic differences among...
Omics analyses are commonly used for identifying pathways and genes responsible for physiologic and pathologic processes. Though sex is considered a biological variable in rigorous assessments of pulmonary responses to oxidant exposures, the contribu...
Respiratory syncytial virus (RSV) is a human respiratory pathogen which remains a leading viral cause of hospitalizations and mortality among infants in their first year of life. Here, we review the biology of RSV, the primary laboratory isolates or...
Background: Left ventricular global longitudinal strain (GLS) measured by speckle-tracking echocardiography (STE) has become a key marker of myocardial systolic function, yet normal reference values remain heterogeneous, and the magnitude of physiolo...
Over the past few years, China has become a hotspot for the domestication of the commercially valuable largemouth bass (Micropterus salmoides). Although the food preference of this fish has been studied, little is known about the genes regulating its...
The frame beam structure of the mine screen, subjected to various excitations, is a critical component of mining machinery. Its stress is intricate, the operational environment is severe, and damage can lead to catastrophic failures resulting in mach...
La Crosse virus (LACV) is the leading cause of pediatric viral encephalitis in North America, and is an important public health pathogen. Historically, studies involving LACV pathogenesis have focused on lineage I strains, but no former work has expl...
The temperature and strain fields monitoring during the preparation process of buoyancy materials, as well as the health status after molding, are important for mastering the mechanical properties of buoyancy materials and ensuring the safety of oper...
Although mycoplasmas have a reduced genome and no cell wall, they have important mechanisms for the antigenic variation in surface lipoproteins that modulate their interactions with the host. Mycoplasma agalactiae, the main etiological agent of conta...
This study completely investigates the damage detection problem based on strain modal characteristics using simply supported wooden beams as the research object. First, modal analysis was performed, and finite element models of both damaged and undam...
Zebrafish (Danio rerio) are becoming one of the most important model organisms in behavioural neuroscience. It has been shown repeatedly that different zebrafish strains show large behavioural differences. These divergent behavioural profiles may hav...
Lactic acid bacteria (LAB) is a collective term for bacteria capable of producing lactic acid from fermentable carbohydrates. Despite their widespread presence in the gastrointestinal tracts of humans and animals, where they play important physiologi...
Many studies have demonstrated significant mouse-strain-specific differences in behavior and response to pathogenic and pharmacological agents. This study seeks to characterize possible differences in microglia activation and overall severity of neur...
Background: During the cultivation of the marine fungus KMM 4668 on solid agar medium, the morphological instability of the strain was observed. As a result of the selection work, five intra-strain variants, named KMM 4711, KMM 4712, KMM 4713, KMM 47...
One of the methods to inactivate viruses is to denature viral proteins using released ions. However, there have been no reports detailing the effects of changes in humidity or contamination with body fluids on the inactivation of viruses. This study...
Boundary value problems in the theory of elasticity are traditionally formulated in terms of displacements, while stresses and strains are calculated from the displacements. Usually, the calculation of stresses and strains is accompanied by approxima...
Real-time online identification of spacecraft segment damage is of great significance for realizing spacecraft structural health monitoring and life prediction. In this paper, a damage response characteristic field inversion algorithm based on the di...
Background: Staphylococcus aureus causes bloodstream and skin infections in humans. The prevalence of multidrug-resistant S. aureus strains means new antibiotics are needed. A novel antimicrobial drug named SK-03-92, a synthetic aromatic organic stil...
In this paper, the data are presented concerning different reactions to seven daily injections of atomoxetine in two mouse strains differing in relative brain weight. Atomoxetine affected the performance in a puzzle-box cognitive test in a complicate...
Yogurt is generally defined as a cultured milk product made using some species of lactic acid bacteria. Moreover, some additive bacteria are frequently involved in yogurts to provide health benefits. The objective of this study was testing the stabil...
To study the dynamic compressive mechanical properties of concrete with different aggregates (limonite and lead-zinc ore), a dynamic mechanical experiment was carried out by the Φ 100 mm SHPB equipment. Based on the coupling of the finite differe...
Rubella virus (RV) infection impacts cellular metabolic activity in a complex manner with strain-specific nutritional requirements. Here we addressed whether this differential metabolic influence was associated with differences in oxidative stress in...
Background: Ventricular function assessments in Fontan patients remain challenging. Ejection fraction (EF) lacks sensitivity for early dysfunction, and the roles of strain and advanced imaging in systemic left ventricle (LV) physiology are not fully...
Streptococcus suis is a porcine and zoonotic pathogen in the upper respiratory tract, expressing different capsular serotypes and virulence-associated factors. Given its genomic and phenotypic diversity, the virulence potential of S. suis cannot be a...
Background: Fibromyalgia (FM) is a chronic pain condition primarily linked to central sensitization, although peripheral tissue-related factors have also been suggested. Ultrasound strain elastography (SEL) provides a semi-quantitative, operator-depe...
A total of 29.5 million people aged 12 and older met the diagnostic criteria for alcohol use disorder (AUD) in the United States in 2021, which presents a significant social and economic burden to modern society. Impaired nutritional status has been...
The spatiotemporal deformation response of a seismogenic fault to a large earthquake is of great significance to understanding the nucleation and occurrence of the next strong earthquake. The Longmeshan fault, where the 2008 Wenchuan MS 8.0 earthquak...
The effects of residual radiation from atomic bombs have been considered to be minimal because of its low levels of external radioactivity. However, studies involving atomic bomb survivors exposed to only residual radiation in Hiroshima and Nagasaki...
Strain-related differences in arteriogenesis in inbred mouse strains have already been studied excessively. However, these analyses missed evaluating the mouse strain-related differences in ischemia-induced angiogenic capacities. With the present stu...
6 November 2026
Digital technologies increasingly mediate managerial practices, but the robustness of associations between digitally mediated managerial control (DMMC), negative digital work consequences (NDWC), organizational resources, and work-related strain rema...
Background: Pregnancy induces substantial cardiovascular remodeling, yet whether maternal cardiac adaptation differs across ethnic groups remains unclear. Body size, ventricular geometry, and thoracoabdominal configuration may modulate key functional...
This paper studied the fracability of tight sandstone reservoirs by means of incorporating geomechanics properties and surrounding in situ stresses into a new model. The new fracability evaluation model consists of variables such as brittleness index...
Rock–socketed pile under lateral loading is important in engineering practice. It is very significant to calculate the lateral bearing capacity of rock–socketed piles since few studies focus on this problem. The rock cohesion and instanta...
Since the elimination of smallpox, mpox (monkeypox) is the most medically significant orthopoxvirus infection. As a result of numerous regional, national and global outbreaks of MPXV (mpox virus), there is an abundance of new data available on the ef...
With the conventional mechanical rotation measurement of joints, only static measurements are possible with the patient at rest. In the future, it would be interesting to carry out dynamic rotation measurements, for example, when walking or participa...
Chronic orofacial pain conditions can be particularly difficult to diagnose and treat because of their complexity and limited understanding of the mechanisms underlying their aetiology and pathogenesis. Furthermore, there is considerable variability...
The Crabtree and Warburg effects both involve elevated glycolytic flux and fermentation under aerobic conditions, yet their regulatory bases differ fundamentally. In the Crabtree effect, high-glucose concentrations suppress mitochondrial respiration,...
Long Interspersed Nuclear Element 1 (LINE-1) retrotransposons are the major repetitive elements in mammalian genomes. LINE-1s are well-accepted as driving forces of evolution and critical regulators of the expression of genetic information. Alteratio...
One of the hallmarks of the acute toxicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) is a drastically reduced feed intake by an unknown mechanism. To further elucidate this wasting syndrome, we followed the effects of a single large dose (100 μg/...
Colitis is a major risk factor for the development of colorectal cancer, leading to colitis-associated colorectal cancer (CAC). The most commonly used animal model to study CAC is the azoxymethane-dextran sulphate-sodium (AOM/DSS) model. The ideal ex...
This paper addresses the elastoplastic torsion and tension of a prismatic bar with a multiply connected circular cross-section containing one central and four symmetrically arranged lateral holes. The relevance of this problem stems from the fact tha...
Submarine landslides are a major geohazard in deep water, posing a severe threat to the safety of seabed infrastructure. Progressive failure on gentle slopes is commonly governed by strain softening of soils and shear band propagation (SBP). Several...
The new Ti–Zr (Roxolid®) mini-implants have not yet been fully researched. We analyzed peri-implant and posterior edentulous area microstrains during mandibular overdenture (OD) loading at different sites with different extents of forces wh...
Background: Caring for dependent older relatives is thought to influence caregivers’ personal views of aging (VoA)—that is, perceptions regarding their own aging self. This study aimed to examine personal VoA, particularly felt age (FA) a...
Foot-and-mouth disease (FMD) vaccine efficacy is mainly determined by the content of intact virions (146S) and empty capsids (75S). Both particles may dissociate into 12S subunits upon vaccine manufacturing, formulation, and storage, reducing vaccine...
The primary neuronal and astrocyte culture described here is from the stress-hyperreactive Wistar Kyoto (WKY) More Immobile (WMI) rat with premature aging-related memory deficit, and its nearly isogenic control, the Less Immobile (WLI) strain. Primar...
Bellows compensators are critical components in pipeline systems, designed to absorb thermal expansions, vibrations, and pressure reflections. Ensuring their operational reliability requires accurate prediction of the stress–strain state (SSS)...
Welded joints in grid structures are susceptible to damage and destruction when exposed to random excitation. The complexity of the grid structure poses challenges for realizing the damage recognition of welded joints. In this study, a two-step metho...
21 July 2023
Kratom (Mitragyna speciosa) is a Southeast Asian plant containing various alkaloids that induce pharmacological effects in humans. In Western countries, online vendors sell a variety of different kratom strains which are marketed to have distinct eff...
The bacterium Deinococcus radiodurans is known to efficiently and accurately reassemble its genome after hundreds of DNA double-strand breaks (DSBs). Only at very large amounts of radiation-induced DSBs is this accuracy affected in the wild-type D. r...
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