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New Advances in Cardiovascular Diseases: The Cutting Edge
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New Advances in Cardiovascular Diseases: The Cutting Edge

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Cardiovascular Medicine".

Deadline for manuscript submissions: 20 July 2025 | Viewed by 1671

Special Issue Editor

Dr. Fabiana Lucà

E-Mail Website
Guest Editor
Department of Cariology, Big Metropolitan Hospital of Reggio Calabria, 89129 Reggio Calabria, Italy
Interests: atrial fibrillation; supraventricular arrhythmias; ventricular arrhythmias; sudden cardiac death (SCD); acute and chronic heart failure; ischemic heart disease; pacemaker; cardiac resynchronization therapy (CRT); implantable cardioverter defibrillator (ICD)
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Cardiovascular disease (CVD) is one of the foremost contributors to global mortality. Prevention, early identification, and efficacious treatment are paramount for enhancing quality of life and mitigating mortality rates. Within this context, cardiologists assume a pivotal role in mitigating risk factors, treating cardiac disorders and reducing the likelihood of recurrence. In recent years, continual advancements in research within the field have been reported, along with the development of novel therapeutic strategies and advancements in patient outcomes. This Special Issue aims to address contemporary challenges within clinical, interventional and preventive cardiology. It offers current and comprehensive insights into CVD, emphasizing recent breakthroughs in diagnostic and therapeutic techniques, cardiac pharmacology and the intricate cellular and molecular pathophysiology underlying CVD. Covering a broad spectrum within cardiology, it explores areas such as coronary artery disease (CAD), heart failure (HF), atrial fibrillation (AF), supraventricular and ventricular arrhythmias.

Dr. Fabiana Lucà
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Clinical Medicine is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • cardiovascular disease (CVD)
  • preventive cardiology
  • cardiac pharmacology
  • coronary artery disease (CAD)
  • heart failure (HF)
  • atrial fibrillation (AF)
  • supraventricular and ventricular arrhythmias

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Published Papers (1 paper)

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Research

13 pages, 274 KiB  
Article
Clinical and Psychological Factors Associated with Frailty in Patients with Heart Failure
by Bernadetta Żółkowska, Christopher S. Lee, Quin E. Denfeld, Maria Jędrzejczyk, Dorota Diakowska, Magdalena Lisiak, Marta Wleklik, Michał Czapla and Izabella Uchmanowicz
J. Clin. Med. 2024, 13(23), 7345; https://doi.org/10.3390/jcm13237345 - 2 Dec 2024
Viewed by 1160
Abstract
Background/Objectives: Heart failure (HF) is a significant public health issue with high morbidity and mortality rates. This study aims to investigate the interrelationships between frailty, cognitive impairment, and depression in older adults with HF, specifically focusing on how the physical and neuropsychiatric [...] Read more.
Background/Objectives: Heart failure (HF) is a significant public health issue with high morbidity and mortality rates. This study aims to investigate the interrelationships between frailty, cognitive impairment, and depression in older adults with HF, specifically focusing on how the physical and neuropsychiatric dimensions of frailty contribute to cognitive decline. Methods: This study included 250 patients aged 60 years or older, diagnosed with HF and hospitalized for acute decompensated HF. The patients were assessed using standardized protocols for frailty, cognitive function, and depression. The frailty was evaluated using Fried’s phenotype criteria, cognitive function with MMSE and MoCA, and depression and anxiety with HADS and PHQ-9. Statistical analyses included univariable and multivariable linear regression to identify the predictors of frailty. Results: Of the 250 patients, 151 (60.4%) were identified as frail. The frail patients were older (mean age 73.58 ± 6.80 years) compared to the non-frail patients (mean age 70.39 ± 6.16 years, p = 0.0002). Significant differences were observed in the NYHA class, length of the hospital stay, and prevalence of diabetes mellitus. The frail patients had worse cognitive (MMSE: 27.39 ± 2.12 vs. 28.13 ± 1.72, p = 0.004; MoCA: 24.68 ± 3.65 vs. 25.64 ± 3.98, p = 0.050) and psychological outcomes (higher prevalence of marked depression based on HADS categories: 8.61% vs. 1.01%, p = 0.021; and PHQ-9 categories: severe depression: 2.65% vs. 1.01%, p < 0.001). Conclusions: Age, C-reactive protein (CRP) levels, and anxiety were identified as independent predictors of frailty in the patients with heart failure. Depression, cognitive dysfunction, and the length of the hospital stay showed significant differences between the frail and non-frail patients in the group comparisons but were not independent predictors. Full article
(This article belongs to the Special Issue New Advances in Cardiovascular Diseases: The Cutting Edge)
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