DNA Methylation

Dear Colleagues,

Methylation of cytosine is a long-term epigenetic modification of the genome. Epigenetic deregulation of genes is achieved by aberrant DNA methylation of promoter sequences in different human malignancies, including cancer. The discovery of proteins that oxidase 5-methylcytosine (5mC) to 5-hydroxymethylcytosine (5hmC) has extended our knowledge of how aberrant DNA methylation is coupled to gene regulation in cancer and other human malignancies. Current models propose that 5hmC is an intermediate base in the DNA demethylation process, or a bivalent chromatin marker found in cancer and stem cells.

In this Special Issue of IJMS we invite you to submit an original research report or review article deciphering the role of DNA methylation in malignancies, aging or differentiation.

Prof. Dr. Reinhard Dammann
Assoc. Prof. Alexander Dobrovic
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.