Background: In vitro skin models are widely used in dermal and transdermal drug development, yet their pharmacokinetic interpretation often remains endpoint-dependent and does not fully capture cutaneous disposition, including partitioning, local met...
Background/Objectives: Transdermal delivery of hydrophilic drugs remains limited by poor partitioning into the lipid-rich stratum corneum (SC). This study systematically investigated how ternary nanoemulsion composition and surfactant architecture jo...
The early monitoring of cardiovascular biomarkers is essential for the prevention and management of some cardiovascular diseases. Here, we present a novel, compact, and highly integrated skin electrode as a mechanical–electrochemical dual-model...
Explainable Artificial Intelligence (XAI) has become a critical requirement in medical image analysis, where transparency and interpretability are essential for clinical trust and decision support. Melanoma is recognized as one of the most deadly typ...
Human skin fibroblasts are an excellent in vitro model for tracking the processes occurring in human skin and studying the potential impact of various biologically active substances on these processes. Two plant hormones, which are included in the cy...
Cancer is one of the leading significant causes of illness and chronic disease worldwide. Skin cancer, particularly melanoma, is becoming a severe health problem due to its rising prevalence. The considerable death rate linked with melanoma requires...
Internet of Things (IoT)-assisted skin cancer recognition integrates several connected devices and sensors for supporting the primary analysis and monitoring of skin conditions. A preliminary analysis of skin cancer images is extremely difficult beca...
Excised human skin is utilized for in vitro permeation experiments to evaluate the safety and effect of topically-applied drugs by measuring its skin permeation and concentration. However, ethical considerations are the major problem for using human...
The tailoring of the skin microbiome is challenging and is a research hotspot in the pathogenesis of immune-mediated inflammatory skin diseases such as acne. Commonly encountered preservatives used as functional ingredients have an impact on the skin...
Conventional or fixed wings require a certain thickness of skin material selection that guarantees structurally reliable strength under expected aerodynamic loadings. However, skin structures of morphing wings need to be flexible as well as stiff eno...
Probiotic strains with multifunctional skin-beneficial properties represent promising candidates for next-generation cosmetic ingredients. In this study, a systematic stepwise screening strategy was applied to an in-house bacterial library comprising...
Background: Excessive or poorly distributed contact loading of the hand and forearm can cause pain, functional limitation, skin breakdown, and deep soft-tissue injury, motivating reliable quantification of local soft-tissue deformation and stress. Al...
Conventional fixed wing aircraft require a selection of certain thickness of skin material that guarantees structural strength for aerodynamic loadings in various flight modes. However, skin structures of morphing wings are expected to be flexible as...
Background/Objectives: This is the first study in Eastern Europe to integrate skin and iris phenotypic characteristics with selected polymorphisms in genes related to skin aging, melanogenesis and skin pigmentation, and inflammatory regulation in rel...
Skin cancer is a severe and potentially lethal disease, and early detection is critical for successful treatment. Traditional procedures for diagnosing skin cancer are expensive, time-intensive, and necessitate the expertise of a medical practitioner...
Absorption through the skin of topically applied chemicals is relevant for both formulation development and safety assessment, especially in the early stages of development. However, the supply of human skin is limited, and the traditional in vitro m...
Background/Objectives: Laurocapram (Azone) attracted attention 40 years ago as a compound with the highest skin-penetration-enhancing effect at that time; however, its development was shelved due to strong skin irritation. We had already prepared and...
This study presents the first application of convolutional neural networks to high-frequency ultrasound skin image classification. This type of imaging opens up new opportunities in dermatology, showing inflammatory diseases such as atopic dermatitis...
The skin is a protective organ, able to decode a wide range of tactile, thermal, or noxious stimuli. Some of the sensors belonging to the transient receptor potential (TRP) family, for example, TRPV1, can elicit capsaicin-induced heat pain or histami...
Receptor-interacting protein kinase (RIP) family 1 signaling has complex effects on inflammatory processes and cell death, but little is known concerning allergic skin diseases. We examined the role of RIP1 in Dermatophagoides farinae extract (DFE)-i...
Topical and transdermal drug delivery is an effective, safe, and preferred route of drug administration. As such, skin permeability is one of the critical parameters that should be taken into consideration in the process of drug discovery and develop...
Human skin remains difficult to model in vitro because it brings together stratified epidermal, dermal, hypodermal, vascular, immune, appendageal, neural, and microbial elements within a single tissue. Traditional two-dimensional cultures and animal...
Skin conditions influence people of all ages and genders and impose an enormous strain on worldwide public health. For efficient management and medical treatment, skin disorders must be accurately categorized. However, the conventional method of clas...
During the development of condensate gas reservoirs, the phenomenon of retrograde condensation seriously affects the production of gas wells. The skin factor caused by retrograde condensation pollution is the key to measuring the consequent decrease...
Due to the high similarity in composition and structure between lanolin and human SC lipids, we will work with two models from wool wax. Two types of lanolin were evaluated: one extracted with water and surfactants (WEL) and the other extracted with...
Background/Objectives: The aims of this work were to formulate cannabidiol in different lipid carriers for skin delivery after topical application and to study their stability, interaction with the skin, and antibacterial activity. Methods: Solid lip...
Currently, the number of people who have been investigated for skin cancer has increased significantly worldwide. For prior diagnosis, dermatologists can typically visually inspect skin lesions for abnormalities. However, an expert is required, and t...
Melanoma is the most invasive skin cancer with the highest risk of death. While it is a serious skin cancer, it is highly curable if detected early. Melanoma diagnosis is difficult, even for experienced dermatologists, due to the wide range of morpho...
Background: Reactive oxygen species (ROS) generated by mitochondrial dysfunction damage cellular organelles and contribute to skin aging. Therefore, strategies to reduce mitochondrial ROS production are considered important for alleviating skin aging...
Hyperspectral imaging (HSI) applications for biomedical imaging and dermatological applications have been recently under research interest. Medical HSI applications are non-invasive methods with high spatial and spectral resolution. HS imaging can be...
Skin injury is the most common type of injury, which manifests itself in the form of wounds and cuts. A minor wound repairs itself within a short span of time. However, deep wounds require adequate care and sometime clinical interventions such as sur...
Oxidative stress from exogenous insults is a major driver of skin aging and hyperpigmentation. Plant-derived bioactive compounds represent promising multifunctional agents with protective effects on skin. They meet the demand for natural, safe skin-p...
For many years, an increasing number of diagnosed atopy and skin problems have been observed. For people affected by the problem of atopy, the selection of skin care products, including cosmetics, is extremely important. Cleansing cosmetics, due to t...
The aim of this study was to develop an effective and fast tool to support the automatic segmentation of skin lesions, with particular emphasis on the precise differentiation between malignant and benign lesions. In response to the problem of high fa...
Sunlight, despite its benefits, can pose a threat to the skin, which is a natural protective barrier. Phototoxicity caused by overexposure, especially to ultraviolet radiation (UVR), results in burns, accelerates photoaging, and causes skin cancer fo...
Human skin provides an effective route of delivery for selected drugs. Topical penetration of molecules is largely attributed to passive diffusion, and the degree of penetration can be represented by in silico, in vitro, and ex vivo models. Percutane...
Abstract: This study addresses the current difficulties in accurately controlling the indoor temperature of double-skin facades (DSFs), and its optimization, with a focus on the window opening angles of double-skin facades. The Spearman correlation c...
Acupuncture is one of the most extensively used complementary and alternative medicine therapies worldwide. In this study, we explore the use of near-infrared light-emitting diodes (LEDs) to provide acupuncture-like physical stimulus to the skin tiss...
Impetigo (school sores), a superficial skin infection commonly seen in children, is caused by the gram-positive bacteria Staphylococcus aureus and/or Streptococcus pyogenes. Antibiotic treatments, often topical, are used as the first-line therapy for...
The skin is a complex and selective system from the perspective of permeability to substances from the external environment. Microemulsion systems have demonstrated a high performance in encapsulating, protecting and transporting active substances th...
Traditionally, the first step in physiological measurements based on remote photoplethysmography (rPPG) is localizing the region of interest (ROI) that contains a desired pulsatile information. Recently, approaches that do not require this step have...
Effects of pre- and probiotics on intestinal health are well researched and microbiome-targeting solutions are commercially available. Even though a trend to appreciate the presence of certain microbes on the skin is seeing an increase in momentum, o...
A large number of models are now available for the investigation of skin wound healing. These can be used to study the processes that take place in a phase-specific manner under both physiological and pathological conditions. Most models focus on wou...
Teleosts have more types of chromatophores than other vertebrates and the genetic basis for pigmentation is highly conserved among vertebrates. Therefore, teleosts are important models to study the mechanism of pigmentation. Although functional genes...
Human skin is the most exposed part of the human body that needs constant protection and care from heat, light, dust, and direct exposure to other harmful radiation, such as UV rays. Skin cancer is one of the dangerous diseases found in humans. Melan...
Psoriasis (Ps), commonly perceived as a skin and joint disorder, has a complex basis and results from disturbances in the sophisticated network between skin and the immune system. This makes it difficult to properly depict the complete pathomechanism...
In cutaneous leishmaniasis (CL), parasites reside in the dermis, creating an opportunity for local drug administration potentially reducing adverse effects and improving treatment adherence compared to current therapies. Polymeric film-forming system...
The neuropeptide oxytocin (OXT) is involved in social bonding, reproduction, and childbirth. Its activity is mediated by the oxytocin receptor (OXTR), also expressed in the skin. OXT alleviates dermal fibroblast senescence, and OXT levels correlate w...
At present, the surface quality of Yuba skin is determined by sensory methods. In order to realize the intelligent classification detection of Yuba skin quality, this study designed a system that automatically determines the quality of Yuba skin surf...
The article considers a mathematical model of the hydrolithospheric process taking into account the skin effect. A methodology for using the results of groundwater inflow testing to determine the parameters of approximating models that take into acco...
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