Benchmark datasets are essential for developing and evaluating remote sensing image retrieval (RSIR) approaches. However, most of the existing datasets are single-labeled, with each image in these datasets being annotated by a single label representi...
Over the decades, a tremendous increase has been witnessed in the production of documents available in digital form. The increased production of documents has gained so much momentum that their rate of production jumps two-fold every five years. Thes...
Accurate classification of lymphoma cell subtypes is essential for disease diagnosis and therapeutic decision-making, yet conventional approaches often rely on fluorescence labeling, labor-intensive sample preparation, and specialized instrumentation...
A liquid crystal (LC)-based single-substrate biosensor was developed by spin-coating an LC thin film on a dimethyloctadecyl[3-(trimethoxysilyl)propyl]ammonium chloride (DMOAP)-decorated glass slide. Compared with the conventional sandwiched cell conf...
A miniature label-free biosensor based on a chemically etched single-mode optical fiber (SMF) is reported for the detection of matrix metalloproteinase-8 (MMP-8), a salivary biomarker of active periodontitis with a clinical decision threshold of 20 n...
Nanopipette-based single-molecule sensing offers a label-free route to protein analysis, but distinguishing structurally different proteins from ionic current traces remains difficult. Here, we classified three clinically important proteins (CCL5, MM...
Nanoaperture optical tweezers (NOTs) were used to analyze conalbumin in various forms. By analyzing the power spectrum of the NOT-transmitted laser signal, differences between iron and iron-free conalbumin were observed; the corner frequency extrapol...
The brain network consists of ten billion neurons and is the most complex structure in the universe. Understanding the structure of complex brain networks and neuronal functions is one of the main goals of modern neuroscience. Since the seminal inven...
Single-cell data analysis has been at forefront of development in biology and medicine since sequencing data have been made available. An important challenge in single-cell data analysis is the identification of cell types. Several methods have been...
Quantum dots (QDs) provide rapid, continuous, and prolonged imaging of individual molecules and viruses, offering more comprehensive dynamic data than traditional fluorophores. However, their application in visualizing viral infections is limited, mo...
The integration of Context-Aware Systems (CASs) in Future Operating Rooms (FORs) aims to enhance surgical workflows and outcomes through real-time data analysis. CASs require accurate classification of surgical tools, enabling the understanding of su...
In vivo optical Imaging is an inexpensive and highly sensitive modality to investigate and follow up diseases like breast cancer. However, fluorescence labels and specific tracers are still works in progress to bring this promising modality into the...
To address dimensional reduction for continuous single-label and multi-label data, this paper proposes an improved variable precision rough set method based on maximal consistent blocks. We formulate dimensional reduction as an attribute reduction pr...
Intraoperative guidance using targeted fluorescent tracers can potentially provide surgeons with real-time feedback on the presence of tumor tissue in resection margins. To overcome the limited depth penetration of fluorescent light, combining fluore...
Label-free, fast, and single nanoparticle detection is demanded for the in situ monitoring of nano-pollutants in the environment, which have potential toxic effects on human health. We present the label-free imaging of single nanoparticles by using t...
Glucose-stimulated insulin secretion is the central functional readout of pancreatic islets, yet existing assays often require offline processing or pooling of multiple islets, limiting real-time assessment of single-islet function. Here we report a...
Over-expression of fluorescently-labeled markers for extracellular vesicles is frequently used to visualize vesicle up-take and transport. EVs that are labeled by over-expression show considerable heterogeneity regarding the number of fluorophores on...
Multi-class classification is a very important technique in engineering applications, e.g., mechanical systems, mechanics and design innovations, applied materials in nanotechnologies, etc. A large amount of research is done for single-label classifi...
Quantitative measurement of single cells can provide in-depth information about cell morphology and metabolism. However, current live-cell imaging techniques have a lack of quantitative detection ability. Herein, we proposed a label-free and quantita...
Laser interference microscopy (LIM) is a promising label-free method for single-cell research applicable to cell viability assessment in the studies of mammalian cells. This paper describes the development of a sensitive and reproducible method for a...
Background/Objectives: The main objective of this study was to describe the prevalence and prescribing patterns of off-label and unlicensed medication use in a tertiary neonatal intensive care unit in Serbia and to evaluate differences according to g...
The replication of a virus within its host cell involves numerous interactions between viral and cellular factors, which have to be tightly controlled in space and time. The intricate interplay between viral exploitation of cellular pathways and the...
Transcriptome analysis in single cells, enabled by single-cell RNA sequencing, has become a prevalent approach in biomedical research, ranging from investigations of gene regulation to the characterization of tissue organization. Over the past decade...
Interpreting multi-component 1H NMR spectra is difficult due to peak overlap, concentration variability, and low-abundance signals. We cast mixture identification as a single-pass multi-label task. A compact CNN–Transformer (“Hybrid&rdquo...
Background: Performance estimates in medical-imaging artificial intelligence may depend not only on model architecture but also on dataset integrity, label reproducibility, and the complexity of the prediction target. This study evaluated deep learni...
Direct antibody labeling is essential for immunoassays, multiplexed imaging, and biosensing; however, current methods are often time-consuming, restricted by antibody source, risk compromising protein performance, or vary with multiple steps. We intr...
Changes in molecular conformations are one of the major driving forces of complex biological processes. Many studies based on single-molecule techniques have shed light on conformational dynamics and contributed to a better understanding of living ma...
Although various methods for selective protein tagging have been established, their ap plications are limited by the low fluorescent tagging efficiency of specific terminal regions of the native proteins of interest (NPIs). In this study, the highly...
Printed circuit board (PCB) defect detection is critical to manufacturing quality, yet tiny, low-contrast defects and limited annotations challenge conventional systems. This study develops an ECA–DCN-lite–BiFPN–CARAFE-enhanced YOLO...
Phenotyping extracellular vesicles (EVs), where surface receptor expression is often as low as one molecule per EV, remains problematic due to the inability of commercial flow cytometers to provide single-fluorescent molecule sensitivity. While EVs a...
Optical biosensors based on scattered-light measurements are being developed for rapid and label-free detection of single virions captured from body fluids. Highly controlled, stable, and non-biohazardous reference materials producing virus-like sign...
In the modern electromagnetic environment, the intra-pulse modulations of radar emitter signals have become more complex. Except for the single-component radar signals, dual-component radar signals have been widely used in the current radar systems....
The epidermal growth factor receptor HER2 is overexpressed in 20% of breast cancer cases. HER2 is an orphan receptor that is activated ligand-independently by homodimerization. In addition, HER2 is able to heterodimerize with EGFR, HER3, and HER4. He...
Background/Objectives: Functional constipation is common in older adults and impairs quality of life. Evidence for multi-strain orally disintegrating (OD) probiotic formulations in this population remains limited. Methods: In this single-center, open...
Biocytin, a chemical compound that is an amide formed from the vitamin biotin and the amino acid L-lysine, has been used as a histological dye to stain nerve cells. Electrophysiological activity and morphology are two key characteristics of neurons,...
Brassinosteroids, the steroid hormones of plants, control physiological and developmental processes through its signaling pathway. The major brassinosteroid signaling network components, from the receptor to transcription factors, have been identifie...
Stress associated with veterinary visits represents a significant concern for cats, as well as a primary challenge for both caregivers and veterinary practitioners. Based on previous in vitro and in vivo studies on imepitoin, this pilot study was con...
The importance of microarrays in diagnostics and medicine has drastically increased in the last few years. Nevertheless, the efficiency of a microarray-based assay intrinsically depends on the density and functionality of the biorecognition elements...
Deformations introduced during the production of plastic components degrade the accuracy of their 3D geometric information, a critical aspect of object inspection processes. This phenomenon is prevalent among primary plastic products from manufacture...
Background/Objectives: Supervised electrocardiography-based sleep apnea detection often depends on dense segment-level annotations, creating substantial expert burden. To reduce this dependence, we investigated whether adjacent temporal context could...
Topical cyclosporine (CSA) has been reported as an alternative treatment in steroid-refractory oral lichen planus (OLP), but evidence is limited and conflicting. An N-of-1 trial setting could be appropriate to evaluate interindividual differences in...
Background/Objective: Hypertension and other modifiable risk factors for cardiovascular disease are characterized by a dysfunctional vascular endothelium and decreased nitric oxide (NO) bioavailability. The oral supplementation of inorganic nitrate (...
Over the last decade, the growing need in disease diagnostics has stimulated rapid development of new technologies with unprecedented capabilities. Recent emerging infectious diseases and epidemics have revealed the shortcomings of existing diagnosti...
Biological macromolecules, the fundamental building blocks of life, exhibit dynamic structures in their natural environment. Traditional structure determination techniques often oversimplify these multifarious conformational spectra by capturing only...
Nanomaterial-based field-effect transistors (FETs) have been proposed for real-time, label-free detection of various biological species. However, screening of the analyte charge by electrolyte ions (Debye screening) has so far limited their use in p...
The quantitative detection of critical biomolecules and in particular low-abundance biomarkers in biofluids is crucial for early-stage diagnosis and management but remains a challenge largely owing to the insufficient sensitivity of existing ensemble...
For high-resolution range profile (HRRP)-based radar automatic target recognition (RATR), adequate training data are required to characterize a target signature effectively and get good recognition performance. However, collecting enough training dat...
The detection and quantification of nanoplastics in aquatic environments is one of the major challenges in environmental and analytical research nowadays. The use of common analytical techniques for this purpose is not only hampered by the size of na...
Background: In China, the current national immunisation schedule extends only to 4 years of age, and no polio booster dose is recommended for adolescents or adults, with data on immunogenicity and safety in these populations lacking. This phase IV tr...
The faint characteristic signatures and strong susceptibilities to noise interference of a single-phase earth fault pose great challenges to accurate fault location. Existing traveling wave-based fault location technologies generally suffer from low...
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