Optical Biosensors for Healthcare: An Artificial Intelligence Approach

A special issue of Biosensors (ISSN 2079-6374). This special issue belongs to the section "Biosensors and Healthcare".

Deadline for manuscript submissions: 1 April 2026 | Viewed by 500

Special Issue Editors

School of Medicine and Bioinformatics Engineering, Northeastern University, Shenyang, China
Interests: biomedical imaging and sensing; biomedical spectroscopy; hyperspectral imaging; computational optical sensing and imaging; deep learning
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Guest Editor
State Key Laboratory of Extreme Photonics and Instrumentation, College of Optical Science and Engineering, Zhejiang University, Hangzhou, China
Interests: fluorescence imaging; computational imaging; fluorescence probes; deep learning
A*STAR Skin Research Labs (A*SRL), Agency for Science, Technology and Research (A*STAR), 31 Biopolis Way, Singapore 138669, Singapore
Interests: biosensing and imaging; photoacoustics; Raman spectroscopy; diffuse optics; machine learning
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Advances in healthcare demand innovative technologies that enable rapid, accurate, and personalized diagnoses. Optical biosensors have emerged as a transformative tool, offering high sensitivity, real-time detection, and non-invasive monitoring of biomarkers for various diseases. In recent years, artificial intelligence (AI)-enhanced optical biosensors have grown into a rapidly advancing field, integrating state-of-the-art AI approaches into cutting-edge optical biosensor techniques to improve their performance and benefit outcomes in their healthcare applications. Following these AI advancements, notable progress has been made in optimal biosensor design, improved signal acquisition, transmission, and storage, along with more precise data analyses being instituted to fulfill the growing demand for optical biosensors in healthcare. This Special Issue aims to investigate how AI can redefine optical biosensor techniques to revolutionize healthcare applications, and encourages collaborations between engineers, data scientists, and clinicians to address challenges in this interdisciplinary field. All submissions of original research, reviews, and perspectives in topics related to recent and crucial insights into using AI approaches in optical biosensors for healthcare applications are encouraged and welcome, including, but not limited, to AI-based sensing theory, smart biosensor systems, wearable optical devices, and AI models, as well as their healthcare applications.

Dr. Shuo Chen
Prof. Dr. Min Guo
Dr. Renzhe Bi
Guest Editors

Manuscript Submission Information

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Keywords

  • optical biosensors
  • healthcare
  • machine learning
  • deep learning
  • Internet of Things
  • point-of-care testing
  • diagnosis and prognosis

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Published Papers (1 paper)

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Research

19 pages, 8504 KiB  
Article
Fiber-Based Ultra-High-Speed Diffuse Speckle Contrast Analysis System for Deep Blood Flow Sensing Using a Large SPAD Camera
by Quan Wang, Renzhe Bi, Songhua Zheng, Ahmet T. Erdogan, Yi Qi, Chenxu Li, Yuanyuan Hua, Mingliang Pan, Yining Wang, Neil Finlayson, Malini Olivo, Robert K. Henderson and David Uei-Day Li
Biosensors 2025, 15(8), 514; https://doi.org/10.3390/bios15080514 - 7 Aug 2025
Viewed by 337
Abstract
Diffuse speckle contrast analysis (DSCA), also called speckle contrast optical spectroscopy (SCOS), has emerged as a groundbreaking optical imaging technique for tracking dynamic biological processes, including blood flow and tissue perfusion. Recent advancements in single-photon avalanche diode (SPAD) cameras have unlocked exceptional sensitivity, [...] Read more.
Diffuse speckle contrast analysis (DSCA), also called speckle contrast optical spectroscopy (SCOS), has emerged as a groundbreaking optical imaging technique for tracking dynamic biological processes, including blood flow and tissue perfusion. Recent advancements in single-photon avalanche diode (SPAD) cameras have unlocked exceptional sensitivity, time resolution, and high frame-rate imaging capabilities. Despite this, the application of large-format SPAD arrays in speckle contrast analysis is still relatively uncommon. This study introduces a pioneering use of a large-format SPAD camera for DSCA. By harnessing the camera’s high temporal resolution and photon-detection efficiency, we significantly enhance the accuracy and robustness of speckle contrast measurements. Our experimental results demonstrate the system’s remarkable ability to capture rapid temporal variations over a broad field of view, enabling detailed spatiotemporal analysis. Through simulations, phantom experiments, and in vivo studies, we validated the proposed approach’s potential for cerebral blood flow and functional tissue monitoring. This work highlights the transformative impact of large SPAD cameras on DSCA, setting the stage for breakthroughs in optical imaging. Full article
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