Next-Generation Sequencing and Whole-Genome Sequencing in Molecular Research

Dear Colleagues,

Since its emergence approximately two decades ago, High-Throughput or Next-Generation Sequencing (HTS/NGS) has continuously advanced, significantly influencing a wide array of scientific disciplines, including biology, genetics, genomics, physiology, ecology, chemistry, and biochemistry. Researchers and practitioners worldwide, working in governmental, academic, and industrial sectors, have adopted this technology as an essential tool for unraveling profound scientific inquiries, as well as in response to the serious challenges of our times that have tremendous implications for human health and the well-being of plants, animals, and even our planet.

HTS is a fast-moving technology characterized by ongoing improvements in quality, length, depth, and the number of sequences, complemented by innovative breakthroughs in biochemistry, design, and engineering. These developments have led to the introduction of more powerful instruments with increasing throughput power year by year. The numerous applications of HTS, such as Whole-Genome Sequencing (WGS), RNA-Seq, and Amplicon or Shotgun Mass Sequencing, have greatly contributed to the advancement of metagenomics, transcriptomics, proteomics, metabolomics, and phylogenomics, fostering the rapid development of novel investigative, diagnostic, and analytical methods, thus harnessing the full potential of this transformative technology.

Finally, HTS has become one of the main contributors to ‘big data’, a valuable resource for predictive modeling through the application of machine learning and artificial intelligence (AI). In this Special Issue, we cordially invite you to share your HTS-based research and review papers, emphasizing your latest discoveries and the transformative power and influence of this technology, as well as its numerous applications within varied domains of study and organizations.

Dr. Behzad Imanian
Guest Editor

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