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8,124 Results Found

  • Feature Paper
  • Article
  • Open Access
2 Citations
2,644 Views
27 Pages

Mortality/Longevity Risk-Minimization with or without Securitization

  • Tahir Choulli,
  • Catherine Daveloose and
  • Michèle Vanmaele

10 July 2021

This paper addresses the risk-minimization problem, with and without mortality securitization, à la Föllmer–Sondermann for a large class of equity-linked mortality contracts when no model for the death time is specified. This framework includes situa...

  • Article
  • Open Access
3 Citations
2,477 Views
15 Pages

Gradient Learning under Tilted Empirical Risk Minimization

  • Liyuan Liu,
  • Biqin Song,
  • Zhibin Pan,
  • Chuanwu Yang,
  • Chi Xiao and
  • Weifu Li

9 July 2022

Gradient Learning (GL), aiming to estimate the gradient of target function, has attracted much attention in variable selection problems due to its mild structure requirements and wide applicability. Despite rapid progress, the majority of the existin...

  • Article
  • Open Access
3 Citations
1,669 Views
18 Pages

15 February 2023

This paper is devoted to studying the influence of the structure of a complex system on its integral risk. When solving risk management problems, it often becomes necessary to take into account structural effects, which most often include risk transf...

  • Article
  • Open Access
4,763 Views
26 Pages

7 July 2016

We study risk-minimization for a large class of insurance contracts. Given that the individual progress in time of visiting an insurance policy’s states follows an F -doubly stochastic Markov chain, we describe different state-dependent types of...

  • Article
  • Open Access

Incidence of Adverse Drug Reactions at the University Hospital Center of Libreville, Gabon: From Data Collection to a Risk Minimization Plan

  • Pierre Constant Ntoutoume Nzoghe,
  • Rim Lakhmiri,
  • Sophie Coniquet,
  • Solange Ntsame,
  • Ihsane Hmamouchi,
  • Yahia Cherrah and
  • Samira Serragui
Pharmacoepidemiology2026, 5(1), 4;https://doi.org/10.3390/pharma5010004 
(registering DOI)

16 January 2026

Background: According to the literature, adverse drug reactions (ADRs) account for 5–10% of hospital admissions and affect 25–30% of hospitalized patients, but no data are available for Gabon. Objectives: To estimate the incidence of ADRs...

  • Article
  • Open Access
1,086 Views
28 Pages

Efficient Naval Surveillance: Addressing Label Noise with Rockafellian Risk Minimization for Water Security

  • Gabriel Custódio Rangel,
  • Victor Benicio Ardilha da Silva Alves,
  • Igor Pinheiro de Araújo Costa,
  • Miguel Ângelo Lellis Moreira,
  • Arthur Pinheiro de Araújo Costa,
  • Marcos dos Santos and
  • Eric Charles Eckstrand

31 January 2025

This study proposes developing a resilient machine learning algorithm based on neural networks to classify naval images used in surveillance, search, and detection operations in vast coastal and marine environments. Coastal areas critical for water r...

  • Article
  • Open Access
1 Citations
1,542 Views
28 Pages

26 November 2024

Multi-hole pressure probes are crucial for turbomachinery flow measurements, yet conventional data processing methods often lack generalization for complex flows. This study introduces an innovative approach by integrating machine learning techniques...

  • Article
  • Open Access
418 Views
16 Pages

5 December 2025

Background/Objectives: Risk minimization measures, including a pregnancy prevention program (PPP), have been established by the European Medicine Agency to strengthen the restrictions on valproate (VPA) use in pregnant women/women with childbearing p...

  • Article
  • Open Access
2,757 Views
27 Pages

1 April 2025

We introduce a new coherent risk measure, the minimal-entropy risk measure, which is built on the minimal-entropy σ-martingale measure—a concept inspired by the well-known minimal-entropy martingale measure used in option pricing. While t...

  • Article
  • Open Access
4,673 Views
14 Pages

This article describes development and confirmatory testing of a method to study the evaporation of a volatile solvent containing ignitable ingredients in an isolated subsurface structure, a type of confined space. Accidental spillage and surreptitio...

  • Article
  • Open Access
1 Citations
2,105 Views
22 Pages

31 January 2024

The paper examines the valuation and hedging of life insurance obligations in the presence of mortality risk using the local risk-minimizing hedging approach. Roughly speaking, it is assumed that the lifetime of policyholders in an insurance portfoli...

  • Article
  • Open Access
2,082 Views
18 Pages

This paper aims to improve the response speed of SPDC (stochastic primal–dual coordinate ascent) in large-scale machine learning, as the complexity of per-iteration of SPDC is not satisfactory. We propose an accelerated stochastic primal–...

  • Article
  • Open Access
8 Citations
3,369 Views
12 Pages

Risk Assessment Model for Complications in Minimally Invasive Hysterectomy: A Pilot Study

  • Matteo Bruno,
  • Francesco Legge,
  • Cosimo Gentile,
  • Vito Carone,
  • Guglielmo Stabile,
  • Federico Di Leo,
  • Manuela Ludovisi,
  • Christian Di Florio and
  • Maurizio Guido

Objective: To estimate the rate of intra-operative and postoperative complications, and to define the risk of 30-day major postoperative complications (Clavien-Dindo > 2) according to the presence of one of 10 different variables of minimally inva...

  • Article
  • Open Access
1,317 Views
15 Pages

16 August 2025

Conventional health risk assessments do not adequately reflect short-term exposure characteristics following chemical accidents. We aimed to evaluate the efficacy of existing assessment methods and propose a more suitable risk assessment approach for...

  • Article
  • Open Access
2 Citations
2,600 Views
16 Pages

At the Crossroads of Minimally Invasive Mitral Valve Surgery—Benching Single Hospital Experience to a National Registry: A Plea for Risk Management Technology

  • Riccardo Cocchieri,
  • Bertus van de Wetering,
  • Sjoerd van Tuijl,
  • Iman Mousavi,
  • Robert Riezebos and
  • Bastian de Mol

Almost 30 years after the first endoscopic mitral valve repair, Minimally Invasive Mitral Valve Surgery (MIMVS) has become the standard at many institutions due to optimal clinical results and fast recovery. The question that arises is can already go...

  • Article
  • Open Access
3 Citations
3,368 Views
22 Pages

The 2021 flooding events in The Netherlands, Belgium and Germany have sensitized many municipalities across Europe and especially in Germany, the federal states of North Rhine-Westphalia (NRW) and Rhineland-Palatinate, having been particularly affect...

  • Article
  • Open Access
12 Citations
3,723 Views
28 Pages

10 January 2023

In this paper, we propose dynamic, short-term, financial risk management strategies for small electricity producers and buyers that trade in the wholesale electricity markets. Since electricity is mostly nonstorable, financial risk coming from extrem...

  • Article
  • Open Access
8 Citations
11,148 Views
20 Pages

3 February 2023

Minimal risk maneuvers (MRMs), as part of highly automated systems, aim at minimizing the risk during a transition phase from automated to manual driving. Previous studies show that many drivers have an urge to intervene in transition phases despite...

  • Article
  • Open Access
4 Citations
3,087 Views
20 Pages

8 June 2021

Strategic and managemerial decision-making in an organization can have a crucial effect for the whole entity; however, it rarely involves the organization’s employees evenly at the different organizational levels. The result is—what is addressed in t...

  • Article
  • Open Access
1,044 Views
10 Pages

16 December 2024

Objectives: The objective of this study was to evaluate the impact of diabetes mellitus (DM) on the outcome of Schlemm’s canal-based minimally invasive glaucoma surgery (MIGS). Methods: In a retrospective interventional cohort study, postoperat...

  • Review
  • Open Access
2 Citations
6,880 Views
20 Pages

22 April 2023

Despite the development of anti-myeloma therapeutics, such as proteasome inhibitors, immunomodulatory drugs, anti-CD38 monoclonal antibodies, and autologous stem cell transplantation (ASCT), multiple myeloma remains incurable. A trial treatment combi...

  • Article
  • Open Access
4 Citations
2,928 Views
13 Pages

Minimal extrathyroid extension (mETE) effect on papillary thyroid carcinoma (PC) prognosis is still debated even more so now that this factor has been removed in the 8th AJCC Edition, supporting the hypothesis that mETE is not associated with aggress...

  • Article
  • Open Access
1 Citations
1,937 Views
15 Pages

Propensity Matched Outcomes of Minimally Invasive Mitral Surgery: Does a Heart-Team Approach Eliminate Female Gender as an Independent Risk Factor?

  • Laina Passos,
  • Isabel Lavanchy,
  • Thierry Aymard,
  • Mohammed Morjan,
  • Ioannis Kapos,
  • Roberto Corti,
  • Juerg Gruenenfelder,
  • Patric Biaggi and
  • Diana Reser

Background: There is increasing evidence that female gender is an independent risk factor for cardiac surgery. Minimally invasive mitral surgery (MIV) has proven to have excellent long-term results, but little is known about gender-dependent outcomes...

  • Article
  • Open Access
10 Citations
2,880 Views
19 Pages

13 October 2021

As an important improvement to naive Bayes, Tree-Augmented Naive Bayes (TAN) exhibits excellent classification performance and efficiency since it allows that every attribute depends on at most one other attribute in addition to the class variable. H...

  • Article
  • Open Access
7 Citations
2,738 Views
22 Pages

13 July 2022

In the wine industry, task planning is based on decision-making processes that are influenced by technical and organizational constraints as well as regulatory limitations. A characteristic constraint inherent to this sector concerns occupational ris...

  • Article
  • Open Access
5 Citations
3,193 Views
24 Pages

29 August 2022

Hyperspectral image classification technology is important for the application of hyperspectral technology. Support vector machines (SVMs) work well in supervised classifications of hyperspectral images; however, they still have some shortcomings, an...

  • Article
  • Open Access
8 Citations
7,230 Views
20 Pages

Quadratic Hedging of Basis Risk

  • Hardy Hulley and
  • Thomas A. McWalter

This paper examines a simple basis risk model based on correlated geometric Brownian motions. We apply quadratic criteria to minimize basis risk and hedge in an optimal manner. Initially, we derive the Föllmer–Schweizer decomposition for a European c...

  • Article
  • Open Access
15 Citations
5,458 Views
22 Pages

A popular risk measure, conditional value-at-risk (CVaR), is called expected shortfall (ES) in financial applications. The research presented involved developing algorithms for the implementation of linear regression for estimating CVaR as a function...

  • Article
  • Open Access
9 Citations
7,672 Views
15 Pages

Quantitative Evaluation of Compliance with Recommendation for Sulfonylurea Dose Co-Administered with DPP-4 Inhibitors in Japan

  • Tomomi Kimura,
  • Kazuhito Shiosakai,
  • Yasuaki Takeda,
  • Shinji Takahashi,
  • Masahiko Kobayashi and
  • Motonobu Sakaguchi

19 September 2012

After the launch of dipeptidyl peptidase-4 (DPP-4), a new oral hypoglycemic drug (OHD), in December 2009, severe hypoglycemia cases were reported in Japan. Although the definite cause was unknown, co-administration with sulfonylureas (SU) was suspect...

  • Article
  • Open Access
6 Citations
6,140 Views
29 Pages

11 November 2013

Value-at-risk (VaR) and conditional value-at-risk (CVaR) are popular risk measures from academic, industrial and regulatory perspectives. The problem of minimizing CVaR is theoretically known to be of a Neyman–Pearson type binary solution. We add a c...

  • Article
  • Open Access
3 Citations
982 Views
16 Pages

Assessment of Risks of Voltage Quality Decline in Load Nodes of Power Systems

  • Pylyp Hovorov,
  • Roman Trishch,
  • Romualdas Ginevičius,
  • Vladislavas Petraškevičius and
  • Karel Šuhajda

21 March 2025

The results of numerous studies show that the control of power grid modes is carried out mainly using a technical criterion. The economic criterion is taken into account through the use of complex and inaccurate models that do not accurately predict...

  • Review
  • Open Access
7 Citations
9,561 Views
24 Pages

MRD-Based Therapeutic Decisions in Genetically Defined Subsets of Adolescents and Young Adult Philadelphia-Negative ALL

  • Manuela Tosi,
  • Orietta Spinelli,
  • Matteo Leoncin,
  • Roberta Cavagna,
  • Chiara Pavoni,
  • Federico Lussana,
  • Tamara Intermesoli,
  • Luca Frison,
  • Giulia Perali and
  • Renato Bassan
  • + 3 authors

27 April 2021

In many clinical studies published over the past 20 years, adolescents and young adults (AYA) with Philadelphia chromosome negative acute lymphoblastic leukemia (Ph− ALL) were considered as a rather homogeneous clinico-prognostic group of patients su...

  • Article
  • Open Access
2 Citations
1,696 Views
18 Pages

Prognostic Value of Post-Transplant MRD Negativity in Standard Versus High- and Ultra-High-Risk Multiple Myeloma Patients

  • Lea Jasmin Kündgen,
  • Dilara Akhoundova,
  • Michele Hoffmann,
  • Myriam Legros,
  • Inna Shaforostova,
  • Katja Seipel,
  • Ulrike Bacher and
  • Thomas Pabst

4 May 2025

Background: Cytogenetic abnormalities and the persistence of minimal residual disease (MRD) following autologous stem cell transplantation (ASCT) are two established prognostically unfavorable biomarkers in multiple myeloma (MM). Previous studies hav...

  • Article
  • Open Access
5 Citations
4,183 Views
21 Pages

A Software Vulnerability Management Framework for the Minimization of System Attack Surface and Risk

  • Panagiotis Sotiropoulos,
  • Christos-Minas Mathas,
  • Costas Vassilakis and
  • Nicholas Kolokotronis

Current Internet of Things (IoT) systems comprise multiple software systems that are deployed to provide users with the required functionalities. System architects create system blueprints and draw specifications for the software artefacts that are n...

  • Article
  • Open Access
1,648 Views
17 Pages

27 October 2024

This paper integrates L1-norm structural risk minimization with L1-norm approximation error to develop a new optimization framework for solving the parameters of sparse kernel regression models, addressing the challenges posed by complex mo...

  • Article
  • Open Access
24 Citations
6,357 Views
22 Pages

Combining Data Envelopment Analysis and Machine Learning

  • Nadia M. Guerrero,
  • Juan Aparicio and
  • Daniel Valero-Carreras

11 March 2022

Data Envelopment Analysis (DEA) is one of the most used non-parametric techniques for technical efficiency assessment. DEA is exclusively concerned about the minimization of the empirical error, satisfying, at the same time, some shape constraints (c...

  • Feature Paper
  • Article
  • Open Access
1,300 Views
13 Pages

Prognostic Role of the Modified Frailty Index in Octogenarians Undergoing Minimally Invasive Aortic Valve Replacement

  • Beatrice Bacchi,
  • Francesco Cabrucci,
  • Dario Petrone,
  • Giulia Bessi,
  • Tommaso Pacini,
  • Aleksander Dokollari and
  • Massimo Bonacchi

8 July 2025

Objectives: Frailty is increasingly recognized as a key determinant of surgical risk in elderly patients undergoing aortic valve replacement (AVR). This study aimed to evaluate the prognostic value of the modified Frailty Index (mFI) in a homogeneous...

  • Article
  • Open Access
365 Views
9 Pages

Gait and Stability Analysis of People After Osteoporotic Spinal Fractures Treated with Minimally Invasive Surgery

  • Szymon Kaczor,
  • Michalina Blazkiewicz,
  • Malgorzata Kowalska,
  • Adam Hermanowicz,
  • Ewa Matuszczak,
  • Justyna Zielińska-Turek and
  • Justyna Hermanowicz

Background: Osteoporotic vertebral fractures in the thoracic–lumbar spine are common in older adults and can lead to pain, kyphotic posture, impaired postural control, and altered gait. These changes increase the risk of falls and reduce functi...

  • Article
  • Open Access
22 Citations
4,146 Views
12 Pages

Postoperative acute kidney injury (AKI) is still a concern in partial nephrectomy (PN), even with the development of minimally invasive technique. We aimed to compare AKI incidence between patients with and without diabetes mellitus (DM) and to deter...

  • Article
  • Open Access
1 Citations
3,806 Views
9 Pages

3 April 2018

To describe the movement of asset prices accurately, we employ the non-extensive statistical mechanics and the semi-Markov process to establish an asset price model. The model can depict the peak and fat tail characteristics of returns and the regime...

  • Review
  • Open Access
9 Citations
13,116 Views
56 Pages

29 January 2025

Machine learning has become indispensable across various domains, yet understanding its theoretical underpinnings remains challenging for many practitioners and researchers. Despite the availability of numerous resources, there is a need for a cohesi...

  • Review
  • Open Access
2 Citations
3,843 Views
14 Pages

13 July 2022

Mantle cell lymphoma (MCL), a type of B-cell non-Hodgkin lymphoma characterized by the t(11;14)(q13q32) translocation, is a clinically heterogenous disease which can range from indolent to highly aggressive. Numerous prognostic factors have been iden...

  • Article
  • Open Access
90 Citations
13,157 Views
15 Pages

21 March 2019

Engineering systems such as energy production facilities, aviation systems, maritime vessels, etc. continue to grow in size and complexity. This growth has made the identification, quantification and mitigation of risks associated with the failure of...

  • Article
  • Open Access
12 Citations
3,909 Views
13 Pages

Association between Augmented Renal Clearance and Inadequate Vancomycin Pharmacokinetic/Pharmacodynamic Targets in Chinese Adult Patients: A Prospective Observational Study

  • Jinjin Zhao,
  • Yaxin Fan,
  • Minjie Yang,
  • Xiaoyu Liang,
  • Jufang Wu,
  • Yuancheng Chen,
  • Beining Guo,
  • Huifang Zhang,
  • Ruilan Wang and
  • Jing Zhang
  • + 2 authors

This study aimed to examine the risk factors of augmented renal clearance (ARC) and the association between ARC and vancomycin pharmacokinetic/pharmacodynamic (PK/PD) indices in Chinese adult patients. A prospective, observational, multicenter study...

  • Article
  • Open Access
3,541 Views
10 Pages

Evaluation of Surgical Approaches and Use of Adjuvant Radiotherapy with Respect to Oncologic Outcomes in the Management of Clinically Early-Stage Cervical Carcinoma

  • Laura Burgess,
  • Wafa AlDuwaisan,
  • Tinghua Zhang,
  • Krystine Lupe,
  • Michael Fung-Kee-Fung,
  • Wylam Faught,
  • Tien Le and
  • Rajiv Samant

5 December 2022

The standard of care for early-stage cervix cancer is radical hysterectomy with pelvic lymphadenectomy. Adjuvant radiotherapy (RT) or chemoradiotherapy may be administered to reduce the risk of recurrence in patients considered to be at elevated risk...

  • Review
  • Open Access
1 Citations
2,374 Views
13 Pages

Neuroendoscopy and Postoperative Nausea and Vomiting: Pathophysiology, Incidence and Management Strategies

  • Vincenzo Pota,
  • Francesco Coletta,
  • Francesca Pascazio,
  • Pasquale Rinaldi,
  • Antonio Tomasello,
  • Giovanna Paola De Marco,
  • Francesca Schettino,
  • Maria Beatrice Passavanti,
  • Pasquale Sansone and
  • Francesco Coppolino
  • + 3 authors

Neuroendoscopy is a minimally invasive surgical technique used to treat brain pathologies such as hydrocephalus, arachnoid cysts, and skull base tumors. While it offers several advantages, including reduced tissue trauma and lower morbidity, it is as...

  • Article
  • Open Access
1,744 Views
19 Pages

5 March 2025

The impact of immediate emotions on human decision-making has been extensively studied; however, their role within human–machine interactive systems remains underexplored. This study investigates how emotional states influence decision-making b...

  • Article
  • Open Access
1 Citations
1,481 Views
15 Pages

This paper investigates a financial market where asset prices follow a multi-dimensional Brownian motion process and a multi-dimensional Poisson process characterized by diverse credit and deposit rates where the credit rate is higher than the deposi...

  • Article
  • Open Access
5 Citations
2,525 Views
13 Pages

Impairment of Nutritional Status and Quality of Life Following Minimal-Invasive Esophagectomy—A Prospective Cohort Analysis

  • Grace Oberhoff,
  • Lena Schooren,
  • Florian Vondran,
  • Andreas Kroh,
  • Alexander Koch,
  • Jan Bednarsch,
  • Ulf P. Neumann,
  • Sophia M. Schmitz and
  • Patrick H. Alizai

8 January 2024

Minimal-invasive resection of the esophagus for esophageal cancer has led to a relevant decrease in postoperative morbidity. Postoperatively, patients still suffer from surgical and adjuvant therapy-related symptoms impairing nutrition and quality of...

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