184 Results Found

The successful treatment of peripheral arterial disease (PAD) depends on adequate adherence to medications including antiplatelet agents. The aims of this study were (a) to identify the proportion of nonpersistent patients who reinitiated antiplatele...

Upstream open reading frames (uORFs) are a frequent feature of eukaryotic mRNAs. Upstream ORFs govern main ORF translation in a variety of ways, but, in a nutshell, they either filter out scanning ribosomes or allow downstream translation initiation...

Angiotensin-converting enzyme inhibitors (ACEIs) or angiotensin-receptor blockers (ARBs) are recommended in the treatment of arterial hypertension in patients with peripheral arterial disease (PAD). The aims of our study were: (a) to analyse the exte...

Upon oxidative stress, mammalian cells rapidly reprogram their translation. This is accompanied by the formation of stress granules (SGs), cytoplasmic ribonucleoprotein condensates containing untranslated mRNA molecules, RNA-binding proteins, 40S rib...

The Global Maximum Power (GMP) of photovoltaic (PV) systems changes its location on the power–voltage (P–V) curve as the shading pattern (SP) changes over time. Although the original Particle Swarm Optimization (PSO) technique can catch t...

The re-initialization of precise point positioning (PPP) can be avoided by cycle slip detection and correction. Ionospheric delay is critical for cycle slip detection and correction, especially for a long data gap. The frequency diversity from GNSS m...

Introduction: Small-cell lung cancer (SCLC) is an aggressive form of cancer with a poor prognosis. The two-year survival rate is 8% of all cases. Case presentation: We present the case of a male patient who was 50 years old at the time of diagnosis i...

Two different molecular mechanisms, sliding and hopping, are employed by DNA-binding proteins for their one-dimensional facilitated diffusion on nonspecific DNA regions until reaching their specific target sequences. While it has been controversial w...

The present study aims to prospectively assess the influence of respiratory disorders on smoking cessation and re-initiation. Three population-based Italian cohorts answered a questionnaire on respiratory health and smoking habits during 1998–2...

We introduce an improved conservative direct re-initialization (ICDR) method (for two-phase flow problems) as a new and efficient geometrical re-distancing scheme. The ICDR technique takes advantage of two mass-conserving and fast re-distancing schem...

Arrhythmogenic cardiomyopathy is a heritable heart disease associated with desmosomal mutations, especially premature termination codon (PTC) variants. It is known that PTC triggers the nonsense-mediated decay (NMD) mechanism. It is also accepted tha...

Here, a pure and systematic numerical study is conducted to investigate the detonation propagation in a curvature bend by focusing on the combined effect of curvature and cross-section area with a simple two-step chemical reaction model. In a channel...

In this review, we provide an overview of the strategies developed by caliciviruses to subvert or regulate the host protein synthesis machinery to their advantage. As intracellular obligate parasites, viruses strictly depend on the host cell resource...

Isocontour mapping is efficient for extracting meaningful information from a biomedical image in a topographic analysis. Isocontour extraction from real world medical images is difficult due to noise and other factors. As such, adaptive selection of...

This paper presents a PREcise and Fast Method of Ambiguity Reinitialization/Resolution (PREFMAR) for L1 and L2 in GPS measurements. The method determines NL1 and NL2 ambiguities based on the ambiguity functions: Ψ(NL1)NL1NL2 and Ψ(NL2)NL2NL1....

We propose a novel variant of the gradient descent bit-flipping (GDBF) algorithm for decoding low-density parity-check (LDPC) codes over the binary symmetric channel. The new bit-flipping rule is based on the reliability information passed from neigh...

It has been known for decades that eukaryotic cellular mRNAs are frequently translated by multiple ribosomes organized into polysomes of diverse topology, including circular arrangements. The closed-loop model, in which the 5′ cap and 3′...

The complex and specialized terminology of financial language in Portuguese-speaking markets create significant challenges for natural language processing (NLP) applications, which must capture nuanced linguistic and contextual information to support...

The closed-loop model of eukaryotic translation states that mRNA is circularized by a chain of the cap-eIF4E-eIF4G-poly(A)-binding protein (PABP)-poly(A) interactions that brings 5′ and 3′ ends together. This circularization is thought to promote the...

In all eukaryotic cells, the nucleus forms a prominent cellular compartment containing the cell’s nuclear genome. Although structurally similar, animal and plant nuclei differ substantially in details of their architecture. One example is the nuclear...

This study aims to assess the performance of different dynamical downscaling methods using updated land surface information. Particular attention is given to obtaining high-resolution climate information over China by the combination of an appropriat...

The COVID-19 pandemic has been deemed a global health pandemic. The early detection of COVID-19 is key to combating its outbreak and could help bring this pandemic to an end. One of the biggest challenges in combating COVID-19 is accurate testing for...

The periderm plays a crucial role in trees, acting as a barrier protecting internal tissues against biotic and abiotic stresses, thus having an impact on tree physiology, ecology, and general performance. It consists of the meristematic phellogen, wh...

The first nationally representative cross-sectional HIV drug resistance (HIVDR) survey was conducted in Uruguay in 2018–2019 among adults diagnosed with HIV and initiating or reinitiating antiretroviral therapy (ART). Protease, reverse transcri...

Partial shading of PV systems generates many peaks in the P–V curve. These peaks have one global peak (GP), the remaining being local peaks (LPs). Metaheuristic techniques such as PSO have proven superiority in capturing the GP and avoiding ent...

Introduction: There is growing recognition of immune related adverse events (irAEs) from immune checkpoint therapies being correlated with treatment outcomes in certain malignancies. There are currently limited data or consensus to guide management o...

Here we describe the combined process of surface modification with electrochemical atom transfer radical polymerization (e-ATRP) initiated from the surface of a modified gold-electrode in a pure aqueous solution without any additional supporting elec...

We examined the influence of a parent on robot-assisted activities for a child with Autism Spectrum Disorder. We observed the interactions between a robot and the child wearing a wearable device during free play sessions. The child participated in fo...

Background: We sought to characterize the outcomes of patients with primary pulmonary coccidioidomycosis whose post-treatment complement fixation (CF) titer increased by more than 2 dilutions (serologic rebound) after discontinuation of antifungal tr...

The NF-κB signaling pathway is a master and commander in ovarian cancer (OC) that promotes chemoresistance, cancer stem cell maintenance, metastasis and immune evasion. Many signaling pathways are dysregulated in OC and can activate NF-κB...

Lately, the interest in long non-coding RNAs (lncRNAs) as potential drug targets and predictive markers in the context of HIV-1 has peaked, but their in vivo expression and regulation remains largely unexplored. Therefore, the present study examined...

This article describes research that investigated the ability of a carbon nanotube (CNT) sensor to detect and monitor fatigue crack initiation and propagation in metal structures. The sensor consists of a nonwoven carrier fabric with a thin film of C...

Infliximab drug level checking has started to revolutionize the treatment of inflammatory bowel disease, allowing for more accurate dosing. Recently, Brandse and colleagues and Gagniere and colleagues both noted the potential benefit of a re-introduc...

The Ensemble Intermediate Coupled Model (EICM) is a model used for studying the El Niño-Southern Oscillation (ENSO) phenomenon in the Pacific Ocean, which is anomalies in the Sea Surface Temperature (SST) are observed. This research aims to implement...

Anemia is a common finding in cancer patients, most often as a result of chemotherapy. Management of anemia requires a comprehensive approach of appropriate diagnosis, exclusion of reversible causes, use of erythropoiesis-stimulating agents (esas), a...

Outbound logistics is a crucial field of logistics management. This study considers a planning distribution for the poultry industry in Thailand. The goal of the study is to minimize the transportation cost for the multi-depot vehicle-routing problem...

The current publication deals with the fracture toughness of polymeric multi-layer materials. In detail, the crack initiation and growth, crack arrest, and crack re-initiation of a multi-layer material are examined. The aim is to develop a numerical...

This paper proposes a hybrid harmony search algorithm that incorporates a method of reinitializing harmonies memory using a particle swarm optimization algorithm with an improved opposition-based learning method (IOBL) to solve continuous optimizatio...

Short-term load forecasting (STLF) in buildings differs from its broader counterpart in that the load to be predicted does not seem to be stationary, seasonal and regular but, on the contrary, it may be subject to sudden changes and variations on its...

In order to promote the development of low-carbon logistics and economize logistics distribution costs, the vehicle routing problem with split deliveries by backpack is studied. With the help of the model of classical capacitated vehicle routing prob...

The dynamic contact problem describing collision of an elastic bar with a rigid obstacle, prescribed by an initial velocity, is considered in a variational formulation. The non-smooth, piecewise-linear solution is constructed analytically using parti...

Here, for the first time, a 2D and leaf-like zeolitic imidazolate framework (ZIF-L) is reported for the synthesis of ultrahigh molecular weight (UHMW) poly(methyl methacrylate) (PMMA) with M_n up to 1390 kg mol⁻¹. This synthesis method is a one-...

This paper proposes a Hybrid Recursive Trigonometric (HRT) technique for FPGA-based direct digital frequency synthesizers. The HRT technique integrates a recursive cosine generator with periodic reinitialization via a second-order Taylor polynomial t...

The ability to learn continuously is crucial for a robot to achieve a high level of intelligence and autonomy. In this paper, we consider continual reinforcement learning (RL) for quadruped robots, which includes the ability to continuously learn sub...

Bovine herpesvirus (BoHV) type 1 is an important agricultural pathogen that infects cattle and other ruminants worldwide. Acute infection of the oro-respiratory tract leads to immune suppression and allows commensal bacteria to infect an otherwise he...

Alignment of picornavirus proteinase/polymerase sequences reveals this family evolved into five ‘supergroups’. Interestingly, the nature of the 2A region of the picornavirus polyprotein is highly correlated with this phylogeny. Viruses wi...

With the discovery of tyrosine kinase inhibitors (TKIs), overall survival in patients with chronic myeloid leukemia (CML) now approaches that of the general population. While these TKIs have proven to be lifesaving, remaining on them lifelong creates...

Brain storm optimization algorithm (BSO) is a popular swarm intelligence algorithm. A significant part of BSO is to divide the population into different clusters with the clustering strategy, and the blind disturbance operator is used to generate off...

Metastasis, a multistep process during which tumor cells disseminate to secondary organs, represents the main cause of death for cancer patients. Metastatic dormancy is a late stage during cancer progression, following extravasation of cells at a sec...

Progression from localized to metastatic disease requires cancer cells spreading to distant organs through the bloodstream. Only a small proportion of these circulating tumor cells (CTCs) survives dissemination due to anoikis, shear forces and elimin...