Next Article in Journal
Validation of the Filovirus Plaque Assay for Use in Preclinical Studies
Next Article in Special Issue
Respiratory Syncytial Virus and Cellular Stress Responses: Impact on Replication and Physiopathology
Previous Article in Journal
ESCRT Requirements for Murine Leukemia Virus Release
Previous Article in Special Issue
Shutoff of Host Gene Expression in Influenza A Virus and Herpesviruses: Similar Mechanisms and Common Themes
Open AccessReview

Translational Control during Calicivirus Infection

Faculty of Health and Medical Sciences, School of Biosciences and Medicine, University of Surrey, Guildford GU2 7HX, UK
Author to whom correspondence should be addressed.
Academic Editor: Craig McCormick
Viruses 2016, 8(4), 104;
Received: 29 February 2016 / Revised: 14 April 2016 / Accepted: 15 April 2016 / Published: 20 April 2016
(This article belongs to the Special Issue Viral Subversion of Stress Responses and Translational Control)
In this review, we provide an overview of the strategies developed by caliciviruses to subvert or regulate the host protein synthesis machinery to their advantage. As intracellular obligate parasites, viruses strictly depend on the host cell resources to produce viral proteins. Thus, many viruses have developed strategies that regulate the function of the host protein synthesis machinery, often leading to preferential translation of viral mRNAs. Caliciviruses lack a 5′ cap structure but instead have a virus-encoded VPg protein covalently linked to the 5′ end of their mRNAs. Furthermore, they encode 2–4 open reading frames within their genomic and subgenomic RNAs. Therefore, they use alternative mechanisms for translation whereby VPg interacts with eukaryotic initiation factors (eIFs) to act as a proteinaceous cap-substitute, and some structural proteins are produced by reinitiation of translation events. This review discusses our understanding of these key mechanisms during caliciviruses infection as well as recent insights into the global regulation of eIF4E activity. View Full-Text
Keywords: calicivirus; VPg; reinitiation calicivirus; VPg; reinitiation
Show Figures

Figure 1

MDPI and ACS Style

Royall, E.; Locker, N. Translational Control during Calicivirus Infection. Viruses 2016, 8, 104.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

Back to TopTop