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1,061 Results Found

  • Article
  • Open Access
6 Citations
4,121 Views
25 Pages

The paper presents an analysis of power losses in a three-phase T-type neutral point clamped converter with insulated gate bipolar transistors. The paper’s main aim is to perform a detailed analysis of power losses in the converter operating as...

  • Article
  • Open Access
1 Citations
3,647 Views
17 Pages

10 June 2018

This paper investigates the approximated arbitrage bounds of option prices in an incomplete market setting and draws implications for option pricing and risk management. It gives consideration to periods of global financial crisis and European sovere...

  • Article
  • Open Access
2,099 Views
32 Pages

Structural characterization of natural products in complex herbal extracts remains a major challenge in phytochemical analysis. In this study, we present a novel post-acquisition data-processing strategy—key ion diagnostics–neutral loss f...

  • Article
  • Open Access
3 Citations
1,914 Views
18 Pages

Phenylalanine Losses in Neutralization Dialysis: Modeling and Experiment

  • Anton Kozmai,
  • Mikhail Porozhnyy,
  • Violetta Gil and
  • Lasaad Dammak

A non-steady state mathematical model of an amino acid (phenylalanine (Phe)) and mineral salt (NaCl) solution separation by neutralization dialysis (ND) carried out in a batch mode is proposed. The model takes into account the characteristics of memb...

  • Feature Paper
  • Article
  • Open Access
1,804 Views
9 Pages

2 September 2023

In the diffusion approximation of the neutral Wright–Fisher model, the expected time until fixation or loss of a neutral allele is proportional to the initial entropy of the distribution of the allele in the population. No explanation is known...

  • Article
  • Open Access
8 Citations
5,739 Views
22 Pages

DNA Copy Number Alterations and Copy Neutral Loss of Heterozygosity in Adult Ph-Negative Acute B-Lymphoblastic Leukemia: Focus on the Genes Involved

  • Natalya Risinskaya,
  • Maria Gladysheva,
  • Abdulpatakh Abdulpatakhov,
  • Yulia Chabaeva,
  • Valeriya Surimova,
  • Olga Aleshina,
  • Anna Yushkova,
  • Olga Dubova,
  • Nikolay Kapranov and
  • Elena Parovichnikova
  • + 4 authors

18 December 2023

The landscape of chromosomal aberrations in the tumor cells of the patients with B-ALL is diverse and can influence the outcome of the disease. Molecular karyotyping at the onset of the disease using chromosomal microarray (CMA) is advisable to ident...

  • Article
  • Open Access
5 Citations
2,990 Views
16 Pages

Changes in Cell Wall Sugar Neutral Composition Contribute to Apple Texture Loss during Storage among Cultivars

  • Hui Liu,
  • Shiyu Lin,
  • Mengyuan Zhang,
  • Yanrong Lv,
  • Yanping Ma,
  • Jingping Rao and
  • Qinggang Zhu

Fruit texture affects apples’ quality, consumer preference, and shelf life. The cell wall neutral sugar composition was reported to contribute to apples’ mechanical properties at harvest. However, the contributions of cell wall neutral su...

  • Article
  • Open Access
1 Citations
2,129 Views
16 Pages

A Critical Analysis of Target Ionization and Projectile Electron Loss in Neutral– and Ion–Atom Collisions

  • Michele A. Quinto,
  • Nicolás J. Esponda,
  • Maria F. Rojas,
  • Roberto D. Rivarola and
  • Juan M. Monti

21 November 2023

Electron removal (target ionization and/or projectile electron loss) in neutral–atom collisions is theoretically studied for the impact of H0, He0 and He+ beams on noble gases (He, Ne and Ar). These reactions are investigated theoretically with...

  • Article
  • Open Access
1,603 Views
21 Pages

27 December 2023

This paper gives an overview of the operating characteristics of the railway interline power flow controller (RIPFC) regarding the capability of transferring active power between two sections of an electrified railway line separated by a neutral zone...

  • Article
  • Open Access
835 Views
15 Pages

Efficiency Performance of 7-Level Multiplexed and 3-Level Neutral Point Clamped (NPC) Converters

  • Shafquat Hussain,
  • Simone Cosso,
  • Massimiliano Passalacqua,
  • Luis Ramon Vaccaro,
  • Andrea Formentini and
  • Mario Marchesoni

23 April 2025

In medium-voltage AC applications, multilevel converters are essential due to their ability to achieve high efficiency and significantly reduce total harmonic distortion (THD), ensuring improved performance and power quality. This paper presents a de...

  • Article
  • Open Access
3 Citations
1,777 Views
17 Pages

28 May 2024

The aim of this paper was to explore the application of multi-channel synchronized dynamic strain gauges in monitoring the neutral axis (N.A.) position of prestressed concrete box girders. The N.A. position has recently been proposed as an indicator...

  • Article
  • Open Access
1,097 Views
21 Pages

The non-uniform thermal distribution in the active neutral-point clamped (ANPC) topology causes significant thermal gradients during high-power operation, restricting its use in large-capacity power conversion systems like variable-speed pumped stora...

  • Article
  • Open Access
2,467 Views
14 Pages

17 May 2024

Mealworms (Tenebrio molitor) have been used as an alternative source of proteins and lipids. Triacylglycerols (TAGs) are major sources of energy and have been used to provide essential fatty acids. They are also the main components of mealworm oil, a...

  • Article
  • Open Access
2 Citations
2,450 Views
14 Pages

Utilizing Nano-Adsorbents and Electrostatic Field Treatment for Sustainable Refinement of Crude Canola Oil

  • Li Zhou,
  • Timothy J. Tse,
  • Farley Chicilo,
  • Jianheng Shen,
  • Venkatesh Meda and
  • Martin J. T. Reaney

27 August 2024

Removal of polar impurities, such as phospholipids, free fatty acids (FFA), and peroxides, can be challenging during the refining of crude canola oil. Current conventional refining methods are energy-intensive (e.g., hot water washes) and can generat...

  • Article
  • Open Access
69 Citations
6,966 Views
17 Pages

20 October 2017

Schisandra chinensis (known in Chinese as WuWeiZi, WWZ) has observable effects such as astringing the lung to stop coughs, arresting sweating, preserving semen and preventing diarrhea. The major components of WWZ include lignans, triterpenoids, organ...

  • Article
  • Open Access
6 Citations
2,987 Views
19 Pages

Tumor Predisposing Post-Zygotic Chromosomal Alterations in Bladder Cancer—Insights from Histologically Normal Urothelium

  • Wiktoria Stańkowska,
  • Daniil Sarkisyan,
  • Bożena Bruhn-Olszewska,
  • Katarzyna Duzowska,
  • Michał Bieńkowski,
  • Marcin Jąkalski,
  • Magdalena Wójcik-Zalewska,
  • Hanna Davies,
  • Kinga Drężek-Chyła and
  • Jan P. Dumanski
  • + 18 authors

27 February 2024

Bladder urothelial carcinoma (BLCA) is the 10th most common cancer with a low survival rate and strong male bias. We studied the field cancerization in BLCA using multi-sample- and multi-tissue-per-patient protocol for sensitive detection of autosoma...

  • Review
  • Open Access
45 Citations
10,611 Views
17 Pages

21 October 2017

Abstract The antioxidant astaxanthin is known to accumulate in Haematococcus pluvialis algae under unfavorable environmental conditions for normal cell growth. The accumulated astaxanthin functions as a protective agent against oxidative stress damag...

  • Article
  • Open Access
9 Citations
2,767 Views
23 Pages

16 April 2021

This paper presents a new soft-switching solution recommended for three-level neutral-point-clamped inverters. The operation principles of the proposed solution, working stages, selection of elements, and the control algorithm are comprehensively dis...

  • Article
  • Open Access
5 Citations
6,647 Views
20 Pages

10 April 2020

An increase in the neutral current results in a malfunction of the low energy over current (LCO) protective relay and raises the neutral-to-ground voltage in three-phase, four-wire radial distribution feeders. Thus, the key point for mitigating its e...

  • Article
  • Open Access
4 Citations
2,362 Views
15 Pages

This paper introduces a state-of-the-art inverter–machine codesign methodology for achieving an energy-efficient electric drive system. The methodology is applied in an optimal design case study with the context of the latest trend in the 800 V...

  • Article
  • Open Access
14 Citations
5,356 Views
12 Pages

Copy Neutral LOH Affecting the Entire Chromosome 6 Is a Frequent Mechanism of HLA Class I Alterations in Cancer

  • Maria Antonia Garrido,
  • Francisco Perea,
  • Jose Ramon Vilchez,
  • Teresa Rodríguez,
  • Per Anderson,
  • Federico Garrido,
  • Francisco Ruiz-Cabello and
  • Natalia Aptsiauri

9 October 2021

Total or partial loss of HLA class I antigens reduce the recognition of specific tumor peptides by cytotoxic T lymphocytes favoring cancer immune escape during natural tumor evolution. These alterations can be caused by genomic defects, such as loss...

  • Article
  • Open Access
3 Citations
2,623 Views
17 Pages

27 March 2019

The current network information asymmetry is infringing the interests of end users in non-neutral network environment. To empower users, application-level performance measurements are usually used to rebalance the information asymmetry currently disf...

  • Article
  • Open Access
3 Citations
2,610 Views
36 Pages

2 February 2024

Ophiopogonis Radix (OR) is a traditional Chinese medicine. In recent years, in order to achieve the purpose of drying, bleaching, sterilizing and being antiseptic, improving appearance, and easy storage, people often use sulfur fumigation for its pro...

  • Article
  • Open Access
31 Citations
5,117 Views
16 Pages

Predictive Multi Experiment Approach for the Determination of Conjugated Phenolic Compounds in Vegetal Matrices by Means of LC-MS/MS

  • Eleonora Oliva,
  • Federico Fanti,
  • Sara Palmieri,
  • Eduardo Viteritti,
  • Fabiola Eugelio,
  • Alessia Pepe,
  • Dario Compagnone and
  • Manuel Sergi

Polyphenols (PCs) are a numerous class of bioactive molecules and are known for their antioxidant activity. In this work, the potential of the quadrupole/linear ion trap hybrid mass spectrometer (LIT-QqQ) was exploited to develop a semi-untargeted me...

  • Proceeding Paper
  • Open Access
3 Citations
1,907 Views
11 Pages

Active Fault Detection Device for LV Electrical Installations with Goertzel-Based Impedance Estimation and IoT Connectivity

  • Christos Pechlivanis,
  • Nick Rigogiannis,
  • Andreas Tichalas,
  • Syllas Frantzeskakis,
  • Christos Christodoulou and
  • Nick Papanikolaou

16 January 2024

An active (harmonic-injection based) fault detection device, relevant to low voltage electrical installations is studied in this paper. This compact and flexible device is compatible with TN/TT earthing systems, and it is capable of detecting power t...

  • Article
  • Open Access
1,150 Views
17 Pages

PSG and Other Candidate Genes as Potential Biomarkers of Therapy Resistance in B-ALL: Insights from Chromosomal Microarray Analysis and Machine Learning

  • Valeriya Surimova,
  • Natalya Risinskaya,
  • Ekaterina Kotova,
  • Abdulpatakh Abdulpatakhov,
  • Anastasia Vasileva,
  • Yulia Chabaeva,
  • Sofia Starchenko,
  • Olga Aleshina,
  • Nikolay Kapranov and
  • Elena Parovichnikova
  • + 6 authors

Chromosomal microarray analysis (CMA) was performed for 40 patients with B-ALL undergoing treatment according to the ALL-2016 protocol to investigate the copy number alterations (CNAs) and copy neutral loss of heterozygosity (cnLOH) associated with m...

  • Article
  • Open Access
1 Citations
2,065 Views
25 Pages

Enhanced Efficiency on ANPC-DAB through Adaptive Model Predictive Control

  • Adriano Nardoto,
  • Lucas Encarnação,
  • Walbermark Santos,
  • Arthur Amorim,
  • Rodrigo Fiorotti,
  • David Molinero and
  • Emilio Bueno

19 December 2023

This work studies the DC-DC conversion stage in solid-state transformers (SST). The traditional two- or three-level dual active bridge (DAB) topology faces limitations in microgrid interconnection due to power and voltage limitations. For this reason...

  • Article
  • Open Access
15 Citations
3,836 Views
24 Pages

10 March 2021

It is usually a tedious task to profile the chemical composition of a given herbal medicine (HM) using high performance liquid chromatography–tandem mass spectrometry (LC–MS/MS) due to the time-consuming sample preparation and laborious post-acquisit...

  • Article
  • Open Access
1 Citations
2,376 Views
11 Pages

Intramedullary Spinal Cord Tumors: Whole-Genome Sequencing to Assist Management and Prognosis

  • Miguel Mayol del Valle,
  • Bryan Morales,
  • Brandon Philbrick,
  • Segun Adeagbo,
  • Subir Goyal,
  • Sarah Newman,
  • Natasha L. Frontera,
  • Edjah Nduom,
  • Jeffrey Olson and
  • Kimberly Hoang
  • + 1 author

18 January 2024

Intramedullary spinal cord tumors (IMSCTs) harbor unique genetic mutations which may play a role in prognostication and management. To this end, we present the largest cohort of IMSCTs with genetic characterization in the literature from our multi-si...

  • Protocol
  • Open Access
12 Citations
3,320 Views
12 Pages

A Novel Strategy for Unveiling Spatial Distribution Pattern of Gallotannins in Paeonia rockii and Paeonia ostii Based on LC–QTRAP–MS

  • Zhangzhen Bai,
  • Rui Yu,
  • Tiantian Zheng,
  • Daoyang Sun,
  • Yang Zhou,
  • Junman Tang,
  • Huili Zhu,
  • Guangning Li,
  • Lixin Niu and
  • Yanlong Zhang
  • + 3 authors

Gallotannins (GTs) are a series of hydrolyzable tannins with multiple health-promoting effects. In this study, an integrated liquid chromatography tandem mass spectrometry (LC–MS/MS) strategy was developed for unveiling the spatial distribution...

  • Article
  • Open Access
7 Citations
3,986 Views
19 Pages

An efficient matrix cleanup method was developed for the rapid screening of 92 illegal adulterants (25 erectile dysfunction drugs, 15 steroids, seven anabolic steroids, 12 antihistamines, 12 nonsteroidal anti-inflammatory drugs (NSAIDs), four diureti...

  • Brief Report
  • Open Access
4 Citations
2,199 Views
7 Pages

Clonal Elimination of the Pathogenic Allele as Diagnostic Pitfall in SAMD9L-Associated Neuropathy

  • K. Eggermann,
  • R. Meyer,
  • M. Begemann,
  • D. Dey,
  • E. Bültmann,
  • I. Kurth,
  • G. C. Korenke and
  • C. Knopp

14 December 2022

Background: Heterozygous gain-of-function variants in SAMD9L are associated with ataxia-pancytopenia syndrome (ATXPC) and monosomy 7 myelodysplasia and leukemia syndrome-1 (M7MLS1). Association with peripheral neuropathy has rarely been described. Me...

  • Communication
  • Open Access
21 Citations
5,479 Views
10 Pages

Neutralization of GDF15 Prevents Anorexia and Weight Loss in the Monocrotaline-Induced Cardiac Cachexia Rat Model

  • Bina Albuquerque,
  • Xian Chen,
  • Dinesh Hirenallur-Shanthappa,
  • Yang Zhao,
  • John C. Stansfield,
  • Bei B. Zhang,
  • Abdul Sheikh and
  • Zhidan Wu

23 March 2022

Growth and differentiation factor 15 (GDF15) is a cytokine reported to cause anorexia and weight loss in animal models. Neutralization of GDF15 was efficacious in mitigating cachexia and improving survival in cachectic tumor models. Interestingly, el...

  • Feature Paper
  • Review
  • Open Access
13 Citations
3,951 Views
33 Pages

19 September 2023

Increased performance requirements in new power electronics areas of application, such as electric aircraft, make innovations on different design levels necessary. In order to quickly compare different topologies, analytical loss equations provide a...

  • Article
  • Open Access
3 Citations
2,338 Views
26 Pages

Rapid Identification of Constituents in Cephalanthus tetrandrus (Roxb.) Ridsd. et Badh. F. Using UHPLC-Q-Exactive Orbitrap Mass Spectrometry

  • Su-Nv Tang,
  • Jian-Bo Yang,
  • Shuai E,
  • Shuo He,
  • Jia-Xin Li,
  • Kai-Quan Yu,
  • Min Zhang,
  • Qing Li,
  • Lei Sun and
  • Hui Li

23 June 2022

Cephalanthus tetrandrus (Roxb.) Ridsd. et Badh. F. (CT) belongs to the Rubiaceae family. Its dried leaves are widely used in traditional Chinese medicine to treat enteritis, dysentery, toothache, furuncles, swelling, traumatic injury, fracture, bleed...

  • Article
  • Open Access
7 Citations
4,089 Views
31 Pages

AC Current Ripple in Three-Phase Four-Leg PWM Converters with Neutral Line Inductor

  • Aleksandr Viatkin,
  • Riccardo Mandrioli,
  • Manel Hammami,
  • Mattia Ricco and
  • Gabriele Grandi

5 March 2021

This paper presents a comprehensive study of peak-to-peak and root-mean-square (RMS) values of AC current ripples with balanced and unbalanced fundamental currents in a generic case of three-phase four-leg converters with uncoupled AC interface induc...

  • Article
  • Open Access
8 Citations
4,429 Views
22 Pages

A Study on Neutral-Point Potential in Three-Level NPC Converters

  • Maosong Zhang,
  • Ying Cui,
  • Qunjing Wang,
  • Jun Tao,
  • Xiuqin Wang,
  • Hongsheng Zhao and
  • Guoli Li

1 September 2019

This paper proposes an accurate mathematical model of three-level neutral-point-clamped (NPC) converters that can accurately represent the midpoint potential drift of the DC link with parameter perturbation. The mathematical relationships between the...

  • Article
  • Open Access
6 Citations
2,626 Views
21 Pages

Reduced Switch Count in Space Vector PWM for Three-Level NPC Inverter

  • Ryszard Beniak,
  • Krzysztof Górecki,
  • Piotr Paduch and
  • Krzysztof Rogowski

14 November 2020

The aim of this paper is to present the real-time implementation and measurements of a reduced switch count in space vector pulse width modulation for three-level neutral point clamped inverters (3L-NPC). We implement space vector pulse width modulat...

  • Perspective
  • Open Access
52 Citations
7,588 Views
20 Pages

The Future of DNA Adductomic Analysis

  • Peter W. Villalta and
  • Silvia Balbo

Covalent modification of DNA, resulting in the formation of DNA adducts, plays a central role in chemical carcinogenesis. Investigating these modifications is of fundamental importance in assessing the mutagenicity potential of specific exposures and...

  • Review
  • Open Access
22 Citations
4,891 Views
50 Pages

A Review of Recombination Coefficients of Neutral Oxygen Atoms for Various Materials

  • Domen Paul,
  • Miran Mozetic,
  • Rok Zaplotnik,
  • Gregor Primc,
  • Denis Đonlagić and
  • Alenka Vesel

21 February 2023

Relevant data on heterogeneous surface recombination of neutral oxygen atoms available in the scientific literature are reviewed and discussed for various materials. The coefficients are determined by placing the samples either in non-equilibrium oxy...

  • Article
  • Open Access
8 Citations
2,985 Views
16 Pages

7 November 2022

Sabia schumanniana Diels (SSD) is a plant whose stems are used in traditional folk medicine for the treatment of lumbago and arthralgia. Previous studies have revealed chemical constituents of SSD, including triterpenoids and aporphine alkaloids. Apo...

  • Article
  • Open Access
3 Citations
2,621 Views
19 Pages

A Generalized Approach for Determining the Current Ripple RMS in Four-Leg Inverters with the Neutral Inductor

  • Riccardo Mandrioli,
  • Francesco Lo Franco,
  • Mattia Ricco and
  • Gabriele Grandi

8 February 2023

This manuscript proposes a novel approach for determining phase and neutral-current-ripple RMS in grid-connected four-leg inverters with the neutral inductor. The harmonic pollution is determined for any arbitrary pulse width modulation (PWM) techniq...

  • Review
  • Open Access
13 Citations
10,767 Views
19 Pages

Optimal Pharmacologic Treatment Strategies in Obesity and Type 2 Diabetes

  • Gayotri Goswami,
  • Nataliya Shinkazh and
  • Nichola Davis

18 June 2014

The prevalence of obesity has increased to pandemic levels worldwide and is related to increased risk of morbidity and mortality. Metabolic comorbidities are commonly associated with obesity and include metabolic syndrome, pre-diabetes, and type 2 di...

  • Review
  • Open Access
98 Citations
16,076 Views
34 Pages

Mass Spectrometry-Based Methods for Identifying Oxidized Proteins in Disease: Advances and Challenges

  • Ivan Verrastro,
  • Sabah Pasha,
  • Karina Tveen Jensen,
  • Andrew R. Pitt and
  • Corinne M. Spickett

14 April 2015

Many inflammatory diseases have an oxidative aetiology, which leads to oxidative damage to biomolecules, including proteins. It is now increasingly recognized that oxidative post-translational modifications (oxPTMs) of proteins affect cell signalling...

  • Article
  • Open Access
3 Citations
2,406 Views
16 Pages

6.5 kV SiC PiN and JBS Diodes’ Comparison in Hybrid and Full SiC Switch Topologies

  • Lucas Barroso Spejo,
  • Lars Knoll and
  • Renato Amaral Minamisawa

19 November 2024

This work investigates the performance of state-of-the-art non-commercial 6.5 kV Silicon Carbide (SiC) PiN and Junction Barrier Schottky (JBS) diodes in hybrid (Si IGBT with SiC diode) and full SiC (SiC MOSFET with SiC diode) switch topologies. The s...

  • Article
  • Open Access
1,942 Views
31 Pages

Natural Cubic Spline Approximation of Risk-Neutral Density

  • Shuang Zhou,
  • Liyuan Jiang,
  • Keren Li,
  • Fangfang Wang and
  • Jie Yang

The risk-neutral density is a fundamental concept in pricing financial derivatives, risk management, and assessing financial markets’ perceptions over significant political or economic events. In this paper, we propose a new nonparametric metho...

  • Article
  • Open Access
1,851 Views
12 Pages

5 February 2025

Understanding characteristic post-source decay (PSD) fragmentation patterns in tandem mass spectrometry (MS/MS) is important for the identification of target molecules. In this study, we explored the characteristic PSD patterns associated with O-link...

  • Article
  • Open Access
11 Citations
3,353 Views
22 Pages

Power Loss Modelling and Performance Comparison of Three-Level GaN-Based Inverters Used for Electric Traction

  • Arjun Sujeeth,
  • Angelo Di Cataldo,
  • Luigi Danilo Tornello,
  • Mario Pulvirenti,
  • Luciano Salvo,
  • Angelo Giuseppe Sciacca,
  • Giacomo Scelba and
  • Mario Cacciato

26 January 2024

The main aim of this work is to present a step-by-step procedure to model and analyze the power loss distribution of three-level Gallium Nitride (GaN) inverters. It has been applied to three distinct three-phase three-level voltage source inverters u...

  • Article
  • Open Access
24 Citations
4,390 Views
20 Pages

SARS-CoV-2 Delta Variant Displays Moderate Resistance to Neutralizing Antibodies and Spike Protein Properties of Higher Soluble ACE2 Sensitivity, Enhanced Cleavage and Fusogenic Activity

  • Sabari Nath Neerukonda,
  • Russell Vassell,
  • Sabrina Lusvarghi,
  • Richard Wang,
  • Fernando Echegaray,
  • Lisa Bentley,
  • Ann E. Eakin,
  • Karl J. Erlandson,
  • Leah C. Katzelnick and
  • Wei Wang
  • + 1 author

11 December 2021

The SARS-CoV-2 B.1.617 lineage variants, Kappa (B.1.617.1) and Delta (B.1.617.2, AY) emerged during the second wave of infections in India, but the Delta variants have become dominant worldwide and continue to evolve. Here, we compared B.1.617 varian...

  • Article
  • Open Access
3 Citations
2,427 Views
12 Pages

3 August 2022

The use of pig slurry as organic fertilizer in intensive horticulture could be possible after hygienization to avoid contamination of products. This research aimed to evaluate a mixture of a tomato waste and rice husk as biofilter media to reduce NH3...

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