For simultaneous screening of mixed features (MF) by DSM-5 and mixed depression (MD) by Benazzi, useful symptoms were extracted from our 12-item dimensional scale for depressive mixed state (DMX-12). Subjects were 190 consecutive cases with major dep...
The relationship between depression and post-COVID-19 disease syndrome (post-COVID-19 syndrome) is established. Nevertheless, few studies have investigated the association between post-COVID-19 syndrome and mixed depression, i.e., a specific sub-form...
Nowadays, controversy exists regarding the influence of comorbid depression on cognition in old age. Additionally, we still know little about the influence of depression in mixed dementia (MD), that is, in cases where there is the co-existence of Alz...
The debate on mixed states (MS) has been intense for decades. However, several points remain controversial from a nosographic, diagnostic, and therapeutic point of view. The different perspectives that have emerged over the years have turned into a l...
Effective pharmacotherapy of bipolar depression with mixed features defined by DSM-5 remains unclear in clinical treatment guidelines. Quetiapine (QTP) and valproate have potential treatment utility but are often inadequate as monotherapy. Meanwhile,...
Evidence supporting the use of second generation antipsychotics (SGAs) in the treatment of acute depression with mixed features (MFs) associated with bipolar disorder (BD) is scarce and equivocal. Therefore, we conducted a systematic review and preli...
Relatively little attention has been given to mixed anxiety and depression in autistic youth, particularly how this differs between males and females. This study investigated sex-based differences in the prevalence and correlates of mixed anxiety and...
Background/Objectives: Adolescent mental health is a growing public health concern in Thailand, with high rates of stress and depressive symptoms among secondary school students. This study aimed to (1) quantitatively examine changes in resilience, p...
We recently developed a series of nalfurafine analogs (TK10, TK33, and TK35) that may serve as non-addictive candidate analgesics. These compounds are mixed-action agonists at the kappa and delta opioid receptors (KOR and DOR, respectively) and produ...
The floatability of scheelite and calcite in the presence of single depressant (SHMP or H3Cit) and mixed depressant (SHMP/H3Cit) was studied by microflotation experiments and artificial mixed mineral experiments. Solution chemical calculation, zeta p...
Depression is a serious mental health disorder affecting cognition, emotions, and behavior. It impacts over 300 million people globally, with mental health care costs exceeding $1 trillion annually. Traditional diagnostic methods are often expensive,...
The concept of the bipolar-spectrum and of mixed features being a bridge between major depressive disorders and bipolar disorders (BDs) has become increasingly important in mood-disorder diagnoses. Under these circumstances, antidepressants (ADs) and...
Objective: The goal of this study is to validate the psychometric properties of the Modified Dental Anxiety Scale (MDAS) and the Dental Fear Scale (DFS) at three different times: seven days before, immediately after, and seven days after watching a v...
Phosphate ore is an important strategic mineral resource. The efficient utilization of phosphate resources faces challenges such as low grade of raw ore and difficulty in discharging gangue minerals. One of the key problems to be solved urgently in t...
Background/Objectives: Parent–child attachment and family relationships have been identified as risk factors for childhood internalising symptoms such as anxiety and depressive symptoms. This mixed-methods evaluation examined the feasibility of...
The Kuqa Depression is rich in oil and gas resources and serves as a key production area in the Tarim Basin. However, controversy persists over the genesis of oil and gas in the various structural zones of the Kuqa Depression. This study employs natu...
28 December 2020
Depression and suicidality are characterized by negative imagery as well as impoverished positive imagery. Although some evidence exists supporting the link between positive imagery and enhanced mood, much work needs to be done. This study explored t...
Background: early onset is frequent in Bipolar Disorders (BDs), and it is characterised by the occurrence of mixed states (or mixed features). In this systematic review, we aimed to confirm and extend these observations by providing the prevalence ra...
Background/Objectives: Cariprazine, a D3/D2 partial agonist, is one of the few recommended treatment options for bipolar 1 disorder (BP1D) in Southeast Asia. This study aims to generate insights from leading experts on the safe and effective use of c...
We developed an mHealth application that can help alleviate the problematic use of smartphones and allied psychological symptoms. This study observed the change in patterns of users’ problematic smartphone use, depression, and anxiety while using the...
Sleep disturbance is a central feature of depression and a proposed pathway through which Bright-Light Therapy (BLT) exerts antidepressant effects. However, little is known about how sleep reorganises day by day during BLT or whether these dynamics r...
14 November 2026
Background/Objectives: Symptoms and daily-life outcomes after psychiatric discharge may differ from those near discharge. We compared these assessments in children and adolescents with recorded depressive-disorder discharge diagnoses. Methods: This r...
Data regarding older age bipolar disorder (OABD) are sparse. Two major groups are classified as patients with first occurrence of mania in old age, the so called “late onset” patients (LOBD), and the elder patients with a long-standing clinical histo...
24 September 2015
Objective: To assess the variation of relative efficacy and tolerability of an antidepressant versus others based on both pre-marketing (registration studies) and post-marketing studies versus pre-marketing studies only in patients with major depress...
23 March 2024
The COVID-19 pandemic has been particularly challenging for the mental health of African American (AA) birthing people. The pandemic necessitated shifting mental health care to online interventions. The goals of this study were to (1) describe an ada...
Background: Mental health outcomes among female refugees are complex and multifaceted. This study examines the mental health outcomes and coping resources of female Ukrainian refugees in Germany using a mixed methods approach with qualitative focus g...
Women survivors of domestic violence often experience persistent psychological distress, yet evidence supporting community-based arts interventions remains limited, particularly in mainland China. This mixed-methods pilot study evaluated the prelimin...
Depressive symptoms are common in older adults and may be influenced by environmental element exposure. This study evaluated associations of individual and mixed blood element concentrations with depressive symptoms in older adults. A total of 1302 c...
Background. Depression and anxiety among young people in Africa are highly prevalent and a significant public health concern. Evidence-based interventions (EBIs) tailored to this demographic’s unique cultural and contextual needs are limited. M...
Introduction: This study aims to verify if older adults with mixed anxiety-depressive disorder are more prone to euthanasia and identify factors that interfere with their satisfaction with health and capacity for well-informed decisions. Material and...
On 25 May 2023, the Portuguese parliament approved the decriminalisation of euthanasia for incurable illnesses. As the experiences of other countries show us, it will be a matter of time before mental disorders are addressed. Studying the phenomenon,...
12 February 2023
Background: Several studies have found a strong relationship between physical activity and mental depression in older adults. Despite this, the social isolation, limited physical activity, and decreased social interactions caused by the 2020 COVID-19...
31 December 2020
Premature birth is stressful for infants and parents and can adversely affect the parent–infant dyad. This mixed-methods pilot study evaluates whether creative music therapy (CMT) can alleviate anxiety, stress, and depressive symptoms in parent...
Introduction: Severe depression is prevalent in young persons and can lead to disability and elevated suicidal risk. Objectives: To identify clinical and demographic factors associated with the severity of depression in juveniles diagnosed with a maj...
1 November 2022
Globally, dyslipidemia is now become a leading risk factor for many adverse health outcomes, especially in the middle-aged and elderly. Recent evidence suggests that exposure to greenness and the relief of a psychological burden may decrease the prev...
New digital interventions have shown potential in managing asthma and improving patients’ quality of life compared with conventional interventions. Our objective was to conduct an exhaustive survey of the application of digital health technolog...
Correct classification of irritability is extremely important to assess prognosis and treatment indications of juvenile mood disorders. We assessed factors associated with low versus high parent- and self-rated irritability using the affective reacti...
Background/Objectives: Sexual health is frequently under-addressed after stroke, despite its relevance to intimacy, identity, relationships, and rehabilitation. This convergent mixed-methods study integrated sex-specific screening with descriptive na...
The study of the depression effect of non-toxic depressants on the flotation separation of chalcopyrite from galena is of great importance for both industrial applications and theoretical research. The mixed depressant (DFinal) of four common inhibit...
(S)-Ketamine is the first rapid-acting antidepressant drug (RAAD) introduced for the treatment of depression. However, research is still being carried out on the search for further RAADs that will be not only effective but also safe to use. Recent da...
12 July 2025
Depression and cognitive impairment frequently co-occur in older adults, but their temporal relationship remains unclear. While depression is often considered a risk factor for cognitive decline, evidence is mixed, particularly in individuals with mi...
Previous research has found an association between PM2.5 exposure and worsening depression; however, studies specifically examining the harmful effects of individual PM2.5 components are relatively limited. This national survey enrolled individuals a...
Even though pseudodementia has been historically linked to depression, other psychiatric conditions may cause reversible cognitive alterations. The purpose of this study is to improve our understanding of pseudodementia occurring throughout the entir...
The uniform design method was used to screen the solidifying point depressing effects of 18 traditional diesel cold flow improvers on biodiesel derived from waste cooking oil. The cold flow improvers with good effects were selected for orthogonal opt...
9 September 2026
Depression is a common mental health issue among migrant workers. This study was designed to investigate the effectiveness of a LINE-application-based PASS program on depression scores among Myanmar migrant factory workers in Samut Prakan, Thailand....
Sodium metabisulfite (MBS) was used in this study for selective flotation of chalcopyrite and molybdenite. Microflotation tests of single and mixed minerals were performed to assess the floatability of chalcopyrite and molybdenite. The results of mic...
3 May 2013
Research shows that one in four migrant farmworkers experienced an episode of one or more mental health disorders such as stress, depression, or anxiety in their lifetime. The purpose of this mixed methods study was to explore experiences and percept...
Previous research suggests that inflammation triggers cancer-treatment-related symptoms (i.e., fatigue, depression, and disruptions in sleep and physical activity), but evidence is mixed. This study examined relationships between inflammatory biomark...
Background: Brominated flame retardants (BFRs) are a type of widespread pollutant that can be transmitted through particulate matter, such as dust in the air, and have been associated with various adverse health effects, such as diabetes, metabolic s...
Background/Objectives: Digital media use is integral to the daily lives of children and adolescents, intensifying concerns regarding potential associations with mental health. However, much of the literature linking gaming and depression is based on...
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