Antidepressants and Mood Stabilizers: Novel Research Avenues and Recent Evidence-Based Clinical Insights

Dear Colleagues,

Within the past few decades, the release of novel compounds occurred for the sole antidepressant class, rather than lithium or traditional anticonvulsant mood-stabilizers. Shifting of the boundary (and largely flawed) “class-effect” and the monoamine-modulation approach may have played a role on the latter scenario, especially in view of concurrent preliminary evidence suggesting a potential trans-nosological effect of selected second-generation antipsychotics, beyond only schizophrenia-spectrum disorders.

The present Special Issue aims at providing an overview on both the current and most promising novel avenues, of both standard antidepressant and “mood-stabilizer” agents in a broader sense, thus encompassing both boundary diagnostic systems, as well as alternative, evidence- and spectrum-based approaches, ideally driving a conscious prescription of pharmacological agents that are effective both in the treatment of major depressive episodes and the ideal longitudinal stabilization of bipolar disorder.

Prof. Dr. Domenico De Berardis
Dr. Michele Fornaro
Guest Editors

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