Skip Content
You are currently on the new version of our website. Access the old version .

18,989 Results Found

  • Review
  • Open Access
35 Citations
8,363 Views
15 Pages

Recent advances in information and communications cloud-based services hold the potential to overcome the scalability and complex maintenance limitations of traditional networks. Software Defined Networking (SDN) surfaced as a promising paradigm to m...

  • Review
  • Open Access
31 Citations
5,959 Views
20 Pages

28 September 2021

Graphene-based film attracts tremendous interest in many potential applications due to its excellent thermal, electrical, and mechanical properties. This review focused on a critical analysis of fabrication, processing methodology, the interfacial mo...

  • Review
  • Open Access
10 Citations
3,730 Views
16 Pages

Forward Genetics-Based Approaches to Understanding the Systems Biology and Molecular Mechanisms of Epilepsy

  • Anton D. Shevlyakov,
  • Tatiana O. Kolesnikova,
  • Murilo S. de Abreu,
  • Elena V. Petersen,
  • Konstantin B. Yenkoyan,
  • Konstantin A. Demin and
  • Allan V. Kalueff

Epilepsy is a highly prevalent, severely debilitating neurological disorder characterized by seizures and neuronal hyperactivity due to an imbalanced neurotransmission. As genetic factors play a key role in epilepsy and its treatment, various genetic...

  • Article
  • Open Access
21 Citations
6,544 Views
21 Pages

A Quantum-Based Similarity Method in Virtual Screening

  • Mohammed Mumtaz Al-Dabbagh,
  • Naomie Salim,
  • Mubarak Himmat,
  • Ali Ahmed and
  • Faisal Saeed

2 October 2015

One of the most widely-used techniques for ligand-based virtual screening is similarity searching. This study adopted the concepts of quantum mechanics to present as state-of-the-art similarity method of molecules inspired from quantum theory. The re...

  • Review
  • Open Access
31 Citations
6,880 Views
47 Pages

Advancements in the Additive Manufacturing of Magnesium and Aluminum Alloys through Laser-Based Approach

  • Sachin Kumar Sharma,
  • Harpreet Singh Grewal,
  • Kuldeep Kumar Saxena,
  • Kahtan A. Mohammed,
  • Chander Prakash,
  • J. Paulo Davim,
  • Dharam Buddhi,
  • Ramesh Raju,
  • Dhanesh G. Mohan and
  • Jacek Tomków

16 November 2022

Complex structures can now be manufactured easily utilizing AM technologies to meet the pre-requisite objectives such as reduced part numbers, greater functionality, and lightweight, among others. Polymers, metals, and ceramics are the few materials...

  • Article
  • Open Access
1,431 Views
22 Pages

21 November 2025

This study presents a comprehensive examination of the risks associated with SQL Injection attacks, with a particular focus on the Union Select technique. This method is frequently exploited by attackers to retrieve unauthorized data by appending mal...

  • Article
  • Open Access
2 Citations
1,797 Views
17 Pages

22 September 2023

To address the presence of network-induced delays in networked control systems (NCSs), a dual event-triggered mechanism (DETM) is used to investigate the problem of reducing network delays and controller co-design. Firstly, the DETM of the sensor&nda...

  • Review
  • Open Access
8 Citations
4,581 Views
19 Pages

11 September 2023

Due to their unique surface-active functionalities, graphene and its derivatives, i.e., graphene oxide (GO) and reduced graphene oxide (rGO), have received enormous research attention in recent decades. One of the most intriguing research hot spots i...

  • Review
  • Open Access
21 Citations
5,623 Views
26 Pages

Mechanisms Involved in Microglial-Interceded Alzheimer’s Disease and Nanocarrier-Based Treatment Approaches

  • Shadab Md,
  • Nabil A. Alhakamy,
  • Mohamed A. Alfaleh,
  • Obaid Afzal,
  • Abdulmalik S. A. Altamimi,
  • Ashif Iqubal and
  • Rasheed A. Shaik

29 October 2021

Alzheimer’s disease (AD) is a common neurodegenerative disorder accountable for dementia and cognitive dysfunction. The etiology of AD is complex and multifactorial in origin. The formation and deposition of amyloid-beta (Aβ), hyperphosphorylated tau...

  • Article
  • Open Access
578 Views
24 Pages

Surrogate-Model Prediction of Mechanical Response in Architected Ti6Al4V Cylindrical TPMS Metamaterials

  • Mansoureh Rezapourian,
  • Ali Cheloee Darabi,
  • Mohammadreza Khoshbin,
  • Siegfried Schmauder and
  • Irina Hussainova

15 December 2025

A Machine Learning (ML)-based surrogate modeling framework is presented for mapping structure–property relationships in architected Ti6Al4V cylindrical TPMS metamaterials subjected to quasi-static compression. A Python–nTop pipeline autom...

  • Review
  • Open Access
10 Citations
6,563 Views
27 Pages

A Framework for Analyzing Co-Creation Value Chain Mechanisms in Community-Based Approaches: A Literature Review

  • Satoshi Ohnishi,
  • Masahiro Osako,
  • Shogo Nakamura,
  • Takuya Togawa,
  • Kosuke Kawai,
  • Kaoru Suzuki,
  • Aya Yoshida,
  • Kei Gomi and
  • Takashi Tsuji

31 March 2024

Community co-creation is critical for tackling complex challenges and building a sustainable future, and necessitates collaboration between public and private sectors to co-create value chains. This paper highlights existing frameworks and proposes a...

  • Review
  • Open Access
45 Citations
12,096 Views
14 Pages

The cellular signalling process is a highly complex mechanism, involving multiple players, which together orchestrate the cell’s response to environmental changes and perturbations. Given the multitude of genes that participate in the process of cell...

  • Feature Paper
  • Article
  • Open Access
32 Citations
5,556 Views
18 Pages

14 July 2020

Aluminum–silicon alloys are commonly used in die-cast and additively manufactured (AM) light-weight components due to their good processability and high strength-to-weight ratio. As both processing routes lead to the formation of defects such a...

  • Review
  • Open Access
973 Citations
46,516 Views
33 Pages

22 October 2015

The skin offers an accessible and convenient site for the administration of medications. To this end, the field of transdermal drug delivery, aimed at developing safe and efficacious means of delivering medications across the skin, has in the past an...

  • Review
  • Open Access
100 Citations
10,867 Views
30 Pages

Recent Advances in Biochar Polymer Composites

  • Mattia Bartoli,
  • Rossella Arrigo,
  • Giulio Malucelli,
  • Alberto Tagliaferro and
  • Donatella Duraccio

20 June 2022

“Biochar” (BC) is the solid residue recovered from the thermal cracking of biomasses in an oxygen-poor atmosphere. Recently, BC has been increasingly explored as a sustainable, inexpensive, and viable alternative to traditional carbonaceo...

  • Article
  • Open Access
8 Citations
4,816 Views
21 Pages

1 October 2023

Polyscias fruticosa leaf (PFL) has been used in food and traditional medicine for the treatment of rheumatism, ischemia, and neuralgia. However, the lipophilic components of PFL and their biological properties remain unknown. This study, integrating...

  • Review
  • Open Access
5 Citations
3,225 Views
27 Pages

30 October 2024

The Amazon rainforest is an important reservoir of biodiversity, offering vast potential for the discovery of new bioactive compounds from plants. In vitro studies allow for the investigation of biological processes and interventions in a controlled...

  • Article
  • Open Access
1 Citations
856 Views
15 Pages

A Vector-Based Motion Retargeting Approach for Exoskeletons with Shoulder Girdle Mechanism

  • Jiajia Wang,
  • Shuo Pei,
  • Junlong Guo,
  • Mingsong Bao and
  • Yufeng Yao

Shoulder girdle plays a dominant role in coordinating the natural movements of the upper arm. Inverse kinematics, optimization, and data-driven approaches are usually used to conduct motion retargeting. However, these methods do not consider shoulder...

  • Article
  • Open Access
43 Citations
7,308 Views
23 Pages

14 December 2020

A damage mechanism based approach to the structural health monitoring of wind turbine blades is formulated. Typical physical mechanisms of wind turbine blade degradation, including surface erosion, adhesive fatigue, laminate cracking and in some case...

  • Article
  • Open Access
1 Citations
6,020 Views
18 Pages

18 February 2025

Valerian possesses a multitude of pharmacological effects, including sedative and hypnotic properties, antihypertensive effects, antibacterial activity, and liver protection. Insomnia, one of the most prevalent disorders in contemporary society, sign...

  • Article
  • Open Access
11 Citations
7,272 Views
28 Pages

25 January 2022

Missing data occur in almost all surveys; in order to handle them correctly it is essential to know their type. Missing data are generally divided into three types (or generating mechanisms): missing completely at random, missing at random, and missi...

  • Article
  • Open Access
16 Citations
3,940 Views
11 Pages

15 December 2023

Solvent-based and mechanical recycling technology approaches were compared with respect to each process’s decontamination efficiency. Herein, post-consumer polystyrene (PS) feedstock was recycled by both technologies, yielding recycled PS resin...

  • Article
  • Open Access
3 Citations
4,088 Views
19 Pages

Dimensional Tolerances in Mechanical Assemblies: A Cost-Based Optimization Approach

  • Eduardo Umaras,
  • Ahmad Barari,
  • Oswaldo Horikawa and
  • Marcos Sales Guerra Tsuzuki

13 August 2023

There is a widely accepted consensus that component manufacturing precision is directly correlated with improved functional performance. However, this increase in precision comes at the expense of higher manufacturing costs, resulting in a trade-off...

  • Review
  • Open Access
1 Citations
2,029 Views
18 Pages

Targeting Irritable Bowel Syndrome Through Diet and Mechanism-Based Therapies: A Pathophysiological Approach

  • Ioanna Aggeletopoulou,
  • Katerina Karaivazoglou,
  • Maria Kalafateli and
  • Christos Triantos

17 November 2025

Irritable Bowel Syndrome (IBS) is a prevalent and heterogeneous functional gastrointestinal disorder with a complex and multifactorial pathophysiology. Traditional treatment approaches have focused on symptom relief, often overlooking the underlying...

  • Article
  • Open Access
19 Citations
4,372 Views
17 Pages

The Gray-Box Based Modeling Approach Integrating Both Mechanism-Model and Data-Model: The Case of Atmospheric Contaminant Dispersion

  • Bin Chen,
  • Yiduo Wang,
  • Rongxiao Wang,
  • Zhengqiu Zhu,
  • Liang Ma,
  • Xiaogang Qiu and
  • Weihui Dai

6 February 2020

With the profound understanding of the world, modeling and simulation has been used to solve the problems of complex systems. Generally, mechanism-models are often used to model the engineering systems following the Newton laws, and this kind of mode...

  • Review
  • Open Access
9 Citations
3,946 Views
17 Pages

Image-Based Finite Element Modeling Approach for Characterizing In Vivo Mechanical Properties of Human Arteries

  • Liang Wang,
  • Akiko Maehara,
  • Rui Lv,
  • Xiaoya Guo,
  • Jie Zheng,
  • Kisten L. Billiar,
  • Gary S. Mintz and
  • Dalin Tang

11 September 2022

Mechanical properties of the arterial walls could provide meaningful information for the diagnosis, management and treatment of cardiovascular diseases. Classically, various experimental approaches were conducted on dissected arterial tissues to obta...

  • Concept Paper
  • Open Access
9 Citations
6,322 Views
16 Pages

An Empirical Approach to Correlating Thermo-Mechanical Fatigue Behaviour of a Polycrystalline Ni-Base Superalloy

  • Mark Whittaker,
  • Robert Lancaster,
  • William Harrison,
  • Christopher Pretty and
  • Stephen Williams

15 November 2013

Assessment of thermo-mechanical fatigue behaviour of the polycrystalline nickel alloy RR1000 reveals a significant effect of phase angle on fatigue life. The current paper explores two scenarios: the first where the mechanical strain range is held co...

  • Article
  • Open Access
162 Views
17 Pages

In order to solve the problem of traditional methods not being able to discover hidden attack trajectories, we propose a cyber attack path prediction approach based on a text-enhanced graph attention mechanism in this paper. Specifically, we design a...

  • Review
  • Open Access
41 Citations
6,431 Views
15 Pages

1 November 2018

Platycodon grandiflorum (PG) is widely used in Asia for its various beneficial effects. Although many studies were conducted to understand the molecular mechanisms of PG, it is still unclear how the combinations of multiple ingredients work together...

  • Article
  • Open Access
2 Citations
3,365 Views
16 Pages

23 March 2022

The focused infrared (IR) heating method is an energy-efficient heating technology for engineering applications. Numerical models of focused IR heating technology have been introduced based on the theory of ray optics. The ray optics-based IR models...

  • Article
  • Open Access
16 Citations
3,312 Views
23 Pages

A DLSTM-Network-Based Approach for Mechanical Remaining Useful Life Prediction

  • Yan Liu,
  • Zhenzhen Liu,
  • Hongfu Zuo,
  • Heng Jiang,
  • Pengtao Li and
  • Xin Li

29 July 2022

Remaining useful life prediction is one of the essential processes for machine system prognostics and health management. Although there are many new approaches based on deep learning for remaining useful life prediction emerging in recent years, thes...

  • Review
  • Open Access
4 Citations
4,563 Views
17 Pages

FLT3 mutations are the most frequently identified genetic alterations in acute myeloid leukemia (AML) and are associated with poor clinical outcome, relapse and chemotherapeutic resistance. Elucidating the molecular mechanisms underlying FLT3-depende...

  • Article
  • Open Access
1 Citations
7,368 Views
22 Pages

Arterial Mechanical Motion Estimation Based on a Semi-Rigid Body Deformation Approach

  • Pablo Guzman,
  • Ghassan Hamarneh,
  • Rafael Ros and
  • Eduardo Ros

27 May 2014

Arterial motion estimation in ultrasound (US) sequences is a hard task due to noise and discontinuities in the signal derived from US artifacts. Characterizing the mechanical properties of the artery is a promising novel imaging technique to diagnose...

  • Article
  • Open Access
5 Citations
2,368 Views
19 Pages

20 April 2023

The work is focused on the mechanical behavior description of porous filled composites that is not based on simulations or exact physical models, including different assumptions and simplifications with further comparison with real behavior of materi...

  • Article
  • Open Access
24 Citations
5,226 Views
12 Pages

Mechanical Rupture-Based Antibacterial and Cell-Compatible ZnO/SiO2 Nanowire Structures Formed by Bottom-Up Approaches

  • Taisuke Shimada,
  • Takao Yasui,
  • Akihiro Yonese,
  • Takeshi Yanagida,
  • Noritada Kaji,
  • Masaki Kanai,
  • Kazuki Nagashima,
  • Tomoji Kawai and
  • Yoshinobu Baba

24 June 2020

There are growing interests in mechanical rupture-based antibacterial surfaces with nanostructures that have little toxicity to cells around the surfaces; however, current surfaces are fabricated via top-down nanotechnologies, which presents difficul...

  • Article
  • Open Access
7 Citations
3,437 Views
20 Pages

15 September 2022

A numerical characterization of a fractured rock mass and its mechanical behavior using a discontinuum approach was carried out utilizing lattice-spring-based synthetic rock mass (LS-SRM) models. First, LS-SRM models on a laboratory scale were create...

  • Article
  • Open Access
2,261 Views
18 Pages

22 July 2021

The suitability of replacing mineral aggregate with carbon-negative ones mainly depends on the properties of the aggregates produced from waste recycling, reducing CO2 emissions. This study aimed to investigate the predictive approaches adapted to co...

  • Article
  • Open Access
8 Citations
3,369 Views
16 Pages

An Approach to In Situ Evaluation of Timber Structures Based on Equalization of Non-Destructive and Mechanical Test Parameters

  • Andrej Josifovski,
  • Nebojša Todorović,
  • Jelena Milošević,
  • Marko Veizović,
  • Filip Pantelić,
  • Marina Aškrabić,
  • Miomir Vasov and
  • Aleksandar Rajčić

This paper addresses the challenges in evaluating the structural performance of built structures using non-destructive methods and in situ tests. Such an examination of structural properties, without their sampling, is a diagnostic improvement, espec...

  • Proceeding Paper
  • Open Access
1,553 Views
8 Pages

27 October 2023

Accurate fatigue life prediction is essential for ensuring the reliability of engineering designs, particularly under thermo-mechanical fatigue conditions. This study focuses on investigating the isothermal and thermo-mechanical low-cycle fatigue of...

  • Article
  • Open Access
6 Citations
16,205 Views
44 Pages

Multiple (TEES)-Criteria-Based Sustainable Planning Approach for Mesh-Configured Distribution Mechanisms across Multiple Load Growth Horizons

  • Syed Ali Abbas Kazmi,
  • Usama Ameer Khan,
  • Waleed Ahmad,
  • Muhammad Hassan,
  • Fahim Ahmed Ibupoto,
  • Syed Basit Ali Bukhari,
  • Sajid Ali,
  • M. Mahad Malik and
  • Dong Ryeol Shin

27 May 2021

Modern distribution mechanisms within the smart grid paradigm are considered both reliable in nature and interconnected in topology. In this paper, a multiple-criteria-based sustainable planning (MCSP) approach is presented that serves as a future pl...

  • Article
  • Open Access
15 Citations
3,080 Views
15 Pages

16 January 2022

This paper introduces a new loading condition considering the combined thermo-electro-mechanical coupling effect in a series solution-based approach to analyze the free-edge interlaminar stresses in smart composite laminates. The governing equations...

  • Article
  • Open Access
1 Citations
1,530 Views
22 Pages

17 April 2025

For the satellite orbit pursuit–evasion game problem, this paper proposes a multi-stage optimization-based solution aimed at improving the confrontation strategies between task satellites and target satellites in complex space environments. The...

  • Article
  • Open Access
11 Citations
5,816 Views
15 Pages

CT-Based Micro-Mechanical Approach to Predict Response of Closed-Cell Porous Biomaterials to Low-Velocity Impact

  • Mehrdad Koloushani,
  • Reza Hedayati,
  • Mojtaba Sadighi and
  • Mohammad Mohammadi-Aghdam

In this study, a new numerical approach based on CT-scan images and finite element (FE) method has been used to predict the mechanical behavior of closed-cell foams under impact loading. Micro-structural FE models based on CT-scan images of foam spec...

  • Article
  • Open Access
3 Citations
2,545 Views
16 Pages

1 November 2022

Blood cell detection is an essential branch of microscopic imaging for disease diagnosis. TE-YOLOF is an effective model for blood cell detection, and was recently found to have an outstanding trade-off between accuracy and model complexity. However,...

  • Article
  • Open Access
2 Citations
3,110 Views
13 Pages

16 July 2022

Structures made of the thermoplastic polymer polyether ether ketone (PEEK) are widely used in dynamically-loaded applications due to their high-temperature resistance and high mechanical properties. To design these dynamic applications, in addition t...

  • Article
  • Open Access
2 Citations
2,384 Views
20 Pages

17 July 2024

Selecting the optimal settings for the production of rubber goods can be a very time-consuming and resource-intensive process. A promising method for optimizing rubber processing in a short period of time is the use of simulation routines. However, p...

  • Article
  • Open Access
1 Citations
2,109 Views
16 Pages

1 March 2024

Coverage-guided fuzzing has been widely applied in software error and security vulnerability detection. The fuzzing technique based on AFL (American Fuzzy Loop) is a common coverage-guided fuzzing method. The code coverage during AFL fuzzing is highl...

  • Article
  • Open Access
18 Citations
3,500 Views
16 Pages

26 June 2019

In this paper, an image-based micromechanical model for an asphalt mixture’s rheological mechanical response is introduced. Detailed information on finite element (FE) modeling based on X-ray computed tomography (X-ray CT) is presented. An impr...

  • Article
  • Open Access
4 Citations
3,818 Views
24 Pages

13 February 2025

Maintenance strategies such as condition-based maintenance and predictive maintenance of machines have gained importance in industrial automation firms as key concepts in Industry 4.0. As a result, online condition monitoring of electromechanical sys...

  • Article
  • Open Access
19 Citations
4,384 Views
17 Pages

Mechanism-Based Approach to New Antibiotic Producers Screening among Actinomycetes in the Course of the Citizen Science Project

  • Inna A. Volynkina,
  • Yuliya V. Zakalyukina,
  • Vera A. Alferova,
  • Albina R. Belik,
  • Daria K. Yagoda,
  • Arina A. Nikandrova,
  • Yuliya A. Buyuklyan,
  • Andrei V. Udalov,
  • Evgenii V. Golovin and
  • Ilya A. Osterman
  • + 5 authors

5 September 2022

Since the discovery of streptomycin, actinomycetes have been a useful source for new antibiotics, but there have been diminishing rates of new finds since the 1960s. The decreasing probability of identifying new active agents led to reduced interest...

of 380