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57 Results Found

  • Feature Paper
  • Article
  • Open Access
20 Citations
3,629 Views
15 Pages

21 June 2022

Survival and reliability analyses deal with incomplete failure time data, such as censored and truncated data. Recently, the classical left-truncation scheme was generalized to analyze “field data”, defined as samples collected within a f...

  • Feature Paper
  • Article
  • Open Access
1 Citations
2,510 Views
17 Pages

30 October 2023

Insurance loss data are usually in the form of left-truncation and right-censoring due to deductibles and policy limits, respectively. This paper investigates the model uncertainty and selection procedure when various parametric models are constructe...

  • Article
  • Open Access
3 Citations
2,291 Views
25 Pages

21 December 2022

In this paper, a competing risks model with dependent causes of failure is considered under left-truncated and right-censoring scenario. When the dependent failure causes follow a Marshall–Olkin bivariate exponential distribution, estimation of...

  • Article
  • Open Access
590 Views
17 Pages

14 November 2025

Deep learning has demonstrated better performance than traditional regression methods in handling right-censored cancer survival data; however, its application in survival analysis remains limited due to censoring-related data loss and the lack of ap...

  • Communication
  • Open Access
2 Citations
2,059 Views
10 Pages

Female “Paradox” in Atrial Fibrillation—Role of Left Truncation Due to Competing Risks

  • Tomoki Nakamizo,
  • Munechika Misumi,
  • Tetsuya Takahashi,
  • Satoshi Kurisu,
  • Masayasu Matsumoto and
  • Akira Tsujino

5 May 2023

Female sex in patients with atrial fibrillation (AF) is a controversial and paradoxical risk factor for stroke—controversial because it increases the risk of stroke only among older women of some ethnicities and paradoxical because it appears t...

  • Article
  • Open Access
673 Views
22 Pages

16 September 2025

The process capability indices Cp and Cpk are commonly used in industry to evaluate process capability, but they usually require that quality data follow a normal distribution. However, in the actual supply–demand relationship, some suppliers a...

  • Article
  • Open Access
1,696 Views
13 Pages

Regression Analysis of Dependent Current Status Data with Left Truncation

  • Mengyue Zhang,
  • Shishun Zhao,
  • Tao Hu,
  • Da Xu and
  • Jianguo Sun

16 August 2023

Current status data are encountered in a wide range of applications, including tumorigenic experiments and demographic studies. In this case, each subject has one observation, and the only information obtained is whether the event of interest happene...

  • Article
  • Open Access
6 Citations
3,419 Views
18 Pages

8 December 2021

Wind shear can occur at all flight levels; however, it is particularly dangerous at low levels, from the ground up to approximately 2000 feet. If this phenomenon can occur during the take-off and landing of an aircraft, it may interfere with the norm...

  • Article
  • Open Access
14 Citations
3,653 Views
16 Pages

20 July 2021

Tree diameter measurements are repetitive, time-consuming, and laborious but necessary to obtain the diameter distribution of the stands. Tree diameter distribution provides much of the information necessary for sustainable management and can be pred...

  • Article
  • Open Access
1 Citations
2,069 Views
26 Pages

17 October 2022

Left-truncated and right-censored data are widely used in lifetime experiments, biomedicine, labor economics, and actuarial science. This article discusses how to resolve the problems of statistical inferences on the unknown parameters of the exponen...

  • Article
  • Open Access
2 Citations
2,181 Views
11 Pages

6 October 2023

Many African nations continue to grapple with persistently high under-five child mortality rates, particularly those situated in the Sub-Saharan region, including South Africa. A multitude of socio-economic factors are identified as key contributors...

  • Article
  • Open Access
10 Citations
3,127 Views
22 Pages

16 March 2021

Point and interval estimations are taken into account for a progressive first-failure censored left-truncated normal distribution in this paper. First, we derive the estimators for parameters on account of the maximum likelihood principle. Subsequent...

  • Communication
  • Open Access
1 Citations
3,809 Views
7 Pages

Left Ventricular Volume in Bovines: The Correlation between Teichholz’s Medical Mathematical Method and the Volume of the Truncated Prolate Spheroid

  • José Sérgio Domingues,
  • Ravel Alvarenga Coelho,
  • Francielly Dos Santos Bento,
  • Brenda Cristina Almeida and
  • Ayanne Oliveira De Castro

11 September 2018

The main objective of this article is to determine the existing linear correlation between the real left ventricular volume (RV) from the heart of bovines and the volumes obtained by Teichholz’s mathematical model and the volume of the truncate...

  • Article
  • Open Access
6 Citations
3,249 Views
24 Pages

25 October 2021

In this paper, statistical inference and prediction issue of left truncated and right censored dependent competing risk data are studied. When the latent lifetime is distributed by Marshall–Olkin bivariate Rayleigh distribution, the maximum likelihoo...

  • Case Report
  • Open Access
3 Citations
2,408 Views
9 Pages

Different Phenotypes of Sarcomeric MyBPC3-Cardiomyopathy in the Same Family: Hypertrophic, Left Ventricular Noncompaction and Restrictive Phenotypes (in Association with Sarcoidosis)

  • Olga Blagova,
  • Ekaterina Pavlenko,
  • Vsevolod Sedov,
  • Evgeniya Kogan,
  • Margarita Polyak,
  • Elena Zaklyazminskaya and
  • Yulia Lutokhina

27 July 2022

The same variants in sarcomeric genes can lead to different cardiomyopathies within the same family. This gave rise to the concept of a continuum of sarcomeric cardiomyopathies. However, the manifestations and evolution of these cardiomyopathies in p...

  • Article
  • Open Access
4 Citations
3,238 Views
10 Pages

Borrowing Concurrent Information from Non-Concurrent Control to Enhance Statistical Efficiency in Platform Trials

  • Jialing Liu,
  • Chengxing Lu,
  • Ziren Jiang,
  • Demissie Alemayehu,
  • Lei Nie and
  • Haitao Chu

31 March 2023

A platform trial is a trial involving an innovative adaptive design with a single master protocol to efficiently evaluate multiple interventions. It offers flexible features such as dropping interventions for futility and adding new interventions to...

  • Article
  • Open Access
3 Citations
4,578 Views
15 Pages

11 October 2018

Based on suitable left-truncated or censored data, two flexible classes of M-estimations of Weibull tail coefficient are proposed with two additional parameters bounding the impact of extreme contamination. Asymptotic normality with n -rate of...

  • Article
  • Open Access
2 Citations
2,195 Views
13 Pages

1 October 2022

Truncation data arise when the interested event time can be observed only if it satisfies a certain condition. Most of the existing approaches analyze this kind of data by assuming the truncated variable is quasi-independent of the interested event t...

  • Article
  • Open Access
1 Citations
3,368 Views
16 Pages

15 May 2019

Quantiles of probability distributions play a central role in the definition of risk measures (e.g., value-at-risk, conditional tail expectation) which in turn are used to capture the riskiness of the distribution tail. Estimates of risk measures are...

  • Article
  • Open Access
1,408 Views
22 Pages

27 August 2025

The phase-type aging model (PTAM) belongs to a class of Coxian-type Markovian models that can provide a quantitative description of well-known aging characteristics that are part of a genetically determined, progressive, and irreversible process. Due...

  • Article
  • Open Access
1 Citations
2,083 Views
26 Pages

5 August 2024

Developing an informed lapse management strategy (LMS) is critical for life insurers to improve profitability and gain insight into the risk of their global portfolio. Prior research in actuarial science has shown that targeting policyholders by maxi...

  • Article
  • Open Access
5 Citations
4,286 Views
15 Pages

The luminosity function for quasars (QSOs) is usually fitted by a Schechter function. The dependence of the number of quasars on the redshift, both in the low and high luminosity regions, requires the inclusion of a lower and upper boundary in the Sc...

  • Review
  • Open Access
5 Citations
3,412 Views
9 Pages

20 June 2022

Purpose: The purpose of the study was to review the literature on the shape of the mandibular lingula. Methods: English articles published from 1970 to 2021 in databases (PubMed, Web of Science, and Embase) were selected. Articles meeting the search...

  • Article
  • Open Access
7 Citations
4,007 Views
10 Pages

A Splice Variant of the MYH7 Gene Is Causative in a Family with Isolated Left Ventricular Noncompaction Cardiomyopathy

  • Roman P. Myasnikov,
  • Olga V. Kulikova,
  • Alexey N. Meshkov,
  • Anna A. Bukaeva,
  • Anna V. Kiseleva,
  • Alexandra I. Ershova,
  • Anna V. Petukhova,
  • Mikhail G. Divashuk,
  • Evgenia D. Zotova and
  • Oxana M. Drapkina
  • + 12 authors

28 September 2022

Variants of the MYH7 gene have been associated with a number of primary cardiac conditions, including left ventricular noncompaction cardiomyopathy (LVNC). Most cases of MYH7-related diseases are associated with such variant types as missense substit...

  • Article
  • Open Access
5 Citations
2,987 Views
11 Pages

The patterns of the lingula and antilingula are crucial surgical reference points for ramus osteotomy. Cone-beam computed tomography (CBCT) provides three-dimensional images, and patient radiation dose is significantly lower for CBCT than for medical...

  • Article
  • Open Access
5 Citations
8,736 Views
12 Pages

18 November 2019

Two major uses of linear perspective are in planar paintings—the flat canvas is incongruent with the painted 3-D scene—and in forced perspectives, such as theater stages that are concave truncated pyramids, where the physical geometry and...

  • Case Report
  • Open Access
775 Views
3 Pages

Early Onset Filamin C Cardiomyopathy

  • Catarina Ribeiro Carvalho,
  • Marta Catarina Bernardo,
  • Ana Baptista and
  • Ilídio Moreira

We present the case of a 27-year-old man who was admitted with new-onset acute heart failure. The echocardiogram revealed biventricular dilatation with a severely reduced systolic function. A genetic study identified a truncated variant of the filami...

  • Case Report
  • Open Access
14 Citations
3,309 Views
15 Pages

The Double Mutation DSG2-p.S363X and TBX20-p.D278X Is Associated with Left Ventricular Non-Compaction Cardiomyopathy: Case Report

  • Roman Myasnikov,
  • Andreas Brodehl,
  • Alexey Meshkov,
  • Olga Kulikova,
  • Anna Kiseleva,
  • Greta Marie Pohl,
  • Evgeniia Sotnikova,
  • Mikhail Divashuk,
  • Marina Klimushina and
  • Oxana Drapkina
  • + 11 authors

Left ventricular non-compaction cardiomyopathy (LVNC) is a rare heart disease, with or without left ventricular dysfunction, which is characterized by a two-layer structure of the myocardium and an increased number of trabeculae. The study of familia...

  • Article
  • Open Access
20 Citations
10,985 Views
14 Pages

Compact and High Gain 4 × 4 Circularly Polarized Microstrip Patch Antenna Array for Next Generation Small Satellite

  • Manzoor Elahi,
  • Son Trinh-Van,
  • Youngoo Yang,
  • Kang-Yoon Lee and
  • Keum-Cheol Hwang

23 September 2021

In this article, a high gain and compact 4 × 4 circularly polarized microstrip patch antenna array is reported for the data transmission of the next-generation small satellite. The radiating element of the circularly polarized antenna array is realiz...

  • Article
  • Open Access
208 Views
33 Pages

Particle-in-Cell (PIC) simulations require accurate solutions of the electrostatic Poisson equation, yet accuracy often degrades near irregular Dirichlet boundaries on Cartesian meshes. While prior work has focused on left-hand-side (LHS) discretizat...

  • Article
  • Open Access
2 Citations
1,773 Views
15 Pages

7 September 2023

This paper introduces an efficient approach for solving Lane–Emden–Fowler problems. Our method utilizes two Nyström schemes to perform the integration. To overcome the singularity at the left end of the interval, we combine an optimi...

  • Article
  • Open Access
18 Citations
3,963 Views
32 Pages

The Array Optimization of Vertical Axis Wind Turbine Based on a New Asymmetric Wake Model

  • Zheng Yuan,
  • Qihu Sheng,
  • Ke Sun,
  • Jun Zang,
  • Xuewei Zhang,
  • Fengmei Jing and
  • Renwei Ji

With the increasing demand for wind energy, the vertical axis wind turbine (VAWT) is attracting more and more attention. In order to design the VAWT array for better performance, the VAWT wake model needs to reflect the wake characteristics well. Bas...

  • Case Report
  • Open Access
555 Views
9 Pages

10 November 2025

Background: Mullegama–Klein–Martinez syndrome (MKMS; OMIM #301022) is an X-linked cohesinopathy caused by pathogenic variants in STAG2, which encodes a subunit of the cohesin complex responsible for chromosomal segregation and transcripti...

  • Article
  • Open Access
13 Citations
3,158 Views
15 Pages

Tirzepatide is a dual glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP) receptor agonist and a promising therapy for type 2 diabetes mellitus (T2DM). GLP-1 is an incretin hormone with therapeutic potential beyond...

  • Article
  • Open Access
17 Citations
3,456 Views
27 Pages

Probability distributions are very useful in modeling lifetime datasets. However, no specific distribution is suitable for all kinds of datasets. In this study, the bounded truncated Cauchy power exponential distribution is proposed for modeling data...

  • Article
  • Open Access
26 Citations
5,018 Views
14 Pages

16 December 2019

Survival models can support the estimation of the resources needed for future renovations of sewer systems. They are particularly useful, when a large share of network will need renovation. This paper studies modelling sewer deterioration in a contex...

  • Article
  • Open Access
8 Citations
4,638 Views
16 Pages

Titin-Related Dilated Cardiomyopathy: The Clinical Trajectory and the Role of Circulating Biomarkers in the Clinical Assessment

  • Przemysław Chmielewski,
  • Grażyna Truszkowska,
  • Ilona Kowalik,
  • Małgorzata Rydzanicz,
  • Ewa Michalak,
  • Małgorzata Sobieszczańska-Małek,
  • Maria Franaszczyk,
  • Piotr Stawiński,
  • Małgorzata Stępień-Wojno and
  • Zofia T. Bilińska
  • + 6 authors

Titin truncating variants (TTNtv) are known as the leading cause of inherited dilated cardiomyopathy (DCM). Nevertheless, it is unclear whether circulating cardiac biomarkers are helpful in detection and risk assessment. We sought to assess 1) early...

  • Article
  • Open Access
3 Citations
1,977 Views
17 Pages

A Multifractal Cascade Model for Energy Evolution and Dissipation in Ocean Turbulence

  • Xiuyan Liu,
  • Yufei Zhang,
  • Dalei Song,
  • Hua Yang and
  • Xinyu Li

10 September 2023

Scale properties and energy dissipation in the turbulent energy transfer process play an important role in deeply understanding the features of ocean turbulence. In this paper, a universal multifractal cascade model is applied to investigate scale an...

  • Case Report
  • Open Access
15 Citations
3,319 Views
14 Pages

Mesonephric adenocarcinoma (MA) of the female genital tract is a rare but distinct entity, exhibiting unique morphological, immunophenotypical, and molecular characteristics. Vaginal MA is hypothesized to arise from the mesonephric remnants located i...

  • Case Report
  • Open Access
3 Citations
4,096 Views
9 Pages

A Novel Nonsense Pathogenic TTN Variant Identified in a Patient with Severe Dilated Cardiomyopathy

  • Caterina Micolonghi,
  • Marco Fabiani,
  • Erika Pagannone,
  • Camilla Savio,
  • Marta Ricci,
  • Silvia Caroselli,
  • Vittoria Gambioli,
  • Beatrice Musumeci,
  • Aldo Germani and
  • Maria Piane
  • + 6 authors

Both genetic and environmental factors contribute to the development of dilated cardiomyopathy. Among the genes involved, TTN mutations, including truncated variants, explain 25% of DCM cases. We performed genetic counseling and analysis on a 57-year...

  • Case Report
  • Open Access
211 Views
15 Pages

Digenic Contribution of Heterozygous ALPK3 and TRIM63 Variants to End-Stage Hypertrophic Cardiomyopathy in a Young Adult

  • Olga S. Chumakova,
  • Natalia V. Milovanova,
  • Elena A. Mershina,
  • Sergey I. Kutsev and
  • Ekaterina Y. Zakharova

Hypertrophic cardiomyopathy (HCM), the most common inherited cardiac disorder, is usually caused by pathogenic variants in sarcomeric genes and is inherited in an autosomal dominant manner. Around 5% of cases are caused by variants in non-sarcomeric...

  • Article
  • Open Access
20 Citations
5,257 Views
15 Pages

DSP-Related Cardiomyopathy as a Distinct Clinical Entity? Emerging Evidence from an Italian Cohort

  • Francesca Di Lorenzo,
  • Enrica Marchionni,
  • Valentina Ferradini,
  • Andrea Latini,
  • Laura Pezzoli,
  • Annamaria Martino,
  • Fabiana Romeo,
  • Annamaria Iorio,
  • Stefano Bianchi and
  • Federica Sangiuolo
  • + 4 authors

27 January 2023

Variants in desmoplakin gene (DSP MIM *125647) have been usually associated with Arrhythmogenic Cardiomyopathy (ACM), or Dilated Cardiomyopathy (DCM) inherited in an autosomal dominant manner. A cohort of 18 probands, characterized as heterozygotes f...

  • Article
  • Open Access
8 Citations
5,923 Views
11 Pages

20 February 2019

Retroviruses have invaded vertebrate hosts for millions of years and left an extensive endogenous retrovirus (ERV) record in the host genomes, which provides a remarkable source for an evolutionary perspective on retrovirus-host associations. Here we...

  • Review
  • Open Access
23 Citations
13,945 Views
17 Pages

26 August 2020

Titin is the largest human protein and an essential component of the cardiac sarcomere. With multiple immunoglobulin(Ig)-like domains that serve as molecular springs, titin contributes significantly to the passive tension, systolic function, and dias...

  • Feature Paper
  • Article
  • Open Access
4 Citations
3,634 Views
27 Pages

Abnormal Cellular Phenotypes Induced by Three TMPO/LAP2 Variants Identified in Men with Cardiomyopathies

  • Nathalie Vadrot,
  • Flavie Ader,
  • Maryline Moulin,
  • Marie Merlant,
  • Françoise Chapon,
  • Estelle Gandjbakhch,
  • Fabien Labombarda,
  • Pascale Maragnes,
  • Patricia Réant and
  • Brigitte Buendia
  • + 5 authors

16 January 2023

A single missense variant of the TMPO/LAP2α gene, encoding LAP2 proteins, has been associated with cardiomyopathy in two brothers. To further evaluate its role in cardiac muscle, we included TMPO in our cardiomyopathy diagnostic gene panel. A s...

  • Review
  • Open Access
1,324 Views
14 Pages

Risk Stratification and Optimal Use of Implantable Cardioverter-Defibrillator Therapy in Primary Prevention of Sudden Cardiac Death in Genetic Cardiomyopathies, with Assessment of the Role of Genetic Variants in Guiding Therapeutic Decisions

  • Eleonora Ruscio,
  • Roberto Scacciavillani,
  • Filippo Luca Gurgoglione,
  • Gaetano Pinnacchio,
  • Gianluigi Bencardino,
  • Francesco Perna,
  • Maria Lucia Narducci,
  • Gemma Pelargonio,
  • Giampaolo Niccoli and
  • Francesco Burzotta
  • + 1 author

Genetic background is a critical determinant of disease expression, arrhythmic vulnerability, and therapeutic response in inherited cardiomyopathies. Implantable cardioverter-defibrillators (ICD) remain the cornerstone for primary prevention of sudde...

  • Article
  • Open Access
7 Citations
2,903 Views
11 Pages

Does Older Age Modify Associations between Endocrine Disrupting Chemicals and Fecundability?

  • Anna Z. Pollack,
  • Jenna R. Krall,
  • Shanna H. Swan and
  • Germaine M. Buck Louis

Urinary concentrations of several endocrine disrupting chemicals, including phthalate metabolites, bisphenol A (BPA), and benzophenone (BP)-type ultraviolet (UV) filters, have been associated with a longer time-to-pregnancy (TTP). Potential modificat...

  • Article
  • Open Access
4 Citations
4,343 Views
19 Pages

17 November 2020

We introduce a Virtual Studio Technology (VST) 2 audio effect plugin that performs convolution reverb using synthetic Room Impulse Responses (RIRs) generated via a Genetic Algorithm (GA). The parameters of the plugin include some of those defined und...

  • Article
  • Open Access
1 Citations
1,271 Views
13 Pages

Spontaneous Resolution of Ventricular Pre-Excitation During Childhood: A Retrospective Study

  • Antonio Sanzo,
  • Alessandro Seganti,
  • Andrea Demarchi,
  • Riccardo Simone Fino,
  • Irene Raso,
  • Alessia Claudia Codazzi,
  • Barbara Petracci,
  • Andrea Bongiorno,
  • Roberto Rordorf and
  • Savina Mannarino

29 March 2025

Background/Objectives: Ventricular pre-excitation (VP) increases the risk of sudden cardiac death among children. While transcatheter ablation could potentially be therapeutic, it is not without risk, especially in smaller children. Accessory pathway...

  • Feature Paper
  • Article
  • Open Access
1 Citations
378 Views
24 Pages

31 October 2025

A variety of methods that provide approximate piecewise- analytical solutions to initial-value problems governed by scalar, nonlinear, first-order, ordinary differential equations is presented. The methods are based on fixing the independent variable...

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