The drying unit of a continuous from-powder-to-tablet manufacturing line based on twin-screw granulation (TSG) is a crucial intermediate process step to achieve the desired tablet quality. Understanding the size reduction of pharmaceutical granules b...
Co-processing is commonly used approach to improve functional characteristics of pharmaceutical excipients to become suitable for tablet production by direct compression. This study aimed to improve tableting characteristics of lactose monohydrate (L...
In this study, a hybrid multi-scale model has been developed for a continuous fluid bed wet granulation process by dynamically coupling computational fluid dynamics (CFD) with a discrete element model (DEM) and population balance model (PBM). In this...
This study describes an innovative in-line near-infrared (NIR) process monitoring method for the quantification of the total polyphenolic content (TPC) of Ajuga genevensis dry extracts. The dry extract was obtained in a fluidized bed processor, by sp...
The article includes the study and reconstruction of a fluid bed device with the purpose of separating the granular material from the grinding process of rapid antigen tests. The following techniques were performed, with the purpose of characterisati...
Process intensification of catalytic fixed-bed reactors is of vital interest and can be conducted on different length scales, ranging from the molecular scale to the pellet scale to the plant scale. Particle-resolved computational fluid dynamics (CFD...
Ammonia synthesis by the Haber–Bosch method is a typical and effective implementation of the chemical process in the large-scale fertiliser industry. Due to the growing demand for fertilisers and food, it is desirable to study this process thor...
The problematic cohesiveness of food powders can commonly be solved using pulsed fluidized-bed agglomeration. However, progressively larger granules may result in unstable fluidization. The aims of this research study were to investigate fluid bed ex...
In this paper, a data preprocessing methodology, EDA (Exploratory Data Analysis), is used for performing an exploration of the data captured from the sensors of a fluid bed dryer to reduce the energy consumption during the preheating phase. The objec...
The efficiency of a fluidized bed reactor depends on the bed fluid dynamic behavior, which is significantly influenced by the bubble properties. This work investigates the bubble properties of a bubbling fluidized bed reactor using computational part...
In order to track the free interface of the melt pool and understand the evolution of the melt pool, the flow of fluid, and the interface behavior of gas and liquid, a physical model is developed by using the VOF method in this paper. Its characteris...
Slender packed beds are widely used in the chemical and process industry for heterogeneous catalytic reactions in tube-bundle reactors. Under safety and reaction engineering aspects, good radial heat transfer is of outstanding importance. However, be...
In the last decade, twin-screw wet granulation became an essential technology for continuous pharmaceutical tablet production. Consequently, interest in (semi-)continuous fluidized bed drying systems as a subsequent processing unit has grown. In para...
The seed coating with sodium alginate plasticized by glycerol was simulated in batch mode using SuperPro Designer 10. The effect of changing certain inputs such as the seed size, film thickness, and the price of the seeds on the capital and operating...
In the present review, 32 studies, published between 2020 and 2026, were reviewed to identify recent advances in pharmaceutical granulation. Emphasis is placed on the integration of real-time monitoring technologies, recent Process Analytical Technol...
Due to the significant increase in heavy feedstocks being transported to refineries and the hydrocracking process, the significance of adopting an ebullated bed reactor has been reemphasized in recent years. The predictive modelling of gas hold-up in...
This paper describes the importance of computational fluid dynamics (CFD) as a tool for the design, analysis, and optimization of the different sections of catalytic hydrotreating (HDT) reactors. This paper describes the genesis and evolution of CFD,...
A critical challenge underpinning the adoption of Additive Manufacture (AM) as a technology is the postprocessing of manufactured components. For Powder Bed Fusion (PBF), this can involve the removal of powder from the interior of the component, ofte...
Background/Objectives: Controlling the critical quality attributes (CQAs), such as granule moisture level and particle size distribution, that impact product performance is essential for ensuring product quality in medicine manufacture. Oral solid do...
Petroleum refining has been, is still, and is expected to remain in the next decades the main source of energy required to drive transport for mankind. The demand for automotive and aviation fuels has urged refiners to search for ways to extract more...
An experimental study in industry was previously carried out on a batch fluid bed granulation system by varying the inlet fluidizing air temperature, binder liquid spray atomization pressure, the binder liquid spray rate and the disintegrant composit...
The effective utilization of shale bedding fractures is of great significance to improve shale gas recovery efficiency. Taking the Wufeng–Longmaxi Formation shale in Sichuan Basin as the research object, the formation process and mechanism of b...
The process of hydraulic fracturing makes use of a liquid to fracture reservoir rocks for the exploitation of unconventional resources. Hence, it is vital to understand the processes that produce the fracture networks that occur during hydraulic frac...
The flowback rate of fracturing fluid in shale reservoirs is often notably low, primarily due to the spontaneous imbibition of the water-based fracturing fluid. Despite their significance, the factors influencing spontaneous imbibition in shale reser...
The storage of thermal energy has been hindered by the low heat-transfer rate of the solid phase of the phase-changing materiel. With water being the heat-transfer fluid as well as the liquid phase in the liquid–solid two-phase system, a novel...
The distribution of beddings varies greatly in shale reservoirs. The influence of beddings on hydraulic fracture propagation has often been studied using simplified geological models, i.e., uniformly distributed bedding models. However, the propagati...
Fluid flows through packed beds occur in many chemical processes [...]
The pharmaceutical industry is facing significant economic challenges due to measures aimed at containing healthcare costs and evolving healthcare regulations. In this context, pharmaceutical laboratories seek to extend the lifespan of their machiner...
According to the Quality by Design (QbD) concept, Design of Experiment (DoE) was used to indicate critical process parameters and optimize the fluid bed coating of minitablets in a laboratory size batch. Full factorial design was employed to increase...
The second law of thermodynamics is indispensable in engineering applications. It allows us to determine if a given process is feasible or not, and if the given process is feasible, how efficient or inefficient is the process. Thus, the second law pl...
Particle coating using fluid bed technology such as Wurster chamber is a common process in pharmaceutical technology. [...]
This paper develops a numerical model to study fracture network evolution during the nitrogen fracturing process in shale reservoirs. This model considers the differences of incompressible and compressible fluids, shear and tensile failure modes, sha...
This work studies heat transport in the fluid–solid interface of a packed bed to demonstrate the feasibility of preheating lumpy manganese ores to 600 °C with air at 750 °C. Preheated manganese ores aim to reduce furnace energy consumpt...
Fluid bed granulation is faced with a high level of complexity due to the simultaneous occurrence of agglomeration, breakage, and drying. These complexities should be thoroughly investigated through particle–particle, particle–droplet, an...
The pharmaceutical industry is in the midst of a transition from traditional batch processes to continuous manufacturing. However, the challenges in making this transition vary depending on the selected manufacturing process. Compared with other oral...
Pervaporation is a peculiar membrane separation process, which is considered for integration with a variety of reactions in promising new applications. Pervaporation membrane reactors have some specific uses in sustainable chemistry, such as the este...
This mathematical evaluation focuses on iron ore ultra-fines for their use in a novel hydrogen-based fluidized bed direct reduction process. The benefits of such a process include reduced CO2 emissions and energy consumption per ton of product, lower...
To investigate the pore structure distribution and the coupled heat and moisture transfer during the drying process of the grains, this study focuses on fixed-bed corn drying with varying levels of broken kernel rate. A model of internal flow and con...
Thermal energy storage (TES) systems are essential components of concentrating solar power (CSP) plants that enable uniform generation of green electricity and process heat. The performance of sensible heat TES systems based on granular material and...
The work presents a detailed analysis of the possibilities of the thermal processing of clay raw material granulates in a fluidized bed reactor powered by coal fuel. Potential customers of calcined granulates include the following: plants producing r...
Recent advances in particle fluidization focus on improving the efficiency and control of various processes used in different industries. New technologies, such as spouted beds and circulating fluidized beds, have emerged to improve particle distribu...
Market globalisation, shortened patent lifetimes and the ongoing shift towards personalised medicines exert unprecedented pressure on the pharmaceutical industry. In the push for continuous pharmaceutical manufacturing, processes need to be shown to...
Biomass gasification is nowadays considered a viable option for clean energy production. Furthermore, still more efforts need to be spent to make this technology fully available at commercial scale. Drawbacks that greatly limit the full-time plant av...
We study numerically the effects of a viscous fluid seabed on wave scattering with a solid obstacle of rectangular shape fixed at the free surface, on the seafloor, or internally within the water layer. The computational model is based on OpenFOAM an...
The University of Newcastle (UON) and Jord International Pty Ltd. (Jord) have jointly developed a novel concept for the storage of energy from renewable and fossil fuel sources. The process, referred to as the pressurized regenerative calcium cycle (...
The gas–liquid multiphase process plays a crucial role in the chemical industry, and the utilization of packed beds enhances separation efficiency by increasing the contact area and promoting effective gas–liquid interaction during the se...
This review focuses on the usability of iron ore ultra-fines for hydrogen-based direct reduction. Such technology is driven by the need to lower CO2 emissions and energy consumption for the iron and steel industry. In addition, low operational and ca...
Currently, various industrial processes are carried out in fluidized bed reactors. Knowing its internal dynamics is fundamental for the intensification of these processes. This work assesses the motion of fluidized calcium alginate spheres under the...
The efficient use of renewable energy is receiving more and more attention in the context of “carbon neutrality” and “carbon peaking”. For a long time, biomass has been used less efficiently as a renewable energy source, but w...
We studied wave-created high-density mud suspensions (fluid mud) using a one-dimensional water column (1DV) model that includes k-ε turbulence closure at a high vertical resolution with a vertical grid spacing of 1 mm. The k-ε turbulence model includ...
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