Today’s academics have a major hurdle in solving combinatorial problems in the actual world. It is nevertheless possible to use optimization techniques to find, design, and solve a genuine optimal solution to a particular problem, despite the l...
In applications of software testing, the cause–effect graph method is an approach often used to design test cases by analyzing various combinations of inputs with a graphical approach. However, not all inputs have equal impacts on the results,...
In complex testing scenarios of large-scale information systems, communication networks, and the Internet of Things, exhaustive testing is always prohibitively expensive and time-consuming. T-way combinatorial testing has emerged as a cost-effective...
The preliminary task of a project consists of the definition of the scenarios that will guide further development work and validate the results. In this paper, we present an approach for the systematic generation of validation scenarios using a speci...
A combinatorial material adhesion study was used to optimize the composition of an adhesion promoting layer for a nanocrystalline diamond (NCD) coating on silicon. Three different adhesion promoting metals, namely W, Cr, and Ta, were selected to fabr...
Hongze Lake plays a key role in flood and waterlogging prevention, analyzing the variation process and characteristics of multi-time scales will have a great practical significance to water resources management and regulation in the Huaihe River basi...
Collision avoidance algorithms play a crucial role in ensuring the safety and effectiveness of autonomous ships, which require comprehensive testing in realistic multi-ship encounter scenarios. However, existing scenario generation methods often inad...
We demonstrate the utility of non-contact printing to fabricate the mAST—an easy-to-operate, microwell-based microfluidic device for combinatorial antibiotic susceptibility testing (AST) in a point-of-care format. The wells are prefilled with a...
We used high-power impulse magnetron sputtering (HiPIMS) to deposit tungsten carbide films for superior wear protection in abrasive environments. In order to sample different W-to-C ratios more efficiently, a combinatorial approach was chosen. A sing...
Given the increasing use of lithium-ion batteries, which is driven in particular by electromobility, the characterization of cells in production and application plays a decisive role in quality assurance. The detection of defects particularly motivat...
The efficiency of conventional screening programs to identify early-stage malignancies can be limited by the low number of cancers recommended for screening as well as the high cumulative false-positive rate, and associated iatrogenic burden, resulti...
Malware classification is a well-known problem in computer security. Hyper-parameter optimisation (HPO) using covering arrays (CAs) is a novel approach that can enhance machine learning classifier accuracy. The tuning of machine learning (ML) classif...
Locating arrays (LAs) can be used to detect and identify interaction faults among factors in a component-based system. The optimality and constructions of LAs with a single fault have been investigated extensively under the assumption that all the fa...
(1) Background: The basophil activation test (BAT) is a functional whole blood-based ex vivo assay to quantify basophil activation after allergen exposure by flow cytometry. One of the most important prerequisites for the use of the BAT in the routin...
In deep foundation pit engineering, the rational arrangement of internal struts plays a crucial role in controlling diaphragm wall displacement and minimizing environmental impacts. This study investigates the effects of servo steel struts through mo...
This paper investigates the impact of several hyperparameters on static malware detection using deep learning, including the number of epochs, batch size, number of layers and neurons, optimisation method, dropout rate, type of activation function, a...
Although combinatorial testing has been widely studied and used, there are still some situations and requirements that combinatorial testing does not apply to well, such as a system under test whose test cases need to be performed contiguously. For t...
This paper presents a novel incentive-based load shedding management scheme within a microgrid environment equipped with the required IoT infrastructure. The proposed mechanism works on the principles of reverse combinatorial auction. We consider a r...
A keylogger is a type of spyware that records keystrokes from the user’s keyboard to steal confidential information. The problems with most keylogger methods are the lack of simulated keylogger patterns, the failure to maintain a database of cu...
Combinatorial investigations require rapid screening techniques to test and evaluate variations of composition, structure and property within a material library. [...]
A novel artificial intelligence-assisted evaluation of the X-ray diffraction (XRD) peak profiles was elaborated for the characterization of the nanocrystallite microstructure in a combinatorial Co-Cr-Fe-Ni compositionally complex alloy (CCA) film. Th...
Introduction: Candidozyma auris (Cz. auris) has emerged globally, and diseases caused by it are associated with a mortality rate of 30–72%. This yeast is often multidrug-resistant and challenging to treat. A synthetic peptide, consisting of 11...
Humans are able to quickly adapt to new situations, learn effectively with limited data, and create unique combinations of basic concepts. In contrast, generalizing out-of-distribution (OOD) data and achieving combinatorial generalizations are fundam...
Numerous technological advancements in the 21st century depend on the creation of novel materials possessing enhanced properties; there is a growing reliance on materials that can be optimized to serve multiple functions. To efficiently save time and...
Traditionally, drug development involved the individual synthesis and biological evaluation of hundreds to thousands of compounds with the intention of highlighting their biological activity, selectivity, and bioavailability, as well as their low tox...
Solving combinatorial problems on complex networks represents a primary issue which, on a large scale, requires the use of heuristics and approximate algorithms. Recently, neural methods have been proposed in this context to find feasible solutions f...
Kolmogorov complexity of a finite binary word reflects both algorithmic structure and the empirical distribution of symbols appearing in the word. Words with symbol frequencies far from one half belong to smaller combinatorial classes and therefore a...
Tephritid fruit flies are among the most destructive agricultural pests of fruits and vegetables worldwide and can impose trade barriers against the movement of fresh tropical commodities. Primary pre-harvest control methods for these flies rely on t...
The fibroblast growth factor/fibroblast growth factor receptor (FGF/FGFR) signaling pathway plays crucial roles in cell proliferation, angiogenesis, migration, and survival. Aberration in FGFRs correlates with several malignancies and disorders. FGFR...
In this work, an approach is proposed to solve binary combinatorial problems using continuous metaheuristics. It focuses on the importance of binarization in the optimization process, as it can have a significant impact on the performance of the algo...
The constrained bi-objective stochastic optimization problem (CBSOP) considers the optimization problem with stochastic bi-objective functions subject to deterministic constraints. The CBSOP is part of a set of hard combinatorial optimization problem...
Biomimetic ligands are synthetic compounds that mimic the structure and binding properties of natural biological ligands. The first uses of textile dyes as pseudo-affinity ligands paved the way for the rational design and de novo synthesis of low-cos...
The human fungal pathogen Candida albicans can form biofilms on biotic and abiotic surfaces, which are inherently resistant to antifungal drugs. We screened the Chembridge Small Molecule Diversity library containing 30,000 “drug-like” sma...
Ionic Liquids (IL) are a unique class of molten salts, with specific formulations exhibiting antimicrobial properties. Several recent studies have highlighted the ability of ILs to form micelles, permeabilize the plasma membrane, and destabilize cell...
This paper presents a robust quadratic convex model for the optimal scheduling of photovoltaic generators in unbalanced bipolar DC grids. The proposed model is based on Taylor’s series expansion which relaxes the hyperbolic relation between con...
Accounting for about 2% of cancers diagnosed worldwide, thyroid cancer has caused about 41,000 deaths in 2018. Despite significant progresses made in recent decades in the treatment of thyroid cancer, many resistances to current monotherapies are obs...
The coronavirus disease 2019 (COVID-19) represents a global public health burden. In addition to vaccination, safe and efficient antiviral treatment strategies to restrict the viral spread within the patient are urgently needed. An alternative approa...
Alcohol use disorder (AUD) affects over 18 million people in the US. Unfortunately, pharmacotherapies available for AUD have limited clinical success and are under prescribed. Previously, we established that avermectin compounds (ivermectin [IVM] and...
The study examines the cumulative impact of factors that affect usability testing for user-centered web design, namely the so-called ‘contextual fidelity model’ factors that include product properties, task features, user traits, and envi...
Cervical cancer ranks seventh overall among all types of cancer in women. Although several treatments, including radiation, surgery and chemotherapy, are available to eradicate or reduce the size of cancer, many cancers eventually relapse. Thus, it i...
Diabetes poses a high risk for debilitating complications in neural tissues, regulating glucose uptake through insulin-dependent and predominantly insulin-independent pathways. Supramolecular nanostructures provide a flexible strategy for combinatori...
DNA molecules, as a storage medium, possess unique advantages. Not only does DNA storage exhibit significantly higher storage density compared to electromagnetic storage media, but it also features low energy consumption and extremely long storage ti...
Metabolite structure identification remains a significant challenge in nontargeted metabolomics research. One commonly used strategy relies on searching biochemical databases using exact mass. However, this approach fails when the database does not c...
Based on bee foraging behaviour, the Bees Algorithm (BA) is an optimisation metaheuristic algorithm which has found many applications in both the continuous and combinatorial domains. The original version of the Bees Algorithm has six user-selected p...
Presented here is a method for rapidly testing the reactivity of carboxylic acids in amide-forming reactions. For this, a mixture of two acids, one a reference compound, and one acid whose reactivity is unknown, are coupled to an aminoacylated tetrak...
Lung cancer, both non-small cell and small cell, harbors a high propensity for spreading to the central nervous system. Radiation therapy remains the backbone of the management of brain metastases. Recent advances in stereotactic radiosurgery have ex...
Alternaria molds simultaneously produce a large variety of mycotoxins, of which several were previously reported to induce enzymes of phase I metabolism through aryl hydrocarbon receptor activation. Thus, we investigated the potential of naturally oc...
As histone deacetylase inhibitors (HDACIs) have limited efficacy against solid tumors, we investigated whether and how oxidative stress is involved in sensitivity to HDACIs to develop a novel therapeutic option of HDACIs treatment. We first tested wh...
Background: The rise of multidrug-resistant (MDR) bacteria poses a significant challenge to global public health, contributing to increased morbidity and mortality rates. In this context, the repurposing of existing drugs has emerged as a promising s...
Biocatalytic processes are increasingly used in organic synthesis for the preparation of targeted molecules or the generation of molecular diversity. The search for the biocatalyst is often the bottleneck in the development of the process. We describ...
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