Human cleft lip morphopathogenesis is a complicated process involving multiple genes and proteins. Certain factors like muscle segment homeobox 1 (MSX1) and 2 (MSX2) as well as receptor-like tyrosine kinase (RYK) are important during lip embryogenesi...
Previously, we demonstrated that the homeoprotein Msx1 interaction with p53 inhibited tumor growth by inducing apoptosis. However, Msx1 can exert its tumor suppressive effect through the inhibition of angiogenesis since growth of the tumor relies on...
Prognostic factors are of great interest in patients with endometrial cancer. One potential factor could be the protein MSX1, a transcription repressor, that has an inhibitory effect on the cell cycle. For this study, endometrioid endometrial carcino...
Pulmonary arterial hypertension (PAH) is a progressive lung disease caused by thickening of the pulmonary arterial wall and luminal obliteration of the small peripheral arteries leading to increase in vascular resistance which elevates pulmonary arte...
It is known that genetic factors determine odontogenesis; furthermore, studies have revealed that various genes in humans can regulate the development of different types and generations of teeth. In this study it has been assumed that tooth impaction...
Background: Tooth agenesis is the most frequently occurring genetic developmental anomaly in clinical dentistry. The MSX1 gene, essential for tooth development, has been associated with non-syndromic tooth agenesis. This study aims to identify novel...
The compound L-valine-3-{8-[(E)-2-[3-methoxyphenyl)ethenyl]-7-methyl-1-propargylxanthine-3-yl}propyl ester hydrochloride (MSX-4) was synthesized as an aminoacid ester prodrug of the adenosine A2A receptor antagonist MSX-2. It was found to bestable in...
MSX1 is an important member of the muscle segment homeobox gene (Msh) family and acts as a transcription factor to regulate tissue plasticity, yet its role in goat endometrium remodeling remains elusive. In this study, an immunohistochemical analysis...
In recent research, there has been a growing awareness of the role of genetic factors in the positioning and eruption of teeth in the maxilla and mandible. This study aimed to evaluate the potential of specific polymorphic markers of single nucleotid...
Background: Tooth development or odontogenesis is a complicated, multi-staged process, regulated by a plethora of genes. Disruptions during the early stages of odontogenesis may cause the complete absence of one or more teeth, known as tooth agenesis...
The expression pattern of the markers p19, Ki-67, MSX1, MSX2, PDL1, pRB, and CYCLINA2 was quantitatively and semiquantitatively analyzed in histologic sections of the developing and postnatal human eye at week 8, in retinoblastoma, and in various uve...
It is important to maintain the safety of road driving by automatically performing a series of processes to automatically measure and repair damage to the road pavement. However, road pavements include not only damages such as longitudinal cracks, tr...
Typically, computer-based tools built on mathematical models define the time-series behavior of contaminants, in dissolved or colloidal form, within the spatial boundaries of water distribution systems (WDS). EPANET-MSX has become a standard tool for...
(1) Background: Hypodontia has a multifactorial aetiology, in which genetic factors are a major component. Associated with this congenital absence, the formed teeth may show differences in size and shape, which may vary with the specific genetic vari...
Cherubism is nowadays classified as an autoimmune disease and was first described in 1933. Although suspected at that time to be the result of defective tooth development, it was primarily classified as a bone disease caused by a mutation in the SH3B...
Craniofacial development including palatogenesis is a complex process which requires an orchestrated and spatiotemporal expression of various genes and factors for proper embryogenesis and organogenesis. One such group of genes essential for craniofa...
Drinking water disinfection by water utilities aims to ensure the safety and high quality of the provided water; however, it can pose a threat to human health due to the formation of disinfection byproducts (DBPs). The prediction and modeling of DBPs...
The neural crest (NC) comprises a multipotent cell population that produces peripheral neurons, cartilage, and smooth muscle cells, among other phenotypes. The participation of Hes1 and Msx1 when expressed in mouse embryonic stem cells (mESCs) underg...
Cutaneous melanoma represents one of the deadliest types of skin cancer. The prognosis strongly depends on the disease stage, thus early detection is crucial. New therapies, including BRAF and MEK inhibitors and immunotherapies, have significantly im...
Temperature is a crucial factor that can influence chemical and microbiological activities within building water systems. Due to factors like widespread water conservation programs or shutdowns resulting from events like the COVID-19 pandemic, water...
The formation of bacterial regrowth and disinfection by-products is ubiquitous in chlorinated water distribution systems (WDSs) operated with organic loads. A generic, easy-to-use mechanistic model describing the fundamental processes governing the i...
2,4,6-trichloroanisole (2,4,6-TCA) formation is often reported as a cause of taste and odor (T&O) problems in water distribution systems (WDSs). The biosynthesis via microbial O-methylation of 2,4,6-trichlorophenol (2,4,6-TCP) is the dominant for...
The Wnt and bone morphogenetic protein (BMP) signaling pathways are known to be crucial in the development of neural crest lineages, including the sympathetic nervous system. Surprisingly, their role in paediatric neuroblastoma, the prototypic tumor...
The osteoblast differentiation capacity of mesenchymal stem cells must be tightly regulated, as inadequate bone mineralization can lead to osteoporosis, and excess bone formation can cause the heterotopic ossification of soft tissues. The balanced pr...
Water distribution networks (WDNs) are critical infrastructure yet vulnerable to contamination, thereby threatening public health. Rapid contaminant detection through sensor systems is essential for water safety. This study compares topological and o...
Predicting Legionella concentrations reaching users through building water systems requires a comprehensive water quality modeling approach. We integrate various frameworks and data to test the effect of nutrient availability, temperature, chlorine,...
Eastern oysters, Crassostrea virginica, are ecologically and economically important coastal species which provide a commercially valuable food product while also improving water quality through filtration, protecting shorelines, and providing habitat...
The ability to accurately recognize fruit on trees is a critical step in robotic harvesting. Many researchers have investigated a variety of image analysis methods based on different imaging technologies for fruit recognition. However, challenges sti...
Oxidative stress contributes significantly to cancer development. Recent studies have demonstrated that oxidative stress could alter the epigenome and, in particular, DNA methylation. This study aimed to explore the potential link between oxidative s...
Maple water (maple sap) products are produced from sap tapped directly from maple trees, but there is confusion and lack of industry consensus and consumer knowledge as to what constitutes ‘authentic’ maple water. With an immense potentia...
Background: Dulaglutide, a GLP-1-IgG4 Fc fusion, is a long-acting GLP-1 receptor agonist used for type 2 diabetes therapy and other emerging indications. It is produced commercially in Chinese hamster ovary (CHO) cells. The supply of the original dru...
Nitrogen starvation acclimation in non-diazotrophic cyanobacteria is characterized by a process termed chlorosis, where the light harvesting pigments are degraded and the cells gradually tune down photosynthetic and metabolic activities. The chlorosi...
Glutamine synthetase, a critical enzyme catalyzing the conversion of glutamate and ammonia into glutamine, has been shown to influence sperm development in mammals. Here, we carried out functional analysis of Bombyx mori homolog of glutamine syntheta...
In this study, Fe3O4/Ag magnetite-silver (MSx) nanocomposites were investigated as catalysts for advanced oxidation processes by coupling the plasmonic effect of silver nanoparticles and the ferromagnetism of iron oxide species. A surfactant-free co-...
Vascular calcification associated with high plasma phosphate (Pi) level is a frequent complication of hyperglycemia, diabetes mellitus, and chronic kidney disease. BGP-15 is an emerging anti-diabetic drug candidate. This study was aimed to explore wh...
Deep learning techniques underpinned by extensive data sources encompassing complex pavement features have proven effective in early pavement damage detection. With pavement features exhibiting temperature variation, inexpensive infra-red imaging tec...
Background/Objectives: There is a lack of cohesion in integrating current knowledge on the genetic and environmental etiology of dental impaction. The primary aim of this article is to review the current literature to identify candidate genes involve...
The analysis of the spatial distribution of drinking water temperature (DWT) in the drinking water distribution system (DWDS) can allow for the detection of hotspots and the identification of suitable mitigation interventions to enhance the climate r...
Recently, we have described physiological expression patterns of NKL homeobox genes in early hematopoiesis and in subsequent lymphopoiesis. We identified nine genes which constitute the so-called NKL-code. Aberrant overexpression of code-members or e...
This article presents a method for the Maximum Power Point Tracking (MPPT) of a Photovoltaic (PV) panels array with partial shading, applying an Improved Pattern Search Method (IPSM). The method is simulated in PSIM
Degenerative retinal diseases associated with photoreceptor loss are a leading cause of visual impairment worldwide, with limited treatment options. Phenotypic profiling coupled with medicinal chemistry were used to develop a small molecule with prol...
Automatic damage detection using deep learning warrants an extensive data source that captures complex pavement conditions. This paper proposes a thermal-RGB fusion image-based pavement damage detection model, wherein the fused RGB-thermal image is f...
The present work provides a numerical comparison of different techniques that can be adopted to guarantee sufficient disinfectant residuals in a water distribution network (WDN) when chlorine or chloramine is used as disinfectant. First, while consid...
While addressing the issue of improving the performance of Photovoltaic (PV) systems, the simulation results are highly influenced by the PV model accuracy. Building the PV module mathematical model is based on its I-V characteristic, which is a high...
Cleft lip and palate are common congenital pathologies that affect the human population worldwide. The formation of cleft lip is associated with multiple genes and their coded proteins, which regulate the development of craniofacial region, but the e...
Non-syndromic tooth agenesis (ns-TA) is one of the most common dental anomalies characterized by the congenital absence of at least one permanent tooth (excluding third molars). Regarding the essential role of genetic factors in ns-TA aetiology, the...
Tooth agenesis (TA), the congenital absence of one or more teeth, is the most common manifestation of defective dental morphogenesis in humans. TA can occur as an isolated (non-syndromic) condition or as part of a broader syndromic presentation. In t...
In a previous study using transgenic mice ectopically expressing Hoxa2 during chondrogenesis, we associated the animal phenotype to human idiopathic proportionate short stature. Our analysis showed that this overall size reduction was correlated with...
Deciduous tooth agenesis is a severe craniofacial developmental defect because it affects masticatory function from infancy and may result in delayed growth and development. Here, we aimed to identify the crucial pathogenic genes and clinical feature...
Small space targets are usually present in the form of point sources when observed by space-based sensors. To ease the difficulty of obtaining real observation images and overcome the limitations of the existing Systems Tool Kit/electro-optical and i...
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