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Deregulated NKL Homeobox Genes in B-Cell Lymphoma

Leibniz-Institute DSMZ, Department of Human and Animal Cell Lines, 38124 Braunschweig, Germany
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Cancers 2019, 11(12), 1874; https://doi.org/10.3390/cancers11121874
Received: 18 October 2019 / Revised: 22 November 2019 / Accepted: 25 November 2019 / Published: 26 November 2019
(This article belongs to the Special Issue Recent Advances in the Pathogenesis of B Cell Malignancies)
Recently, we have described physiological expression patterns of NKL homeobox genes in early hematopoiesis and in subsequent lymphopoiesis. We identified nine genes which constitute the so-called NKL-code. Aberrant overexpression of code-members or ectopically activated non-code NKL homeobox genes are described in T-cell leukemia and in T- and B-cell lymphoma, highlighting their oncogenic role in lymphoid malignancies. Here, we introduce the NKL-code in normal hematopoiesis and focus on deregulated NKL homeobox genes in B-cell lymphoma, including HLX, MSX1 and NKX2-2 in Hodgkin lymphoma; HLX, NKX2-1 and NKX6-3 in diffuse large B-cell lymphoma; and NKX2-3 in splenic marginal zone lymphoma. Thus, the roles of various members of the NKL homeobox gene subclass are considered in normal and pathological hematopoiesis in detail. View Full-Text
Keywords: homeobox; homeodomain; NKL-code homeobox; homeodomain; NKL-code
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Nagel, S.; Drexler, H.G. Deregulated NKL Homeobox Genes in B-Cell Lymphoma. Cancers 2019, 11, 1874.

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