Special Issue "The Chondrocyte Phenotype in Cartilage Biology"
Deadline for manuscript submissions: closed (30 June 2014).
Interests: cartilage biology; arthritis biomarkers; comparative medicine/comparative physiology; Techniques: quantitative immunohistochemical and immunomorhological techniques; post-genomic techniques including tissue microarray technology; proteomics; metabolomics and bioinformatics
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Articular cartilage is an avascular load-bearing connective tissue with a very limited capacity for intrinsic repair. As a consequence, it is highly prone to structural degradation, making it particularly difficult to restore once it is damaged or lost. The chondrocyte is the only cell type that resides within articular cartilage and is solely responsible for the synthesis and turnover of the extracellular matrix (ECM). For more than two decades chondrocytes have been used clinically in cell-based cartilage repair strategies. However, in most cases dedifferentiated cells are used in procedures such as autologous chondrocyte implantation (ACI). Cell based repair strategies require large numbers of undifferentiated cells. This special issue is entitled "The Chondrocyte Phenotype in Cartilage Biology". It is dedicated to recent progress in our understanding of the unique chondrocyte phenotype and how it can be manipulated for ensuring successful cell-based cartilage repair strategies.
Dr. Ali Mobasheri
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. Papers will be published continuously (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are refereed through a peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed Open Access semimonthly journal published by MDPI.
- articular cartilage
- cell culture
- cell-based repair
- autologous chondrocyte implantation