2,866 Results Found

Compared to multiple other European countries, Germany still lists among those countries restricting the operation of most retail activities on Sundays as well as public holidays. For a long time, the German populace backed this decision. The COVID-1...

Food and nutrition trends cater for many more functions than simply satisfying the physical need for food. Given the fundamental significance of everyday food it seems clear that it is also relevant in urban development processes. Nutrition trends an...

Founded in 1967 under the name Kunstmarkt Köln, today’s ART COLOGNE was the first art fair worldwide to specialize in contemporary art. Its primary objectives were to further the art trade in Germany, promote German artists, and establish...

This article discusses the visual perception of selected buildings located in the historic centre of Cologne, Germany, that have been designed by outstanding architects. It presents eye-tracking research, both from a theoretical perspective and that...

Phthalate esters are used in colognes and other cosmetics and related products to maintain fragrance. Additionally, phthalates can dissolve and stabilize certain aroma ingredients and essential oils. The results of a five-year study (2016–2020)...

Background and Methods: Vaccination is currently considered the most successful strategy for combating the SARS-CoV-2 virus. According to short-term clinical trials, protection against infection is estimated to reach up to 95% after complete vaccinat...

The transdisciplinary project “Heat-Health Action Plan for Elderly People in Cologne” addresses the most heat-vulnerable risk group, people over 65 years of age. A quantitative study aimed to better understand heat perception and coping strategies of...

Juvenile obesity is associated with a lower self-concept. Given the continued prevalence of obesity, we examined the secular trend of body mass index standard deviation score (BMI-SDS) and self-concept in participants of a German weight management pr...

Sarcopenic obesity is increasingly found in youth, but its health consequences remain unclear. Therefore, we studied the prevalence of sarcopenia and its association with cardiometabolic risk factors as well as muscular and cardiorespiratory fitness...

Almost two and a half years after the appearance of the first cases of SARS-CoV-2 in December 2019, more than 500 million people have been infected with SARS-CoV-2 and over 6 million have died of it worldwide. In terms of the pediatric cohort, it alr...

Juvenile obesity is associated with insulin resistance, among other comorbidities. In the pathogenesis of insulin-resistance-related diseases, including obesity and diabetes, Vitamin D deficiency is very common. Therefore, the relationship between in...

Value-based healthcare (VBC) represents one strategy to meet growing challenges in healthcare systems. To date, VBC is not implemented broadly in the German healthcare system. A Delphi survey was conducted to explore stakeholders’ perspectives...

The Passion of Christ is not only an important theme in Christian theological and devotional literature, iconography, and music, but it is likewise the focus of considerable attention in contemplative, mystical literature. This contribution focuses o...

Measures taken to contain the COVID-19 pandemic are particularly stressful for families. Limited data is available regarding the effects of a mandatory quarantine on the psychological stress of children, adolescents and their parents. Quarantined ind...

Background: The aim of this study was to establish a deep learning prediction model for neoadjuvant FLOT chemotherapy response. The neural network utilized clinical data and visual information from whole-slide images (WSIs) of therapy-naïve gast...

Mental illnesses in adolescence and young adulthood are steadily increasing. Thus, mental disorders represent an individual and societal challenge and an enormous health economic burden, creating an urgent need for research and action. Mental health...

Debates about archaeological heritage in Egypt are commonly focused on the spectacular monuments of the Pharaonic, Greek, and Roman periods. In contrast, landscapes and the long prehistory of Northeast Africa receive far more limited attention. The C...

Health literacy can be described as a complex process shaped by individual resources and preferences and by the nature and quality of health-related information people encounter. The main objective of this study was to explore the views of health car...

Early risk stratification is mandatory in acute upper gastrointestinal bleeding (AUGIB) to guide optimal treatment. Numerous risk scores were introduced, but lack of practicability led to limited use in daily clinical practice. Lactate clearance is a...

Big Data approaches raise hope for a paradigm shift towards illness prevention, while others are concerned about discrimination resulting from these approaches. This will become particularly important for people with mental disorders, as research on...

Resistance to therapy is a major obstacle to cancer treatment. It may exist from the beginning, or it may develop during therapy. The review focusses on oncolytic Newcastle disease virus (NDV) as a biological agent with potential to break therapy res...

In about 20% of all cases, the fine needle aspiration cytology (FNAC) results are equivocal, delivering the two common categories of indeterminate cytology, Bethesda III and IV. The observed rates of malignancy vary widely among institutions, with th...

The influence of digitalization on information-seeking, decision-making properties of patients, therapy monitoring, and patient–physician interactions has and will change the global health sector tremendously. With this study, we add knowledge...

Mental and cognitive disorders (MCD) negatively affect the incidence and prognosis of coronary heart disease (CHD). Medical guidelines recommend the appropriate management of comorbid MCD in patients with CHD, yet there is evidence that the implement...

Early-onset colorectal cancer has been on the rise in Western populations. Here, we compare patient characteristics between those with early- (<50 years) vs. late-onset (≥50 years) disease in a large multinational cohort of colorectal cancer patie...

Compared to its more common counterpart papillary thyroid cancer (PTC), follicular thyroid cancer (FTC) has a less favorable outcome, due to its higher incidence of distant metastases and advanced stages at diagnosis. Despite radioiodine (RAI) avidit...

Certain medications may adversely affect health during hot days and heatwaves by altering chronic conditions, comorbidities, fluid balance, or impairing heat adaptation. This study aims to develop evidence-based cross-sectoral recommendations for the...

Risk-reducing mastectomy (RRM) is the most efficient form of breast cancer (BC) risk reduction in BRCA1/2 pathogenic variant (pV) carriers. However, this intervention in physical integrity is associated with significant morbidity. We assessed long-te...

The trend towards higher bypass ratios and downsized cores in modern compressors leads to locally reduced Reynolds numbers, intensifying flow separation and unsteadiness, which limits the reliability of RANS models and motivates the use of LES as a f...

Resistance to multiple antiretroviral drugs among people living with HIV (PLWH) can result in a high pill burden, causing toxicity and drug interactions. Thus, the goal is to simplify treatment regimens while maintaining effectiveness. However, forme...

Although adjuvant therapies with immune checkpoint inhibitors (ICI) and BRAF/MEK inhibitors improve recurrence-free survival (RFS) in stage III melanoma patients significantly, prognostic factors are needed to identify patients with a high risk of di...

Scimitar syndrome is a rare disease characterized by hypoplasia of the right lung and partial anomalous pulmonary venous drainage to the inferior vena cava. All cases with a prenatal diagnosis of scimitar syndrome with or without associated malformat...

Multidrug-resistant Gram-negative bacteria (MDR-GNB) cause serious infections and aggravate disease progression. Last resort antibiotics are effective against MDR-GNB and are reimbursed by flat rates based on German diagnosis-related groups (G-DRG)....

Age-associated cognitive impairment in general and dementia in particular are a global concern. Preventive lifestyle strategies are highly used but there is a lack of information on the reciprocal relationships between nutrition biomarkers and measur...

Background: Although there have been no reported cardiac arrests in space to date, the risk of severe medical events occurring during long-duration spaceflights is a major concern. These critical events can endanger both the crew as well as the missi...

Oncolytic viruses and combinatorial immunotherapy for cancer (this Special Issue) are both part of cancer treatment at IOZK. This review focusses on an individual multimodal cancer immunotherapy concept developed by IOZK, Cologne, Germany. The scient...

Water distribution networks are the backbone of any municipal water supply. Their task is to supply the population regardless of the respective demand. High resilience of these infrastructures is of great importance and has brought these infrastructu...

Introduction: Vulvar carcinoma is a rare malignancy with approximately 3090 cases annually in Germany. Squamous cell carcinoma of the vulva (SCC) can be HPV-associated or non-HPV-associated. Surgical excision is the primary treatment, but the optimal...

The German Aerospace Center designed, aero-mechanically optimized and experimentally investigated its own counter-rotating shrouded fan stage in the frame of the project CRISPmulti. Their target and the motivation of this work was, on the one hand, t...

Since its first description in November 2021, the SARS-CoV-2 variant of concern Omicron (B.1.1.529) has emerged as the dominant strain in the COVID-19 pandemic. To date, it remains unclear if boosted vaccination protects against transmission. Using d...

Background/Objectives: The aim of the present study was to assess the influence of physical activity on retinal microvascularization in patients with uveal melanoma (UM) and nevus. In addition, vascular differences between tumor and nevus patients as...

In this report, we present the contributions, outcomes, ideas, discussions and conclusions obtained at the PaleoMaps Workshop 2019, that took place at the Institute of Geography of the University of Cologne on 23 and 24 September 2019. The twofold ai...

Background: Persistent infection with high-risk human papillomavirus (HR-HPV) is the primary cause of cervical intraepithelial neoplasia (CIN) and cervical cancer. While HPV testing has become central to screening programs and the frequency of detect...

Children are considered at higher risk for harmful noise effects due to their sensitive development phase. Here, we investigated the effects of nocturnal aircraft noise exposure on short-term annoyance assessed in the morning in 51 primary school chi...

While immune checkpoint inhibitors (ICIs) in combination with radiotherapy (RT) are widely used for patients with brain metastasis (BM), markers that predict treatment response for combined RT and ICI (RT-ICI) and their optimal dosing and sequence fo...

For nearly six decades, Gerhard Richter has challenged the conceptual and visual limits of contemporary painting. His 2011 work Strip overloads the viewer’s visual perception. Richter created this unique digital print using a process that delib...

Health and social care organizations are under pressure of organizing care around patients’ needs and preferences while complying with regulatory frameworks and constraint resources. To implement patient-centered care in health and social care...

Background: Cervical cancer is a leading cause of morbidity and mortality among women globally. Currently, treatment is primarily based on tumor staging; however, discrepancies between preoperative and postoperative tumor staging remain a significant...

Background: Uterine rupture is a rare but severe obstetric complication with significant maternal and neonatal consequences. While partial uterine ruptures (PURs) are generally associated with less severe outcomes, complete uterine ruptures (CURs) ca...

In this paper, an experimental and numerical investigation of the effect of leading-edge erosion in transonic blades was performed. The measurements were carried out on a linear blade cascade in the Transonic Cascade Wind Tunnel of DLR in Cologne at...