The Predictive Value of Preoperative Histological Risk Factors in Early Cervical Cancer
Abstract
:1. Introduction
2. Materials and Methods
3. Results
3.1. Demographic Data
3.2. Pre- and Postoperative Histopathological Findings
3.3. Correlation of Histopathological Findings, Demographic Data, and Preclinical Risk Factors
3.4. Recurrence-Free Survival
4. Discussion
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
Abbreviations
G | Grading |
L | Lymphovascular space invasion |
N | Regional lymph node involvement |
M | Metastases |
V | Venous invasion |
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Total (n = 42) | |
---|---|
Age at first diagnosis (years) | |
45 [36–54] | |
BMI (kg/m2) unknown | 25.1 [20.7–26.4] 6 |
Smoking yes no unknown | |
9 (25.7%) | |
26 (74.3%) | |
7 | |
HPV negative HPV 16-positive HPV 18-positive other high-risk HPV other low-risk HPV unknown | 1 (3.6%) 18 (64.3%) 2 (7.1%) 6 (21.4%) 1 (3.6%) |
14 | |
Cone biopsy yes no unknown | 25 (62.5%) 15 (37.5%) 2 |
Clinical FIGO stage FIGO I FIGO II unknown | 23 (85.2%) 4 (14.8%) 15 |
Postoperative T stage pT1 pT2 unknown | 40 (95.2%) 2 (4.8%) 0 |
Postoperative N stage pN0 pN1 unknown | 36 (97.3%) 1 (2.7%) 5 |
Clinical M stage cM0 unknown | 32 (100%) 10 |
Preoperative | Postoperative | ||
---|---|---|---|
Grading | G1 | 6 (14.3%) | 3 (7.1%) |
G2 | 25 (59.5%) | 25 (59.5%) | |
G3 | 11 (26.2%) | 14 (33.3%) | |
Venous invasion | V0 | 28 (100%) | 40 (95.2%) |
V1 | 0 | 2 (4.8%) | |
unknown | 14 | 0 | |
Lymphovascular space invasion | L0 | 24 (80.0%) | 34 (81.0%) |
L1 | 6 (20.0%) | 8 (19.0%) | |
unknown | 12 | 0 |
G (n = 42) | V (n = 28) | LVSI (n = 30) | |||||||
---|---|---|---|---|---|---|---|---|---|
Equal | Higher | p Value | Equal | Higher | p Value | Lower | Equal | p Value | |
Age (years) | |||||||||
<40 | 17 (47.2%) | - | 0.075 | 13 (48.1%) | - | 0.107 | - | 14 (50.0%) | 0.372 |
40–59 | 14 (38.9%) | 5 (83.3%) | 12 (44.4%) | - | 2 (100%) | 11 (39.3%) | |||
>60 | 5 (13.9%) | 1 (16.7%) | 2 (7.4%) | 1 (100%) | - | 3 (10.7%) | |||
BMI | |||||||||
underweight | 1 (3.2%) | - | 0.490 | - | - | 0.208 | - | - | 0.697 |
normal | 20 (64.5%) | 2 (40%) | 13 (56.5%) | - | 1 (50.0%) | 13 (56.5%) | |||
overweight | 10 (32,3%) | 3 (60%) | 10 (43.5%) | 1 (100%) | 1 (50.0%) | 10 (43.4%) | |||
unknown | 5 | 1 | 4 | - | - | 5 | |||
HPV | |||||||||
negative | 1 (4.0%) | - | 1 | - | - | 1 | - | - | 1 |
HPV16 | 16 (64.0%) | 2 (66.7%) | 14 (70%) | 1 (100%) | 2 (100%) | 14 (70.0%) | |||
HPV18 | 2 (8.0%) | - | 2 (10%) | - | - | 2 (10.0%) | |||
other HPV | 6 (24.0%) | 1 (33.3%) | 4 (20%) | - | - | 4 (20.0%) | |||
unknown | 11 | 3 | 7 | - | - | 8 | |||
Smoking | |||||||||
yes | 7 (22.6%) | 2 (50%) | 0.268 | 4 (18.2%) | - | 1 | 1 (50.0%) | 4 (18.2%) | 0.380 |
no | 24 (77.4%) | 2 (50%) | 18 (81.8%) | 1 (100%) | 1 (50.0%) | 18 (81.8%) | |||
unknown | 5 | 2 | 5 | - | - | 6 | |||
Conization | |||||||||
yes | 23 (65.7%) | 2 (40%) | 0.345 | 21 (77.8%) | - | 0.250 | 2 (100%) | 21 (75.0%) | 1 |
no | 12 (34.3%) | 3 (60%) | 6 (22.2%) | 1 (100%) | - | 7 (25.0%) | |||
unknown | 1 | 1 | - | - | - | - |
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Adams, J.; Wingels, A.; Amir-Kabirian, C.; Jeschke, J.K.; Gesemann, L.; Eser, B.; Lenz, C.; Morgenstern, B.; Thangarajah, F. The Predictive Value of Preoperative Histological Risk Factors in Early Cervical Cancer. J. Clin. Med. 2025, 14, 3277. https://doi.org/10.3390/jcm14103277
Adams J, Wingels A, Amir-Kabirian C, Jeschke JK, Gesemann L, Eser B, Lenz C, Morgenstern B, Thangarajah F. The Predictive Value of Preoperative Histological Risk Factors in Early Cervical Cancer. Journal of Clinical Medicine. 2025; 14(10):3277. https://doi.org/10.3390/jcm14103277
Chicago/Turabian StyleAdams, Jana, Amelie Wingels, Constanze Amir-Kabirian, Janice Katharina Jeschke, Lara Gesemann, Büsra Eser, Caroline Lenz, Bernd Morgenstern, and Fabinshy Thangarajah. 2025. "The Predictive Value of Preoperative Histological Risk Factors in Early Cervical Cancer" Journal of Clinical Medicine 14, no. 10: 3277. https://doi.org/10.3390/jcm14103277
APA StyleAdams, J., Wingels, A., Amir-Kabirian, C., Jeschke, J. K., Gesemann, L., Eser, B., Lenz, C., Morgenstern, B., & Thangarajah, F. (2025). The Predictive Value of Preoperative Histological Risk Factors in Early Cervical Cancer. Journal of Clinical Medicine, 14(10), 3277. https://doi.org/10.3390/jcm14103277