Journal Menu
► ▼ Journal Menu-
- Cells Home
- Aims & Scope
- Editorial Board
- Reviewer Board
- Topical Advisory Panel
- Early Career Editorial Board
- Instructions for Authors
- Special Issues
- Topics
- Sections & Collections
- Article Processing Charge
- Indexing & Archiving
- Editor’s Choice Articles
- Most Cited & Viewed
- Journal Statistics
- Journal History
- Journal Awards
- Society Collaborations
- Conferences
- Editorial Office
Journal Browser
► ▼ Journal BrowserNeed Help?
Announcements
16 December 2025
Cells | Highly Cited Papers Published in 2024 in the “Cellular Aging” Section
The “Cellular Aging” Section of Cells (ISSN: 2073-4409) publishes high-quality research articles and review papers focusing on cellular and organismal aging, as well as related areas including stem cell biology and regeneration.
All our readers can enjoy free and unlimited access to the full texts of all of the open access articles published in our journal. We welcome you to read our most highly cited papers published in 2024, which are listed below:
1. “Senolytics and Senomorphics Targeting p38MAPK/NF-κB Pathway Protect Endothelial Cells from Oxidative Stress-Mediated Premature Senescence”
by Jingyuan Ya and Ulvi Bayraktutan
Cells 2024, 13(15), 1292; https://doi.org/10.3390/cells13151292
Available online: https://www.mdpi.com/2073-4409/13/15/1292
2. “Developmental Ethanol Exposure Impacts Purkinje Cells but Not Microglia in the Young Adult Cerebellum”
by MaKenna Y., Cealie, James C. Douglas, Hannah K. Swan, Erik D. Vonkaenel, Matthew N. McCall, Paul D. Drew and Ania K. Majewska
Cells 2024, 13(5), 386; https://doi.org/10.3390/cells13050386
Available online: https://www.mdpi.com/2073-4409/13/5/386
3. “Cell Senescence-Independent Changes of Human Skin Fibroblasts with Age”
by Nicola Fullard, James Wordsworth, Ciaran Welsh, Victoria Maltman, Charlie Bascom, Ryan Tasseff, Robert Isfort, Lydia Costello, Rebekah-Louise Scanlan, Stefan Przyborski et al.
Cells 2024, 13(8), 659; https://doi.org/10.3390/cells13080659
Available online: https://www.mdpi.com/2073-4409/13/8/659
4. “The Effects of Smoking on Telomere Length, Induction of Oncogenic Stress, and Chronic Inflammatory Responses Leading to Aging”
by Shreya Deb, Joseph Berei, Edward Miliavski, Muhammad J. Khan, Taylor J. Broder, Thomas A. Akurugo, Cody Lund, Sara E. Fleming, Robert Hillwig, Joseph Ross et al.
Cells 2024, 13(11), 884; https://doi.org/10.3390/cells13110884
Available online: https://www.mdpi.com/2073-4409/13/11/884
5. “In Vitro Investigation of Therapy-Induced Senescence and Senescence Escape in Breast Cancer Cells Using Novel Flow Cytometry-Based Methods”
by Fanni Tóth, Zahra Moftakhar, Federica Sotgia and Michael P. Lisanti
Cells 2024, 13(10), 841; https://doi.org/10.3390/cells13100841
Available online: https://www.mdpi.com/2073-4409/13/10/841
6. “Upregulation of Mitochondrial Sirt3 and Alleviation of the Inflammatory Phenotype in Macrophages by Estrogen”
by Maria Luisa Barcena, Céline Christiansen-Mensch, Muhammad Aslam, Natalie Haritonow, Yury Ladilov and Vera Regitz-Zagrosek
Cells 2024, 13(17), 1420; https://doi.org/10.3390/cells13171420
Available online: https://www.mdpi.com/2073-4409/13/17/1420
7. “Stimuli-Specific Senescence of Primary Human Lung Fibroblasts Modulates Alveolar Stem Cell Function”
by Maria Camila Melo-Narváez, Nora Bramey, Fenja See, Katharina Heinzelmann, Beatriz Ballester, Carina Steinchen, Eshita Jain, Kathrin Federl, Qianjiang Hu, Deepesh Dhakad et al.
Cells 2024, 13(13), 1129; https://doi.org/10.3390/cells13131129
Available online: https://www.mdpi.com/2073-4409/13/13/1129
8. “The Molecular Mechanisms in Senescent Cells Induced by Natural Aging and Ionizing Radiation”
by Milana Ibragimova, Assiya Kussainova, Akmaral Aripova, Rakhmetkazhi Bersimbaev and Olga Bulgakova
Cells 2024, 13(6), 550; https://doi.org/10.3390/cells13060550
Available online: https://www.mdpi.com/2073-4409/13/6/550
9. “Psychiatric Comorbidities of Inflammatory Bowel Disease: It Is a Matter of Microglia’s Gut Feeling”
by Gohar Fakhfouri, Nataša R. Mijailović and Reza Rahimian
Cells 2024, 13(2), 177; https://doi.org/10.3390/cells13020177
Available online: https://www.mdpi.com/2073-4409/13/2/177
by Sushil Kumar Dubey, Rashmi Dubey and Mark Ellsworth Kleinman
Cells 2024, 13(4), 320; https://doi.org/10.3390/cells13040320
Available online: https://www.mdpi.com/2073-4409/13/4/320
15 December 2025
Cells | Highly Cited Papers Published in 2024 in the “Plant, Algae and Fungi Cell Biology” Section
We are pleased to share a selection of highly cited papers published in Cells (ISSN: 2073-4409) in the Section “Plant, Algae and Fungi Cell Biology” in 2024.
1. "Real-Time Dynamics of Water Transport in the Roots of Intact Maize Plants in Response to Water Stress: The Role of Aquaporins and the Contribution of Different Water Transport Pathways"
by Maksim Suslov, Amina Daminova and Juluskhan Egorov
Cells 2024, 13(2), 154. https://doi.org/10.3390/cells13020154
Available online: https://www.mdpi.com/2073-4409/13/2/154
2. "Mitigating Effect of Trans-Zeatin on Cadmium Toxicity in Desmodesmus armatus"
by Alicja Piotrowska-Niczyporuk, Elżbieta Bonda-Ostaszewska and Andrzej Bajguz
Cells 2024, 13(8), 686. https://doi.org/10.3390/cells13080686
Available online: https://www.mdpi.com/2073-4409/13/8/686
3. "Mitigation of UV-B Radiation Stress in Tobacco Pollen by Expression of the Tardigrade Damage Suppressor Protein (Dsup)"
by Cecilia Del Casino, Veronica Conti, Silvia Licata, Giampiero Cai, Anna Cantore, Claudia Ricci and Silvia Cantara
Cells 2024, 13(10), 840. https://doi.org/10.3390/cells13100840
Available online: https://www.mdpi.com/2073-4409/13/10/840
4. "Velvet Family Protein FpVelB Affects Virulence in Association with Secondary Metabolism in Fusarium pseudograminea"
by Yuxing Wu, Sen Han, Yajiao Wang, Qiusheng Li and Lingxiao Kong
Cells 2024, 13(11), 950. https://doi.org/10.3390/cells13110950
Available online: https://www.mdpi.com/2073-4409/13/11/950
5. "Tomato Spotted Wilt Virus Suppresses the Antiviral Response of the Insect Vector, Frankliniella occidentalis, by Elevating an Immunosuppressive C18 Oxylipin Level Using Its Virulent Factor, NSs"
by Niayesh Shahmohammadi, Falguni Khan, Gahyeon Jin, Minji Kwon, Donghee Lee and Yonggyun Kim
Cells 2024, 13(16), 1377. https://doi.org/10.3390/cells13161377
Available online: https://www.mdpi.com/2073-4409/13/16/1377
6. "Investigation of Biological Activity of Fucoidan and Laminarin as Bioactive Polysaccharides from Irish Brown Macroalgae"
by Shanmugapriya Karuppusamy, Janith Wanigasekara, Stephen Fitzpatrick, Henry Lyons, James Curtin, Gaurav Rajauria, Brijesh K. Tiwari and Colm O’Donnell
Cells 2024, 13(23), 1938. https://doi.org/10.3390/cells13231938
Available online: https://www.mdpi.com/2073-4409/13/23/1938
7. "The Microalgae Chlamydomonas for Bioremediation and Bioproduct Production"
by Carmen M. Bellido-Pedraza, Maria J. Torres and Angel Llamas
Cells 2024, 13(13), 1137. https://doi.org/10.3390/cells13131137
Available online: https://www.mdpi.com/2073-4409/13/13/1137
8. "Enhancing Photosynthesis and Plant Productivity through Genetic Modification”
by Mansoureh Nazari, Mojtaba Kordrostami, Ali Akbar Ghasemi-Soloklui, Julian J. Eaton-Rye, Pavel Pashkovskiy, Vladimir Kuznetsov and Suleyman I. Allakhverdiev
Cells 2024, 13(16), 1319. https://doi.org/10.3390/cells13161319
Available online: https://www.mdpi.com/2073-4409/13/16/1319
9. "Single-Cell Transcriptomics Applied in Plants"
by Yanyan Sun, Jian Sun, Chunjing Lin, Jingyong Zhang, Hao Yan, Zheyun Guan and Chunbao Zhang
Cells 2024, 13(18), 1561. https://doi.org/10.3390/cells13181561
Available online: https://www.mdpi.com/2073-4409/13/18/1561
10. "The Long-Distance Transport of Some Plant Hormones and Possible Involvement of Lipid-Binding and Transfer Proteins in Hormonal Transport"
by Guzel Akhiyarova, Ekaterina I. Finkina, Kewei Zhang, Dmitriy Veselov, Gulnara Vafina, Tatiana V. Ovchinnikova and Guzel Kudoyarova
Cells 2024, 13(5), 364. https://doi.org/10.3390/cells13050364
Available online: https://www.mdpi.com/2073-4409/13/5/364
11 December 2025
Article Layout and Template Revised for Future Volumes
We are pleased to announce updates to our article template, aimed at improving the readability and visual appeal of our publications. The following updates will be applied to articles published in volumes in 2026, starting from 19 December 2025.
Left information bar:
- Updated the logo and URL for “Check for updates”;
- Removed the “Citation” section (Note: Citation details remain accessible via “Cite” in the online article version);
- Changed the link in “Copyright” to a hyperlink format.
Footer:
- Added a DOI link at the bottom-right corner of each page.
The updated template is now available for download from the Instructions for Authors page of each journal.
We hope that the new version of the template will provide users with better experience and make the process more convenient.
For any questions or suggestions, please contact our production team at production@mdpi.com.
9 December 2025
Cells | Highly Cited Papers Published in 2024 in the “Cellular Metabolism” Section
The “Cellular Metabolism” Section of Cells (ISSN: 2073-4409) aims to stimulate research that focuses on the cell in its environment over the course of development, maintenance, and aging in order to understand how cells and cellular networks may reprogram the metabolism to ensure functionality, and how changes in the metabolism may impact cellular homeostasis and activity in normal and disease conditions. We welcome manuscripts, including original research, review articles, communications, and technical notes, that emphasize the role of cell-autonomous and non-cell-autonomous mechanisms in priming metabolic states and tuning metabolic responses at the cell and cell-network levels. We welcome studies that link cellular metabolism with molecular sciences, cell biology, and physiology, as well as innovative studies based on multi-disciplinary approaches. We also welcome systems modeling studies that are based on original datasets.
1. “Breast Cancer: Mitochondria-Centered Metabolic Alterations in Tumor and Associated Adipose Tissue”
by Tamara Zakic, Andjelika Kalezic, Zorka Drvendzija, Mirjana Udicki, Tatjana Ivkovic Kapicl, Biljana Srdic Galic, Aleksandra Korac, Aleksandra Jankovic and Bato Korac
Cells 2024, 13(2), 155; https://doi.org/10.3390/cells13020155
Available online: https://www.mdpi.com/2073-4409/13/2/155
2. “Allopurinol Disrupts Purine Metabolism to Increase Damage in Experimental Colitis”
by Corey S. Worledge, Rachael E. Kostelecky, Liheng Zhou, Geetha Bhagavatula, Sean P. Colgan and J. Scott Lee
Cells 2024, 13(5), 373; https://doi.org/10.3390/cells13050373
Available online: https://www.mdpi.com/2073-4409/13/5/373
3. “The Role of β3-Adrenergic Receptors in Cold-Induced Beige Adipocyte Production in Pigs”
by Shuo Yang, Hong Ma, Liang Wang, Fang Wang, Jiqiao Xia, Dongyu Liu, Linlin Mu, Xiuqin Yang and Di Liu
Cells 2024, 13(8), 709; https://doi.org/10.3390/cells13080709
Available online: https://www.mdpi.com/2073-4409/13/8/709
4. “Polyamine Catabolism Revisited: Acetylpolyamine Oxidase Plays a Minor Role due to Low Expression”
by Olga N. Ivanova, Anna V. Gavlina, Inna L. Karpenko, Martin A. Zenov, Svetlana S. Antseva, Natalia F. Zakirova, Vladimir T. Valuev-Elliston, George S. Krasnov, Irina T. Fedyakina, Pavel O. Vorobyev et al.
Cells 2024, 13(13), 1134; https://doi.org/10.3390/cells13131134
Available online: https://www.mdpi.com/2073-4409/13/13/1134
5. “Insights into PCSK9-LDLR Regulation and Trafficking via the Differential Functions of MHC-I Proteins HFE and HLA-C”
by Sepideh Mikaeeli, Ali Ben Djoudi Ouadda, Alexandra Evagelidis, Rachid Essalmani, Oscar Henrique Pereira Ramos, Carole Fruchart-Gaillard and Nabil G. Seidah
Cells 2024, 13(10), 857; https://doi.org/10.3390/cells13100857
Available online: https://www.mdpi.com/2073-4409/13/10/857
6. “Synergistic Protection of Retinal Ganglion Cells (RGCs) by SARM1 Inactivation with CNTF in a Rodent Model of Nonarteritic Anterior Ischemic Optic Neuropathy”
by Yan Guo, Zara Mehrabian, Jeffrey Milbrandt, Aaron DiAntonio and Steven L. Bernstein
Cells 2024, 13(3), 202; https://doi.org/10.3390/cells13030202
Available online: https://www.mdpi.com/2073-4409/13/3/202
7. “Border Control: The Role of the Microbiome in Regulating Epithelial Barrier Function”
by Fernanda Schreiber, Iulia Balas, Matthew J. Robinson and Ghaith Bakdash
Cells 2024, 13(6), 477; https://doi.org/10.3390/cells13060477
Available online: https://www.mdpi.com/2073-4409/13/6/477
8. “Unraveling Adipose Tissue Dysfunction: Molecular Mechanisms, Novel Biomarkers, and Therapeutic Targets for Liver Fat Deposition”
by Marta Lopez-Yus, Carlos Hörndler, Sofia Borlan, Vanesa Bernal-Monterde and Jose M. Arbones-Mainar
Cells 2024, 13(5), 380; https://doi.org/10.3390/cells13050380
Available online: https://www.mdpi.com/2073-4409/13/5/380
9. “Kynurenines as a Novel Target for the Treatment of Inflammatory Disorders”
by Adrian Mor, Anna Tankiewicz-Kwedlo, Marianna Ciwun, Janina Lewkowicz and Dariusz Pawlak
Cells 2024, 13(15), 1259; https://doi.org/10.3390/cells13151259
Available online: https://www.mdpi.com/2073-4409/13/15/1259
10. “Emerging Role of Autophagy in Governing Cellular Dormancy, Metabolic Functions, and Therapeutic Responses of Cancer Stem Cells”
by Meenakshi Tiwari, Pransu Srivastava, Sabiya Abbas, Janani Jegatheesan, Ashish Ranjan, Sadhana Sharma, Ved Prakash Maurya, Ajit Kumar Saxena and Lokendra Kumar Sharma
Cells, 2024, 13(5), 447; https://doi.org/10.3390/cells13050447
Available online: https://www.mdpi.com/2073-4409/13/5/447
4 December 2025
Cells | Highly Cited Papers Published in 2024 in the “Autophagy” Section
Macro-autophagy, micro-autophagy, and chaperone-mediated autophagy are lysosomal degradative processes that allow cells to eliminate unwanted or dysfunctional protein/protein complexes, superfluous or damaged organelles, and invading pathogens. In most scenarios, autophagy processes specifically target structures that cells do not want. As a result, they are involved in a multitude of physiological functions and pathological situations. Autophagy is currently one of the fastest-growing research areas in life and medical sciences.
The “Autophagy” Section of Cells (ISSN 2073-4409) aims to be an active part of the international autophagy research community and aims to attract manuscripts detailing the latest cutting-edge research on autophagy across kingdoms.
1. “Bitter Taste Receptor T2R14 and Autophagy Flux in Gingival Epithelial Cells”
by Nisha Singh, Ben Ulmer, Manoj Reddy Medapati, Christine Zhang, Robert J. Schroth, Saeid Ghavami and Prashen Chelikani
Cells 2024, 13(6), 531; https://doi.org/10.3390/cells13060531
Available online: https://www.mdpi.com/2073-4409/13/6/531
2. “TRIM44, a Novel Prognostic Marker, Supports the Survival of Proteasome-Resistant Multiple Myeloma Cells”
by Trung Vu, Yuqin Wang, Annaliese Fowler, Anton Simieou and Nami McCarty
Cells 2024, 13(17), 1431; https://doi.org/10.3390/cells13171431
Available online: https://www.mdpi.com/2073-4409/13/17/1431
3. “Lysosome-Disrupting Agents in Combination with Venetoclax Increase Apoptotic Response in Primary Chronic Lymphocytic Leukemia (CLL) Cells Mediated by Lysosomal Cathepsin D Release and Inhibition of Autophagy”
by Madhumita S. Manivannan, Xiaoyan Yang, Nirav Patel, Anthea Peters, James B. Johnston and Spencer B. Gibson
Cells 2024, 13(12), 1041; https://doi.org/10.3390/cells13121041
Available online: https://www.mdpi.com/2073-4409/13/12/1041
4. “An Intrinsic Host Defense against HSV-1 Relies on the Activation of Xenophagy with the Active Clearance of Autophagic Receptors”
by Camila Pino-Belmar, Rayén Aguilar, Guillermo E. Valenzuela-Nieto, Viviana A. Cavieres, Cristóbal Cerda-Troncoso, Valentina C. Navarrete, Paula Salazar, Patricia V. Burgos, Carola Otth and Hianara A. Bustamante
Cells 2024, 13(15), 1256; https://doi.org/10.3390/cells13151256
Available online: https://www.mdpi.com/2073-4409/13/15/1256
5. “Distinct UPR and Autophagic Functions Define Cell-Specific Responses to Proteotoxic Stress in Microglial and Neuronal Cell Lines”
by Helena Domínguez-Martín, Elena Gavilán, Celia Parrado, Miguel A. Burguillos, Paula Daza and Diego Ruano
Cells 2024, 13(24), 2069; https://doi.org/10.3390/cells13242069
Available online: https://www.mdpi.com/2073-4409/13/24/2069
6. “Molecular Mechanism of Autophagosome–Lysosome Fusion in Mammalian Cells”
by Po-Yuan Ke
Cells 2024, 13(6), 500; https://doi.org/10.3390/cells13060500
Available online: https://www.mdpi.com/2073-4409/13/6/500
7. “The Yin and Yang of Microglia-Derived Extracellular Vesicles in CNS Injury and Diseases”
by Mousumi Ghosh and Damien D. Pearse
Cells 2024, 13(22), 1834; https://doi.org/10.3390/cells13221834
Available online: https://www.mdpi.com/2073-4409/13/22/1834
8. “Molecular Mechanisms of Autophagy Decline during Aging”
by Shaun H. Y. Lim, Malene Hansen and Caroline Kumsta
Cells 2024, 13(16), 1364; https://doi.org/10.3390/cells13161364
Available online: https://www.mdpi.com/2073-4409/13/16/1364
20 November 2025
Cells | Highly Cited Papers Published in 2024 in the “Cell Proliferation and Division” Section
All cells are exposed to diverse and partially conflicting exogenous or endogenous signaling events that govern cell proliferation, cell cycle arrest, or cell cycle exit into quiescence, temporal or terminal differentiation, or senescence. These signaling events are connected to the machinery that controls the cell division cycle. Within the Section “Cell Proliferation and Division” of Cells (ISSN: 2073-4409), we encourage the submission of manuscripts (original work or reviews) focusing on all aspects of mitogen, metabolic and antiproliferative signaling, and its connection to cell cycle machinery, as well as mechanistical or structural studies of cell cycle control and cell cycle checkpoints. These can include various model systems studying normal cell proliferation or cancer biology. We also encourage the submission of studies addressing all aspects of cell cycle control.
You have free and unlimited access to the full texts of all of the open access articles published in our journal. We welcome you to read our most highly cited papers published in 2024 below:
1. “Nuclear mTOR Signaling Orchestrates Transcriptional Programs Underlying Cellular Growth and Metabolism”
by Tinghan Zhao, Jialin Fan, Ahmed Abu-Zaid, Stephen K. Burley and X.F. Steven Zheng
Cells 2024, 13(9), 781; https://doi.org/10.3390/cells13090781
Available online: https://www.mdpi.com/2073-4409/13/9/781
2. “Globospiramine from Voacanga globosa Exerts Robust Cytotoxic and Antiproliferative Activities on Cancer Cells by Inducing Caspase-Dependent Apoptosis in A549 Cells and Inhibiting MAPK14 (p38α): In Vitro and Computational Investigations”
by Joe Anthony H. Manzano, Elian Angelo Abellanosa, Jose Paolo Aguilar, Simone Brogi, Chia-Hung Yen, Allan Patrick G. Macabeo and Nicanor Austriaco
Cells 2024, 13(9), 772; https://doi.org/10.3390/cells13090772
Available online: https://www.mdpi.com/2073-4409/13/9/772
3. “Uncovering miRNA–mRNA Regulatory Networks Related to Olaparib Resistance and Resensitization of BRCA2MUT Ovarian Cancer PEO1-OR Cells with the ATR/CHK1 Pathway Inhibitors”
by Łukasz Biegała, Damian Kołat, Arkadiusz Gajek, Elżbieta Płuciennik, Agnieszka Marczak, Agnieszka Śliwińska, Michał Mikula and Aneta Rogalska
Cells 2024, 13(10), 867; https://doi.org/10.3390/cells13100867
Available online: https://www.mdpi.com/2073-4409/13/10/867
4. “Expression Profiling Identified TRPM7 and HER2 as Potential Targets for the Combined Treatment of Cancer Cells”
by Miyuki Egawa, Eva Schmücker, Christian Grimm, Thomas Gudermann and Vladimir Chubanov
Cells 2024, 13(21), 1801; https://doi.org/10.3390/cells13211801
Available online: https://www.mdpi.com/2073-4409/13/21/1801
5. “Preserving Genome Integrity: Unveiling the Roles of ESCRT Machinery”
by Mattia La Torre, Romina Burla and Isabella Saggio
Cells 2024, 13(15), 1307; https://doi.org/10.3390/cells13151307
Available online: https://www.mdpi.com/2073-4409/13/15/1307
6. “Cytosolic and Acrosomal pH Regulation in Mammalian Sperm”
by Julio C. Chávez, Gabriela Carrasquel-Martínez, Sandra Hernández-Garduño, Arturo Matamoros Volante, Claudia L. Treviño, Takuya Nishigaki and Alberto Darszon
Cells 2024, 13(10), 865; https://doi.org/10.3390/cells13100865
Available online: https://www.mdpi.com/2073-4409/13/10/865
7. “The Crosstalk of Apoptotic and Non-Apoptotic Signaling in CD95 System”
by Kamil Seyrek, Johannes Espe, Elisabeth Reiss and Inna N. Lavrik
Cells 2024, 13(21), 1814; https://doi.org/10.3390/cells13211814
Available online: https://www.mdpi.com/2073-4409/13/21/1814
8. “Peto’s “Paradox” and Six Degrees of Cancer Prevalence”
by Andras Szasz
Cells 2024, 13(2), 197; https://doi.org/10.3390/cells13020197
Available online: https://www.mdpi.com/2073-4409/13/2/197
11 November 2025
Cells | Highly Cited Papers Published in 2024 in the “Cell and Gene Therapy” Section
Cell gene therapy involves two aspects: cell therapy and gene therapy. Cell therapy is a method that uses the patient’s own cells or donor cells to stimulate an immune response or cell regeneration to kill pathogens and tumor cells. It includes immune cell therapy, stem cell therapy, and somatic cell therapy. Gene therapy is an approach based on treating disease by modifying (through introduction, removal, and change) the patient's genes. In recent decades, research on cell and gene therapy has developed rapidly, and this is now emerging as an alternative therapy for many diseases.
The “Cell and Gene Therapy” Section of Cells (ISSN: 2073-4409) aims to support research that focuses on the research progress of cell gene therapy in tumors, genetic diseases, cardiovascular diseases, autoimmune diseases, and certain rare diseases. We welcome original research articles, review articles, and communications on topics in this field.
You have free and unlimited access to the full texts of all of the open access articles published in our journal. We invite you to read our most highly cited papers published in 2024, which are listed below:
1. “Dual Targeting of Glioblastoma Cells with Bispecific Killer Cell Engagers Directed to EGFR and ErbB2 (HER2) Facilitates Effective Elimination by NKG2D-CAR-Engineered NK Cells”
by Anne Kiefer, Maren Prüfer, Jasmin Röder, Jordi Pfeifer Serrahima, Malena Bodden, Ines Kühnel, Pranav Oberoi and Winfried S. Wels
Cells 2024, 13(3), 246; https://doi.org/10.3390/cells13030246
Available online: https://www.mdpi.com/2073-4409/13/3/246
2. “Decorin (DCN) Downregulation Activates Breast Stromal Fibroblasts and Promotes Their Pro-Carcinogenic Effects through the IL-6/STAT3/AUF1 Signaling”
by Wafaa A. Aljagthmi, Manal A. Alasmari, Maha H. Daghestani, Layla A. Al-Kharashi, Falah H. Al-Mohanna and Abdelilah Aboussekhra
Cells 2024, 13(8), 680; https://doi.org/10.3390/cells13080680
Available online: https://www.mdpi.com/2073-4409/13/8/680
3. “Comparison of Minced Cartilage Implantation with Autologous Chondrocyte Transplantation in an In Vitro Inflammation Model”
by Robert Ossendorff, Lisa Grede, Sebastian Scheidt, Andreas C. Strauss, Christof Burger, Dieter C. Wirtz, Gian M. Salzmann and Frank A. Schildberg
Cells 2024, 13(6), 546; https://doi.org/10.3390/cells13060546
Available online: https://www.mdpi.com/2073-4409/13/6/546
4. “Synthetic mRNAs Containing Minimalistic Untranslated Regions Are Highly Functional In Vitro and In Vivo”
by Shahab Mamaghani, Rocco Roberto Penna, Julia Frei, Conrad Wyss, Mark Mellett, Thomas Look, Tobias Weiss, Emmanuella Guenova, Thomas M. Kündig, Severin Lauchli et al.
Cells 2024, 13(15), 1242; https://doi.org/10.3390/cells13151242
Available online: https://www.mdpi.com/2073-4409/13/15/1242
5. “Interaction between NSCLC Cells, CD8+ T-Cells and Immune Checkpoint Inhibitors Potentiates Coagulation and Promotes Metabolic Remodeling—New Cues on CAT-VTE”
by Catarina Freitas-Dias, Filipe Gonçalves, Filipa Martins, Isabel Lemos, Luís G. Gonçalves and Jacinta Serpa
Cells 2024, 13(4), 305; https://doi.org/10.3390/cells13040305
Available online: https://www.mdpi.com/2073-4409/13/4/305
6. “Lung Transplant Immunomodulation with Genetically Engineered Mesenchymal Stromal Cells—Therapeutic Window for Interleukin-10”
by Antti I. Nykänen, Andrea Mariscal, Allen Duong, Aadil Ali, Akihiro Takahagi, Xiaohui Bai, Guan Zehong, Betty Joe, Mamoru Takahashi, Manyin Chen et al.
Cells 2024, 13(10), 859; https://doi.org/10.3390/cells13100859
Available online: https://www.mdpi.com/2073-4409/13/10/859
7. “Allogeneic CAR-T Therapy Technologies: Has the Promise Been Met?”
by Caroline Lonez and Eytan Breman
Cells 2024, 13(2), 146; https://doi.org/10.3390/cells13020146
Available online: https://www.mdpi.com/2073-4409/13/2/146
8. “The Role of Stem Cells as Therapeutics for Ischaemic Stroke”
by Jingyuan Ya, Jessica Pellumbaj, Arshad Hashmat and Ulvi Bayraktutan
Cells 2024, 13(2), 112; https://doi.org/10.3390/cells13020112
Available online: https://www.mdpi.com/2073-4409/13/2/112
9. “Variation of Structure and Cellular Functions of Type IA Topoisomerases across the Tree of Life”
by Kemin Tan and Yuk-Ching Tse-Dinh
Cells 2024, 13(6), 553; https://doi.org/10.3390/cells13060553
Available online: https://www.mdpi.com/2073-4409/13/6/553
10. “Navigating the CRISPR/Cas Landscape for Enhanced Diagnosis and Treatment of Wilson’s Disease”
by Woong Choi, Seongkwang Cha and Kyoungmi Kim
Cells 2024, 13(14), 1214; https://doi.org/10.3390/cells13141214
Available online: https://www.mdpi.com/2073-4409/13/14/1214
6 November 2025
Meet Us at the Multiomics and Precision Medicine Joint Conference 2025 (MOPM2025), 8–9 November 2025, Taipei, Taiwan
Conference: Multiomics and Precision Medicine Joint Conference 2025
Date: 8–9 November 2025
Place: Taipei, Taiwan
We are excited to announce that MDPI will be attending the Multiomics and Precision Medicine Joint Conference 2025 (MOPM 2025) as an exhibitor and proud sponsor of the Special Poster Award Sponsorship, which will recognize six recipients of the MDPI Rising Star Poster Awards.
Now in its seventh edition, MOPM serves as Taiwan’s leading academic platform dedicated to integrative multiomics and precision medicine research. Organized jointly by six major scientific societies, the conference promotes interdisciplinary collaboration across life sciences, medicine, and data science.
This year’s theme, “Big Data and AI Revolution for Next-Generation Precision Medicine”, will highlight cutting-edge applications of artificial intelligence and big data in biotechnology and healthcare. The program will feature plenary talks from international experts, poster presentations, industry showcases, and exhibitions of the latest research and technologies — fostering dialogue and collaboration among scholars and professionals across disciplines.
The following MDPI journals will be represented:
- Proteomes;
- Sclerosis;
- Metabolites;
- Biomolecules;
- Cancers;
- Cells;
- Journal of Clinical Medicine (JCM);
- Journal of Personalized Medicine (JPM);
- Pharmaceuticals.
If you will be attending this conference, our delegates look forward to meeting you in person and answering any questions you may have. For more information about the conference, please visit the following website: https://www.mopmtaiwan.com.
6 November 2025
MDPI Launches the Michele Parrinello Award for Pioneering Contributions in Computational Physical Science
MDPI is delighted to announce the establishment of the Michele Parrinello Award. Named in honor of Professor Michele Parrinello, the award celebrates his exceptional contributions and his profound impact on the field of computational physical science research.
The award will be presented biennially to distinguished scientists who have made outstanding achievements and contributions in the field of computational physical science—spanning physics, chemistry, and materials science.
About Professor Michele Parrinello
"Do not be afraid of new things. I see it many times when we discuss a new thing that young people are scared to go against the mainstream a little bit, thinking what is going to happen to me and so on. Be confident that what you do is meaningful, and do not be afraid, do not listen too much to what other people have to say.”
——Professor Michele Parrinello
![]() |
Born in Messina in 1945, he received his degree from the University of Bologna and is currently affiliated with the Italian Institute of Technology. Professor Parrinello is known for his many technical innovations in the field of atomistic simulations and for a wealth of interdisciplinary applications ranging from materials science to chemistry and biology. Together with Roberto Car, he introduced ab initio molecular dynamics, also known as the Car–Parrinello method, marking the beginning of a new era both in the area of electronic structure calculations and in molecular dynamics simulations. He is also known for the Parrinello–Rahman method, which allows crystalline phase transitions to be studied by molecular dynamics. More recently, he has introduced metadynamics for the study of rare events and the calculation of free energies. |
For his work, he has been awarded many prizes and honorary degrees. He is a member of numerous academies and learned societies, including the German Berlin-Brandenburgische Akademie der Wissenschaften, the British Royal Society, and the Italian Accademia Nazionale dei Lincei, which is the major academy in his home country of Italy.
Award Committee
![]() |
The award committee will be chaired by Professor Xin-Gao Gong, a computational condensed matter physicist, academician of the Chinese Academy of Sciences, and professor at the Department of Physics, Fudan University. Professor Xin-Gao Gong will lead a panel of several senior experts in the field to oversee the evaluation and selection process. The Institute for Computational Physical Sciences at Fudan University (Shanghai, China), led by Professor Xin-Gao Gong, will serve as the supporting institute for the award. |
"We hope the Michele Parrinello Award will recognize scientists who have made significant contributions to the field of computational condensed matter physics and at the same time set a benchmark for the younger generation, providing clear direction for their pursuit—this is precisely the original intention behind establishing the award."
——Professor Xin-Gao Gong
The first edition of the award was officially launched on 1 November 2025. Nominations will be accepted before the end of March 2026. For further details, please visit mparrinelloaward.org.
About the MDPI Sustainability Foundation and MDPI Awards 
The Michele Parrinello Award is part of the MDPI Sustainability Foundation, which is dedicated to advancing sustainable development through scientific progress and global collaboration. The foundation also oversees the World Sustainability Award, the Emerging Sustainability Leader Award, and the Tu Youyou Award. The establishment of the Michele Parrinello Award will further enrich the existing award portfolio, providing continued and diversified financial support to outstanding professionals across various fields.
In addition to these foundation-level awards, MDPI journals also recognize outstanding contributions through a range of honors, including Best Paper Awards, Outstanding Reviewer Awards, Young Investigator Awards, Travel Awards, Best PhD Thesis Awards, Editor of Distinction Awards, and others. These initiatives aim to recognize excellence across disciplines and career stages, contributing to the long-term vitality and sustainability of scientific research.
Find more information on awards here.
4 November 2025
MDPI INSIGHTS: The CEO's Letter #28 - WSF11, Nobel Laureates, Proofig AI, Romania Summit, STM and FBF
Welcome to the MDPI Insights: The CEO's Letter.
In these monthly letters, I will showcase two key aspects of our work at MDPI: our commitment to empowering researchers and our determination to facilitating open scientific exchange.
Opening Thoughts

Highlights from the 11th World Sustainability Forum in Barcelona
I’m pleased to share some highlights from the 11th World Sustainability Forum (WSF 11), held in Barcelona on 2–3 October 2025 under the theme Sustainable and Resilient Cities.
Why WSF matters
The WSF series is a flagship initiative for MDPI and is supported by the MDPI Sustainability Foundation. It serves as a transdisciplinary platform for researchers, policymakers, and stakeholders to engage on sustainability challenges. WSF is now held annually as part of our commitment to maintain momentum in the sustainability discourse.
|
|
|
|
This year’s Barcelona edition focused on urban resilience, landscape design, and social community impact in the sustainability space. Over 48 hours of sessions, we brought together leading minds across disciplines to translate vision into practice. With participants from 53 countries across all continents, WSF 11 was truly global in scope.

“WSF is now held annually as part of our commitment to maintain momentum in the sustainability discourse”
What made WSF 11 especially successful (from my vantage point) was the level of positive engagement with our participants. Chief editors, researchers, and attendees repeatedly told me how professionally executed the event was, highlighting the high energy, logistical smoothness and quality of MDPI’s event management. That kind of recognition from peers really builds our reputation as more than just a publisher, but as a convener of meaningful scientific dialogue.
Our conferences are a form of experiential marketing as they create memorable and immersive connections between a brand and attendees. These positive associations build promotion and brand loyalty, ultimately impacting the MDPI’s trust and reputation for the better.
WSF 11: By the numbers
Here’s a quick snapshot of WSF 11’s scale and reach:
- 181 registrations across global participants.
- 8 keynote speakers and 5 invited speakers.
- 144 abstracts accepted (over 355 submitted), resulting in 75 short talks and 69 posters.
- 53 countries were represented across all continents, making it a truly international event.
- First time that we ran parallel sessions for WSF (an ambitious program).
- A dedicated awards ceremony to honour outstanding sustainability research: World Sustainability Award (WSA) x 2 winners, and Emerging Sustainability Leader Award (ESLA) x 3 winners.
Interviews with our World Sustainability Award Winners
One of the most rewarding parts of WSF is recognizing researchers whose work advances sustainability in powerful ways. In our Blog series, Daniella Maritan-Thomson (Content Specialist, MDPI) interviewed the two winners of the World Sustainability Award, Professor Dr. Stuart Pimm and Dr. Abdelbagi M. Ismail, who offered insights to the human side of sustainability research, the people behind the data, and the stories behind the science.
|
|
Prof. Stuart Pimm, whose decades of conservation work make him a leader in biodiversity preservation, reflected on his WSF Award experience and research in this interview: [Interview: Prof Stuart Pimm] |
|
|
Dr. Abdelbagi M. Ismail, an expert in crop improvement and winner of the WSF Award, shares his journey and perspectives here: [Interview: Dr Abdelbagi M. Ismail] |
“Our conferences create memorable and immersive connections”
Emerging Sustainability Leader Award winners

Stefan Tochev (CEO, MDPI), Prof. Dr. Vhahangwele Masindi, Dr. Katya Rhodes, and Prof. Dr. Myriam Ertz (left to right).
We also recognized three recipients of the Emerging Sustainability Leader Award: Prof. Dr. Vhahangwele Masindi, Dr. Katya Rhodes, and Prof. Dr. Myriam Ertz, for their contributions as early-career researchers advancing sustainability through innovation, impact, and academic excellence across the field.
What this means for MDPI
- Building our global identity in events
WSF is a marquee MDPI event, not just a gathering, but a statement of how we wish to position ourselves in the global sustainability ecosystem. The positive feedback helps us build on our approach for future editions, so that we remain a reference point for quality, relevance, and engagement. - Expanding capacity across offices
The success of WSF 11 in Barcelona’s would not have happened without great teamwork from Basel, Barcelona, Romania, the UK, and the APAC Conference team. Thanks to everyone for their work to bring this ambitious event to life. - Supporting MDPI’s mission
At this event, I had the opportunity to present on MDPI's role in Open Access, sustainability publishing, and the intersection of science and policy. WSF is not only about the science; it’s also a platform for us to position MDPI as a thought leader and a collaborator in shaping the future of sustainable research.
I look forward to the WSF momentum as we work towards WSF 12 in Hong Kong, which is scheduled for August 2026.

MDPI Colleagues at the 11th World Sustainability Forum in Barcelona, Spain, 2–3 October 2025.
Impactful Research

Celebrating 2025 Nobel Laureates who have published with MDPI
October is always an inspiring month in science. It’s when the world turns its attention to the Nobel Prize announcements, recognizing discoveries that have changed how we understand the world.
Over the years, many distinguished researchers who have received the Nobel Prize have chosen to publish their work with MDPI. These are scientists whose breakthroughs have shaped entire fields of research, and who have entrusted our Open Access journals to share their findings with the world.
“The work we support can be world-class and world-changing”
Congratulations to the 2025 Laureates
Dozens of Nobel Laureates have published in our journals: as at 2024, more than 40 laureates had contributed over 115 articles across more than 35 MDPI journals. Congratulations to the three 2025 Nobel prize-winners who have published with MDPI during their careers. Below are links to their MDPI publications and announcements for further reading:
- Omar M. Yaghi (Chemistry)
- Awarded for his pioneering work on metal-organic frameworks (MOFs). MDPI published his article “Covalent Organic Frameworks: Organic Chemistry Beyond the Molecule” in Molecules (2017).
- MDPI Announcement: https://www.mdpi.com/news/13455
- Nobel Prize in Chemistry – The Science Behind the Prize
- Shimon Sakaguchi (Medicine)
- Recognized for discoveries in immune-system self-tolerance and regulatory T-cells. Published in Cancers (2021).
- MDPI Announcement: https://www.mdpi.com/news/13443
- Nobel Prize in Physiology or Medicine – The Science Behind the Prize
- John M. Martinis (Physics)
- Recognized for quantum tunnelling in electrical circuits. MDPI’s Journal of Nuclear Engineering (2025) includes his co-authored work.
- MDPI Announcement: https://www.mdpi.com/news/13450
- Nobel Prize in Physics – The Science Behind the Prize
These connections strengthen our mission to make research freely available and ensure that transformative ideas reach the widest possible audience.
Publishing at the leading edge of knowledge
The privilege of hosting such contributors resonates deeply with our editorial teams. It shows that top-tier scientific work has a home at MDPI, which builds our visibility in the research community. It signals that our publishing model, our editorial workflows, and our commitment to Open Access are respected at the very highest levels of science. It also gives our authors, reviewers, editors and staff the message that the work we support can be world-class and world-changing.
Publishing at the leading edge of knowledge isn’t just about individual papers – it’s about the ecosystem of support, transparency, and accessibility that makes discovery possible. Let’s continue to build a publishing platform and provide a service that attracts and enables both everyday research and the breakthroughs of tomorrow.
Inside MDPI

Strengthening Research Integrity: MDPI partners with Proofig AI
I’m pleased to share that MDPI has entered a multi-year partnership with Proofig AI, a leader in AI-driven proofing and integrity software for scientific publishing. This follows the success of our pilot program, in which Proofig AI proved highly effective in detecting duplicated, altered, and manipulated images across biomedical submissions.
Safeguarding the credibility of the research we publish
Research integrity is at the core of MDPI’s mission. The life sciences, in particular, face increasing risks of image-related issues due to advanced editing tools and generative AI. By integrating Proofig AI into our workflows, we improve our ability to detect issues early, reduce post-publication corrections, and safeguard the credibility of the research we publish.
Pilot outcomes
- Successful detection of duplicated confocal and histology images, even when altered to disguise similarities.
- Early results showed a significant drop in post-publication image manipulation flags year-on-year.
- Positive feedback from editors and staff highlighted the tool’s ease of use and reliability.

Dr. Dror Kolodkin-Gal (co-founder and CEO of Proofig AI) said:
“The MDPI team conducted a highly professional and carefully monitored pilot, achieving excellent results in detecting problematic images.
Their fast and effective integration process was impressive, and we are excited to contribute to this important collaboration.”

Sanita Meijere (IT Product and Project Manager, MDPI), shared:
“For more than a year, we’ve tested all the available image manipulation detection tools. Proofig AI’s quality and ease of use, alongside positive feedback from our internal users, made their software a clear stand-out.
We’re thrilled to be moving forward with this partnership, ensuring we do our utmost to protect MDPI’s biomedical journals. Using this advanced image proofing software reaffirms MDPI’s commitment to maintaining the highest standards in research integrity.”
Raising the bar for integrity
This partnership sets a new benchmark for quality control in biomedical publishing.

As Tim Tait-Jamieson (Head of Publication Ethics, MDPI), explains:
“The life sciences are disproportionately affected by research integrity issues, making vigilance in this field especially critical. This is driven, in part, by the increasing sophistication of image editing software and generative AI.
Whether accidental or deliberate, image manipulation can have a lasting impact on credibility. By integrating Proofig AI into our editorial workflows, we strengthen our ability to detect scientific misconduct early and reduce post-publication amendments.”
Faster and more accurate quality control
Proofig will automatically flag potentially problematic images during submission checks, giving our editors more confidence in the integrity of manuscripts and freeing up time to focus on editorial decisions. The tool will also reduce the burden of manual checks, while supporting faster and more accurate quality control. This partnership reinforces MDPI's reputation as a publisher that takes integrity seriously and continues to invest in tools to support authors, editors, and reviewers alike.
A big thank-you to all colleagues who supported the pilot and rollout. You can read more in our MDPI Blog post.
Coming Together for Science

The MDPI Romania Summit 2025
On 21–22 October, I had the pleasure of joining our colleagues in Bucharest for the MDPI Romania Summit 2025. The event was organized by our Romania Marketing team, with support from colleagues across our Romanian offices. It brought together academics, policymakers, and collaborators to discuss the country’s evolving research landscape.
Over two days, we welcomed more than 30 participants, including Editorial Board Members, Guest Editors, and policy-makers from the Romanian research and education sectors, including representatives from the Romanian Academy and the National Commission for the Accreditation of Academic Titles (CNATDCU).
The discussions and presentations reflected the strength and growth of Romania’s research community and its active engagement in Open Access publishing.
|
|
|
|
“The discussions and presentations reflected the strength and growth of Romania’s research community”
Romania’s role in Open Access
Romania loves Open Access and has emerged as one of MDPI’s most engaged national research communities. The numbers speak for themselves:
- 67% of all publications in Romania were Open Access in 2024.
- MDPI accounts for 39% of the country’s total OA publications (14,779 in 2024).
- Over the last five years (2020–2024), Romanian institutions published over 33,000 papers with MDPI.
- There are 460 active Editorial Board Members from Romania, including 8 Chief Editors.
- 29 institutions are part of our Institutional Open Access Program (IOAP), with 8 new members joining in 2025.
These numbers reflect the trust and reliable partnership we have built with the Romanian academic community.
Highlights from the Summit
The program covered a wide range of topics from MDPI’s achievements and updates to our editorial processes, peer-review quality, AI in publishing, IOAP and Open Access funding models, and publication ethics.
|
|
|
|
|
|
|
|
Agenda Highlights:
- MDPI Introduction, Performance & Achievements, and Collaboration with Romania – Stefan Tochev (CEO, MDPI).
- Trust the Process: Editorial Workflow and Quality in Publishing – Dr. Liliane Auwerter (Scientific Review Group).
- Publication Ethics at MDPI: Safeguarding the Integrity of the Published Scholarly Record – Diana Cristina Apodaritei (Research Integrity Specialist).
- Institutional Partnerships – Becky Castellon (Institutional Partnerships Manager, MDPI).
- AI in Publishing and MDPI's Actions – Sanita Meijere (AI Product Manager).
- Closing Remarks – Stefan Tochev (CEO, MDPI).
Participants shared feedback and ideas for future collaborations, including organizing author workshops, possible conference collaborations, and strengthening our engagement with national institutions such as the Ministry of Education and Research and the National Council of Romanian Rectors.
As Acad. Dr. Nicolae-Victor Zamfir, Vice President of the Romanian Academy, noted during the discussions:
“The organization of the event is very timely, because MDPI is a publishing house in full development and expansion. The opinion of researchers is important for increasing the quality of published works.”
A collaborative future
Events like this remind us how essential it is to engage locally and listen directly to the voices of our editors, authors, and institutional partners. They help us build relationships, improve our understanding of the local market, and align our shared goals in advancing Open Access and research quality.
Thank you to everyone involved, especially our Romania Marketing team, who organized the event, and to all colleagues who continue to build relationships with our academic communities around the world.

Thank you!
A special thank-you to the Romanian Marketing team and all colleagues behind the scenes who made this Summit such a success. Your efforts are greatly appreciated. We look forward to building on this momentum with future Summits in Europe and beyond.
Closing Thoughts

STM and FBF 2025: Connecting Through Science and Publishing

Stefan Tochev (CEO, MDPI), Constanze Schelhorn (Head of Indexing, MDPI) at STM Conference, Frankfurt, 14 October 2025.
On 13–14 October, I attended the STM Frankfurt Conference 2025, my fourth visit to the Frankfurt event, and it continues to be one of the most valuable gatherings in our industry.
The STM meeting brings together the publishing community and key opinion leaders to speak on current trends and challenges shaping our industry.
This year’s theme – “Science Diplomacy: What is it and How Does it Work?” – unpacked the growing intersection of science, policy, and publishing.
Discussion topics ranged from what is science diplomacy and how publishers can contribute to global collaboration to how science communication can help maintain trust during an era of disruption.
I was joined by Dr. Constanze Schelhorn, our Head of Indexing, who met with representatives from Scopus, Web of Science, Digital Science, ProQuest, and other partners. These meetings give us a chance to share feedback on our collaborations, learn about new updates being developed, and build our relationships with indexing bodies.
“The STM meeting brings together the publishing community and key opinion leaders”
STM also provides a space to connect with industry peers, as I did with colleagues from Elsevier, Frontiers, Clarivate, Sage, and STM itself, reinforcing MDPI’s engagement within the broader publishing community. It was also nice to bump into some former colleagues and see them continuing to grow in their publishing careers.
At the Frankfurt Book Fair

The MDPI booth at the 2025 Frankfurt Book Fair.
Following STM, I spent the next day at the Frankfurt Book Fair (15–19 October) – one of the largest and most influential events in the publishing world.
It’s always inspiring to see the scale and energy of this global gathering, which spans everything from books and education to digital innovation and academic publishing.
We set up an MDPI booth to host discussions with partners, vendors, and researchers.
The Fair ran into the weekend, with colleagues from several MDPI departments attending to represent the company and connect with the scholarly community.
Events like STM and FBF are a nice reminder of how dynamic and interconnected our industry is, and how important it is for MDPI to continue taking part in global conversations about science, communication, and the future of publishing.
Chief Executive Officer
MDPI AG















