Plant diseases are globally causing substantial losses in staple crop production, undermining the urgent goal of a 60% increase needed to meet the food demand, a task made more challenging by the climate changes. Main consequences concern the reducti...
Insect meal has shown promise as a potentially sustainable source of nutrients for aquafeeds, offering an alternative to expensive and ecologically undesirable ingredients, in the context of population explosion and climate change. Despite this promi...
The COVID-19 pandemic coupled with recent upheavals in global trade and development assistance funding has disrupted routine immunization programmes and diverted health systems from the targets set in the Immunization Agenda 2030. Regulatory systems...
Type I interferons (IFN-I) are one of the primary immune defenses against viruses. Similar to all other molecular mechanisms that are central to eliciting protective immune responses, IFN-I expression is subject to homeostatic controls that regulate...
The COVID-19 era requires research and development into eco-friendly immune technologies in human life. However, such research is limited because of a lack of interest. Therefore, in this study, sub-critical extracts extracted from Rubia hexaphylla l...
The therapeutic inhibition of immune checkpoints, including cytotoxic T lymphocyte-associated protein (CTLA)-4 and programmed cell death 1 (PD-1), through the use of function blocking antibodies can confer improved clinical outcomes by invigorating C...
The development of novel strategies of plant disease management is crucial in view of the growing demand of sustainability in agri-food chains. The use of agrochemicals is not without risk for the consumer and environment in terms of their residues i...
The beneficial effects of butyric acid in poultry production are well documented, while the relationship between sodium butyrate (SB) and microcapsule sustained-release sodium butyrate (MSSB), especially in yellow broilers, remains poorly investigate...
Fusarium head blight (FHB) and Fusarium crown rot (FCR) are managed by the application of imidazole fungicides, which will be strictly limited by 2030, as stated by the European Green Deal. Here, a novel and eco-sustainable nanostructured particle fo...
Root-knot nematodes (RKNs; Meloidogyne spp.) are among the most destructive plant parasites, causing severe yield losses in diverse crops. Reactive oxygen species (ROS), particularly superoxide radicals (O2•−) and hydrogen peroxide (H2O2),...
Background: Aquaculture increasingly seeks sustainable alternatives to fishmeal, a key protein source in fish diets. Black Soldier Fly Larvae (BSFL) meal is a promising substitute, but its effects on fish growth, immunity, and gut health need further...
The rapid expansion of aquaculture is vital for global food security, yet it faces persistent threats from disease outbreaks, vaccine inefficacy, and antibiotic overuse, all of which undermine sustainability. Conventional vaccines often fail to induc...
Sustainable food consumption is an essential component of sustainable development. Previous literature mainly focused on consumers’ environmentally friendly consumption, and paid less attention to their avoidance of unsafe consumption. This art...
With the rapid development of global aquaculture, the frequent occurrence of fish diseases has had a serious impact on the efficiency of aquaculture and the ecological environment. Antimicrobial peptides, as a kind of natural immune active substance...
Innate immunity represents a trait common to animals and plants. Indeed, similar to animals, plants also evolved a complex defense machinery to defend against pest and pathogen attacks. Due to the concerns posed by the intensive use of agrochemicals,...
Vaccination remains a cornerstone of livestock disease control, yet its effectiveness under field conditions is often compromised by concurrent infections, particularly parasitic helminths. This review explores how infections shape vaccine-induced im...
Oxidative stress and inflammation are two tightly interconnected processes that shape the physiological and pathological responses of aquatic animals to environmental and pathogenic challenges. Reactive oxygen species (ROS) act as key molecular media...
Bacterial soft rot, caused by Pectobacterium carotovorum subsp. carotovorum, affects numerous vegetable crops. Beneficial microbes like Bacillus amyloliquefaciens PMB05 offer a sustainable alternative to traditional copper- or antibiotic-based contro...
Although vaccination is still considered to be the cornerstone of public health care, the increase in vaccination coverage has stagnated for many diseases. Most of these vaccines require two or three doses to be administered across several months or...
Global freshwater scarcity necessitates the exploitation of alternative water resources for aquaculture. Chloride-type saline-alkaline water, characterized by high salinity but moderate pH, is widely distributed in arid regions worldwide and represen...
Thrombopoietin mimetics are new treatment options for patients with immune thrombocytopenia (ITP). Because of their mechanism of action, long-term administration was envisioned in order to maintain effective thrombopoiesis. We report on 30 romiplosti...
As biomass power generation projects progress, the supply chain of biomass resources has become a key link for the green development of biomass power facilities. The role of biomass recycling logistics in the sustainable development of biomass resour...
Damping-off disease, caused by Pythium aphanidermatum, significantly impacts tomato production. This study explored the potential of a two-pronged approach for enhanced biocontrol: combining two antagonistic Trichoderma asperellum strains (CB-Pin-01...
In an era with an ever-growing population, sustainability and green transition are the main milestones to be considered within the current European Green Deal program, and the recovery of by-products for the integration of feed with bioactive molecul...
Fermentation, one of the oldest biotransformation processes, has become a key element of contemporary sustainable biotechnology. In modern food systems, it enables the simultaneous resolution of environmental, nutritional, and economic challenges by...
This review investigates genetic strategies aimed at improving robustness in pigs to enhance disease resistance and reduce reliance on antibiotics. Robustness refers to a pig’s ability to stay healthy and productive under stressful or challengi...
Background: The escalating prevalence of food allergies, alongside the global call for environmentally sustainable dietary transitions, has drawn attention to plant-based dietary models—particularly those inspired by the EAT-Lancet Commission....
Rare sugars are monosaccharides with a limited availability in the nature and almost unknown biological functions. The use of industrial enzymatic and microbial processes greatly reduced their production costs, making research on these molecules more...
Chloroplasts are important in plant growth, development, and defense mechanisms, making them central to addressing global agricultural challenges. This review explores the multi-faceted contributions of chloroplasts, including photosynthesis, hormone...
Carp is an important aquaculture species globally, and the production is expected to increase with the growing market demands. Despite that, disease outbreaks remain a major challenge, impeding the development of sustainable carp farming. Moreover, t...
The supplementation of different ω-6/ω-3 ratio to the diets of the laying hens has been studied to evaluate the effects on performance, egg quality, egg health indices, egg fatty acid profiles, and immune response. One-hundred and twenty,...
The implementation of medical drones can quickly and efficiently expand the coverage range of an area, allowing for a faster response to incidences of out-of-hospital cardiac arrest and improving the subsequent survival rate of such incidences, while...
Vaccine adjuvants are crucial for reinforcing the immunogenicity of vaccines. Therefore, they are widely used in the aquaculture sector as vaccine components, facilitating the efficient prevention of infectious diseases and promoting sustainable tele...
The aim of the present study was to investigate the effects of different dietary levels of spent mushroom substrate (SMS) at the expense of wheat straw (WS) on milk characteristics in dairy sheep. Thirty ewes at their final stage of lactation (145 &p...
23 October 2026
Antimicrobial resistance (AMR) is rapidly undermining the effectiveness of existing antibiotics, while the discovery of truly novel antimicrobial agents remains limited. Addressing this crisis requires moving beyond the search for individual molecule...
Vitamin A (VA) is an essential micronutrient that improves growth, immune activity, and antioxidant responses in fish. This study focuses on optimizing VA dietary levels for Oncorhynchus kisutch (Coho salmon) alevins. A 12-week trial was conducted us...
Achieving a balance between enhancing both humoral and cellular immunity while ensuring sustained release for attenuated live vaccines has long been a challenge in the vaccine industry. However, the incorporation of chemical materials as nanoadjuvant...
Guanosine- and uridine-rich single-stranded RNA (GU-rich RNA) is an agonist of Toll-like receptor (TLR) 7 and TLR8 and induces strong immune responses. A nanostructured GU-rich RNA/DNA assembly prepared using DNA nanotechnology can be used as an adju...
Sustained immune responses, particularly antibody responses, are key for protection against many endemic infectious diseases. Antibody responses are often accompanied by T helper (Th) cell immunity. Herein we study small biodegradable poly (ethylene...
Duckweed (Spirodela polyrhiza), a fast-growing aquatic plant rich in protein and bioactive compounds, offers a sustainable alternative to conventional aquafeed protein sources. This study evaluated the effects of incorporating 25–75% duckweed m...
Background/Objectives: Developing durable cellular immunity remains a critical challenge for HIV vaccine development. Methods: We evaluated a sequential and repeated heterologous prime–boost vaccination regimen using four distinct vector-based...
This narrative review examines therapeutic cancer vaccines, which have undergone a profound renaissance, transitioning from early peptide and dendritic cell-based formulations to next-generation mRNA platforms enabling personalized neoantigen targeti...
Background/Objectives: Eliciting robust immune responses against the hepatitis B virus (HBV) through therapeutic vaccination holds promise for curing chronic hepatitis B. We previously developed the heterologous protein prime/viral vector boost clini...
Prostate cancer is the prototypical immunologically cold solid tumor, with objective response rates of only 3–5% to immune checkpoint inhibitors in unselected metastatic castration-resistant disease and an estimated 89.8% of tumors classified a...
Background/Objectives: Respiratory syncytial virus (RSV) poses a substantial global health threat, particularly impacting infants and vulnerable pediatric populations through severe respiratory morbidity. Methods: We developed a novel adenoviral vect...
The sustainable production of Dioscorea polystachya (Chinese yam) is severely compromised by a vicious cycle of excessive chemical dependency and complex biotic stresses including anthracnose, nematodes, thrips and other associated pests and diseases...
Phosphatidylinositol-3-kinase (PI3K) inhibition has emerged as a therapeutic option against indolent lymphoma, including relapsed follicular lymphoma (FL). While inhibition of active signaling in the lymphoma cell represents the primary mode of actio...
The main prognostic factors for patients with head and neck cancer are the tumour site and stage, yet immunological and metabolic factors are certainly important, although knowledge is still limited. Expression of the biomarker p16INK4a (p16) in orop...
The effects of substituting soybean meal with black soldier fly larvae (BSFL) meal on the growth performance, immunological response, intestinal morphology, and gut microbiota of Pekin ducks were assessed. A total of 150 one-day-old Pekin ducks were...
Introduction: Immune thrombocytopenia (ITP) is an autoimmune disorder characterized by reduced platelet counts. Dupilumab, an IL-4 receptor antagonist, is effective in allergic and auto-inflammatory diseases; however, use in ITP remains unexplored. C...
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