To meet the growing demands for competency-based and personalized instruction in high school English reading, this study investigates a quantitative approach to modeling learning pathways and progressions. Traditional assessments often fail to captur...
Destructive earthquakes are natural hazards highlighting the importance of introducing disaster preparedness from early childhood. Preschool children require developmentally appropriate educational approaches that connect scientific understanding wit...
Cholangiocarcinoma (CCA) is a group of complex and heterogeneous tumors originating from the epithelial cells of bile ducts that can occur in intrahepatic, perihilar, or distal localizations [...]
Forest biometrics has emerged as one of the fastest-growing scientific disciplines within environmental sciences. Machine learning (ML), an increasingly essential approach that uses effective algorithms, has proven to be an accurate and cost-efficien...
Previous research has demonstrated a link between prior knowledge and student success in engineering courses. However, while course-to-course relations exist, researchers have paid insufficient attention to internal course performance development. Th...
As artificial intelligence (AI) adoption grows in medical education, AI assistants have become important learning support tools for medical students. However, existing research has primarily focused on learning performance and technology adoption, wh...
Coronary artery disease (CAD), the build-up of atherosclerotic plaques on the wall of blood vessels, causes adverse cardiovascular events. Secondary prevention focuses on treating patients with existing plaques to prevent disease progression. Recent...
Late-onset Alzheimer’s disease (LOAD) is a subtype of dementia that manifests after the age of 65. It is characterized by progressive impairments in cognitive functions, behavioral changes, and learning difficulties. Given the progressive natur...
Tremendous progress has been made in object recognition with deep convolutional neural networks (CNNs), thanks to the availability of large-scale annotated dataset. With the ability of learning highly hierarchical image feature extractors, deep CNNs...
Background: The accurate staging of multiple myeloma (MM) is essential for optimizing treatment strategies, while predicting the progression of asymptomatic patients, also referred to as monoclonal gammopathy of undetermined significance (MGUS), to s...
Background/Objectives: Sepsis is a leading cause of morbidity and mortality due to its rapid progression and variability in care delivery. While existing predictive models estimate sepsis risk using clinical variables, they typically rely on static a...
The past twelve years have seen ubiquitous learning (u-learning) emerging as a new learning paradigm based on ubiquitous technology. By integrating a high level of mobility into the learning environment, u-learning enables learning not only through f...
The environmental persistence of antibiotic residues in aquatic systems represents a critical global challenge, with photolysis serving as a primary abiotic degradation pathway. Traditional approaches to studying antibiotic photodegradation and trans...
The advancements of information technology and related processing techniques have created a fertile base for progress in many scientific fields and industries. In the fields of drug discovery and development, machine learning techniques have been use...
Clinical audit is a method to assess the quality of healthcare services based on whether standards are met or not met. This approach is limited because it fails to recognize how decisions that take place over time and the natural progression of disea...
Glioblastoma (GBM) is an aggressive tumor type known to recur after maximal safe surgical resection followed by concurrent radiation therapy (RT) and chemotherapy (temozolomide—TMZ), and adjuvant TMZ maintenance chemotherapy. It exhibits high i...
The rapid advancement of artificial intelligence relies on massive high-quality data, yet increasingly stringent data privacy regulations have exacerbated the problem of data silos. Federated learning enables collaborative training under privacy prot...
Sepsis is a life-threatening condition driven by dysregulated immune responses, resulting in organ dysfunction and high mortality rates. Identifying key genes and pathways involved in sepsis progression is crucial for improving diagnostic and therape...
It is proposed that the process of learning may be represented as a trajectory within the phase space of long-term memory. The research uses an artificial neural network design to explore, in theory, if starting from different points within the phase...
Objective: This study aims to explore the role of angiogenesis-related genes in chronic lung diseases (ILD and COPD) using bioinformatics methods, with the goal of identifying novel therapeutic targets to slow disease progression and prevent its dete...
Ochratoxin A (OTA), a prevalent food contaminant, has been proposed as a potential contributor to the development of prostate cancer, although its precise mechanisms remain unclear. This study employed a comprehensive approach that integrated network...
Background: Liver fibrosis is a major global public health issue that is only getting worse. The underlying molecular mechanisms of Yindanpinggan Capsule (YDPG), a traditional Chinese medication, are still unknown, although it has shown notable effec...
Background: Keratoconus (KTCN) is a multifactorial disease characterized by progressive corneal degeneration. Recent studies suggest that a gene expression analysis of corneas may uncover potential novel biomarkers involved in corneal matrix remodeli...
Selection history is widely accepted as a vital source in attention control. Reward history indicates that a learned association captures attention even when the reward is no longer presented, while statistical learning indicates that a learned proba...
High-dimensional metabolomics analyses may identify convergent and divergent markers, potentially representing aligned or orthogonal disease pathways that underly conditions such as pulmonary arterial hypertension (PAH). Using a comprehensive PAH met...
Despite recent efforts, prostate cancer (PCa) remains one of the most common cancers in men. Currently, there is no effective treatment for castration-resistant prostate cancer (CRPC). There is, therefore, an urgent need to identify new therapeutic t...
Background: Alzheimer’s disease (AD) is a neurodegenerative disorder that is associated with abnormal cognition. AD is aided in its initiation and progression by hereditary and environmental factors. Aluminum (Al) is a neurotoxic agent that cau...
The cGAS STING pathway has received much attention in recent years, and it has been recognized as an important component of the innate immune response. Since the discovery of STING and that of cGAS, many observations based on preclinical models sugge...
Lifespan is increasing throughout the world leading to a rise in non-communicable diseases in the global population that impacts over 800 million individuals with metabolic disorders, such as diabetes mellitus. Metabolic disease presents a significan...
Background: Upper tract urothelial carcinoma (UTUC) is a rare and aggressive malignancy with limited prognostic tools to predict disease progression. Due to its low incidence, the molecular pathogenesis of UTUC remains poorly understood, and few stud...
Alzheimer’s disease is the most common form of neurodegenerative disease, and increasing evidence shows that insulin signaling has crucial roles in AD initiation and progression. In this study, we explored the effect and underlying mechanism of...
The gut microbiota significantly impacts human health, influencing metabolism, immunological responses, and disease prevention. Dysbiosis, or microbial imbalance, is linked to various diseases, including cancer. It is crucial to preserve a healthy mi...
Space and place, fundamental concepts in geography, uniquely contribute to the development of students’ geographical thinking. Despite this, these concepts are underrepresented in German geography classrooms, partly due to a distinct lack of em...
Background/Objectives: This study uses Sankey diagrams to analyze treatment pathways in patients with peripheral artery disease (PAD), which is a vascular condition characterized by atherosclerotic occlusion of the arteries, particularly in the lower...
Uterine leiomyosarcoma (uLMS) is the most common subtype of uterine sarcomas. They have a poor prognosis with high rates of recurrence and metastasis. The five-year survival for uLMS patients is between 25 and 76%, with survival rates approaching 10&...
BET proteins function as histone code readers of acetylated lysins that determine the positive regulation in transcription of genes involved in cell cycle progression, differentiation, inflammation, and many other pathways. In recent years, thanks to...
Cardiovascular disease is the leading cause of global mortality and responsible for millions of deaths annually. The mortality rate and overall consequences of cardiac disease can be reduced with early disease detection. However, conventional diagnos...
Academic burnout remains a widespread concern in higher education because it impairs students’ learning progress and psychological well-being. Using cross-sectional questionnaire data from 1431 full-time undergraduates, this study examined the...
Jazz music has long been a subject of interest in the field of generative music. Traditional jazz chord progressions follow established patterns that contribute to the genre’s distinct sound. However, the demand for more innovative and diverse...
Engineering education is increasingly required to prepare graduates who can address complex societal challenges by connecting technical expertise with innovation, sustainability, stakeholder needs, and value creation. This article examines how an ite...
As an emerging nano energy technology, nanogenerators have been developed rapidly, which makes it crucial to analyze the evolutionary pathways of advanced technology in this field to help estimate the development trend and direction. However, some li...
During the past decade, accumulating evidence from both clinical and experimental studies has indicated that erythropoietin may have antidepressant effects. In addition to the kidney and liver, many organs have been identified as secretory tissues fo...
The importance of anti-androgen therapy for prostate cancer (PC) has been well recognized. However, the mechanisms underlying prostate cancer resistance to anti-androgens are not completely understood. Therefore, identifying pharmacological targets i...
Medicinal chemistry is facing new challenges in approaching precision medicine. Several powerful new tools or improvements of already used tools are now available to medicinal chemists to help in the process of drug discovery, from a hit molecule to...
Objective: To elucidate the role of cytoskeleton-associated protein 2 (CKAP2) in gastric cancer (GC) progression and evaluate its prognostic and potential protective significance. Methods: The candidate genes for GC were identified using differential...
The ubiquitin and SUMO (small ubiquitin-like modifier) pathways modify proteins that in turn regulate diverse cellular processes, embryonic development, and adult tissue physiology. These pathways were originally discovered biochemically in vitro, le...
In the context of the shipping industry’s transition towards low-carbon solutions, hydrogen energy exhibits substantial application potential in marine propulsion systems. Fuel reforming for hydrogen production represents one of the key technol...
The increasing recognition within the infrastructure sector of the transformative potential of 3D point cloud data for civil structure management has prompted a growing interest. However, the inherent complexity of these data poses significant challe...
Chronic atrophic gastritis (CAG) is a precancerous gastric condition with limited therapeutic interventions, and the mechanisms underlying the benefits of Coptis chinensis Franch. (CCF) remain insufficiently defined. This study employed an integrated...
Progress in cancer research is substantially dependent on innovative technologies that permit a concerted analysis of the tumor microenvironment and the cellular phenotypes resulting from somatic mutations and post-translational modifications. In vie...
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