Special Issue "Disease and the Hippo Pathway: Cellular and Molecular Mechanisms"
Deadline for manuscript submissions: closed (31 March 2019) | Viewed by 46692
A printed edition of this Special Issue is available here.
The Hippo pathway is a highly dynamic cellular signaling nexus, integrating mechanotransduction, cell polarity, inflammation, and numerous types of paracrine signaling. The Hippo pathway plays central roles in multiple cell types and regulates regeneration, metabolism and development. If not tightly regulated, dysregulated Hippo pathway signaling drives the onset and progression of a range of diseases, including fibrosis and cancer. The molecular understanding of the Hippo pathway is rapidly evolving, emphasized by the relative recent seminal discovery of the LATS1/2 mediated, but Hippo independent, kinase regulation of YAP/TAZ via the MAP4K family. The aim of this Special Issue is to provide an overview of how a dysregulated Hippo pathway is a common driver of specific diseases, with a particular focus on the underlying molecular and cellular mechanisms that causes the Hippo pathway to go awry, and how this drives disease. We particularly welcome contributions, in the form of either original research articles or concise reviews, with mechanistic and functional insights into either specific diseases or common pathological phenomena caused by Hippo pathway dysregulation.
We hope that the articles will analyse disease-specific, as well as common themes, which will provide valuable insights into the fundamental molecular mechanisms in the dysfunctioning Hippo pathway, and thereby offer practical insights into potential future therapeutic intervention strategies.
Dr. Carsten Gram Hansen
Manuscript Submission Information
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- Hippo pathway
- disease mechanism