We reported that two microRNAs, miR526b and miR655, are oncogenic in breast cancer (BC). Overexpression of these two miRNAs in poorly metastatic BC cells promotes aggressive BC phenotypes in vitro and in vivo. High expression of each miRNA was associ...
Resolution and mapping bandwidth are the two most important image performance indicators that reflect satellite synthetic aperture radar (SAR) imaging reconnaissance capability. The PRI-staggered signal can simultaneously achieve high resolution in a...
To address the problems of poor adaptability to pulse loss, susceptibility to interfered pulses, and the need of sub-PRI (Pulse Repetition Interval) ranking in the existing signal sorting algorithms, this paper proposes an algorithm for sorting stagg...
Recently, a signal sorting algorithm based on the congruence transform has been proposed, which is effective in dealing with the staggered Pulse Repetition Interval (PRI) signals. It can effectively sort the staggered PRI signals and obtain the sub-P...
MicroRNAs (miRNAs) are small regulatory non-coding RNAs, resulting from the cleavage of long primary transcripts (pri-miRNAs) in the nucleus by the Microprocessor complex generating precursors (pre-miRNAs) that are then exported to the cytoplasm and...
The quantification of isoprene and monoterpene emissions at the ecosystem level with available models and field measurements is not entirely satisfactory. Remote-sensing techniques can extend the spatial and temporal assessment of isoprenoid fluxes....
High-resolution and high-squint spaceborne spotlight synthetic aperture radar (SAR) has significant potential for extensive application in remote sensing, but its swath width effectiveness is constrained by a critical factor: severe range cell migrat...
Background/Objectives: Emerging evidence suggests a role for oral microbiota in mood disorders, particularly bipolar disorder (BD), complementing established links between gut dysbiosis and psychiatric symptoms. This study investigates the compositio...
Background/Objectives: The stem cell transcription factor SOX2 is expressed in more than 20 types of cancer. SOX2 expression is also elevated by a wide range of clinically used drugs and has been linked causally to drug and radiation resistance. Henc...
Some miRNAs are located in RNA precursors (pri-miRNAs) annotated as long non-coding (lncRNAs) due to absence of long open reading frames (ORFs). However, recent studies have shown that some lnc pri-miRNAs encode peptides called miPEPs (miRNA-encoded...
Accurately assessing terrestrial gross primary productivity (GPP) is crucial for characterizing the climate-carbon cycle. Remotely sensing the photochemical reflectance index (PRI) across vegetation functional types and spatiotemporal scales has rece...
The photochemical reflectance index (PRI) and the chlorophyll carotenoid index (CCI) are carotenoid-sensitive vegetation indices, which can monitor vegetation’s photosynthetic activities. One unique satellite named “Global Change Observat...
The photochemical reflectance index (PRI) and red-edge region of the spectrum are known to be sensitive to plant physiological processes, and through measurement of these optical signals it is possible to use non-invasive remote sensing to monitor th...
The majority of patients with testicular germ cell tumors (GCTs) can be cured with cisplatin-based chemotherapy. However, for a subset of patients present with cisplatin-refractory disease, which confers a poor prognosis, the treatment options are li...
Plant polyphenols and vitamins D exhibit chemopreventive and therapeutic anticancer effects. We first evaluated the biological effects of the plant polyphenol resveratrol (RESV) and vitamin D active metabolite PRI-2191 on lung cancer cells having dif...
The photochemical reflectance index (PRI) is a widely used spectral index which can show stress-induced changes in photosynthesis (e.g., increase of the nonphotochemical quenching of chlorophyll fluorescence (NPQ)). The artificial illumination of pla...
Oral infections caused by Candida spp. represent a major health concern due to the increasing resistance of these fungi to conventional antifungal agents. Photodynamic therapy (PDT) is a treatment based on the use of light at a specific wavelength th...
Regulation at the RNA level by RNA-binding proteins (RBPs) and microRNAs (miRNAs) is key to coordinating eukaryotic gene expression. In plants, the importance of miRNAs is highlighted by severe developmental defects in mutants impaired in miRNA bioge...
PriB is a primosomal protein required for the replication fork restart in bacteria. Although PriB shares structural similarity with SSB, they bind ssDNA differently. SSB consists of an N-terminal ssDNA-binding/oligomerization domain (SSBn) and a flex...
In order to estimate vegetation photosynthesis from remote sensing observations; some critical parameters need to be quantified. From all absorbed light; the plant needs to release any excess that is not used for photosynthesis; by non-photochemical...
Soil drought and salinization are key abiotic stressors for agricultural plants; the development of methods of their early detection is an important applied task. Measurement of red-green-blue (RGB) indices, which are calculated on basis of color ima...
Targeted therapies, including treatment with inhibitors of BRAFV600 and MEK kinases, have improved outcomes in advanced melanoma. However, most patients relapse due to acquired resistance, underscoring the need for new drug targets. This study evalua...
High spectral resolution spectrometers were used to detect optical signals ofongoing plant stress in potted white clover canopies subjected to ozone fumigation. Thecase of ozone stress is used in this manuscript as a paradigm of oxidative stress. Ste...
Climatic warming and drying are having profound impacts on terrestrial carbon cycling by altering plant physiological traits and photosynthetic processes, particularly for species in the semi-arid Mediterranean ecosystems. More effective methods of r...
The development of spectral methods of remote sensing, including measurement of a photochemical reflectance index (PRI), is a prospective trend in precision agriculture. There are many works which have investigated the connection between photosynthet...
In this paper, a novel signal processing algorithm for mitigating the radar blind speed problem of moving target indication (MTI) for frequency modulated continuous wave (FMCW) multi-target tracking radars is proposed. A two-phase staggered pulse rep...
29 November 2023
The dysregulation of energetic metabolism is one of the hallmarks of cancer cells. Indeed, the growth of head and neck squamous cell carcinoma (HNSCC) cells depends heavily on glycolytic activity, which can be considered a potential therapeutic targe...
The Wnt/β-catenin, EGFR, and PI3K pathways frequently undergo upregulation in head and neck squamous carcinoma (HNSCC) cells. Moreover, the Wnt/β-catenin pathway together with Hedgehog (Hh) signaling regulate the activity of cancer stem cel...
The real-time imaging research of squint spaceborne synthetic aperture radar (SAR) with high resolution has significant value in both military and civil fields, which makes it a hot issue in SAR research. It is necessary to solve the contradictory pr...
This paper focuses on an improved imaging algorithm for spotlight synthetic aperture radar (SAR) with continuous Pulse Repetition Interval (PRI) variation in extremely high-resolution. Conventional SAR systems are limited in that a wide swath cannot...
This paper makes a theoretical contribution by exploring the integration of sustainability principles into project management. It compares two recent methodologies, PM2 and PRiSMTM, and provides a practical contribution by advocating for the adoption...
1α,25-dihydroxyvitamin D3 (1,25D3) is a powerful differentiation inducer for acute myeloid leukemia (AML) cells. However, 1,25D3 doses required for differentiation of AML cells may cause lethal hypercalcemia in vivo. There is evidence that vitamin D2...
1,25-Dihydroxycholecalciferol, the hormonally active vitamin D3 metabolite, is known to exhibit therapeutic effects against breast cancer, mainly by lowering the expression of estrogen receptors and aromatase activity. Previously, the safety of the v...
Diastereomeric and geometric analogs of calcipotriol, PRI-2202 and PRI-2205, were synthesized as advanced intermediates from vitamin D C-22 benzothiazoyl sulfones and side-chain aldehydes using our convergent strategy. Calcitriol, calcipotriol (PRI-2...
The photochemical reflectance index (PRI) is calculated from vegetation narrowband reflectance in two bands in the visible part of the spectrum. Variations in PRI are associated with changes in the xanthophyll cycle pigments which regulate the light...
Early detection of different types of crop stress under greenhouse cultivations is critical in order to optimize yield and resource use efficiency. The objective of the present work is to develop a system which, based on remote sensing, will recogniz...
Sustainability has become crucial in today’s business landscape. Customers, suppliers, partners, and investors are increasingly demanding that companies be aware of their impacts on the environment and society. Achieving sustainability in busin...
Measurement and analysis of the numerous reflectance indices of plants is an effective approach for the remote sensing of plant physiological processes in agriculture and ecological monitoring. A photochemical reflectance index (PRI) plays an importa...
SMTP (the name SMTP is derived from Stachybotrys microspora triprenyl phenol) is a family of triprenyl phenol secondary metabolites from a black mold, Stachybotrys microspora. Some SMTP congeners exhibit anti-inflammatory and profibrinolytic activiti...
The photochemical reflectance index (PRI) is a proxy for light use efficiency (LUE), and is used in remote sensing to measure plant stress and photosynthetic downregulation in plant canopies. It is known to depend on local light conditions within a c...
The DiGeorge syndrome critical region gene 8 (Dgcr8) knockout strategy has been widely used to study the function of canonical microRNAs (miRNAs) in vitro and in vivo. However, primary miRNA (pri-miRNA) transcripts are accumulated in Dgcr8 knockout c...
The clinical use of 1,25-dihydroxycholecalciferol (1,25D3), the active form of vitamin D3, is limited by its calcemic side effects and rapid metabolic degradation. To overcome these limitations, we designed novel vitamin D analogs with extended, rigi...
Amatoxins and phallotoxins are toxic cyclopeptides found in the genus Amanita and are among the predominant causes of fatal food poisoning in China. In the treatment of Amanita mushroom poisoning, an early and definite diagnosis is necessary for a su...
Nonaqueous capillary electrophoretic (NACE) separation was obtained of analogs of (24R)-1,24-dihydroxyvitamin D3 derivative (calcipotriol) as predicted by quantum chemical calculations supported by the density functional theory (DFT). Among the key e...
In V2G service operations, highly efficient data sharing among participants is useful in grid load balancing and renewable energy integration. However, the data quality and sharing efficiency greatly rely on entities’ willingness to share. More...
Sun-induced Fluorescence (SIF) and Photochemical Reflectance Index (PRI) data were collected in the field over maize to study their diurnal responses to different water stresses at the canopy scale. An automated field spectroscopy system was used to...
Extremely high air temperature at the heading stage of paddy rice causes a yield reduction due to the increasing spikelet sterility. Quantifying the damage to crops caused by high temperatures can lead to more accurate estimates of crop yields. The r...
Salinization is a significant adverse factor that suppresses productivity of agricultural plants. Multispectral imaging and calculation of reflectance indices, including the typical photochemical reflectance index (PRI), can be used for early reveali...
The reaction behaviour of partially reduced iron (PRI) was studied to understand the effect of PRI utilisation in the blast furnace process. For quantitative analysis, the reaction behaviour of PRI under typical operating conditions of a blast furnac...
Plants are affected by numerous environmental factors that influence their physiological processes and productivity. Early revealing of their action based on measuring spectra of reflected light and calculating reflectance indices is an important sta...
of 12