Special Issue "The Wnt Signaling Pathway in Cancer"
Deadline for manuscript submissions: closed (31 May 2020).
Interests: acute lymphoblastic leukemia; drug resistance; microenvironment; integrins; wnt signaling; immunotherapy resistance
This Special Issue focuses on the Wnt Signaling Pathway in Cancer. Wnt signaling has been of considerable interest in both setm cell and cancer biology, both in homeostatic maintenance of tissues and organs through their respective somatic stem cells (SSCs) and in cancer stem cells (CSCs). The functions include cellular processes, including self-renewal capacity, proliferation, differentiation potential, and maintenance of the stem cell niche. The role of aberrant wnt signaling in cancer stem cells (CSCs) has been demonstrated in a wide variety of cancers, including brain tumors, melanoma, breast, liver, pancreatic, and colon cancer, but also hematological malignancies. Wnt siangling has been shown to be involved in initiation of disease, therapeutic resistance, and ultimately, disease relapse. One key focus in cancer research has been to develop therapies to safely eliminate CSCs. The precise understanding of the regulation of wnt signaling, the crosstalk of wnt signaling with other signaling pathways, and downstream targets are key for successful translational efforts, which will be the focus of this Special Edition. Original investigations as well as concise review manuscripts from experts in the relevant research fields will be considered for publication.
Assoc. Prof. Dr. Yong-mi Kim
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- Drug resistance