20 January 2014
Energy becomes a dominating factor for a wide spectrum of computations: from intensive data processing in “big data” companies resulting in large electricity bills, to infrastructure monitoring with wireless sensors relying on energy harvesting. In t...
Scaffolds are an essential component of bone tissue engineering. They provide support and create a physiological environment for cells to proliferate and differentiate. Bone allografts extracted from human donors are promising scaffolds due to their...
Triply periodic minimal surface (TPMS) microarchitectures combine low weight with high mechanical strength, and, in particular, G-gyroid-based microarchitectures represent a promising option for bone substitutes. Most studies on G-gyroid-based bone s...
This research addresses the issue of evaluating CPU rendering performance by introducing the innovative benchmark test suite construction method RenderBench. This method combines CPU microarchitecture features with rendering task characteristics to c...
MRI could be applied for bone microarchitecture assessment; however, this technique is still suffering from low resolution compared to the trabecular dimension. A clear comparative analysis between MRI and X-ray microcomputed tomography (μCT) rega...
Speculative execution attacks are serious security problems that cause information leakage in computer systems by building speculative covert channels. Hardware defenses mitigate speculative covert channels through microarchitectural changes. However...
Background: The combination of pharmacological therapy and exercise is frequently recommended for osteoporosis management; however, whether antiresorptive agents may interfere with exercise-induced bone adaptation remains unclear. This study aimed to...
Despite strontium ranelate use in osteoporosis management being one of the promising concepts in disease treatment, there is no clear evidence that strontium organic compounds are more effective than inorganic ones. The aim of this study was to compa...
Background/Objectives: Zygomatic implants are commonly used to rehabilitate atrophic maxillae and maxillary defects, offering quicker prosthesis placement than bone grafting, but their placement requires technical precision due to the complexity of t...
Background: We evaluated whether mandibular trabecular microarchitecture, measured via fractal dimension (FD), influences Stafne bone cavity (SBC) development. Methods: In this study, 14 images (0.56%) containing SBC were identified among 2500 retros...
In typical computer system design flows, hardware microarchitecture is commonly considered a dynamically developing domain, where abstract mechanisms remain mostly in conceptual form and exhibit poor source code reuse in designs. However, many import...
The maxilla is generally acknowledged as being more trabecular than the mandible. Allograft currently available for use in the maxillofacial region is harvested from the hip and long bones, irrespective of their local characteristics, and grafted ont...
The early phase of bone healing is a complex and poorly understood process. With additive manufacturing, we can generate a specific and customizable library of bone substitutes to explore this phase. In this study, we produced tricalcium phosphate-ba...
Triply periodic minimal surface microarchitectures (TPMS) were developed by mathematicians and evolved in all kingdoms of living organisms. Renowned for their lightweight yet robust attributes, TPMS structures find application in diverse fields, such...
Mobile application workloads are inherently driven by user interactions and are characterized by short execution phases and frequent behavioral changes. These properties make it difficult for traditional micro-architecture analysis approaches, which...
Background: The juvenile-pubertal period is a critical window for linear growth and bone mass accumulation. This study investigated the joint effects of folic acid (FA) and colostrum basic protein (CBP)-fortified milk powder on growth, bone health, a...
The association of obesity with changes in bone mass is not clear. Obese individuals tend to have an increased bone mineral density, but other studies have shown that obesity is a major risk factor for fractures. The mechanisms of bone response durin...
Background: The contribution of specific nutritional biomarkers to skeletal fragility remains poorly understood, in part because most studies include participants with metabolic conditions that obscure nutrient-specific effects. We aimed to examine i...
In this paper, novel micro-architectures with X-type lattice unit cell (namely, face-centered cubic (FCC), and X-type) are constructed and prepared by additive manufacturing technology. The compression behaviors of micro-architectures are explored in...
The Internet-of-Things (IoT) revolution has shaped a new application domain where low-power RISC architectures constitute the standard computational backbone. The current de-facto design practice for such architectures is to extend the ISA and the co...
In this paper, we propose acceleration methods for edge-preserving filtering. The filters natively include denormalized numbers, which are defined in IEEE Standard 754. The processing of the denormalized numbers has a higher computational cost than n...
Background: Local bone quality of the proximal humerus is a key determinant of fracture risk and implant stability in osteoporotic bone. Beyond established HU-based calibration, CT-osteoabsorptiometry (CT-OAM)-derived indices and microarchitecture-or...
The present work presents evaluation and experimental verification of the use of X-ray computed tomographic microscopy (micro-CT) for accurate characterization of geometry, microarchitecture, and stiffness properties of bones. These properties are cr...
To ensure the timely execution of hard real-time applications, scheduling analysis techniques must consider safe upper bounds on the possible execution durations of tasks or runnables, which are referred to as Worst-Case Execution Times (WCET). Bound...
Chimneypieces, washbasins, well heads, and sinks by Andrea Palladio represent refined design works following architectural systems on a reduced scale, even if systematic documentation and analysis of them is still limited. This paper introduces the c...
Background: The purpose of this study was to investigate the relationship between the expression of key degradative enzymes by chondrocytes and the microarchitectural and mineral properties of subchondral bone across different stages of cartilage deg...
Embedded processors are widely used in various systems working on different tasks with different workloads. A more complex micro-architecture leads to better peak performance and worse power consumption. Shutting down the units designed for performan...
Densely integrated microarchitectures spanning three-dimensional integrated circuits (3D-ICs), chiplet-based designs, and system-in-package (SiP) assemblies make heat a first-order security concern rather than a mere reliability issue. This review co...
Recently, computing platforms have been being configured on a large scale to satisfy the diverse requirements of emerging applications like big data and graph processing, neural network, speech recognition and so on. In these computing platforms, eac...
Speculative execution attacks significantly compromise the security of modern processors by enabling information leakage. These well-known attacks exploit speculative cache-based covert channels to effectively exfiltrate secret data by altering cache...
We present a simulation-to-silicon security characterization of microarchitectural side channels on open-source RISC-V cores. Twenty-three attack classes are measured across a six-core corpus that spans the design space from simple in-order pipelines...
The extracellular matrix (ECM) is a three-dimensional, acellular scaffold of living tissues. Incorporating the ECM into cell culture models is a goal of cell biology studies and requires biocompatible materials that can mimic the ECM. Among such mate...
The absence of non-invasive methods for assessing bone material and structural changes is a significant diagnostic challenge. Dual-energy X-ray absorptiometry (DXA) bone mineral density (BMD) testing is the gold standard for osteoporosis diagnosis. B...
Olive oil has been demonstrated to enhance various cardiometabolic risk factors. However, to our knowledge, the association between olive oil intake and cortical and trabecular bone microarchitecture has never been evaluated in Spanish women. We aime...
Previous studies reported that dairy foods are associated with higher areal bone mineral density (BMD) in older adults. However, data on bone strength and bone microarchitecture are lacking. We determined the association of dairy food intake (milk, y...
In the contemporary era of minimally invasive surgery, injectable biomaterial scaffolds have demonstrated significant potential in bone tissue engineering (BTE). Completely injectable hydrogel substratum with microscale bone graft particulates delive...
Cyber-Physical system devices nowadays constitute a mixture of Information Technology (IT) and Operational Technology (OT) systems that are meant to operate harmonically under a security critical framework. As security IT countermeasures are graduall...
Tympanic membrane (TM) perforations, arising from infections, injuries, or chronic otitis media, remain a frequent clinical finding and can lead to hearing problems when the tissue does not regenerate adequately. Although autologous grafts are still...
Spinal cord injury (SCI) induces persistent locomotor deficits that are closely associated with maladaptive structural plasticity of spinal neuronal circuits. Although motor rehabilitation improves functional outcomes, the cellular substrates underly...
Microarchitectural side-channels leak data through caches, branch predictors, store buffers, and speculative execution. Evaluating defenses at cycle-model fidelity has forced a choice between functional tools (Spike, QEMU) and gem5’s hours-long...
Assessing bone quality and quantity at the location of dental implants before dental implantation is crucial. In recent years, dental cone-beam computed tomography (dental CBCT) has often been used to assess bone quality and quantity prior to dental...
Collagen microarchitecture in bone marrow biopsies represents a largely underexplored source of candidate quantitative biomarkers for histopathological diagnostics and analysis of tissue remodeling. While second harmonic generation (SHG) microscopy h...
High-resolution computed tomography images were acquired for 31 proximal human tibiae, age 8 to 37.5 years, from Norris Farms #36 cemetery site (A.D. 1300). Morphometric analysis of subchondral cortical and trabecular bone architecture was performed...
The current protocol used to determine if an individual is osteoporotic relies on assessment of the individual’s bone mineral density (BMD), which allows clinicians to judge the condition of a patient with respect to their peers. This, in essence, ev...
Objectives: This study aimed to create a three-dimensional histological reconstruction through the AI-assisted classification of tissues and the alignment of serial sections. The secondary aim was to evaluate if the novel technique for histological r...
Catch-up growth is a process that promotes weight and height gains to recover normal growth patterns after a transient period of growth inhibition. Accelerated infant growth is associated with reduced bone mass and quality characterized by poor bone...
4 May 2022
The influence of low energy availability (LEA) on bone mineral density (BMD) and trabecular bone microarchitecture in pubescent female athletes is unclear. This study aimed to investigate the influence of LEA on BMD and trabecular bone microarchitect...
Three-dimensional scaffolds based on triply periodic minimal surfaces (TPMSs) have attracted growing interest in bone tissue engineering because of their high interconnectivity and ability to combine high porosity with mechanical integrity. However,...
The stimulatory effects of liposomal propranolol (PRP) on proliferation and differentiation of human osteoblastic cells suggested that the prepared liposomes-encapsulated PRP exerts anabolic effects on bone in vivo. Iontophoresis provides merits such...
Additive manufacturing enables the realization of the macro- and microarchitecture of bone substitutes. The macroarchitecture is determined by the bone defect and its shape makes the implant patient specific. The preset distribution of the 3D-printed...
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