Simulation models are used to design extruders in the polymer processing industry. This eliminates the need for prototypes and reduces development time for extruders and, in particular, extrusion screws. These programs simulate, among other process p...
Grain refiner particles, which are intended to induce the formation of fine equiaxed grain structure during the solidification of aluminum alloys, are prone to settling during the holding of the liquid metal, which phenomenon can affect not only the...
For polymer-processing extruders, designing screws via analytical computational models is helpful for reducing experimental costs. However, the current simulation programs cannot predict the melt quality at the screw tip with sufficient accuracy. The...
In Al-Mg alloys with Mg content 0 ≤ XMg ≤ 6 wt. %, the effects of XMg on dissolved hydrogen content ([H]) and melt quality were investigated. [H] was measured using the Closed-Loop Recirculation method, and the melt quality was quantified using...
The present study investigated the effect of the casting conditions for the reduced pressure test (RPT) on the melt quality of Al-Si alloy. The casting conditions considered in RPT were the atmospheric exposure during melting, sampling method, and mo...
Background: Fused deposition modeling (FDM) is one of the most well-known and often published methods for 3D-printed drug delivery systems. In early scientific reports, the active pharmaceutical ingredients were added by soaking, but later, a new mil...
Background: Hot-melt extrusion (HME) is a scalable pharmaceutical technology increasingly relevant to flexible manufacturing, including small-batch production, personalized dosage-form development, and potential use in pharmacy compounding. When tran...
The effects of degassing, holding time and melt additions (Sr, Sr + Ti, Ti, B and B + Sr) on the quality of A356 melts were examined. A total of 120 reduced pressure test samples were collected. Pores in these samples were analyzed via digital image...
In recent years, with the increasing patient population, the need for complex and patient-centric medications has increased enormously. Traditional manufacturing techniques such as direct blending, high shear granulation, and dry granulation can be u...
As an emerging additive manufacturing technology with potential, selective laser melting (SLM) technology is one of the current mainstream additive manufacturing processes. Many complex conditions affect the quality of the SLM products, such as extre...
Pharmaceutical and medicinal printing technologies allow personalization and on-demand manufacturing of drug and medicinal products. Being able to manufacture patient tailored dosage forms or medical devices in a pharmacy, medical office, dental labo...
Laser powder bed fusion (L-PBF) has emerged as a core metal additive manufacturing technology for high-end sectors, including aerospace and medical device manufacturing. However, melting anomalies that occur during fabrication accumulate layer by lay...
To improve the quality of thick powder bed and realize the matching of thick powder bed and thin powder bed in the later stage, the influence of process parameters for the single-track, multi-layer fabrication, relative density, surface quality, defe...
In addition to impurities in recycled aluminum alloys, non-metallic inclusions are a significant factor that deteriorates the material’s castability and final mechanical properties. This, therefore, restricts the ability to transition from a pr...
Optical coherence tomography (OCT) is an inline process monitoring technology for laser welding with various applications in the pre-, in-, and post-process. In-process monitoring with OCT focuses on the measurement of weld depth by the placement of...
Macroscale modeling plays an essential role in simulating additive manufacturing (AM) processes. However, models at such scales often pay computational time in output accuracy. Therefore, they cannot forecast local quality issues like lack of fusion...
In this study, the optimal conditions of gas bubbling filtration (GBF) treatment for securing highly-clean molten Al-Si-Mg-Cu alloy were identified. The effects of GBF treatment time and stabilization time on the degree of molten metal cleanliness we...
This study systematically investigated the effects of selective laser melting (SLM) process parameters on the forming quality and microstructure of FeCrAl oxide dispersion-strengthened (ODS) alloy. Through orthogonal experimental design, the influenc...
Conventional cyclodextrin complexation enhances the solubility of poorly soluble drugs but is solvent-intensive and environmentally unfavorable. This study evaluated solvent-free hot-melt extrusion (HME) for forming cyclodextrin inclusion complexes t...
Bimetallic materials are important in many industries (aerospace, medicine, etc.) since they allow the creation of constructions that combine specific functional properties, for example, low density (aluminum alloy) and high corrosion resistance (sta...
In this study, a combined simulation and experimental approach is utilized to investigate the influence of hatch spacing on the microstructure and as-built quality of 316L stainless steel (SS) samples fabricated by selective laser melting (SLM). A th...
The quality and reliability in additive manufacturing is an emerging area. To ensure process quality and reliability, the influence of all process parameters and conditions needs to be understood. The product quality and reliability characteristics,...
Research into technological processes, such as welding, provides the basis for optimising the strength and quality of PVC joints, which are becoming increasingly important in the context of sustainable construction. The study analysed the influence o...
The extensive use of polypropylene (PP) in various industries has heightened interest in developing efficient methods for recycling and optimising its mixtures. This study focuses on formulating predictive models for the Melt Flow Rate (MFR) and shea...
In this study, the applicability of an Al-Si alloy with 30 wt% added scrap for automobile pistons was evaluated by investigating the melt quality, microstructural characteristics, and tensile properties under modified GBF (gas bubbling filtration) pr...
In this paper, a naturally pressurized gating system has been designed to reduce the turbulence of the melt during casting. The influence of gate dimensions, foam filters, a trident gate and a vortex element were evaluated. Their effect on melt veloc...
The paper proposes a methodology for assessing the quality of the direct laser melting process of 316L steel powder, which was tested when creating products in a construction furnace of the EOSINT M280 system at different laser powers. The methodolog...
Ti-6Al-4V parts fabricated via selective laser melting (SLM) often exhibit severe surface irregularities that limit their direct engineering application. This study proposes a top-hat beam laser polishing method to improve surface quality. The result...
In the laser powder bed fusion (LPBF) process, the surface quality of intermediate layers impacts interlayer bonding and part forming quality. Due to the complex dynamic process inherent in LPBF, current monitoring methods struggle to achieve high-qu...
This article presents aspects regarding the possibilities of optimizing the quality of the elaboration of metallurgical melts by determining their physical-chemical properties. Thus, the article analyzes and presents methods for determining the visco...
Fused deposition modeling (FDMTM) is a 3D-printing technology of rising interest for the manufacturing of customizable solid dosage forms. The coupling of hot-melt extrusion with FDMTM is favored to allow the production of pharma-grade filaments for...
Selective laser melting (SLM) additive manufacturing (AM) exhibits uncertainties, where variations in build quality are present despite utilizing the same optimized processing parameters. In this work, we identify the sources of uncertainty in SLM pr...
Scientific injection molding technologies involve the integration and collaboration of cyber-physical systems and smart manufacturing. In order to achieve adaptive process control and production optimization, injection molding systems with real-time...
Melt spinning machines must be set up according to the process parameters that result in the best end product quality. In this study, artificial intelligence algorithms were employed to create a system that detects abnormal processing parameters and...
Hot-melt extrusion is increasingly applied in the pharmaceutical area as a continuous processing technology, used to design custom products by co-processing drugs together with functional excipients. In this context, the residence time and processing...
A key principle of developing a new medicine is that quality should be built in, with a thorough understanding of the product and the manufacturing process supported by appropriate process controls. Quality by design principles that have been establi...
New substances and particles appearing in the environment following technological development pose new challenges for separation methods. Moreover, the growing amount of waste also forces us to look for environmentally friendly solutions. One way to...
The present study aims to demonstrate the influence of the polymer-carrier type and proportion on the quality performance of newly developed oral immediate-release tablets containing amiodarone solid dispersions obtained by hot-melt extrusion. Twelve...
Material extrusion (ME), an extrusion-based rapid prototyping technique, has been extensively studied to manufacture final functional products, whose forming quality is significantly influenced by the melt flow behavior (MFB) inside the extrusion liq...
The downstream processing of hot-melt extruded amorphous solid dispersions (ASDs) into tablets is challenging due to the low tabletability of milled ASDs. Typically, the extrudate strand is sized before milling, as the strand cannot be fed directly i...
Laser beam welding is the most modern and promising process for the automatic or robotized welding of structures of the highest Execution Class, EXC3-4, which are made of a variety of weldable structural materials, mainly steel, titanium, and nickel...
The effectiveness of rotary degassing on the defect formation and mechanical properties of the final casting of aluminium alloy EN AC 46000 was investigated, along with its impact on the energy consumption in the casting furnace. In the melt preparat...
Aluminium and its alloys have been widely used in the automotive industry for some time and A356 is one of the most popular aluminium alloys today in the sector. It contains approximately 7 wt.% Si and 0.3 wt.% Mg. Due to the defects that may be pres...
A pediatric dosage form for crizotinib (Xalkori) was commercialized using quality-by-design principles in a material-sparing fashion. The dosage form consists of spherical multiparticulates (microspheres or pellets) that are coated and encapsulated i...
Several literature publications have described the potential application of active pharmaceutical ingredient (API)–polymer phase diagrams to identify appropriate temperature ranges for processing amorphous solid dispersion (ASD) formulations vi...
Meat eating quality with a healthy composition hinges on intramuscular fat (IMF), fat melting point (FMP), tenderness, juiciness, flavour and omega-3 long-chain polyunsaturated fatty acids (n-3 LC-PUFA) content. These health-beneficial n-3 LC-PUFA pl...
Proper management of waste is one of the major challenges for the food industry. Fruit seeds are an example of by-products that are rich in bioactive substances and generated in significant amounts during fruit processing. Oils, including those obtai...
Thermal analysis (TA) has been a valuable tool for controlling the carbon equivalent (CE) of cast irons. Additionally, this technique can provide enhanced control over melt quality, allowing for the avoidance of defects such as undesirable graphite m...
Rivaroxaban (RXB), a novel oral anticoagulant that directly inhibits factor Xa, is a poorly soluble drug belonging to Biopharmaceutics Classification System (BCS) class II. In this study, a hot-melt extruded amorphous solid dispersion (HME-ASD) conta...
Selective laser melting (SLM) is a three-dimensional (3D) printing process that can manufacture functional parts with complex geometries as an alternative to using traditional processes, such as machining wrought metal. If precision and a high surfac...
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