In this work, we used multi-scale computational simulation methods combined with density functional theory (DFT) and finite element analysis (FEA) in order to study the optical properties of substitutional doped aluminium nitride (AlN). There was str...
Magnesium hydroxide (Mg(OH)2) has a wide bandgap of about 5.7 eV and is usually considered an insulator. In this study, the energy levels of impurities introduced into Mg(OH)2 are predicted by first-principles calculations. A supercell of brucite Mg(...
The polymer-derived SiC fibers are mainly used as reinforcing materials for ceramic matrix composites (CMCs) because of their excellent mechanical properties at high temperature. However, decomposition reactions such as release of SiO and CO gases an...
As one of the key components in technetium-labeled radiopharmaceuticals, the quality of the dimercaptosuccinate (DMSA) plays a critical role in determining the safety and efficacy of the final drug product. However, due to its high polarity and susce...
Peptide and oligonucleotide therapeutics are dependent on sequence-defining chemical synthesis, but product complexity additionally arises from structural modifications, formulation and delivery. In this context, their quality cannot be assessed only...
Our main target was to develop methods for the quality control of the tablet «ramipril» according to the indicators of «Quantitative determination», «Impurities» and «Dissolution». New, precise, accurat...
Baijiu, China’s traditional distilled spirit, is produced through solid-state fermentation and distillation of grains, resulting in a highly complex chemical and sensory profile. However, exogenous impurities introduced via raw materials, water...
In recent years, with the excavation of an increasing amount of gold and silver artifacts, there has been an urgent need to optimize the formulations and methods of metallographic etching. Herein, a kinetic control study is performed to investigate t...
A chiral analytical methodology was developed by nano-liquid chromatography (nano-LC) enabling the enantiomeric separation of two chiral drugs, lacosamide (novel antiepileptic drug) and colchicine (antiuremic drug), commercialized as pure enantiomers...
Midecamycin is a 16-membered macrolide antibiotic. It can inhibit the synthesis of bacterial proteins by blocking up the activity of peptidyl transferase in the 50S ribosome. We used high-resolution mass spectrometry to analyze midecamycin, and quant...
The notion of impurity is identified in numerous belief systems, ranging from certain religions to nationalisms. Understanding its nature and functioning beyond its concrete objects is therefore a fundamental anthropological question. This work is gr...
The continuous-feeding Czochralski method is a cost-effective method to grow single silicon crystals. An inner crucible is used to prevent the un-melted silicon feedstock from transferring to the melt-crystal interface in this method. A series of glo...
Background/Objectives: Reference materials are essential for ensuring the accuracy and traceability of measurements in the quality control of medicinal products. This study explores new principles for the preparation of impure materials of active pha...
In this paper, we report a successfully modified single-crystal Si growth furnace for impurity control. Four types of arbitrary magnetic heater (AMGH) systems with 3, 4, 5, and poly parts were designed in a coil shape and analyzed using crystal growt...
The printing adaptability and sintering compactness of photovoltaic back silver paste are highly dependent on the physical properties of the silver powder, such as tap density and particle size distribution, which in turn are directly influenced by t...
Background: Extracellular vesicles (EVs), including exosomes, are promising pharmaceutical modalities. They are purified from cell culture supernatant; however, the preparation may contain EVs with the desired therapeutic effects and different types...
The ever-worsening climate crisis necessitates a shift toward sustainable energy systems that prioritise citizen participation. Renewable Energy Communities (RECs) present a unique opportunity to enhance local resilience, reduce greenhouse gas emissi...
Virus-like particles (VLPs), nanoscale self-assembled structures lacking viral genetic material, have emerged as a versatile platform for vaccines, targeted delivery systems, and gene-editing applications owing to their strong immunogenicity, favorab...
Better quality control for alloy manufacturing and sorting of post-consumer scraps relies heavily on the accurate determination of their chemical composition. In recent decades, analytical techniques, such as X-ray fluorescence spectroscopy (XRF), la...
Manganese-containing anode sludge is a common side-product in the electrowinning of zinc. The anode sludge consists mainly of oxidized manganese, but also lesser amounts of lead, calcium, and other minor metals. The impurities present in the anode sl...
Machine harvesting is an essential step of crop production, considering a dynamic operation, and is subject to losses due to several factors that affect its quality. The objective of this study was to evaluate the quality of mechanized peanut pickers...
We conducted a comprehensive examination of liquid mycotoxin reference standards. A total of 30 different standards were tested, each containing 10 samples of three distinct substances: Aflatoxin B1, Deoxynivalenol, and Zearalenone. The standards wer...
Mannose triflate is an established precursor for nucleophilic 2-deoxy-2-[18F]fluoro-D-glucose ([18F]FDG) production, but same-scale, stage-resolved process behavior is incompletely documented. This retrospective study combines three 100 g D-mannose c...
Impurity concentrations of oxygen, carbon, nitrogen, iron, and other heavy metals should be well controlled in silicon crystals to maintain the crystal quality for application in electronic and solar cell devices. Contamination by impurities occurs d...
In this study, the corrosion behavior of X52 pipeline steel affected by H2O content in supercritical CO2 streams containing O2, H2S, SO2 and NO2 impurities was investigated by the weight loss test and surface characterization. The corrosion differenc...
The presence of impurities above regulatory thresholds has been responsible for recent recalls of pharmaceutical drugs. Crystallization is one of the most used separation processes to control impurities in the final drug. A particular issue emerges w...
Lisinopril is a drug of the angiotensin-converting enzyme (ACE) inhibitor class that is primarily used in the treatment of hypertension. During the scale-up of the lisinopril process, one unknown impurity was observed and is identified. The present w...
Solifenacin (SFC) is a potent muscarinic antagonist that effectively reduces bladder muscle contraction, thereby alleviating symptoms such as frequency of micturition and urgency. Oxidation of SFC leads to the formation of impurities like Impurity K....
Based on a foregoing gram-scale laboratory process, an efficient scale-up preparation process of 5,2′-dibromo-2,4′,5′-trihydroxydiphenylmethanone (LM49-API), a new acute pyelonephritis candidate drug, was developed and validated aim...
We explore the ground-state properties of a single impurity immersed in a one-dimensional quantum droplet medium formed by a two-component Bose mixture. Relying on ab initio simulations, we demonstrate that tuning the impurity–droplet interacti...
Dinotefuran (DNT) is a neonicotinoid insecticide widely used in pest control. Identification of structurally related impurities is indispensable during material purification and pesticide registration and certified reference material development, and...
Supercritical CO2 (sCO2) pipeline transport is a critical link for the large-scale implementation of Carbon Capture, Utilization, and Storage (CCUS) technology, yet its safety is severely challenged by residual impurity gases (e.g., H2O, O2, SO2, H2S...
The CdTe cap layers were grown on CdZnTe-substrated HgCdTe (MCT) LPE epilayers by magnetron sputtering and thermal evaporation. The diffusion behaviors of Cd & Hg components and impurities (As or In) in these CdTe/MCT structures subjected to As i...
A physicochemical characterization of the process-related impurities associated with the synthesis of pemetrexed disodium was performed. The possibility of pemetrexed impurities forming has been mentioned in literature, but no study on their structur...
A notable feature of systems with non-Hermitian skin effects is the sensitivity to boundary conditions. In this work, we introduce one type of boundary condition provided by a coupling impurity. We consider a system where a two-level system as an imp...
(1) Cyclotron production of medical radionuclides can generate unintended radionuclidic impurities, influencing product quality, radiation safety, and radioactive waste management. This review aims to establish a general mechanistic framework for the...
Linagliptin, a xanthine derivative, is a highly potent, selective, long-acting and orally bioavailable DPP-4 inhibitor for the treatment of type 2 diabetes. During the process development of linagliptin, five new process-related impurities were detec...
Barnidipine hydrochloride is a long term dihydropyridine calcium channel blocker used for the treatment of hypertension. During the process development of barnidipine hydrochloride, four barnidipine impurities were detected by high-performance liquid...
The removal of impurities in molybdenum concentrate has become a new challenge for enterprises due to the cancellation of pickling. Whether impurity minerals can be converted into soluble ions during roasting is important for the impurity removal by...
An isocratic reverse-phase high-performance liquid chromatography (RP-HPLC) method, coupled with photodiode array detection (PDA), was developed for the identification and characterization of stress degradation products and an unknown process-related...
The removability of impurities during the aluminum remelting process by oxidation was previously investigated by our research group. In the present work, alternative impurity removal with chlorination has been evaluated by thermodynamic analysis. For...
As a new dosage form, coenzyme Q10 (Co-Q10) soft capsules are easily absorbed and utilized by the human body. Co-Q10 soft capsules can effectively improve the bioavailability and reduce medical costs for patients. A main concern about Co-Q10 as an ac...
The study of the effects of impurity on grain boundaries is a critical aspect of materials science, particularly when it comes to understanding and controlling the properties of materials for specific applications. One of the related key issues is th...
Twelve impurities (process-related and degradation) in lisdexamfetamine dimesylate (LDX), a central nervous system (CNS) stimulant drug, were first separated and quantified by high-performance liquid chromatography (HPLC) and then identified by liqui...
Control of process-related impurities is of critical importance for developing an efficient and suitable synthetic process of an active pharmaceutical ingredient. In the study of a key intermediate of silodosin (KIS), two process-related impurities i...
Online detection of impurities content in the corn deep-bed drying process is the key technology to ensure stable operation and to provide data support for self-adapting control of drying equipment. In this study, an automatic approach to corn image...
Hydrophilic Interaction Liquid Chromatography (HILIC) has emerged as a powerful and versatile analytical technique for the separation and quantification of polar and ionizable compounds, particularly in the field of pharmaceutical impurity profiling....
While numerous studies have explored the mineralogical characteristics and purification techniques of high-purity quartz (HPQ), discussions on impurity control during various purification processes and their applications in photovoltaics, electronics...
The metal impurity assisted ion beam technology has shown its uniqueness and effectiveness in the formation and precise control of nanostructures on the surface of materials. Hence, the investigation in this area is vital. The morphology evolution of...
Two unknown impurities were observed during the process development for multigram-scale synthesis of eplerenone (Inspra®). The new process-related impurities were identified and fully characterized as the corresponding (7β,11α,17α)-11-hydroxy- and (7...
of 14