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Special Issue "Method Development and Validation in Food and Pharmaceutical Analysis"

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Analytical Chemistry".

Deadline for manuscript submissions: 31 December 2019

Special Issue Editors

Guest Editor
Prof. Dr. In-Soo Yoon

Department of Manufacturing Pharmacy, College of Pharmacy, Pusan National University, Geumjeong, Busan 46241, South Korea
E-Mail
Phone: +82-51-510-2806
Interests: bioanalysis; biopharmaceutics; herb–drug interaction; pharmacokinetics
Guest Editor
Prof. Dr. Hyun-Jong Cho

Department of Pharmacy, College of Pharmacy, Kangwon National University, Chuncheon, Gangwon 24341, South Korea
E-Mail
Interests: spectroscopy; imaging analysis; formulation; drug delivery systems

Special Issue Information

Dear Collegues,

Analytical chemistry is the study of separation, identification, and quantification of natural and artificial materials constituting one or more compounds or elements. Rapid growth in food and pharmaceutical industries and production of drugs and functional foods around the world has given rise to an inevitable demand to seek novel and systematic analytical techniques. As a consequence, analytical method development and validation have become a crucial prerequisite for achieving reliable analytical data required to support food and pharmaceutical development processes.

This Special Issue on “Method Development and Validation in Food and Pharmaceutical Analysis” will cover a wide range of topics including, but not limited to, new analytical and bioanalytical methods relevant to the separation, identification, and determination of substances in pharmaceutics, pharmacokinetics, nanobiotechnology, clinical chemistry, and related disciplines; methods for the identification of bioactive compounds in functional foods and medicinal plants; applications of chromatography and allied techniques in biomedical sciences.

We warmly invite our colleagues to submit their original contributions to this Special Issue in order to provide recent updates regarding analytical methods for drugs, biologics, phytochemicals, and other organic/inorganic materials related to food and pharmaceutical sciences that will be of interest to our readers. We would be delighted if you could respond to confirm your contribution and the proposed title by 30 September 2019 to assist in planning the whole project.

Prof. Dr. In-Soo Yoon
Prof. Dr. Hyun-Jong Cho
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • HPLC
  • bioanalysis
  • phytochemicals
  • pharmacokinetics
  • mass spectrometry
  • functional food
  • biopharmaceutics
  • organic/inorganic materials
  • imaging analysis
  • spectroscopy

Published Papers (2 papers)

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Research

Open AccessArticle An Accurate and Effective Method for Measuring Osimertinib by UPLC-TOF-MS and Its Pharmacokinetic Study in Rats
Molecules 2018, 23(11), 2894; https://doi.org/10.3390/molecules23112894
Received: 15 October 2018 / Revised: 29 October 2018 / Accepted: 3 November 2018 / Published: 6 November 2018
PDF Full-text (1769 KB) | HTML Full-text | XML Full-text | Supplementary Files
Abstract
Osimertinib, a new-generation inhibitor of the epidermal growth factor, has been used for the clinical treatment of advanced T790M mutation-positive tumors. In this research, an original analysis method was established for the quantification of osimertinib by ultra-performance liquid chromatography with time of flight
[...] Read more.
Osimertinib, a new-generation inhibitor of the epidermal growth factor, has been used for the clinical treatment of advanced T790M mutation-positive tumors. In this research, an original analysis method was established for the quantification of osimertinib by ultra-performance liquid chromatography with time of flight mass spectrometry (UPLC-TOF-MS) in rat plasma. After protein precipitation with acetonitrile and sorafinib (internal standard, IS), they were chromatographed through a Waters XTerra MS C18 column. The mobile phase was acetonitrile and water (including 0.1% ammonia). The relative standard deviation (RSD) of the intra- and inter-day results ranged from 5.38 to 9.76% and from 6.02 to 9.46%, respectively, and the extraction recovery and matrix effects were calculated to range from 84.31 to 96.14% and from 91.46 to 97.18%, respectively. The results illustrated that the analysis method had sufficient specificity, accuracy and precision. Meanwhile, the UPLC-TOF-MS method for osimertinib was successfully applied into the pharmacokinetics of SD rats. Full article
(This article belongs to the Special Issue Method Development and Validation in Food and Pharmaceutical Analysis)
Figures

Graphical abstract

Open AccessArticle Partial Purification, Identification, and Quantitation of Antioxidants from Wild Rice (Zizania latifolia)
Molecules 2018, 23(11), 2782; https://doi.org/10.3390/molecules23112782
Received: 15 September 2018 / Revised: 23 October 2018 / Accepted: 23 October 2018 / Published: 26 October 2018
PDF Full-text (1190 KB) | HTML Full-text | XML Full-text | Supplementary Files
Abstract
To provide further insights into the potential health-promoting antioxidants from wild rice (Zizania latifolia), which is an abundant but underutilized whole grain resource in East Asia, a partial purification based on D101 macroporous resin was carried out for the purification and
[...] Read more.
To provide further insights into the potential health-promoting antioxidants from wild rice (Zizania latifolia), which is an abundant but underutilized whole grain resource in East Asia, a partial purification based on D101 macroporous resin was carried out for the purification and enrichment of the antioxidants from the bioactive ethanol extracts of wild rice. On that basis, 34 phenolic compounds in the antioxidant fractions were identified by a high-performance liquid chromatography-linear ion trap quadrupole-Orbitrap-mass spectrometry (HPLC-LTQ-Orbitrap-MSn). The results suggested that phenolic acids could be enriched in the 10% ethanol-eluted fraction whereas flavonoids (including procyanidins and flavonoid glycosides) could be enriched in 20–30% ethanol-eluted fractions. A quantitative analysis determined by the multiple reaction monitoring mode of the ultra-performance liquid chromatography-triple quadrupole-tandem mass spectrometry (UPLC-QqQ-MS/MS) revealed a high content of procyanidins in wild rice. Compared with phenolic acids, flavonoids may contribute more to the potent antioxidant activity of wild rice. This is the first study on the antioxidants from wild rice Z. latifolia. These findings provide novel information on the functional components of wild rice, and will be of value to further research and development on Z. latifolia. Full article
(This article belongs to the Special Issue Method Development and Validation in Food and Pharmaceutical Analysis)
Figures

Graphical abstract

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