Next Article in Journal
Development and Validation of a Stability- Indicating RP-HPLC Method for the Assay of Pristinamycin in Bulk and Tablet Dosage Form
Previous Article in Journal
An Alternative Approach to Isoganciclovir: A Prominent Impurity in the Antiviral Drug Ganciclovir
Scientia Pharmaceutica is published by MDPI from Volume 84 Issue 3 (2016). Articles in this Issue were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence. Articles are hosted by MDPI on mdpi.com as a courtesy and upon agreement with Austrian Pharmaceutical Society (Österreichische Pharmazeutische Gesellschaft, ÖPhG).
Open AccessArticle

Synthesis and Characterization of Compounds Related to Lisinopril

1
Chemical Research and Development Department, Aurobindo Pharma Ltd, Survey No:71&72, Indrakaran Village, Sangareddy Mandal, Medak district, Telangana, 502329, India
2
Department of Chemistry, Jawaharlal Nehru Technological University Hyderabad, Kukatpally, Hyderabad, Telangana State, 500085, India
3
Affliated supervisor, Jawaharlal Nehru Technological University Hyderabad, Kukatpally, Hyderabad, Telangana State, 500085, India
*
Author to whom correspondence should be addressed.
Sci. Pharm. 2016, 84(2), 269-278; https://doi.org/10.3797/scipharm.1507-08
Received: 9 July 2015 / Accepted: 18 October 2015 / Published: 18 October 2015
Lisinopril is a drug of the angiotensin-converting enzyme (ACE) inhibitor class that is primarily used in the treatment of hypertension. During the scale-up of the lisinopril process, one unknown impurity was observed and is identified. The present work describes the origin, synthesis, characterization, and control of this impurity. This paper also describes the synthesis and characterization of three other impurities listed in the European Pharmacopoeia 8.4 (Impurity C, D, and F).
Keywords: Lisinopril; Related substances; Origin; Synthesis; Characterization; Impurities Lisinopril; Related substances; Origin; Synthesis; Characterization; Impurities
MDPI and ACS Style

RAGHAVA REDDY, A.V.; GARAGA, S.; TAKSHINAMOORTHY, C.; NAIDU, A.; DANDALA, R. Synthesis and Characterization of Compounds Related to Lisinopril. Sci. Pharm. 2016, 84, 269-278.

Show more citation formats Show less citations formats

Article Access Map by Country/Region

1
Only visits after 24 November 2015 are recorded.
Back to TopTop