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Advanced Analytical Tools for Characterization and Quality Control of Food, Drugs, and Natural Active Ingredients, 3rd Edition

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Analytical Chemistry".

Deadline for manuscript submissions: 31 May 2025 | Viewed by 2058

Special Issue Editors


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Guest Editor

Special Issue Information

Dear Colleagues,

In recent years, we have witnessed notable advancements of analytical methodologies, which can be attributed to two key factors: the emergence of innovative instruments and their synergic combination with chemometrics.

As a result, there is now a wealth of readily accessible informative data, demanding the use of more sophisticated tools. The aim of this Special Issue, ‘Advanced Analytical Tools for Characterization and Quality Control of Food, Drugs, and Natural Active Ingredients, 3rd Edition’ is to collate research on the innovative techniques specifically designed for the characterization, authentication, and tracking of high-value products—such as food, beverages, natural active components, and pharmaceutical drugs—by combining analytical methods with chemometrics. We also encourage submissions of reviews that provide critical analyses of the latest tools in this research domain.

Dr. Alessandra Biancolillo
Dr. Angelo Antonio D'Archivio
Guest Editors

Manuscript Submission Information

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Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • authentication
  • classification
  • pharmaceutical drugs
  • food
  • quality control
  • natural products
  • geographical origin
  • chemometrics

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Published Papers (2 papers)

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Research

18 pages, 2383 KiB  
Article
Authentic Aroma and Compound-Specific Isotope Ratios (δ13C, δ2H) Profiles of Vanilla Pods (V. planifolia and V. tahitensis)
by Long Chen, Purna Kumar Khatri, Mauro Paolini, Tiziana Nardin, Alberto Roncone, Roberto Larcher, Luca Ziller and Luana Bontempo
Molecules 2025, 30(4), 825; https://doi.org/10.3390/molecules30040825 - 11 Feb 2025
Viewed by 812
Abstract
Stable isotope ratio analysis of carbon (δ13C) and hydrogen (δ2H) in vanillin has become a valuable tool for differentiating natural vanilla from synthetic or biosynthetic alternatives and for tracing its geographical origins. However, increasingly sophisticated fraud techniques [...] Read more.
Stable isotope ratio analysis of carbon (δ13C) and hydrogen (δ2H) in vanillin has become a valuable tool for differentiating natural vanilla from synthetic or biosynthetic alternatives and for tracing its geographical origins. However, increasingly sophisticated fraud techniques necessitate ongoing refinement of analytical methods to ensure accurate detection. This study advanced the field by investigating minor volatile organic compounds as potential biomarkers for identifying botanical and geographical origins of vanilla products. Vanilla pods from the two main vanilla species, V. planifolia and V. tahitensis, were investigated using GC-MS/MS to analyze their aromatic profile and GC-C/Py-IRMS to determine compound-specific isotope ratios, providing, for the first time, detailed and authentic isotopic and aromatic profiles. Additionally, the potential natural presence of ethyl vanillin and its corresponding glucoside precursors—molecules commonly used as synthetic vanilla-scented fragrance agents in various foods and industrial products—was explored using UHPLC-HRMS. These findings contribute to robust methods for verifying vanilla authenticity, addressing flavor complexity and isotopic composition, and enhancing the detection of adulteration in vanilla-flavored products. Full article
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16 pages, 3523 KiB  
Article
Study on the Chemical Characterization and Hypolipidemic Function of Nelumbo nucifera Based on Its Flavonoid Components
by Leyi Yang, Chang Zhou, Rong Huang, Yuan Cai, Bin Liu, Mimi Yu and Yanyan Jiang
Molecules 2024, 29(23), 5798; https://doi.org/10.3390/molecules29235798 - 8 Dec 2024
Viewed by 883
Abstract
Nelumbo nucifera has great value and development prospects in hypolipidemic applications. In this study, we comprehensively screened out multi–index components relevant to the quality of N. nucifera based on the hypolipidemic function of the flavonoid fraction of N. nucifera (FFN) combined with chemical [...] Read more.
Nelumbo nucifera has great value and development prospects in hypolipidemic applications. In this study, we comprehensively screened out multi–index components relevant to the quality of N. nucifera based on the hypolipidemic function of the flavonoid fraction of N. nucifera (FFN) combined with chemical characterizations. Firstly, in vitro antioxidant and cell experiments evaluated the hypolipidemic function of the FFN. Secondly, the chemical compositions of N. nucifera were identified by UPLS–MSn technology. Then, the multi–index flavonoid components (rutin, hyperoside, isoquercitrin, quercetin–3–O–β–D–glucuronide, astragalin, and quercetin) were determined using a quantitative fingerprint combined with multivariate statistical data analysis. Finally, the quality of N. nucifera was scientifically evaluated by multi–index quantitative analysis combined with multivariate statistical data analysis, which was used to study the relationship between the content of flavonoid components and the overall quality. The above–mentioned research lays a material foundation for improving the quality standards of N. nucifera, providing a basis for developing functional foods to improve dyslipidemia. Full article
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