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Molecules 2014, 19(1), 1344-1352;

Synthesis and Characterization of Impurities of Barnidipine Hydrochloride, an Antihypertensive Drug Substance

School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China
Wuhan Biocause Pharmaceutical Development Co., Ltd, Wuhan 430056, Hubei, China
College of Chemical Engineering and Pharmacy, Jingchu University of Technology, Jingmen 448000, Hubei, China
Hubei Biocause Heilen Pharmaceutical Co., Ltd, Jingmen 448000, Hubei, China
Authors to whom correspondence should be addressed.
Received: 11 December 2013 / Revised: 15 January 2014 / Accepted: 15 January 2014 / Published: 21 January 2014
(This article belongs to the Section Organic Chemistry)
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Barnidipine hydrochloride is a long term dihydropyridine calcium channel blocker used for the treatment of hypertension. During the process development of barnidipine hydrochloride, four barnidipine impurities were detected by high-performance liquid chromatography (HPLC) with an ordinary column (Agilent ZORBAX Eclipse XDB-C18, 150 mm × 4.6 mm, 5 µm). All these impurities were identified, synthesized, and subsequently characterized by their respective spectral data (MS, 1H-NMR, and 13C-NMR). The identification of these impurities should be useful for quality control in the manufacture of barnidipine. View Full-Text
Keywords: barnidipine hydrochloride; impurities; antihypertensive agent barnidipine hydrochloride; impurities; antihypertensive agent

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Cheng, Z.-G.; Dai, X.-Y.; Li, L.-W.; Wan, Q.; Ma, X.; Xiang, G.-Y. Synthesis and Characterization of Impurities of Barnidipine Hydrochloride, an Antihypertensive Drug Substance. Molecules 2014, 19, 1344-1352.

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