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1,378 Results Found

  • Review
  • Open Access
7 Citations
3,965 Views
21 Pages

A Review of Fluorescent pH Probes: Ratiometric Strategies, Extreme pH Sensing, and Multifunctional Utility

  • Weiqiao Xu,
  • Zhenting Ma,
  • Qixin Tian,
  • Yuanqing Chen,
  • Qiumei Jiang and
  • Liang Fan

pH is a critical parameter requiring precise monitoring across scientific, industrial, and biological domains. Fluorescent pH probes offer a powerful alternative to traditional methods (e.g., electrodes, indicators), overcoming limitations in miniatu...

  • Review
  • Open Access
58 Citations
16,142 Views
19 Pages

3 March 2021

Sulphate-reducing bacteria (SRB) are dominant species causing corrosion of various types of materials. However, they also play a beneficial role in bioremediation due to their tolerance of extreme pH conditions. The application of sulphate-reducing b...

  • Article
  • Open Access
2 Citations
2,876 Views
15 Pages

Stability and Performance of Commercial Membranes in High-Temperature Organic Flow Batteries

  • Chiari J. Van Cauter,
  • Yun Li,
  • Sander Van Herck and
  • Ivo F. J. Vankelecom

15 August 2024

Redox flow batteries (RFB) often operate at extreme pH conditions and may require cooling to prevent high temperatures. The stability of the battery membranes at these extreme pH-values at high temperatures is still largely unknown. In this paper, a...

  • Article
  • Open Access
31 Citations
7,092 Views
25 Pages

Extreme Low Cytosolic pH Is a Signal for Cell Survival in Acid Stressed Yeast

  • Rodrigo Mendonça Lucena,
  • Laura Dolz-Edo,
  • Stanley Brul,
  • Marcos Antonio de Morais and
  • Gertien Smits

16 June 2020

Yeast biomass is recycled in the process of bioethanol production using treatment with dilute sulphuric acid to control the bacterial population. This treatment can lead to loss of cell viability, with consequences on the fermentation yield. Thus, th...

  • Article
  • Open Access
2 Citations
5,429 Views
24 Pages

Operation of an α-hemolysin nanopore transduction detector is found to be surprisingly robust over a critical range of pH (6–9), including physiological pH = 7.4 and polymerase chain reaction (PCR) pH = 8.4, and extreme chaotrope concentration, inclu...

  • Article
  • Open Access
6 Citations
3,058 Views
24 Pages

The Key Enzymes of Carbon Metabolism and the Glutathione Antioxidant System Protect Yarrowia lipolytica Yeast Against pH-Induced Stress

  • Tatyana I. Rakhmanova,
  • Natalia N. Gessler,
  • Elena P. Isakova,
  • Olga I. Klein,
  • Yulia I. Deryabina and
  • Tatyana N. Popova

29 October 2024

In this study, we first thoroughly assayed the response of the key enzymes of energy metabolism and the antioxidant system in Yarrowia lipolytica yeast at extreme pH. The activity of the tricarboxylic acid cycle enzymes, namely NAD-dependent isocitra...

  • Article
  • Open Access
9 Citations
3,377 Views
13 Pages

Reversible Aggregation of Molecular-Like Fluorophores Driven by Extreme pH in Carbon Dots

  • Stefania Mura,
  • Luigi Stagi,
  • Robert Ludmerczki,
  • Luca Malfatti and
  • Plinio Innocenzi

18 August 2020

The origin of carbon-dots (C-dots) fluorescence and its correlation with the dots structure still lack a comprehensive model. In particular, the core-shell model does not always fit with the experimental results, which, in some cases, suggest a molec...

  • Article
  • Open Access
14 Citations
3,919 Views
23 Pages

Proteomics Readjustment of the Yarrowia lipolytica Yeast in Response to Increased Temperature and Alkaline Stress

  • Varvara Y. Sekova,
  • Leonid I. Kovalyov,
  • Marina A. Kovalyova,
  • Natalya N. Gessler,
  • Maria A. Danilova,
  • Elena P. Isakova and
  • Yulia I. Deryabina

Yeasts cope with a wide range of environmental challenges using different adaptive mechanisms. They can prosper at extreme ambient pH and high temperatures; however, their adaptation mechanisms have not been entirely investigated. Previously, we show...

  • Article
  • Open Access
26 Citations
6,529 Views
18 Pages

Unraveling Morphophysiological and Biochemical Responses of Triticum aestivum L. to Extreme pH: Coordinated Actions of Antioxidant Defense and Glyoxalase Systems

  • M. H. M. Borhannuddin Bhuyan,
  • Mirza Hasanuzzaman,
  • Jubayer Al Mahmud,
  • Md. Shahadat Hossain,
  • Tasnim Farha Bhuiyan and
  • Masayuki Fujita

18 January 2019

Soil pH, either low (acidity) or high (alkalinity), is one of the major constraints that affect many biochemical and biological processes within the cell. The present study was carried out to understand the oxidative damage and antioxidant defense in...

  • Article
  • Open Access
3 Citations
2,502 Views
13 Pages

19 March 2023

Solvent flows in the fL/s range across the total surface of a casein microparticle cause its expansion and shrinkage. Microparticles prepared from the milk protein casein have a porous and flexible inner structure with water-filled channels and cavit...

  • Article
  • Open Access
14 Citations
3,975 Views
27 Pages

6 December 2020

Industrial adoption of nanofiltration (NF) for treatment of low-pH wastewater is hindered by the limited membrane lifetime at strongly acidic conditions. In this study, the electroplating wastewater (EPWW) filtration performance of a novel pH-stable...

  • Article
  • Open Access
744 Views
15 Pages

24 October 2025

Background: Pulmonary hypertension (PH) occurs in ~25% of infants with moderate-to-severe bronchopulmonary dysplasia (BPD) and is associated with substantial morbidity and mortality. The American Heart Association and American Thoracic Society recomm...

  • Feature Paper
  • Article
  • Open Access
14 Citations
4,147 Views
15 Pages

Preparation of Extremely Active Ethylene Tetramerization Catalyst [iPrN(PAr2)2−CrCl2]+[B(C6F5)4] (Ar = −C6H4-p-SiR3)

  • Jung Hyun Lee,
  • Jun Won Baek,
  • Dong Geun Lee,
  • Ji Hyeong Ko,
  • Dong Geun Lee,
  • Kye Sung Cho,
  • Jin Woo Lee and
  • Bun Yeoul Lee

18 September 2021

Numerous efforts have been made to achieve “on-purpose” 1-octene production since Sasol discovered a Cr-based selective ethylene tetramerization catalyst in the early 2000s. By preparing a series of bis(phosphine) ligands iPrN(PAr2)2 where the Ar con...

  • Article
  • Open Access
8 Citations
4,459 Views
14 Pages

The locus of heat resistance (LHR) confers resistance to extreme heat, chlorine and oxidative stress in Escherichia coli. This study aimed to determine the function of the LHR in maintaining bacterial cell envelope homeostasis, the regulation of the...

  • Article
  • Open Access
6 Citations
7,181 Views
19 Pages

25 January 2024

Terrestrial algae are a group of photosynthetic organisms that can survive in extreme conditions. pH is one of the most important factors influencing the distribution of algae in both aquatic and terrestrial ecosystems. The impact of different pH lev...

  • Article
  • Open Access
440 Views
21 Pages

29 November 2025

Ocean acidification (OA) is considered a relevant additional threat to marine biodiversity and is linked to the increasing CO2 concentration in the atmosphere. Here, we provide a synthesis on the loss of both taxonomic and functional biodiversity, in...

  • Article
  • Open Access
6 Citations
3,473 Views
11 Pages

Importance of Inactivation Methodology in Enzymatic Processing of Raw Potato Starch: NaOCl as Efficient α-Amylase Inactivation Agent

  • Signe Schram Zinck,
  • Stefan Jarl Christensen,
  • Ole Bandsholm Sørensen,
  • Birte Svensson and
  • Anne S. Meyer

25 March 2023

Efficient inactivation of microbial α-amylases (EC 3.2.1.1) can be a challenge in starch systems as the presence of starch has been shown to enhance the stability of the enzymes. In this study, commonly used inactivation methods, including mult...

  • Article
  • Open Access
89 Citations
7,354 Views
13 Pages

14 September 2021

Breast cancer is the most common type of cancer in women and the most life-threatening cancer in females worldwide. One key feature of cancer cells, including breast cancer cells, is a reversed pH gradient which causes the extracellular pH of cancer...

  • Article
  • Open Access
10 Citations
5,313 Views
20 Pages

Ocean Acidification and Mollusc Settlement in Posidonia oceanica Meadows: Does the Seagrass Buffer Lower pH Effects at CO2 Vents?

  • Alessandra Barruffo,
  • Laura Ciaralli,
  • Giandomenico Ardizzone,
  • Maria Cristina Gambi and
  • Edoardo Casoli

8 July 2021

Ocean acidification has been broadly recognised to have effects on the structure and functioning of marine benthic communities. The selection of tolerant or vulnerable species can also occur during settlement phases, especially for calcifying organis...

  • Article
  • Open Access
23 Citations
4,321 Views
18 Pages

17 December 2022

Nitrogen (N) and phosphorus (P) nutrient enrichment is important for grasslands. This study aimed to determine how soils enriched with N and P influenced soil concentration correlations and affected the growth kinetics, mineral nutrition, and nitroge...

  • Article
  • Open Access
3 Citations
3,240 Views
18 Pages

Kinetic and Regulatory Properties of Yarrowia lipolytica Aconitate Hydratase as a Model-Indicator of Cell Redox State under pH Stress

  • Tatyana I. Rakhmanova,
  • Varvara Yu. Sekova,
  • Natalya N. Gessler,
  • Elena P. Isakova,
  • Yulia I. Deryabina,
  • Tatyana N. Popova,
  • Yevgeniya I. Shurubor and
  • Boris F. Krasnikov

This paper presents an analysis of the regulation activity of the partially purified preparations of cellular aconitate hydratase (AH) on the yeast Yarrowia lipolytica cultivated at extreme pH. As a result of purification, enzyme preparations were ob...

  • Article
  • Open Access
13 Citations
4,212 Views
11 Pages

A Miniature pH Probe Using Functional Microfiber Bragg Grating

  • Yang Ran,
  • Peng Xiao,
  • Yongkang Zhang,
  • Deming Hu,
  • Zhiyuan Xu,
  • Lili Liang and
  • Bai-Ou Guan

11 August 2020

Operando and precisely probing aqueous pH is fundamentally demanded, both in chemical and biological areas. Conventional pH probes, subjected to the larger size, are probably unfit for application in some extreme scenarios, such as a trace amount of...

  • Article
  • Open Access
2 Citations
2,041 Views
17 Pages

25 October 2022

Increasing numbers of exopolysaccharides and their properties have been explored. However, the difficulty of extracting high-viscosity exopolysaccharides has hindered their further industrialization. In this research, we explored a strategy based on...

  • Article
  • Open Access
715 Views
15 Pages

12 September 2025

Soil pH plays a critical role in shaping the structural composition and functional dynamics of grassland ecosystems. The seasonal dynamics of carbon exchange and the factors influencing them in grassland ecosystems along saline–alkaline gradien...

  • Article
  • Open Access
2 Citations
1,164 Views
32 Pages

20 February 2025

Excessive water produced in oil reservoirs reduces oil recovery and increases the cost of water treatment. Conventional water control methods use synthetic polymer gels like PAM-PEI, which are sensitive to harsh reservoir conditions. This study inves...

  • Article
  • Open Access
16 Citations
5,518 Views
11 Pages

The Impact of Gastric Juice pH on the Intraluminal Therapy for Helicobacter pylori Infection

  • Yu-Chio Wang,
  • Yen-Po Chen,
  • Cheng-Yu Ho,
  • Ting-Wen Liu,
  • Cheng-Hsin Chu,
  • Horng-Yuan Wang and
  • Tai-Cherng Liou

14 June 2020

Background: Helicobacter pylori (H. pylori) can be topically eradicated in stomach lumen on endoscopic examination. The procedures of intraluminal therapy for H. pylori infection (ILTHPI) include the control of intragastric pH, mucolytic irrigation o...

  • Article
  • Open Access
1,467 Views
14 Pages

The Reversible Transformation of a Vesicular Aggregate in Response to a pH Oscillation

  • Moeka Shimada,
  • Risa Someya,
  • Yasunao Okamoto,
  • Daigo Yamamoto and
  • Akihisa Shioi

2 March 2024

The transformation of amphiphilic molecular assemblies in response to chemical oscillations is fundamental in biological systems. The reversible transformation of a vesicular aggregate (VA) in response to a pH oscillation is presented in this study....

  • Article
  • Open Access
9 Citations
3,480 Views
14 Pages

Validation of an Optical Technology for the Determination of pH in Milk during Yogurt Manufacture

  • Siqi Liu,
  • Fanny Contreras,
  • Ricardo S. Alemán,
  • Jhunior Marcía Fuentes,
  • Oscar Arango and
  • Manuel Castillo

30 August 2024

Current systems that allow inline pH control in the fermented dairy industry have drawbacks, such as protein adhesion on the non-glass pH probes, measurement distortion, frequent recalibration needs, and sensitivity to extreme pH conditions encounter...

  • Article
  • Open Access
7 Citations
3,306 Views
13 Pages

Low-Power pH Sensor Based on Narrow Channel Open-Gated Al0.25Ga0.75N/GaN HEMT and Package Integrated Polydimethylsiloxane Microchannels

  • Xianghong Yang,
  • Jiapei Ao,
  • Sichen Wu,
  • Shenhui Ma,
  • Xin Li,
  • Long Hu,
  • Weihua Liu and
  • Chuanyu Han

22 November 2020

pH sensors with low-power and strong anti-interference are extremely important for industrial online real-time detection. Herein, a narrow channel pH sensor based on Al0.25Ga0.75N/GaN high electron mobility transistor (HEMT) with package integrated P...

  • Article
  • Open Access
6 Citations
4,777 Views
14 Pages

A New Class of Smart Gadolinium Contrast Agent for Tissue pH Probing Using Magnetic Resonance Imaging

  • Fouzi Mouffouk,
  • Hacene Serrai,
  • Sourav Bhaduri,
  • Rik Achten,
  • Mozhdeh Seyyedhamzeh,
  • Ali A. Husain,
  • Abdullah Alhendal and
  • Mohammed Zourob

26 March 2020

Detecting tissue pH in vivo is extremely vital for medical diagnosis and formulation of treatment decisions. To this end, many investigations have been carried out to develop an accurate and efficient method of in vivo pH measurement. Most of the tec...

  • Article
  • Open Access
46 Citations
14,739 Views
12 Pages

19 November 2021

Anthocyanins from flowers of the butterfly pea (Clitoria ternatea L.) are promising edible blue food colorants. Food processing often faces extreme pHs and temperatures, which greatly affects the color and nutritional values of anthocyanins. This stu...

  • Article
  • Open Access
24 Citations
8,573 Views
14 Pages

Sorption of Lithium on Bentonite, Kaolin and Zeolite

  • Mandy Hoyer,
  • Nicolai-Alexeji Kummer and
  • Broder Merkel

14 April 2015

Li sorption was studied on natural bentonite, kaolin and zeolite in batch experiments at variable Li and Na concentrations (0, 1.5, 15, 150, 750 mM LiCl and 0.01, 0.1, 1, 3, 5 M NaCl). The solid-to-solution ratio was 1:4 and pH ranged from 2 to 10....

  • Article
  • Open Access
14 Citations
7,174 Views
12 Pages

14 January 2014

Degradation of rebaudioside M, a minor sweet component of Stevia rebaudiana Bertoni, under conditions that simulated extreme pH and temperature conditions has been studied. Thus, rebaudioside M was treated with 0.1 M phosphoric acid solution (pH 2.0)...

  • Review
  • Open Access
87 Citations
16,101 Views
55 Pages

7 July 2015

Extreme thermoacidophiles (Topt > 65 °C, pHopt < 3.5) inhabit unique environments fraught with challenges, including extremely high temperatures, low pH, as well as high levels of soluble metal species. In fact, certain members of this group th...

  • Article
  • Open Access
5 Citations
2,861 Views
10 Pages

Alkaline Stress Causes Changes in Polyamine Biosynthesis in Thermus thermophilus

  • Teruyuki Kobayashi,
  • Akihiko Sakamoto,
  • Keiko Kashiwagi,
  • Kazuei Igarashi,
  • Toshiyuki Moriya,
  • Tairo Oshima and
  • Yusuke Terui

4 November 2022

An extreme thermophile, Thermus thermophilus, produces 16 different polyamines including long-chain and branched-chain polyamines. The composition and content of polyamines in the thermophile cells change not only with growth temperature but also wit...

  • Article
  • Open Access
11 Citations
3,768 Views
20 Pages

Spatio-Temporal Variations in Soil pH and Aluminum Toxicity in Sub-Saharan African Croplands (1980–2050)

  • Yves Uwiragiye,
  • Qahtan Abdul Wahid Khalaf,
  • Hayssam M. Ali,
  • Mbezele Junior Yannick Ngaba,
  • Mingxia Yang,
  • Ahmed S. Elrys,
  • Zhujun Chen and
  • Jianbin Zhou

27 February 2023

Soil acidity threatens food production in the tropics. The effect of increasing ammonium-based fertilizer (INF) on soil pH was assessed in sub-Saharan Africa (SSA). A total of 9043 soil data from Africa soil information services, past INF use, and tw...

  • Article
  • Open Access
1 Citations
2,137 Views
13 Pages

Differential Chemical Profile of Metabolite Extracts Produced by the Diaporthe citri (G-01) Endophyte Mediated by Varying the Fermented Broth pH

  • Julio Cesar Polonio,
  • Marcos Alessandro dos Santos Ribeiro,
  • Cintia Zani Fávaro-Polonio,
  • Eduardo Cesar Meurer,
  • João Lúcio Azevedo,
  • Halison Correia Golias and
  • João Alencar Pamphile

Endophytic microorganisms show great potential for biotechnological exploitation because they are able to produce a wide range of secondary compounds involved in endophyte–plant adaptation, and their interactions with other living organisms that shar...

  • Article
  • Open Access
7 Citations
16,922 Views
12 Pages

Effects of Temperature, pH, and Salinity on Seed Germination of Acinos alpinus subsp. Meridionalis and FTIR Analysis of Molecular Composition Changes

  • Mustapha Cherrate,
  • Nabil Radouane,
  • Said Ezrari,
  • Ghizlane Echchgadda,
  • Abdellah Maissour,
  • Kacem Makroum,
  • Gabriel Plavan,
  • Omar H. Abd-Elkader and
  • Mohamed Bourioug

8 March 2023

This study aimed to determine the impact of three abiotic factors (Temperature, pH, and salinity) on the metabolic activities (macromolecules) and germination rate of Acinos alpinus subsp. Meridionalis (Satureja) seeds. In vitro, seed germination tes...

  • Article
  • Open Access
5 Citations
2,159 Views
10 Pages

Arsenic Concentration, Fraction, and Environmental Implication in Fe–Mn Nodules in the Karst Area of Guangxi

  • Wenbing Ji,
  • Rongrong Ying,
  • Zhongfang Yang,
  • Zhewei Hu,
  • Qiong Yang,
  • Xu Liu,
  • Tao Yu,
  • Lei Wang,
  • Jianxun Qin and
  • Tiansheng Wu

26 September 2022

We determined the concentrations, geochemical fractions, and potential environmental implications of arsenic (As) via pH-static extraction experiments, X-ray photoelectron spectroscopy (XPS), and sequential extraction. Compared with the corresponding...

  • Article
  • Open Access
32 Citations
5,761 Views
23 Pages

Evolution of Predicted Acid Resistance Mechanisms in the Extremely Acidophilic Leptospirillum Genus

  • Eva Vergara,
  • Gonzalo Neira,
  • Carolina González,
  • Diego Cortez,
  • Mark Dopson and
  • David S. Holmes

3 April 2020

Organisms that thrive in extremely acidic environments (≤pH 3.5) are of widespread importance in industrial applications, environmental issues, and evolutionary studies. Leptospirillum spp. constitute the only extremely acidophilic microbes in the...

  • Review
  • Open Access
27 Citations
27,745 Views
16 Pages

25 March 2023

Gold mining has serious negative environmental impacts, especially due to pollution emanating from tailings storage facilities (TSFs, tailings dams, slimes dams). The most important forms of pollution from TSFs are acid mine drainage (AMD) and high l...

  • Article
  • Open Access
30 Citations
5,718 Views
18 Pages

Two Novel Palbociclib-Resorcinol and Palbociclib-Orcinol Cocrystals with Enhanced Solubility and Dissolution Rate

  • Chenxin Duan,
  • Wenwen Liu,
  • Yunwen Tao,
  • Feifei Liang,
  • Yanming Chen,
  • Xinyi Xiao,
  • Guisen Zhang,
  • Yin Chen and
  • Chao Hao

Palbociclib (PAL) is an effective anti-breast cancer drug, but its use has been partly restricted due to poor bioavailability (resulting from extremely low water solubility) and serious adverse reactions. In this study, two cocrystals of PAL with res...

  • Article
  • Open Access
2,341 Views
14 Pages

Biochemical, Biophysical, and Structural Analysis of an Unusual DyP from the Extremophile Deinococcus radiodurans

  • Kelly Frade,
  • Célia M. Silveira,
  • Bruno A. Salgueiro,
  • Sónia Mendes,
  • Lígia O. Martins,
  • Carlos Frazão,
  • Smilja Todorovic and
  • Elin Moe

11 January 2024

Dye-decolorizing peroxidases (DyPs) are heme proteins with distinct structural properties and substrate specificities compared to classical peroxidases. Here, we demonstrate that DyP from the extremely radiation-resistant bacterium Deinococcus radiod...

  • Article
  • Open Access
9 Citations
4,368 Views
13 Pages

The ammonium (NH4+) tolerance of plants is an important issue in agriculture, associated with several plant characteristics. So far, plant tissue acidification has been shown as the primary cause of NH4+ toxicity. Suppressed plant growth caused by ex...

  • Article
  • Open Access
8 Citations
3,613 Views
12 Pages

Modified Leach Residues from Processing Deep-Sea Nodules as Effective Heavy Metals Adsorbents

  • Nguyen Hong Vu,
  • Eva Kristianová,
  • Petr Dvořák,
  • Tomasz Abramowski,
  • Ivo Dreiseitl and
  • Aigerim Adrysheva

23 April 2019

The possible use of leaching residue from leaching deep-sea nodules in SO2/H2SO4/H2O medium as a low-cost adsorbent of heavy metals (Pb(II), Cd(II), Cu(II), Ni(II), Co(II), As(V)) was studied. The leaching residue was found to be an effective adsorbe...

  • Article
  • Open Access
1 Citations
1,570 Views
19 Pages

20 March 2025

Accurate soil pH prediction is critical for soil management and ecological environmental protection. Machine learning (ML) models have been widely applied in the field of soil pH prediction. However, when using these models, the spatial heterogeneity...

  • Article
  • Open Access
141 Citations
9,834 Views
14 Pages

11 January 2019

Soil organic matter (SOM) and pH are essential soil fertility indictors of paddy soil in the middle-lower Yangtze Plain. Rapid, non-destructive and accurate determination of SOM and pH is vital to preventing soil degradation caused by inappropriate l...

  • Article
  • Open Access
1 Citations
275 Views
14 Pages

Nb-MOG as a High-Performance Photocatalyst for Cr(VI) Remediation: Optimization and Reuse Cycles

  • Eduardo Abreu,
  • Onelia A. A. dos Santos,
  • Maria E. K. Fuziki,
  • Angelo M. Tusset,
  • Michel Z. Fidelis,
  • Artur J. Motheo and
  • Giane G. Lenzi

4 January 2026

This study describes the removal of Cr(VI) using Nb-MOG (Niobium Metal–Organic Gel) as a photocatalyst. The characterization was performed using various techniques: Scanning Electron Microscopy–Energy Dispersive X-ray Spectroscopy (SEM&nd...

  • Feature Paper
  • Article
  • Open Access
25 Citations
7,030 Views
12 Pages

The Effect of pH and Temperature on Arachidonic Acid Production by Glycerol-Grown Mortierella alpina NRRL-A-10995

  • Aleksei A. Mironov,
  • Vitaly A. Nemashkalov,
  • Nadezda N. Stepanova,
  • Svetlana V. Kamzolova,
  • Waldemar Rymowicz and
  • Igor G. Morgunov

Arachidonic acid (AA) has a wide range of applications in medicine, pharmacology, diet, infant nutrition, and agriculture, due to its unique biological properties. The microbiological processes involved in AA production usually require carbohydrate s...

  • Article
  • Open Access
21 Citations
6,670 Views
19 Pages

25 May 2016

Biomacromolecule activity is usually related to its ability to keep a specific structure. However, in solution, many parameters (pH, ionic strength) and external compounds (polyelectrolytes, nanoparticles) can modify biomacromolecule structure as wel...

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