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Open AccessArticle

A New Class of Smart Gadolinium Contrast Agent for Tissue pH Probing Using Magnetic Resonance Imaging

Department of Chemistry, Kuwait University, P.O. Box 5969, Safat 13060, Kuwait
Department of Diagnostic Sciences, University of Ghent, Gent 9000, Belgium
Department of Chemistry, Alfaisal University, 12713 Riyadh, Saudi Arabia
King Faisal Specialist Hospital and Research Center, 12713 Riyadh, Saudi Arabia
Authors to whom correspondence should be addressed.
Academic Editor: Andrea Trabocchi
Molecules 2020, 25(7), 1513; (registering DOI)
Received: 18 February 2020 / Revised: 13 March 2020 / Accepted: 15 March 2020 / Published: 26 March 2020
(This article belongs to the Special Issue Bioconjugation Strategies in Drug Delivery and Molecular Imaging)
: Detecting tissue pH in vivo is extremely vital for medical diagnosis and formulation of treatment decisions. To this end, many investigations have been carried out to develop an accurate and efficient method of in vivo pH measurement. Most of the techniques developed so far suffer from inadequate accuracy, due to poor sensitivity at low concentration of the target or nonspecific interactions within the tissue matrix. To overcome these issues, we describe herein the development of a simple, yet reliable, way to estimate pH with high precision using a Gd(III)-DOTA-silyl-based acid-labile group as a pH-sensitive contrast agent with Magnetic Resonance Imaging (MRI). With this method, a change in T1 weighted image intensity of the newly developed pH-sensitive contrast is directly linked to the proton concentration in the media. As a result, we were able estimate the pH of the target with 95% reliability.
Keywords: cancer imaging; MRI; pH; sensors cancer imaging; MRI; pH; sensors
MDPI and ACS Style

Mouffouk, F.; Serrai, H.; Bhaduri, S.; Achten, R.; Seyyedhamzeh, M.; Husain, A.A.; Alhendal, A.; Zourob, M. A New Class of Smart Gadolinium Contrast Agent for Tissue pH Probing Using Magnetic Resonance Imaging. Molecules 2020, 25, 1513.

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