Mirtazapine is an established antidepressant with well-documented efficacy demonstrated in controlled clinical trials. However, the gap between the results obtained in controlled clinical trials and everyday clinical practice exists. Therefore, the i...
In order to study the disintegration characteristics of red clay under different moisture content and temperature, red clay taken from Guilin was prepared into samples with different moisture content, and the disintegration test of red clay was carri...
Flood season embankment due to long-term high water immersion environment creates situations where its soil properties will deteriorate, quickly triggering bank slope instability and other dangerous situations. In order to study embankment slope soil...
Guilin is a famous karst area, and currently the view that the disintegration of red clay will cause soil cave collapse is increasingly recognized. In order to study the influence of the coupling effect of moisture content and void ratio on the disin...
This study aimed to evaluate the effects of mechanical disintegration of waste activated sludge (WAS) on full scale anaerobic digestion, considering the possibility of obtaining a positive energy balance. The results showed that an increase in energy...
This study aimed to investigate the disintegration resistance of schist on the eastern slope of the Tongman open-pit mine. It examined the effects of cycle number and mineral composition on the disintegration resistance indexes of four types of schis...
Microbially induced calcium carbonate (CaCO3) precipitation (MICP) is an emerging soil-treatment method. To explore the effect of this technology on granite residual soil, this study investigated the effects of the mechanical properties and disintegr...
The complex red-bed geology is primarily composed of iron-rich sedimentary rock layers with clay minerals as a major component. The soil water content exceeds 30%, and its high viscosity and water content lead to the easy formation of mud cake on the...
The β-γ polymorphic transition of calcium orthosilicate (C2S) is a key phenomenon in cement chemistry. During this transition, the compound expands due to structural changes and a significant reduction in its density is observed, leading to its disin...
Since dispersive soil has the characteristic of dispersing and disappearing when making contact with water, lime, fly ash, and cement are often used to modify dispersive soil in engineering. This often causes environmental pollution. Current studies...
Controlling the time point and site of the release of active ingredients within the gastrointestinal tract after administration of oral delivery systems is still a challenge. In this study, the effect of the combination of small capsules (size 3) and...
The growing prevalence of disposable toilet seat covers in public restrooms stems from concerns about personal hygiene, given the direct contact between the seat and various users’ skin. To enable these disposable cover sheets to be flushed dow...
Coal extraction in China is increasingly moving towards colder regions such as Xinjiang and Inner Mongolia. However, these mines face land restoration challenges due to a scarcity of fertile topsoil. This study explores the potential of coal gangue,...
As final attributes of dosage form largely depend on the properties of excipients used, understanding the effect of physicochemical properties of excipients is important. In the present study, six grades of L-HPC with varying degrees of particle size...
In the present study, we analyzed the bioactive curcuminoids content in eight capsules (DS-1-DS-7 and DS-9), one tablet (DS-8), three ground turmeric samples (DS-10-DS-12), and three ground turmeric rhizomes (TR-1, TR-2, and TR-3). Initial screening...
Fracture expansion in rock masses can be observed by monitoring the break of contacts between the bounding particles via the discrete element method. The latter’s realization in this study via the PFC2D program tracked the evolution process of...
Polyvinyl alcohol (PVA) and hydroxypropyl methylcellulose (HPMC) films plasticized with glycerin or polyethylene glycol (PEG) were investigated to elucidate structure–property relationships in hydrophilic polymeric film systems. Films were prep...
Background and Objectives: The aim of the current study was to establish an osseo-disintegration model initiated with a single microorganism in mini-pigs. Materials and Methods: A total of 36 titanium dental implants (3.5 mm in diameter, 9.5 mm in le...
Magnesium-based multicomponent alloys with different compositions, namely Mg60Al20Zn5Cu10Mn5 (Mg60 alloy), Mg70Al15Zn5Cu5Mn5 (Mg70 alloy), and Mg80Al5Cu5Mn5Zn5 (Mg 80) alloys, were prepared using the disintegrated melt deposition technique. The DMD t...
Moisture-activated dry granulation (MADG) is an eco-friendly granulation method that uses a small amount of water and insoluble excipients to absorb moisture. MADG is expected to improve productivity and reduce costs. Erythritol, an excipient used fo...
Earth dams’ upstream slopes suffer from reservoir water-level fluctuations and long-term immersion, triggering soil softening and disintegration and endangering structural safety. Enzyme-Induced Carbonate Precipitation (EICP) is an eco-friendly...
There has been a concern that the accurate numerical simulation of multi-body flow, which is caused by the multiple disintegrations of expired spacecraft re-entering into the near space, has a critical bottleneck impact on the falling area of the dis...
In this work, films containing AgNPs were obtained by different green synthesis techniques (AgNP in situ and AgNP L). The inclusion of nanoparticles in the starch matrix improved both mechanical and barrier properties. The migration of AgNPs from the...
The aim of the present investigation was to formulate fast disintegrating tablets of meloxicam by wet granulation technique using medium molecular weight chitosan. The orally disintegrating tablets of meloxicam with chitosan showed good mechanical an...
The production of refined ferrochrome is accompanied by the formation of self-disintegrating slags caused by the β→γ-Ca2SiO4 polymorphic transformation during cooling, resulting in environmental and technological problems. This study...
Background/Objectives: Carbamazepine is widely used as a first-line treatment for pediatric patients with benign epilepsy. However, most commercial formulations have doses of 100 mg or higher, limiting their suitability for pediatric use. The aim of...
Studying the slumping disintegration, movement speed, impact intensity, accumulation characteristics, and energy conversion laws of tower-column unstable rock masses (TCURM) is crucial for high-altitude rockfall hazard risk evaluation. Existing PFC-b...
Background/Objectives: Enteric coating protects active pharmaceutical ingredients from gastric degradation, but conventional tablets may present swallowing difficulties in geriatric and pediatric patients. Hence, this study intended to develop pH-res...
Background/Objectives: Functional constipation is common in older adults and impairs quality of life. Evidence for multi-strain orally disintegrating (OD) probiotic formulations in this population remains limited. Methods: In this single-center, open...
Tablet disintegration is an important pre-requisite for drug dissolution and absorption. The disintegration test is typically conducted at 37 °C, but the intragastric temperature may vary due to meals or fever. This study investigated the effects...
The preferred delivery route for drugs targeted for systemic effect is by oral administration. Following oral administration, a solid dosage form must disintegrate and the drug dissolve, thereafter permeating the intestinal mucosa. Several different...
Anaerobic digestion is the most common stabilization process at large sewage treatment plants. To improve its effects, a sludge pre-conditioning process called disintegration is recommended. The aim of the presented study was to compare the direct ef...
To investigate the disintegration and microstructure characteristics of carbonaceous shale in high-latitude cold regions, indoor, outdoor, initial particle size, and freeze–thaw disintegration experiments were conducted concerning dry–wet...
Water–rock interactions and scouring actions are recognized key factors that significantly influence the disintegration of rock on the surface of slopes. However, the research on rock disintegration, specifically under the action of scouring, i...
In South China, due to climatic factors, highly weathered granite is distributed across a large area and easily disintegrates after encountering water, causing many geological disasters and other problems. To determine the disintegration mechanism of...
Granite residual soil is widely distributed in Southeastern China. Such soils exhibit mechanical characteristics such as loose, rich cracks and easy disintegration, resulting in severe soil erosion disasters under rainfall conditions. Microbial-induc...
The aim of this study was to obtain films based on sodium alginate (SA) for disintegration in the oral cavity. The films were prepared with a solvent-casting method, and meloxicam (MLX) as the active ingredient was suspended in a 3% sodium alginate s...
Loess disintegration is a significant physicochemical and mechanical dissolution process that occurs when loess comes into contact with water. This phenomenon contributes to geological disasters such as loess cave erosion, landslides, and debris flow...
Due to the high degree of weathering, the red clay slope has low anti-disintegration performance, and the clay easily becomes wet and disintegrates after soaking in water. It causes geological problems such as slope collapse caused by soil softening....
Disintegration and dispersion are functional properties of tablets relevant for the desired API release. The standard disintegration test (SDT) described in different pharmacopoeias provides only limited information on these complex processes. It is...
Red soil is widely distributed in South America, Africa and Southeast Asia (approximately between the 30° S and 30° N latitudes). These soils are typically formed by the weathering of carbonate or other rocks rich in iron and aluminium oxides...
Orodispersible tablets (ODTs) offer rapid disintegration of the dosage form when placed on the tongue, which leads to fast release of the active pharmaceutical ingredient. Despite increased use in diverse patient populations, there have been numerous...
In this study, the potential for correlation between disintegration and dissolution performance of enteric-coated (EC) dosage forms was investigated. Different enteric hard shell capsule formulations containing caffeine as model drug were tested for...
The fast-disintegrating capsules rapidly disintegrate in various physiological environments, ensuring therapeutic efficacy. The formulation of plant-based capsules with balanced mechanical and fast disintegration characteristics continues to present...
Aiming at the mode of liquid ligament disintegration into droplets in the process of the centrifugal granulation of molten blast furnace slag using a spinning cup, in order to gain an in-depth understanding of the behavior and mechanism of droplet fo...
The food-induced viscosity of the media can alter tablet disintegration and eventually the release of the drug it contains. The extent of this retardation depends on tablet formulation factors, such as the solubility of its excipients. Objectives: Th...
The current study intended to improve the disintegration potential of paper mill sludge through alkyl polyglycoside-coupled disperser disintegration. The sludge biomass was fed to the disperser disintegration and a maximum solubilization of 6% was at...
Background/Objectives: Orally disintegrating tablets (ODTs) are often used for patients with dysphagia; however, their co-administration with “thickened water” in clinical settings can delay disintegration and potentially reduce therapeut...
This paper presents an experimental study to investigate the effect of various disintegration times on the homogeneity of pre-treated natural soil before mixing with cementitious binders. Various disintegration times were applied, ranging from 10 s t...
Natural eco-friendly materials are recently employed in products to replace synthetic materials due to their superior benefits in preserving the environment. The herb Coccinia grandis is widely distributed in continents like Asia and Africa and used...
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