In recent decades, per- and polyfluoroalkyl substances (PFASs) have garnered widespread public attention due to their persistence in the environment and detrimental effects on the health of living organisms, spurring the generation of several transcr...
The temperate and herbaceous genus Vicia L. is a member of the legume tribe Fabeae of the subfamily Papilionoideae. The genus Vicia comprises 166 annual or perennial species distributed mainly in Europe, Asia, and North America, but also extending to...
Understanding the interplay between tree structure and seasonal dynamics, particularly cross-species, is crucial for managing urban forest ecosystems. However, balancing fine-scale inventory of trees with large-area mapping of forest ecosystems is a...
To upscale restoration of tropical forest ecosystems, direct seeding—sowing seeds directly into the ground—is potentially a more cost-effective technique than tree planting. However, its success is limited by seed predation, the harshness...
A coordinated extracellular matrix (ECM) and cytoskeletal remodeling are critical drivers of hepatocellular carcinoma (HCC) progression, yet the upstream post-transcriptional mechanisms regulating these processes in spontaneous canine HCC remain poor...
Background: Severe malaria remains a major cause of morbidity and mortality, yet the conserved molecular signatures underlying complicated infections across Plasmodium vivax (P. vivax) and Plasmodium falciparum (P. falciparum) are not well characteri...
Background: Human brucellosis remains an important One Health problem, yet no vaccine is licensed for human use despite decades of antigen discovery and experimental vaccine development. This review examines why promising Brucella vaccine candidates...
Gene expression changes that occur during mesocarp development are a major research focus in oil palm research due to the economic importance of this tissue and the relatively rapid increase in lipid content to very high levels at fruit ripeness. Her...
Background: The prediction of human clearance (CL) and subcutaneous (SC) bioavailability is a critical aspect of monoclonal antibody (mAb) selection for clinical development. While monkeys are a well-accepted model for predicting human CL, other prec...
Oxidative Balance Score (OBS) summarizes diet- and lifestyle-related exposures relevant to redox homeostasis, but the evolutionary behavior of OBS-associated epigenetic markers remains unclear. In this study, we conducted a covariate-adjusted epigeno...
Background: Spinal cord injury (SCI) triggers secondary injury processes involving neuroinflammation and systemic immune remodeling. The endocannabinoid system (ECS) has been implicated in neuroimmune regulation, but its transcriptional relationship...
The genetic composition of 5797 white oaks assigned in forest inventories as Quercus robur (3342), Quercus petraea (2090), Quercus pubescens (170), or as unspecified Quercus. spp. (195) sampled all over Europe were genotyped at 355 nuclear SNPs and 2...
Cryptosporidiosis is a gastrointestinal disease affecting terrestrial and aquatic vertebrates worldwide. This study investigated molecularly and microscopically the prevalence and the diversity of Cryptosporidium spp. in goats across the Bouira commu...
Simple sequence repeats (SSRs) are prevalent in the genomes of all organisms. They are widely used as genetic markers, and are insertion/deletion mutation hotspots, which directly influence genome evolution. However, little is known about such import...
Plant-phyllosphere feedback (PPF) is an ecological process in which phyllosphere microbiota, originating from plant litter, are transmitted via aerosols and subsequently influence the growth of conspecific or heterospecific plants. However, the cross...
Background/Objectives: Sjögren’s syndrome (SS) is a systemic autoimmune disease characterized by lacrimal and salivary gland dysfunction, leading to dry eye and dry mouth. This study aimed to explore the potential associations between oxid...
Metabolism underlies the pathogenesis of acute myeloid leukemia (AML) and can be influenced by gut microbiota. However, the specific metabolic changes in different tissues and the role of gut microbiota in AML remain unclear. In this study, we analyz...
The skeletal muscle of cattle is the main component of their muscular system, responsible for supporting and movement functions. However, there are still many unknown areas regarding the ranking of the importance of different types of cell population...
Trichogramma wasps, egg parasitoids widely used to control lepidopteran pests, have long eluded in-depth molecular mechanistic studies due to their minute size and genetic tool scarcity. While previous RNAi efforts were restricted to T. dendrolimi, w...
Heart diseases are the leading cause of death for the vast majority of people around the world, which is often due to the limited capability of human cardiac regeneration. In contrast, zebrafish have the capacity to fully regenerate their hearts afte...
Polyphenols are key dietary bioactive compounds, reducing oxidative stress and neurodegeneration. This study investigated the in vitro antioxidant and neuroprotective potential of some edible fruits (apricots, plums, figs) and vegetable (parsley) ext...
The specific differences, unique characteristics, and functional linkages of rumen microbiota and their metabolic pathways across different ruminant species remain poorly understood. To investigate these cross-species relationships, 16 Holstein cows,...
Subcallosal area 25 is one of the least understood regions of the anterior cingulate cortex, but activity in this area is emerging as a crucial correlate of mood and affective disorder symptomatology. The cortical and subcortical connectivity of area...
Maedi-Visna-like genotype A strains and Caprine arthritis encephaltis-like genotype B strains are small ruminant lentiviruses (SRLV) which, for incompletely understood reasons, appear to be more virulent in sheep and goats, respectively. A 9-month in...
Pseudorabies virus (PRV), a member of the Alphaherpesvirinae subfamily, poses a significant economic threat to the global swine industry and has raised growing public health concerns due to its cross-species transmission potential. Given emerging var...
Background/Objectives: Porcine circovirus type 2d (PCV2d) is the predominant genotype associated with porcine circovirus-associated disease (PCVAD), leading to significant economic losses. In South Korea, current vaccine lot-release testing relies on...
Unique skin microbial communities have been shaped by the harsh climatic conditions in high-altitude areas, such as intense ultraviolet radiation and low oxygen concentration. However, it is unknown whether high altitude contributes to shaping common...
The “experimenter gender effect” is a pervasive confound in rodent behavioral neuroscience: the sex of the human handler alters stress, social, and pharmacological responses via olfactory cues and conserved neural circuits. Whether this e...
Acute kidney injury, which is associated with high levels of morbidity and mortality, affects a significant number of individuals, and can be triggered by multiple factors, such as medications, exposure to toxic chemicals or other substances, disease...
Since the delivery of biologic drugs to the brain is greatly hampered by the existence of the blood–brain barrier (BBB), brain shuttles are being developed to enhance therapeutic efficacy. As we have previously shown, efficient and selective br...
Bryophytes possess a gene family repertoire substantially larger than vascular plants, yet the functional evolution of their transcription factors remains poorly understood. We conducted a nested analysis across 144 bryophyte genomes, cataloging 58 t...
Anthropogenic underground systems are challenging to monitor because restricted ventilation, particle retention, resuspension and spatial heterogeneity generate complex elemental patterns. We tested whether controlled active moss-bag biomonitoring su...
The H9 subtype of avian influenza virus (AIV) has been characterized by its rapid spread, wide range of prevalence, and continuous evolution in recent years, leading to an increasing ability for cross-species transmission. This not only severely impa...
The intestine is a tubular organ with multiple functions such as digestion absorption and immunity, but the functions of each intestinal segments are different. Intestinal regionalization is necessary for normal physiological function, but it also me...
Oocytes from women of advanced reproductive age exhibit diminished developmental potential, but the underlying mechanisms remain incompletely defined. Oocyte maturation depends on translational control of maternal mRNA synthesized during growth. We p...
Antineoplastic treatments for cancer and other non-malignant disorders can result in long-term or permanent male infertility by ablating spermatogonial stem cells (SSCs). SSC transplantation using testicular tissue harvested before a sterilizing trea...
Plant extracellular vesicles are non-self-replicating particles released by living plant cells and delimited by a lipid bilayer. They contain a large amount of lipids, RNA, and proteins. Seed vigor plays an important role in agricultural production a...
Volatile organic compounds produced by microbes are increasingly recognized as modulators of microbial interactions and mediators of both intra- and inter-kingdom communication. This study explored the possible ecophysiological roles of nine amides f...
Machine learning based predictions of protein–protein interactions (PPIs) could provide valuable insights into protein functions, disease occurrence, and therapy design on a large scale. The intensive feature engineering in most of these methods make...
Understanding the mechanism of chemical toxicity, which is essential for cross-species and dose extrapolations, is a major challenge for toxicologists. Standard mechanistic studies in animals for examining the toxic and pathological changes associate...
29 September 2019
Recent studies show evidence that human-dog companionship has healthy effects on humans. For example, findings demonstrate that owning a dog leads to a reduction in stress levels. Aspects that have not been taken into consideration so far are underly...
Objectives: Pharmacokinetic issues were the leading cause of drug attrition, accounting for approximately 40% of all cases before the turn of the century. To this end, several high-throughput in vitro assays like microsomal stability have been develo...
Ribulose-1,5-bisphosphate carboxylase/oxygenase (Rubisco) efficiency constrains carbon fixation, making it a high-value target in biotechnology. The core task of this work is a supervised regression and ranking problem on Rubisco: given a numerical r...
The emergence and global dissemination of pandrug-resistant (PDR) Acinetobacter baumannii represents a critical public health crisis. This One Health study provides comprehensive surveillance and molecular characterization of carbapenem-resistant, ex...
Heat coma temperatures (HCTs) and super cooling points (SCPs) were examined for nearly 1000 oceanic sea skaters collected from in the Pacific and Indian Oceans representing four Halobates species; H. germanus, H. micans, H. sericeus, and H. sp. Analy...
In the Serengeti ecosystem of East Africa, grazing ungulates prefer areas with elevated grass Na, suggesting that some grasses tolerate both high soil Na and defoliation. We performed a factorial Na-by-defoliation greenhouse study with five abundant...
The distribution of individuals of different species across different sampling units is typically non-random. This distributional non-independence can be interpreted and modelled as a correlated multivariate distribution. However, this correlation ca...
Crossing genetically distant forms is widely used in breeding programs and allows the introduction of beneficial features from the wild into cultivated species. In this study, agronomic traits of two F2 segregating populations derived from crosses in...
The forests of northern Mexico and the southwestern United States have been subjected to warmer temperatures, persistent drought, and more intense and widespread wildfire. Tree-ring data from four conifer species native to these borderlands forests a...
The accuracy of transport properties, essential to the characterization of technological plasmas of interest in many fields, relies on the fundamental information about the collision integrals for the binary interactions in the system. The phenomenol...
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