Special Issue "Ciliate: From Genomics to Signalling Systems"

A special issue of Microorganisms (ISSN 2076-2607).

Deadline for manuscript submissions: 30 November 2019

Special Issue Editors

Guest Editor
Prof. Dr. Cristina Miceli

School of Biosciences and Veterinary Medicine, University of Camerino, Via Gentile III da Varano, 62032 Camerino, Italy
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Interests: cell biology; protistology; genomics
Guest Editor
Prof. Dr. Adriana Vallesi

School of Biosciences and Veterinary Medicine, University of Camerino, Via Gentile III da Varano, 62032 Camerino, Italy
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Interests: zoology; cell biology; protistology

Special Issue Information

Dear Colleagues,

Ciliates represent a group of single-celled eukaryotes widespread in nature, living in all aquatic habitats, in soil, and as symbionts of animals. They are adapted to different conditions, from very cold to hot temperatures and from clean to polluted environments, and possess complex molecular systems for ciliary beating, as well as for self/non-self recognition, sexual phenomena, and predator–prey interactions. As a consequence, ciliates are able to manage different signals, which can be mainly classified in three categories: (i) intercellular signals, produced by other cells/organisms; (ii) environmental signals not produced by other organisms; and (iii) intracellular signals, produced inside the cell body to mediate the cell response.

Ciliates have two types of genome, the germline micronuclear genome active in conjugation and cell development, and the somatic macronuclear genome responsible for gene transcription during cell growth. While in the last 15 years macronuclear genomes of many species have been investigated and disclosed, the micronuclear genomes of a selected group of species are currently under investigation. Comparative genomics, together with the analysis of transcriptomic data, is going to provide essential information to understand the regulation of signalling systems and the transduction mechanisms in cells. Unraveling signalling systems in ciliates can provide important knowledge for understanding similar systems in higher eukaryotes. For instance, ciliates have shown to be very useful biological models to study evolution of calcium signalling. In addition, the hippo-signalling pathway, known to control the size of organs in animals, has been demonstrated to control cell polarity in ciliates and to specify the relative dimension of the anterior and posterior daughter cells during division. Protein pheromones, which control self-nonself recognition and mating in ciliates, are considered the evolutionary precursors of animal growth factors.

This Special Issue is open to all approaches and studies seeking to understand the complex mechanisms and evolution of signalling systems in ciliates, from the involved genes to the changes in gene expression during cell response, and from the structure and evolution of signal molecules to the membrane traffic in cells and changes in cell structure and organization.

Prof. Dr. Cristina Miceli
Prof. Dr. Adriana Vallesi
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Microorganisms is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1000 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Published Papers

This special issue is now open for submission.
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