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Special Issue "Ciliates as Model Organisms: From ‘omics’ to Genetics, Ecology and Signaling"
A special issue of Microorganisms (ISSN 2076-2607). This special issue belongs to the section "Environmental Microbiology".
Deadline for manuscript submissions: closed (30 November 2022) | Viewed by 25800
Special Issue Editors
Interests: cell biology; protistology; genomics
Interests: cell-cell communication; signaling proteins; bioactive molecules; cold-adaptation; oxidative stress; symbiosis; eukaryotic microbiology; ciliates
Interests: molecular biology; cell biology; genetics; biochemistry; genomics; proteomics; chromatin; epigenetics; gene expression; ciliates
Special Issue Information
Ciliates represent a group of unicellular eukaryotes widespread in nature, living in aquatic habitats, in soil, and as symbionts of animals. They are adapted to different conditions; from very cold to hot temperatures, and from clean to polluted environments, and possess complex molecular systems for many processes such as ciliary beating, for self-/non-self-recognition, sexual phenomena, and predator–prey interactions. To effect these processes, ciliates are able to manage different signals which can be classified in three categories: (i) intercellular signals produced by other cells/organisms; (ii) environmental signals not produced by other organisms; and (iii) intracellular signals produced inside the cell body.
Ciliates are nuclear dimorphic, with two types of genome in a common cytoplasm. The diploid small germline micronucleus (MIC) is mostly transcriptionally silent and the repository of genetic information. The polyploid large somatic macronucleus (MAC) is responsible for gene transcription during cell growth. In the last 15 years, MAC genomes of many species have been investigated and disclosed, and the MIC genomes of a selected group of species are also under investigation. Comparative genomics, together with the analysis of transcriptomic and proteomic data, provides essential information to understand genetics, cell biology, and ecology of ciliates. Unraveling signaling systems in ciliates can provide important knowledge for understanding similar systems in other eukaryotes, including multicellular organisms. For example, ciliates are very useful biological models to study processes such as the evolution of calcium signaling. In addition, the hippo-signaling pathway, known to control the size of organs in animals, has been demonstrated to control cell polarity in ciliates and to specify the relative dimensions of the anterior and posterior daughter cells during division. Protein pheromones, which control self-/non-self-recognition and mating in ciliates, are considered the evolutionary precursors of animal growth factors.
This Special Issue is open to reporting all studies on ciliates as model organisms, seeking to understand their genetics, cell biology, biochemistry, evolution, ecological adaptation, and the complex mechanisms of signaling systems, from the genes involved to the changes in gene expression during cell response, and from the structure and involved evolution of signal molecules to the membrane traffic in the cells.
We look forward to receiving your contributions.
Prof. Dr. Cristina Miceli
Prof. Dr. Adriana Vallesi
Dr. Ronald Edward Pearlman
Manuscript Submission Information
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Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2200 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.