Animal Diseases: Immune Response and Vaccines

A special issue of Vaccines (ISSN 2076-393X). This special issue belongs to the section "Veterinary Vaccines".

Deadline for manuscript submissions: 31 January 2025 | Viewed by 1449

Special Issue Editors


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Guest Editor
Centro de Investigación en Sanidad Animal (CISA), Instituto Nacional de Investigacion y Tecnologia Agraria y Alimentaria (INIA), Consejo Superior de Investigaciones Científicas (CSIC), Valdeolmos, Madrid, Spain
Interests: viral immunology; adenovirus-based vaccines; virus; recombinant adenoviruses; immune response; sheep; BTV; PPRV
Special Issues, Collections and Topics in MDPI journals

E-Mail Website
Guest Editor
Centro de Investigación en Sanidad Animal (CISA), Instituto Nacional de Investigacion y Tecnologia Agraria y Alimentaria, Consejo Superior de Investigaciones Científicas (CSIC), Valdeolmos, Madrid, Spain
Interests: immunology; vaccines; virus; immune response; sheep; BTV; PPRV

E-Mail Website
Guest Editor
Centro de Investigación en Sanidad Animal (CISA), Instituto Nacional de Investigacion y Tecnologia Agraria y Alimentaria, Consejo Superior de Investigaciones Científicas (CSIC), Valdeolmos, Madrid, Spain
Interests: ruminant viruses; viral immunology; adenovirus-based vaccines
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The immune response and the development of effective vaccines play a crucial role in combatting animal diseases, which pose a significant threat to the health of livestock and agricultural productivity. Understanding the intricacies of the immune response of animals that are susceptible to various infectious diseases caused by bacteria, viruses, and parasites is essential to the design and deployment of successful vaccination strategies.

The immune response involves a complex interplay of innate and adaptive immunity, each contributing to defense against pathogens. Innate immunity provides an immediate, non-specific defense mechanism, while adaptive immunity confers long-lasting protection by generating specific antibodies and memory cells. Vaccines harness the immune system's memory capacity to stimulate a controlled immune response and thus prepare the animal to mount a rapid and effective defense upon subsequent exposure to the pathogen.

We encourage the scientific community to contribute to this Special Issue, which explores the fundamental mechanisms underlying the immune response of animals and delves into the challenges and advances associated with the development of vaccines tailored to their specific needs. By enhancing our understanding of the immune response and optimizing vaccination strategies, we can significantly reduce the disease burden, enhance animal welfare, and support sustainable agriculture.

We are looking forward to receiving your manuscripts.

Dr. Verónica Martín
Dr. José M. Rojas
Dr. Noemí Sevilla
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Vaccines is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • immune responses
  • ruminants
  • vaccines
  • animal health

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Published Papers (1 paper)

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Research

12 pages, 1171 KiB  
Article
Changes in the Transcriptome Profile in Young Chickens after Infection with LaSota Newcastle Disease Virus
by Taina S. B. Lopes, Jannis Nankemann, Cassandra Breedlove, Andrea Pietruska, Raimundo Espejo, Camila Cuadrado and Ruediger Hauck
Vaccines 2024, 12(6), 592; https://doi.org/10.3390/vaccines12060592 - 30 May 2024
Viewed by 977
Abstract
Understanding gene expression changes in chicks after vaccination against Newcastle Disease (ND) can reveal vaccine biomarkers. There are limited data on chicks’ early immune response after ND vaccination. Two trials focused on this knowledge gap. In experiment one, 42 13-day-old specific-pathogen-free (SPF) chicks [...] Read more.
Understanding gene expression changes in chicks after vaccination against Newcastle Disease (ND) can reveal vaccine biomarkers. There are limited data on chicks’ early immune response after ND vaccination. Two trials focused on this knowledge gap. In experiment one, 42 13-day-old specific-pathogen-free (SPF) chicks were used. Harderian glands (Hgs) and tracheas (Tcs) from five birds per group were sampled at 12, 24, and 48 h post-vaccination (hpv) to evaluate the gene transcription levels by RNA sequencing (RNA-seq) and RT-qPCR. The results of RNA-seq were compared by glmFTest, while results of RT-qPCR were compared by t-test. With RNA-seq, a significant up-regulation of interferon-related genes along with JAK-STAT signaling pathway regulation was observed in the Hgs at 24 hpv. None of the differentially expressed genes (DEGs) identified by RNA-seq were positive for RT-qPCR. Experiment 2 used 112 SPF and commercial chickens that were 1 day old and 14 days old. Only the commercial birds had maternal antibodies for Newcastle Disease virus (NDV). By RNA-seq, 20 core DEGs associated with innate immunity and viral genome replication inhibition were identified. Genes previously unlinked to NDV response, such as USP41, were identified. This research present genes with potential as immunity biomarkers for vaccines, yet further investigation is needed to correlate the core gene expression with viral shedding post-vaccination. Full article
(This article belongs to the Special Issue Animal Diseases: Immune Response and Vaccines)
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