Special Issue "The Multi-Dimensional Contributions of Prefrontal Circuits to Emotion Regulation during Adulthood and Critical Stages of Development"
Deadline for manuscript submissions: closed (30 April 2019)
The prefrontal cortex (PFC) plays a pivotal role in regulating our emotions as shown by the marked alterations in activity within prefrontal circuits that accompany mood and anxiety disorders. The importance of ventromedial regions in emotion regulation, including the ventral sector of the medial PFC, the medial sector of the orbital cortex and subgenual cingulate cortex, have been recognized for a long time. However, it is increasingly apparent that lateral and dorsal regions of the PFC, as well as neighbouring dorsal anterior cingulate cortex, also play a role. Defining the underlying psychological mechanisms by which these functionally distinct regions modulate positive and negative emotions and the nature and extent of their interactions, is a critical step towards better stratification of the symptoms of mood and anxiety disorders, that will ultimately lead to more effective, individualised treatment strategies. Since many disorders of emotion regulation have their onset during childhood and adolescence it is also important to extend our understanding of these prefrontal circuits in development. Specifically, to determine whether they exhibit differential sensitivity to perturbations by known risk factors e.g. stress and inflammation, at distinct developmental epochs. This special issue aims to bring together the most recent research in humans and other animals that addresses these important issues and in doing so, to highlight the value of the translational approach.Prof. Angela Roberts
Manuscript Submission Information
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- Emotion regulation
- Prefrontal circuits
- Translational Neuroscience
- Developmental models of psychiatric symptoms