Intermittent Hypoxia and Physiological Effects: Interplay Between Oxidative Stress, Inflammation, and Autonomic Dysregulation
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Biology".
Deadline for manuscript submissions: 31 August 2026 | Viewed by 1052
Editors
2. Núcleo Interdisciplinario Fisiología, Biofísica y Fisiopatología, Instituto Ciencias Biomédicas, Facultad de Medicina, Universidad de Chile, Santiago, Chile
Interests: intermittent hypoxia; oxidative stress; animal models; cardiovascular function
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Intermittent hypoxia (IH) acts as a potent biological trigger, driving both adaptive and pathological outcomes depending on dosage and frequency. Using animal models, research demonstrates that IH disrupts the systemic oxidative balance, favoring the overproduction of reactive oxygen species (ROS) and subsequent mitochondrial dysfunction. Mechanistically, this redox imbalance activates pro-inflammatory pathways and autonomic dysregulation, mirroring physiological and clinical observations in cardiovascular disease.
IH could determine pro-inflammatory imbalances that act as a primary factor in tissue remodeling and trigger structural alterations across cardiovascular (hypertrophy), nervous (neuroinflammation), and renal (fibrosis) systems. Such remodeling underscores the transition from acute physiological adaptation to chronic systemic pathology. Understanding these molecular shifts—from oxidative injury to antioxidant defense—is crucial for developing targeted therapies that mitigate systemic damage and harness the therapeutic potential of hypoxic signaling.
Dr. Rodrigo L. Castillo
Guest Editor
Dr. Esteban G. Figueroa
Guest Editor Assistant
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Keywords
- intermittent hypoxia
- cardiovascular and pulmonary effects
- oxidative stress
- autonomic dysfunction
- neuroinflammation
- renal effects
- animal models
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