The anterior labral–ligamentous complex (ALLC), formed by the integration of the anterior inferior glenohumeral ligament and anterior glenoid labrum, plays a critical role in shoulder stability and represents a potential target for regenerative...
This study explored the effectiveness of gas injection for enhanced oil recovery (EOR) in fractured basement complex reservoirs, combining laboratory experiments with numerical simulation analyses. The experiments simulated typical field conditions,...
The structure-activity relationship of mono-ion complexes (MICs) for plasmid DNA (pDNA) delivery by muscular injection is demonstrated. MICs were formed between pDNA and monocationic poly(ethylene glycol) (PEG) macromolecules. As monocationic PEGs, t...
Background: Pediatric hard-to-heal wounds are rare but clinically demanding due to skin immaturity, comorbidities, and infection risk. Methods: This prospective case series evaluated the feasibility, safety, and clinical outcomes of an injectable hya...
Inferring the diffusion mechanisms in complex networks is of outstanding interest since it enables better prediction and control over information dissemination, rumors, innovation, and even infectious outbreaks. Designing strategies for influence max...
The intricate design of real complex injection molds poses significant challenges. Mold design validation often falls to operators with tool-handling experience but limited CAD proficiency. Unlike other industries, the scale and costs of injection mo...
Background/Objectives: This article presents a novel approach that combines the Palatal Silicone Key and Injection Molding techniques as a viable alternative for complex anterior cases with high esthetic demands, where layering multiple shades is ess...
In this study, the metal injection molding (MIM) process is applied to produce Ti-6Al-4V parts using blended and prealloyed powders, respectively. The feedstocks are prepared from a polyformaldehyde-based binder system with a powder loading of 60 vol...
In order to improve the effect of injection–production coupling development to improve crude oil recovery in complex fault-block reservoirs, we carried out a physical simulation experiment based on a sandpack model of transforming water-driven...
With the popularization of natural gas and the requirements for environmental protection, the development and utilization of natural gas is particularly important. The status of natural gas in China’s oil and gas exploration and development is...
We treated a 51-year-old woman with refractory Complex Regional Pain Syndrome type I (CRPS-I) involving her left hand and forearm with subcutaneous injections of BoNT/A. The injections were performed every 3 months, with a total of six treatments. Ea...
We describe a new method using flow-injection analysis with spectro-photometric detection, suitable for the determination of N-acetyl-L-cysteine (NAC). The proposed method is appropriate for the determination of NAC in reaction with Pd2+ ions in the...
The triangular fibrocartilage complex (TFCC) serves as the major stabilizer of the wrist. Its injuries can result from trauma or degeneration, both of which are strongly correlated with the loading stress on the ulnar shaft and carpal joints. The TFC...
The objective of this study was to evaluate physicochemical equivalence between brand (i.e., Ferrlecit) and generic sodium ferric gluconate (SFG) in sucrose injection by conducting a series of comparative in vitro characterizations using advanced ana...
We extend the theory of splits in finite metric spaces to infinite ones. Within this more general framework, we investigate the class of spaces having metrics that are integer-valued and totally split-decomposable, as well as the polyhedral complex s...
Electron transfer dynamics in dye sensitized solar cells (DSSCs) employing triphenylamine Y123 dye were investigated by means of femtosecond broadband transient absorption spectroscopy in the visible and mid-IR range of detection. The electron inject...
Eliminating warpage in injection molded polymeric parts is one of the most important problems in the injection molding industry today. This situation is critical in geometries that are particularly susceptible to warping due to their geometric featur...
Background: Genome editing at specific loci is an innovative therapeutic approach; however, it faces many challenges, so optimizing delivery vectors is essential to enhance the safety and efficacy of the CRISPR/Cas9 system. This study investigated wh...
During the cooling phase of injection molding, the conformal cooling channel system optimizes the uniformity of mold temperature, diminishes warping deformation, and contributes substantially to heightened product precision. The injection molding pro...
The present article introduces a dimensionless number devised to assist composite engineers in the fabrication of continuous fiber composites by Liquid Composite Molding (LCM), i.e., by injecting a liquid polymer resin through a fibrous reinforcement...
The dimensionless “injectability number” was devised to assist composite engineers in the fabrication of continuous fiber composites by Liquid Composite Molding (LCM), i.e., by injecting a liquid polymer resin through a fibrous reinforcem...
The formation of stable binary water-soluble sub-micellar aggregates of cetyltrimethylammonium bromide-copper-pyrocatechol violet complex (CTAB-Cu-PCV) diminishes the stability and absorbance of the Cu-PCV complex. A new flow injection spectrophotome...
The present paper proposes a framework for the systematic and fruitful application of complex-order operators for modeling and control applications. We emphasize that special care must be taken when using complex-order elements to ensure that their r...
In this article, construction of amperometric sensor(s) based on screen-printed carbon electrodes covered by thin layers of two types of carbon nanomaterials serving as amplifiers, and containing [Cu(bipy)2Cl]Cl∙5H2O complex is reported. Their perfor...
Poly(lactic-co-glycolic acid) (PLGA) is one of the preferred polymeric inactive ingredients for long-acting parenteral drug products that are constituted of complex formulations. Despite over 30 years of use, there are still many challenges faced by...
Complex open musculoskeletal wounds are a leading cause of morbidity worldwide, partially due to a high risk of bacterial contamination. Local delivery systems may be used as adjunctive therapies to prevent infection, but they may be nondegradable, p...
Background/Objectives: To design the pDNA delivery carrier for delivery into skeletal muscle, a total of twelve terminal-alkylated PEGs (Cx-I-PEGy) with four alkyl groups of different carbon numbers (Cx: x = 4, 8, 12, 16) modified via an imine spacer...
In order to enhance the development efficiency of thick and complex carbonate reservoirs in the Middle East, a case study was conducted on M oilfield in Iraq. This study focused on reservoir characterization, injection-production modes, well pattern...
In order to reveal the heat transfer mechanism of CO2 injection and extraction in the fracture network of geothermal reservoir rock, based on the assumption of a dual-media model and considering the characteristics of the rock matrix and the fracture...
Background: Treatments for androgenetic alopecia (AGA) include different drugs, but a treatment based on stabilized hyaluronic acid has not been tested. The aim of this study is to clinically evaluate the effect of six sessions of injections using a...
Injections of highly cytotoxic or immunomodulating drugs directly into the inoperable tumor is a procedure that is increasingly applied in the clinic and uses established Pt-based drugs. It is advantageous for less stable anticancer metal complexes t...
Iron deficiency anemia is a common clinical consequence for people who suffer from chronic kidney disease, especially those requiring dialysis. Intravenous (IV) iron therapy is a widely accepted safe and efficacious treatment for iron deficiency anem...
There is some evidence that injections of botulinum neurotoxin effectively reduce pain in complex regional pain syndromes (CRPSs). But no or little experience appears to exist for the application of incobotulinum neurotoxin type A (incoBoNT/A) in com...
Breast cancer is the second most common cancer in women worldwide. Long-term treatment with conventional chemotherapy may result in severe systemic side effects. Therefore, the localized delivery of chemotherapy helps to overcome such a problem. In t...
Relative biodistribution of FDA-approved innovator and generic sodium ferric gluconate (SFG) drug products was investigated to identify differences in tissue distribution of iron after intravenous dosing to rats. Three equal cohorts of 42 male Spragu...
Glioblastoma, an aggressive cancer, is difficult to treat due to its location, late detection, drug resistance, and poor absorption of chemotherapeutics. Intratumoral drug administration offers a promising potential treatment alternative with localiz...
Background/Objectives: Diabetic macular edema (DME) is a major cause of vision impairment in patients with diabetes mellitus, and intravitreal anti-vascular endothelial growth factor (anti-VEGF) therapy is widely used for its management. However, the...
Complex cyber–physical networks combine the prominent features of complex networks and cyber–physical systems (CPSs), and the interconnections between the cyber layer and physical layer usually pose significant impacts on its normal opera...
In this study, seven thermoresponsive methacrylate terpolymers with the same molar mass (MM) and composition but various architectures were successfully synthesized using group transfer polymerization (GTP). These terpolymers were based on tri(ethyle...
With the increasing research and development (R&D) difficulty of new molecular entities (NMEs), novel drug delivery systems (DDSs) are attracting widespread attention. This review investigated the current distribution of Food and Drug Administrat...
Long-acting injectable (LAI) formulations provide sustained drug release over an extended period ranging from weeks to several months to improve efficacy, safety, and compliance. Nevertheless, many challenges arise in the development and regulatory a...
As the interest in short-fiber reinforced polymer (SFRP) composites manufactured by injection molding increases, predicting the failure of SFRP structures becomes important. This study aims to systemize the prediction of failure of SFRP through mecha...
Background/Objectives: Ultrasound-guided transvaginal follicular aspiration is a central procedure in in vitro fertilisation (IVF), aiming to collect oocytes necessary for the success of assisted reproduction treatments. Follicular flushing, proposed...
The paper presents a new design of a triple hook-shaped conformal cooling channels for application in optical parts of great thickness, deep cores, and high dimensional and optical requirements. In these cases, the small dimensions of the core and th...
We characterize computer science as an interplay between two modes of reasoning: the Aristotelian (procedural) method and the Platonic (declarative) approach. We contend that Aristotelian, step-by-step thinking dominates in computer programming, whil...
Exploring engineering methods for increasing fracture network complexity is important for the development of unconventional oil and gas reservoirs. In this study, we conducted a series of fracturing experiments on naturally fractured volcanic samples...
Injection molding is one of the most widely adopted manufacturing methods in the plastics industry, owing to its high efficiency, design flexibility, and mass production capabilities. Throughout the development and application of Injection molding te...
Freeform injection moulding is a novel technology for powder injection moulding where a sacrificial 3D printed mould (i.e., a soft tooling) is used as an insert in the injection process. The use of 3D printed moulds enable a higher geometrical design...
Unstable water injection can effectively improve the recovery ratio of reservoirs with strong heterogeneity. However, the oil displacement mechanism and the determination method of unstable water injection parameters still need to be clarified, espec...
The complexity and the criticality of automotive electronic implanted systems are steadily advancing and that is especially the case for automotive software development. ISO 26262 describes requirements for the development process to confirm the safe...
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