Nanoparticle-Based Gene Delivery
A special issue of Pharmaceutics (ISSN 1999-4923). This special issue belongs to the section "Gene and Cell Therapy".
Deadline for manuscript submissions: 30 June 2025 | Viewed by 967
Special Issue Editors
Interests: drug delivery; gene delivery; nanomedicine; biomaterials
Special Issues, Collections and Topics in MDPI journals
Interests: drug delivery; gene delivery; nanomedicine; cancer research; biomaterials
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Gene therapy involves the introduction of exogenous genetic material into the cells in order to correct a specific inherited or acquired pathological condition. However, efficient delivery of the nucleic acids to the target cells is hampered by a number of extracellular and intracellular barriers which necessitates the use of a suitable gene delivery system. Over the last two decades, there has been a rapid increase in the development of gene therapy products and several new gene therapies have found their way to the market and/or received FDA approval such as Mipomersen (Kynamro®), Inotersen (Tegsedi®), patisiran (Onpattro®) and the mRNA based COVID and cancer vaccines. The fast growth of gene therapies is in part due to the introduction of various types of non-viral nanoparticle-based gene delivery systems most notably lipid-based and polymer-based systems. Compared to viral vectors, the nanoparticle based gene vectors are more versatile, safer (less immunogenic), easier to manufacture and scale up, and have much more potential for functionalization and targeting.
The focus of this issue of Pharmaceutics is novel nanoparticle-based gene delivery systems for highly efficient delivery of nucleic acid therapeutics to different organs and tissues. The scope of the issue covers every kind of nanoparticles made of polymers, lipids, peptides, proteins, metals, and hybrid systems for delivery of all kinds of therapeutic nucleic acids including pDNA, mRNA and oligonucleotides (ASOs, SSOs, siRNA, shRNA, miRNA).
Prof. Dr. Xiubo Zhao
Dr. Roja Hadianamrei
Guest Editors
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Keywords
- nanaoparticles
- gene delivery
- nucleic acids
- DNA
- RNA
- gene therapy
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