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  • Article
  • Open Access
10 Citations
7,329 Views
24 Pages

An ICN-Based IPFS High-Availability Architecture

  • Ruibin Zeng,
  • Jiali You,
  • Yang Li and
  • Rui Han

19 April 2022

The Interplanetary File System (IPFS), a new type of P2P file system, enables people to obtain data from other peer nodes in a distributed system without the need to establish a connection with a distant server. However, IPFS suffers from low resolut...

(This article belongs to the Special Issue 5G Wireless Communication Networks)
  • Article
  • Open Access
5 Citations
3,451 Views
30 Pages

Research on an On-Chain and Off-Chain Collaborative Storage Method Based on Blockchain and IPFS

  • Tianqi Zhu,
  • Yuxiang Huang,
  • Zhihong Liang,
  • Mingming Qin,
  • Ruicheng Niu,
  • Yuanyuan Ma and
  • Qi Feng

10 February 2026

Blockchain technology, with its characteristics of decentralization, immutability, auditability, and traceability, has gradually become a core infrastructure in the digital economy era, demonstrating great potential in fields such as finance, governm...

(This article belongs to the Section Cybersecurity)
  • Article
  • Open Access
48 Citations
9,489 Views
15 Pages

As the importance of vehicle data increases, it has become very important to safely store them. However, because onboard diagnostics scanners generally used to store vehicle data are IoT devices, security and capacity issues exist to store data safel...

(This article belongs to the Section Electrical and Autonomous Vehicles)
  • Article
  • Open Access
9 Citations
4,882 Views
15 Pages

26 October 2021

The current state of the web, which is dominated by centralized cloud services, raises several concerns regarding different aspects such as governance, privacy, surveillance, and security. A way to address these issues is to decentralize the platform...

(This article belongs to the Special Issue Advances in Blockchain Technology and Applications II)
  • Article
  • Open Access
3,717 Views
26 Pages

Hands-On Blockchain Teaching and Learning: Integrating IPFS and Oracles Through Open-Source Practical Use Cases

  • Gabriel Fernández-Blanco,
  • Pedro García-Cereijo,
  • Tiago M. Fernández-Caramés and
  • Paula Fraga-Lamas

16 September 2025

The growing frequency of cybersecurity incidents, coupled with the increasing significance of blockchain technology in today’s digital landscape, highlights the urgent need for enriched, hands-on educational programs within Computer Science and...

(This article belongs to the Section Technology Enhanced Education)
  • Technical Note
  • Open Access
58 Citations
8,192 Views
12 Pages

Blockchain Private File Storage-Sharing Method Based on IPFS

  • Peng Kang,
  • Wenzhong Yang and
  • Jiong Zheng

7 July 2022

Under the current national network environment, anyone can participate in publishing. As an important information resource, knowledge files reflect the workload of publishers. Moreover, high-quality knowledge files can promote the progress of society...

(This article belongs to the Special Issue Advances in Blockchain and Distributed Ledger Technology for Future Internet Models: Technologies, Trends, and Applications)
  • Article
  • Open Access
7 Citations
2,972 Views
23 Pages

A Blockchain and IPFS-Based Anticounterfeit Traceable Functionality of Car Insurance Claims System

  • Chin-Ling Chen,
  • Ying-Ming Zheng,
  • Der-Chen Huang,
  • Ling-Chun Liu and
  • Hsing-Chung Chen

2 December 2023

Due to frequent traffic accidents around the world, people often take out car insurance to mitigate their losses and receive compensation in a traffic accident. However, in the existing car insurance claims process, there are problems such as insuran...

(This article belongs to the Section Internet of Things)
  • Article
  • Open Access
53 Citations
6,252 Views
26 Pages

Enabling Trust and Security in Digital Twin Management: A Blockchain-Based Approach with Ethereum and IPFS

  • Austine Onwubiko,
  • Raman Singh,
  • Shahid Awan,
  • Zeeshan Pervez and
  • Naeem Ramzan

24 July 2023

The emergence of Industry 5.0 has highlighted the significance of information usage, processing, and data analysis when maintaining physical assets. This has enabled the creation of the Digital Twin (DT). Information about an asset is generated and c...

(This article belongs to the Section Sensors Development)
  • Article
  • Open Access
13 Citations
27,055 Views
30 Pages

3 April 2025

The secure and efficient storage and sharing of medical images have become increasingly important due to rising security threats and performance limitations in existing healthcare systems. Centralized systems struggle to provide adequate privacy, rap...

(This article belongs to the Section A: Computer Science)
  • Article
  • Open Access
416 Views
28 Pages

High-stakes online assessment produces suspicious-event records, yet storage placement and burst admission remain insufficiently characterized. This article presents a Kubernetes-deployed provenance pipeline integrating Hyperledger Fabric, IPFS, SHA-...

(This article belongs to the Section Computer Science & Engineering)
  • Article
  • Open Access
3 Citations
2,062 Views
20 Pages

A Cybersecurity Detection Platform Integrating IOTA DLT and IPFS for Vulnerability Management

  • Iuon-Chang Lin,
  • Jyun-Yan Ruan,
  • Ching-Chun Chang,
  • Chin-Chen Chang and
  • Chun-Tse Wang

In response to the Cybersecurity Law, organizations face numerous management and technical requirements. Detection techniques such as vulnerability scanning and penetration testing are employed to identify risks. Addressing these vulnerabilities dema...

(This article belongs to the Section Computer Science & Engineering)
  • Article
  • Open Access
144 Citations
13,802 Views
23 Pages

Hyperledger Healthchain: Patient-Centric IPFS-Based Storage of Health Records

  • Vinodhini Mani,
  • Prakash Manickam,
  • Youseef Alotaibi,
  • Saleh Alghamdi and
  • Osamah Ibrahim Khalaf

2 December 2021

Blockchain-based electronic health system growth is hindered by privacy, confidentiality, and security. By protecting against them, this research aims to develop cybersecurity measurement approaches to ensure the security and privacy of patient infor...

(This article belongs to the Special Issue Blockchain Based Electronic Healthcare Solution and Security)
  • Article
  • Open Access
330 Views
17 Pages

8 August 2026

IoT sensor deployments increasingly export measurement streams to edge gateways and content-addressed storage such as IPFS, but access control decisions must be enforced without disclosing sensor owner policies, requester attributes, or stale data ve...

(This article belongs to the Section Internet of Things)
  • Article
  • Open Access
54 Citations
17,403 Views
23 Pages

Closed-circuit television (CCTV) cameras and black boxes are indispensable for road safety and accident management. Visible highway surveillance cameras can promote safe driving habits while discouraging moving violations. According to CCTV laws, foo...

(This article belongs to the Special Issue Advancement in Blockchain Technology and Applications)
  • Feature Paper
  • Article
  • Open Access
53 Citations
9,896 Views
19 Pages

IPFS-Blockchain Smart Contracts Based Conceptual Framework to Reduce Certificate Frauds in the Academic Field

  • Shaik Arshiya Sultana,
  • Chiramdasu Rupa,
  • Ramanadham Pavana Malleswari and
  • Thippa Reddy Gadekallu

7 August 2023

In the digital age, ensuring the authenticity and security of academic certificates is a critical challenge faced by educational institutions, employers, and individuals alike. Traditional methods for verifying academic credentials are often cumberso...

  • Article
  • Open Access
4 Citations
3,936 Views
16 Pages

Trustworthy Users: Using IOTA and IPFS for Attribute Validation in CP-ABE and dCP-ABE Schemes

  • Aintzane Mosteiro-Sanchez,
  • Marc Barcelo,
  • Jasone Astorga and
  • Aitor Urbieta

10 March 2023

Attribute spoofing is a major security threat in information exchange solutions based on Ciphertext-Policy Attribute-Based-Encryption (CP-ABE) and distributed CP-ABE (dCP-ABE), which can compromise privacy and security. This threat occurs when an att...

(This article belongs to the Special Issue Blockchain for Next-Generation Internet of Things Applications)
  • Article
  • Open Access
425 Views
53 Pages

27 August 2026

Federated learning (FL) enables collaborative model training without centralizing raw training records, but it does not inherently provide verifiable model provenance, enforceable fairness policies, or auditable control over aggregation. This paper p...

(This article belongs to the Special Issue New Trends for Blockchain Technologies)
  • Article
  • Open Access
6 Citations
4,904 Views
13 Pages

Prostaglandin E2 (PGE2) and Roflumilast Involvement in IPF Progression

  • Noa Moshkovitz,
  • Gali Epstein Shochet and
  • David Shitrit

3 August 2023

The ECM propagates processes in idiopathic pulmonary fibrosis (IPF), leading to progressive lung scarring. We established an IPF-conditioned matrix (IPF-CM) system as a platform for testing drug candidates. Here, we tested the involvement of a PGE2 a...

(This article belongs to the Special Issue Advances in Lung Injury, Regeneration, and Fibrosis)
  • Review
  • Open Access
7 Citations
5,023 Views
28 Pages

Comorbidities’ Effect on IPF: Pathogenesis and Management

  • Andrea Salotti,
  • Maria Chianese,
  • Antonio Romallo,
  • Anna De Nes,
  • Darina Angoni,
  • Alessandra Galantino,
  • Maria Chernovsky,
  • Lucrezia Mondini,
  • Francesco Salton and
  • Barbara Ruaro
  • + 8 authors

In recent years, there has been a growing recognition within the medical community that idiopathic pulmonary fibrosis (IPF) cannot be effectively managed through a singular focus on the disease itself. Instead, a dual approach is essential, one that...

(This article belongs to the Section Molecular and Translational Medicine)
  • Article
  • Open Access
34 Citations
7,508 Views
37 Pages

Scheduling Charging of Electric Vehicles in a Secured Manner by Emphasizing Cost Minimization Using Blockchain Technology and IPFS

  • Muhammad Umar Javed,
  • Nadeem Javaid,
  • Abdulaziz Aldegheishem,
  • Nabil Alrajeh,
  • Muhammad Tahir and
  • Muhammad Ramzan

24 June 2020

In this work, Electric Vehicles (EVs) are charged using a new and improved charging mechanism called the Mobile-Vehicle-to-Vehicle (M2V) charging strategy. It is further compared with conventional Vehicle-to-Vehicle (V2V) and Grid-to-Vehicle (G2V) ch...

(This article belongs to the Special Issue Efficiency and Sustainability of the Distributed Renewable Hybrid Power Systems Based on the Energy Internet, Blockchain Technology and Smart Contracts)
  • Review
  • Open Access
21 Citations
8,775 Views
19 Pages

Highlights on Future Treatments of IPF: Clues and Pitfalls

  • Alessandro Libra,
  • Enrico Sciacca,
  • Giuseppe Muscato,
  • Gianluca Sambataro,
  • Lucia Spicuzza and
  • Carlo Vancheri

Idiopathic pulmonary fibrosis (IPF) is an interstitial lung disease characterized by irreversible scarring of lung tissue, leading to death. Despite recent advancements in understanding its pathophysiology, IPF remains elusive, and therapeutic option...

(This article belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
  • Article
  • Open Access
9 Citations
3,780 Views
11 Pages

Radiological and Physiological Predictors of IPF Mortality

  • Tomoo Kishaba,
  • Akiko Maeda,
  • Shoshin Yamazato,
  • Daijiro Nabeya,
  • Shin Yamashiro and
  • Hiroaki Nagano

18 October 2021

Background and Objectives: Idiopathic pulmonary fibrosis (IPF) has a variable clinical course, which ranges from being asymptomatic to progressive respiratory failure. The purpose of this study was to evaluate the novel clinical parameters of IPF pat...

(This article belongs to the Section Pulmonology)
  • Article
  • Open Access
33 Citations
5,514 Views
12 Pages

Extracellular Vesicle Surface Signatures in IPF Patients: A Multiplex Bead-Based Flow Cytometry Approach

  • Miriana d’Alessandro,
  • Piera Soccio,
  • Laura Bergantini,
  • Paolo Cameli,
  • Giulia Scioscia,
  • Maria Pia Foschino Barbaro,
  • Donato Lacedonia and
  • Elena Bargagli

28 April 2021

Background: Extracellular vesicles (EVs) are secreted by cells from their membrane within circulation and body fluids. Knowledge of the involvement of EVs in pathogenesis of lung diseases is increasing. The present study aimed to evaluate the express...

(This article belongs to the Special Issue 10th Anniversary of Cells—Advances in Cellular Pathology)
  • Article
  • Open Access
8 Citations
4,444 Views
15 Pages

Idiopathic pulmonary fibrosis (IPF) is a long-term condition with an unidentified cause, and currently there are no specific treatment options available. Alveolar epithelial type II cells (AT2) constitute a heterogeneous population crucial for secret...

(This article belongs to the Special Issue Machine Learning Applications in Bioinformatics and Biomedicine: 2nd Edition)
  • Article
  • Open Access
11 Citations
5,123 Views
26 Pages

BAL Proteomic Signature of Lung Adenocarcinoma in IPF Patients and Its Transposition in Serum Samples for Less Invasive Diagnostic Procedures

  • Lorenza Vantaggiato,
  • Enxhi Shaba,
  • Paolo Cameli,
  • Laura Bergantini,
  • Miriana d’Alessandro,
  • Alfonso Carleo,
  • Giusy Montuori,
  • Luca Bini,
  • Elena Bargagli and
  • Claudia Landi

Idiopathic pulmonary fibrosis (IPF) is a form of chronic and irreversible fibrosing interstitial pneumonia of unknown etiology. Although antifibrotic treatments have shown a reduction of lung function decline and a slow disease progression, IPF is ch...

(This article belongs to the Special Issue Molecular and Cellular Mechanisms of Idiopathic Pulmonary Fibrosis and Interstitial Lung Diseases)
  • Article
  • Open Access
23 Citations
3,813 Views
27 Pages

Incentive EMR Sharing System Based on Consortium Blockchain and IPFS

  • Wanbing Zhan,
  • Chin-Ling Chen,
  • Wei Weng,
  • Woei-Jiunn Tsaur,
  • Zi-Yi Lim and
  • Yong-Yuan Deng

22 September 2022

Electronic medical records (EMRs) are extremely private data in the medical industry. Clinicians use the patient data that the EMR stores to quickly assess a patient’s status and save diagnostic information. In the conventional medical model, i...

(This article belongs to the Section Healthcare Quality, Patient Safety, and Self-care Management)
  • Article
  • Open Access
9 Citations
1,977 Views
18 Pages

Pulmonary Hypertension Drives Prognosis in Idiopathic Pulmonary Fibrosis: Insights from the European IPF Registry

  • Andreas Guenther,
  • Silke Tello,
  • Marc Carre Schoppe,
  • Joern Pons-Kuehnemann,
  • Werner Seeger,
  • Johannes Stiben,
  • Khodr Tello,
  • Maria Molina Molina,
  • Carlo Vancheri and
  • Ekaterina Krauss
  • + 1 author

17 October 2025

Background/Objectives: In patients with idiopathic pulmonary fibrosis (IPF), a progressive disease characterized by lung tissue scarring, the impact of comorbidities is only partially understood. In particular, the prognostic implications of pulmonar...

(This article belongs to the Special Issue Advances in Pulmonary Hypertension and Idiopathic Pulmonary Fibrosis)
  • Review
  • Open Access
10 Citations
5,555 Views
12 Pages

Imaging Review of the Lung Parenchymal Complications in Patients with IPF

  • Elisa Baratella,
  • Ilaria Fiorese,
  • Cristina Marrocchio,
  • Francesco Salton and
  • Maria Assunta Cova

20 September 2019

Idiopathic pulmonary fibrosis (IPF) is a chronic, pulmonary-limited, interstitial lung disease with a poor prognosis. This condition is characterized by different clinical scenarios, ranging from the most typical slow and progressive deterioration of...

(This article belongs to the Special Issue Idiopathic Pulmonary Fibrosis Research)
  • Review
  • Open Access
150 Citations
21,917 Views
18 Pages

Regeneration or Repair? The Role of Alveolar Epithelial Cells in the Pathogenesis of Idiopathic Pulmonary Fibrosis (IPF)

  • Paola Confalonieri,
  • Maria Concetta Volpe,
  • Justin Jacob,
  • Serena Maiocchi,
  • Francesco Salton,
  • Barbara Ruaro,
  • Marco Confalonieri and
  • Luca Braga

30 June 2022

Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive interstitial lung disease (ILD) with unknown etiology in which gradual fibrotic scarring of the lungs leads to usual interstitial pneumonia (UIP) and, ultimately, to death. IPF affects thr...

(This article belongs to the Special Issue Epithelial Cells Role in Lung Diseases)
  • Article
  • Open Access
7 Citations
3,666 Views
22 Pages

Differential Transcriptomic Signatures of Small Airway Cell Cultures Derived from IPF and COVID-19-Induced Exacerbation of Interstitial Lung Disease

  • Katie Uhl,
  • Shreya Paithankar,
  • Dmitry Leshchiner,
  • Tara E. Jager,
  • Mohamed Abdelgied,
  • Bhavna Dixit,
  • Raya Marashdeh,
  • Dewen Luo-Li,
  • Kaylie Tripp and
  • Xiaopeng Li
  • + 9 authors

21 October 2023

Idiopathic pulmonary fibrosis (IPF) is a pathological condition wherein lung injury precipitates the deposition of scar tissue, ultimately leading to a decline in pulmonary function. Existing research indicates a notable exacerbation in the clinical...

  • Article
  • Open Access
12 Citations
3,452 Views
14 Pages

Adipose-Derived Mesenchymal Stem Cells (ADSCs) Have Anti-Fibrotic Effects on Lung Fibroblasts from Idiopathic Pulmonary Fibrosis (IPF) Patients

  • Noriko Ouji-Sageshima,
  • Aiko Hiyama,
  • Makiko Kumamoto,
  • Masahiro Kitabatake,
  • Atsushi Hara,
  • Ryutaro Furukawa,
  • Shigeto Hontsu,
  • Takeshi Kawaguchi,
  • Noriyoshi Sawabata and
  • Toshihiro Ito
  • + 1 author

12 December 2024

Idiopathic pulmonary fibrosis (IPF) is the most common type of fibrosis in lungs, characterized as a chronic and progressive interstitial lung disease involving pathological findings of fibrosis with a median survival of 3 years. Despite the knowledg...

(This article belongs to the Section Stem Cells)
  • Article
  • Open Access
2 Citations
3,703 Views
14 Pages

Differences in Treatment Response in Bronchial Epithelial Cells from Idiopathic Pulmonary Fibrosis (IPF) Patients: A First Step towards Personalized Medicine?

  • C. Veith,
  • M. A. Schneider,
  • L. Maas,
  • A. van der Vliet,
  • F. J. van Schooten,
  • M. Kreuter,
  • M. Meister,
  • A. W. Boots and
  • N. Kahn

10 February 2023

Idiopathic pulmonary fibrosis (IPF) has a detrimental prognosis despite antifibrotic therapies to which individual responses vary. IPF pathology is associated with oxidative stress, inflammation and increased activation of SRC family kinases (SFK). T...

(This article belongs to the Special Issue Redox Regulation in Pulmonary Diseases)
  • Article
  • Open Access
11 Citations
3,934 Views
18 Pages

Evaluation of Regional Pulmonary Ventilation in Spontaneously Breathing Patients with Idiopathic Pulmonary Fibrosis (IPF) Employing Electrical Impedance Tomography (EIT): A Pilot Study from the European IPF Registry (eurIPFreg)

  • Ekaterina Krauss,
  • Daniel van der Beck,
  • Isabel Schmalz,
  • Jochen Wilhelm,
  • Silke Tello,
  • Ruth C. Dartsch,
  • Poornima Mahavadi,
  • Martina Korfei,
  • Eckhard Teschner and
  • Andreas Guenther
  • + 1 author

7 January 2021

Objectives: In idiopathic pulmonary fibrosis (IPF), alterations in the pulmonary surfactant system result in an increased alveolar surface tension and favor repetitive alveolar collapse. This study aimed to assess the usefulness of electrical impedan...

(This article belongs to the Special Issue The New Perspective in Pulmonary Fibrosis)
  • Article
  • Open Access
19 Citations
4,897 Views
16 Pages

Exhalative Breath Markers Do Not Offer for Diagnosis of Interstitial Lung Diseases: Data from the European IPF Registry (eurIPFreg) and Biobank

  • Ekaterina Krauss,
  • Maike Froehler,
  • Maria Degen,
  • Poornima Mahavadi,
  • Ruth C. Dartsch,
  • Martina Korfei,
  • Clemens Ruppert,
  • Werner Seeger and
  • Andreas Guenther

Background: New biomarkers are urgently needed to facilitate diagnosis in Interstitial Lung Diseases (ILD), thus reducing the need for invasive procedures, and to enable tailoring and monitoring of medical treatment. Methods: In this study we investi...

(This article belongs to the Special Issue The New Frontier in Pulmonary Fibrosis)
  • Article
  • Open Access
5 Citations
6,199 Views
15 Pages

Exogenous Thymosin Beta 4 Suppresses IPF-Lung Cancer in Mice: Possibly Associated with Its Inhibitory Effect on the JAK2/STAT3 Signaling Pathway

  • Rui Yu,
  • Dandi Gao,
  • Jiali Bao,
  • Ronghao Sun,
  • Mengqi Cui,
  • Yunyun Mao,
  • Kai Li,
  • Enbo Hu,
  • Yanfang Zhai and
  • Junjie Xu
  • + 5 authors

14 February 2023

Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive, fibrotic interstitial lung disease of unknown etiology. At present, the mortality rate of the deadly disease is still very high, while the existing treatments only delay the progression o...

(This article belongs to the Special Issue Cytotoxicity, Antioxidant and Anticancer Activity of Natural Products)
  • Article
  • Open Access
6 Citations
2,923 Views
11 Pages

Radiological Assessment in Idiopathic Pulmonary Fibrosis (IPF) Patients According to MUC5B Polymorphism

  • Elisabetta Cocconcelli,
  • Nicol Bernardinello,
  • Chiara Giraudo,
  • Gioele Castelli,
  • Clorinda Greco,
  • Roberta Polverosi,
  • Marina Saetta,
  • Paolo Spagnolo and
  • Elisabetta Balestro

14 December 2022

The MUC5B rs35705950 mutant T allele is the strongest genetic risk factor for familial and sporadic IPF. We sought to determine whether MUC5B genotype influences radiological patterns of IPF at diagnosis, as well as their change over time, in patient...

(This article belongs to the Special Issue Molecular and Cellular Mechanisms of Idiopathic Pulmonary Fibrosis and Interstitial Lung Diseases)
  • Article
  • Open Access
6 Citations
3,007 Views
18 Pages

Cell-Specific Response of NSIP- and IPF-Derived Fibroblasts to the Modification of the Elasticity, Biological Properties, and 3D Architecture of the Substrate

  • Natalia Janiszewska,
  • Barbara Orzechowska,
  • Kamil Awsiuk,
  • Jakub Rysz,
  • Svitlana Tymetska and
  • Joanna Raczkowska

25 November 2022

The fibrotic fibroblasts derived from idiopathic pulmonary fibrosis (IPF) and nonspecific interstitial pneumonia (NSIP) are surrounded by specific environments, characterized by increased stiffness, aberrant extracellular matrix (ECM) composition, an...

(This article belongs to the Special Issue Molecular and Cellular Mechanisms of Idiopathic Pulmonary Fibrosis and Interstitial Lung Diseases)
  • Review
  • Open Access
67 Citations
10,510 Views
13 Pages

Mitochondrial Quality Control in COPD and IPF

  • Hiromichi Hara,
  • Kazuyoshi Kuwano and
  • Jun Araya

24 July 2018

Mitochondria play important roles in the maintenance of intracellular homeostasis; hence, the quality control of mitochondria is crucial for cell fate determination. Mitochondria dynamics and mitochondria-specific autophagy, known as mitophagy, are t...

(This article belongs to the Special Issue Mitochondrial Biology in Health and Disease)
  • Article
  • Open Access
7 Citations
4,420 Views
11 Pages

Quantitative Evaluation of Fibrosis in IPF Patients: Meaning of Diffuse Pulmonary Ossification

  • Monica Palermo,
  • Francesco Tiralongo,
  • Giulio Distefano,
  • Ada Vancheri,
  • Mauro Giuffrè,
  • Fabio Pino,
  • Pietro Valerio Foti,
  • Gianluca Sambataro,
  • Carlo Vancheri and
  • Antonio Basile
  • + 1 author

To investigate the role of diffuse pulmonary ossification (DPO) in disease severity in a population of Idiopathic Pulmonary Fibrosis (IPF) patients. This retrospective study was carried out on 95 IPF patients—44 with DPO on high resolution comp...

(This article belongs to the Special Issue Clinical and Radiological Features of Interstitial Lung Diseases 2.0)
  • Review
  • Open Access
6 Citations
1,299 Views
4 Pages

29 December 2017

In this article the co-existence of pulmonary emphysema with lung fibrosis of typical pattern and distribution for usual interstitial pneumonia (UIP) was compared with idiopathic pulmonary fibrosis (IPF) alone. Author discusses the etiopathogenesis o...

  • Article
  • Open Access
7 Citations
5,399 Views
12 Pages

Angiotensin-Converting Enzyme 2 (ACE2), Transmembrane Peptidase Serine 2 (TMPRSS2), and Furin Expression Increases in the Lungs of Patients with Idiopathic Pulmonary Fibrosis (IPF) and Lymphangioleiomyomatosis (LAM): Implications for SARS-CoV-2 (COVID-19) Infections

  • Wenying Lu,
  • Mathew Suji Eapen,
  • Gurpreet Kaur Singhera,
  • James Markos,
  • Greg Haug,
  • Collin Chia,
  • Josie Larby,
  • Samuel James Brake,
  • Glen P. Westall and
  • Sukhwinder Singh Sohal
  • + 5 authors

31 January 2022

We previously reported higher ACE2 levels in smokers and patients with COPD. The current study investigates if patients with interstitial lung diseases (ILDs) such as IPF and LAM have elevated ACE2, TMPRSS2, and Furin levels, increasing their risk fo...

(This article belongs to the Special Issue 10th Anniversary of JCM— Pathophysiological Mechanisms, Diagnostics for Lung Diseases, and Therapeutic Modalities)
  • Article
  • Open Access
1 Citations
2,595 Views
16 Pages

Caveolin Scaffolding Domain (CSD) Peptide LTI-2355 Modulates the Phagocytic and Synthetic Activity of Lung-Derived Myeloid Cells in Idiopathic Pulmonary Fibrosis (IPF) and Post-Acute Sequelae of COVID Fibrosis (PASC-F)

  • Brecht Creyns,
  • BreAnne MacKenzie,
  • Yago Amigo Pinho Jannini Sa,
  • Ana Lucia Coelho,
  • Dale Christensen,
  • Tanyalak Parimon,
  • Brian Windsor and
  • Cory M. Hogaboam

Rationale: The role of the innate immune system in idiopathic pulmonary fibrosis (IPF) remains poorly understood. However, a functional myeloid compartment is required to remove dying cells and cellular debris, as well as to mediate innate immune res...

(This article belongs to the Special Issue The Molecular Basis of the Immune Response in Pulmonary Fibrosis)
  • Communication
  • Open Access
4 Citations
2,997 Views
11 Pages

Ischemia-Modified Albumin (IMA) Is Associated with Poor Survival in Patients with Newly Diagnosed Idiopathic Pulmonary Fibrosis (IPF): A Pilot Study

  • Angelo Zinellu,
  • Stefano Zoroddu,
  • Simona Fois,
  • Sabrina Mellino,
  • Chiara Scala,
  • Erika Virdis,
  • Elisabetta Zinellu,
  • Salvatore Sotgia,
  • Panagiotis Paliogiannis and
  • Alessandro G. Fois
  • + 3 authors

25 February 2024

There are increasing efforts to better predict adverse outcomes for idiopathic pulmonary fibrosis (IPF). Our aim was to assess the prognostic potential of ischemia-modified albumin (IMA), an established circulating marker of ischemia and, more recent...

(This article belongs to the Special Issue Oxidative Stress in Respiratory Diseases)
  • Article
  • Open Access
17 Citations
4,186 Views
19 Pages

Assessing the Effectiveness of Pirfenidone in Idiopathic Pulmonary Fibrosis: Long-Term, Real-World Data from European IPF Registry (eurIPFreg)

  • Ekaterina Krauss,
  • Silke Tello,
  • Jochen Wilhelm,
  • Johanna Schmidt,
  • Mark Stoehr,
  • Werner Seeger,
  • Ruth C. Dartsch,
  • Bruno Crestani and
  • Andreas Guenther

22 November 2020

Background: Idiopathic pulmonary fibrosis (IPF) is a chronic progressive fibrotic pulmonary disease with rising incidence. In this study the effectiveness of pirfenidone, as measured by longitudinal change in individual slope of forced vital capacity...

(This article belongs to the Section Respiratory Medicine)
  • Article
  • Open Access
5 Citations
3,968 Views
23 Pages

Discrimination between NSIP- and IPF-Derived Fibroblasts Based on Multi-Parameter Characterization of Their Growth, Morphology and Physic-Chemical Properties

  • Barbara Orzechowska,
  • Kamil Awsiuk,
  • Dawid Wnuk,
  • Joanna Pabijan,
  • Tomasz Stachura,
  • Jerzy Soja,
  • Krzysztof Sładek and
  • Joanna Raczkowska

15 February 2022

Background: The aim of the research presented here was to find a set of parameters enabling discrimination between three types of fibroblasts, i.e., healthy ones and those derived from two disorders mimicking each other: idiopathic pulmonary fibrosis...

(This article belongs to the Special Issue Fibroblasts in Health and Disease)
  • Article
  • Open Access
15 Citations
4,207 Views
21 Pages

8 June 2024

This study examines the issues of privacy protection, data security, and query efficiency in blockchain-based electronic medical record (EMR) sharing. It proposes a secure storage and sharing scheme for EMR based on Hyperledger Fabric and the InterPl...

(This article belongs to the Special Issue Advanced Technologies in Data and Information Security III)
  • Article
  • Open Access
33 Citations
4,628 Views
13 Pages

16 October 2019

Background: There is an increasing interest in employing electronic nose technology in the diagnosis and monitoring of lung diseases. Interstitial lung diseases (ILD) are challenging in regard to setting an accurate diagnosis in a timely manner. Thus...

(This article belongs to the Special Issue The New Frontier in Pulmonary Fibrosis)
  • Article
  • Open Access
493 Views
22 Pages

18 June 2026

Building information modeling (BIM)-based collaborative design can support sustainable construction, but current workflows often transmit complete models even when minor changes have been made and rely on centrally controlled records. This study prop...

(This article belongs to the Special Issue Advancing Sustainable Construction Through BIM Adoption: Innovations, Challenges, and Opportunities)
  • Review
  • Open Access
846 Views
5 Pages

21 May 2018

W artykule porównano rozedmę płuc współistniejącą z włóknieniem płuc o typie zwykłego śródmiąższowego zapalenia płuc (CPFE) z samoistnym włóknieniem płuc (IPF). Przedyskutowano różnice w etiopatogenezie, odmienności przewodzenia sygnałów na poziomie...

  • Article
  • Open Access
60 Citations
14,432 Views
43 Pages

Addressing the Challenges of Electronic Health Records Using Blockchain and IPFS

  • Iris Cathrina Abacan Pilares,
  • Sami Azam,
  • Serkan Akbulut,
  • Mirjam Jonkman and
  • Bharanidharan Shanmugam

26 May 2022

Electronic Health Records (EHR) are the healthcare sector’s core digital strategy meant to improve the quality of care provided to patients. Despite the benefits afforded by this digital transformation initiative, adoption among healthcare orga...

(This article belongs to the Section Internet of Things)

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