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Antioxidants
Volume 13
Issue 3
10.3390/antiox13030278
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Communication

Ischemia-Modified Albumin (IMA) Is Associated with Poor Survival in Patients with Newly Diagnosed Idiopathic Pulmonary Fibrosis (IPF): A Pilot Study

by
Angelo Zinellu
1,*,
Stefano Zoroddu
1,
Simona Fois
2,3,
Sabrina Mellino
1,
Chiara Scala
2,3,
Erika Virdis
2,3,
Elisabetta Zinellu
2,
Salvatore Sotgia
1,
Panagiotis Paliogiannis
3,
Arduino A. Mangoni
4,5,
Ciriaco Carru
1,
Pietro Pirina
2,3 and
Alessandro G. Fois
2,3,*
1
Department of Biomedical Sciences, University of Sassari, 07100 Sassari, Italy
2
Department of Respiratory Diseases, University Hospital Sassari (AOU), 07100 Sassari, Italy
3
Department of Medicine, Surgery and Pharmacy, University of Sassari, 07100 Sassari, Italy
4
Discipline of Clinical Pharmacology, College of Medicine and Public Health, Flinders University, Bedford Park, SA 5042, Australia
5
Department of Clinical Pharmacology, Flinders Medical Centre, Southern Adelaide Local Health Network, Bedford Park, SA 5042, Australia
*
Authors to whom correspondence should be addressed.
Antioxidants 2024, 13(3), 278; https://doi.org/10.3390/antiox13030278
Submission received: 16 January 2024 / Revised: 23 February 2024 / Accepted: 23 February 2024 / Published: 25 February 2024
(This article belongs to the Special Issue Oxidative Stress in Respiratory Diseases)
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Abstract

There are increasing efforts to better predict adverse outcomes for idiopathic pulmonary fibrosis (IPF). Our aim was to assess the prognostic potential of ischemia-modified albumin (IMA), an established circulating marker of ischemia and, more recently, oxidative stress, in a cohort of 56 IPF patients recruited between 2015 and 2023 at the University of Sassari, Italy. Demographic and functional parameters and serum IMA concentrations were measured at baseline. Non-survivors had significantly higher IMA concentrations vs. survivors (508 ± 64 vs. 474 ± 42 mABSU, respectively; p = 0.035). The Kaplan–Meier analysis showed a significant association between higher IMA values and poor survival (HR: 3.32, 95% CI from 1.06 to 10.4, p = 0.039). In the Cox regression analysis, this association remained significant after adjusting for the force expiratory volume at 1 s, the total lung capacity, lymphocyte count, and pharmacological treatment (HR: 1.0154, 95% CI from 1.0035 to 1.0275, p = 0.01). IMA, an oxidative stress biomarker measurable using relatively simple and available methods, is independently associated with mortality in IPF. Therefore, its determination may enhance risk stratification and treatment decisions. Prospective studies involving larger cohorts are needed to confirm this association and to endorse the use of IMA in routine practice.
Keywords: ACB test; IMA; IPF; survival ACB test; IMA; IPF; survival

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MDPI and ACS Style

Zinellu, A.; Zoroddu, S.; Fois, S.; Mellino, S.; Scala, C.; Virdis, E.; Zinellu, E.; Sotgia, S.; Paliogiannis, P.; Mangoni, A.A.; et al. Ischemia-Modified Albumin (IMA) Is Associated with Poor Survival in Patients with Newly Diagnosed Idiopathic Pulmonary Fibrosis (IPF): A Pilot Study. Antioxidants 2024, 13, 278. https://doi.org/10.3390/antiox13030278

AMA Style

Zinellu A, Zoroddu S, Fois S, Mellino S, Scala C, Virdis E, Zinellu E, Sotgia S, Paliogiannis P, Mangoni AA, et al. Ischemia-Modified Albumin (IMA) Is Associated with Poor Survival in Patients with Newly Diagnosed Idiopathic Pulmonary Fibrosis (IPF): A Pilot Study. Antioxidants. 2024; 13(3):278. https://doi.org/10.3390/antiox13030278

Chicago/Turabian Style

Zinellu, Angelo, Stefano Zoroddu, Simona Fois, Sabrina Mellino, Chiara Scala, Erika Virdis, Elisabetta Zinellu, Salvatore Sotgia, Panagiotis Paliogiannis, Arduino A. Mangoni, and et al. 2024. "Ischemia-Modified Albumin (IMA) Is Associated with Poor Survival in Patients with Newly Diagnosed Idiopathic Pulmonary Fibrosis (IPF): A Pilot Study" Antioxidants 13, no. 3: 278. https://doi.org/10.3390/antiox13030278

APA Style

Zinellu, A., Zoroddu, S., Fois, S., Mellino, S., Scala, C., Virdis, E., Zinellu, E., Sotgia, S., Paliogiannis, P., Mangoni, A. A., Carru, C., Pirina, P., & Fois, A. G. (2024). Ischemia-Modified Albumin (IMA) Is Associated with Poor Survival in Patients with Newly Diagnosed Idiopathic Pulmonary Fibrosis (IPF): A Pilot Study. Antioxidants, 13(3), 278. https://doi.org/10.3390/antiox13030278

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